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1. 发明授权

US07394592B2 Confocal microscope for imaging of selected locations of the body of a patient 有权
标题翻译：共焦显微镜，用于对患者身体的选定位置进行成像
公开(公告)号：US07394592B2
公开(公告)日：2008-07-01
申请号：US10557461
申请日：2004-05-20
申请人： William J. Fox , Christopher C. DiStasio , Scott R. Grodevant
发明人： William J. Fox , Christopher C. DiStasio , Scott R. Grodevant
IPC分类号： G02B21/00
CPC分类号： G02B21/0048 , A61B5/0064 , A61B5/0068 , A61B5/6835 , G02B21/0012 , G02B21/0028 , G02B21/008 , G02B21/362
摘要： A confocal imaging microscope, especially for the cellular imaging of the skin at selected locations. An imaging head (28) is gimble mounted on a multi-axis compound arm (34) to allow for precise placement of a confocal objective (116) extending from the head at selected locations against the skin of the patient. The arm (34) attaches the head to an upright station (10) which may be movable along the floor on which the station is disposed. The station (10) has a platform (16) on which a keyboard (24) and a display (22) for monitoring the images is supported. The head (28) contains an integrated assembly of the optical and mechanical components of the microscope, which control scanning and may also control fine positioning of the locations being imaged. The head (28) is detachable from the arm for manual disposition.
摘要翻译：共焦成像显微镜，特别适用于选定位置的皮肤细胞成像。成像头（28）被安装在多轴复合臂（34）上，以允许在选定位置处从头部延伸的共焦物镜（116）精确地放置在患者皮肤上。臂（34）将头部附接到直立站（10），其可以沿着设置站的地板移动。站（10）具有平台（16），支撑用于监视图像的键盘（24）和显示器（22）。头部（28）包含显微镜的光学和机械部件的集成组件，其控制扫描并且还可以控制被成像位置的精细定位。头部（28）可从手臂上拆下来进行手动配置。

2. 发明授权

US07859749B2 Confocal microscope for imaging of selected locations of the body of a patient 有权
标题翻译：共焦显微镜，用于对患者身体的选定位置进行成像
公开(公告)号：US07859749B2
公开(公告)日：2010-12-28
申请号：US12154981
申请日：2008-05-29
申请人： William J. Fox , Christopher C. DiStasio , Scott R. Grodevant
发明人： William J. Fox , Christopher C. DiStasio , Scott R. Grodevant
IPC分类号： G02B21/00
CPC分类号： G02B21/0048 , A61B5/0064 , A61B5/0068 , A61B5/6835 , G02B21/0012 , G02B21/0028 , G02B21/008 , G02B21/362
摘要： A confocal imaging microscope, especially for the cellular imaging of the skin at selected locations, is ergonomic in use, compact, and positionable at the locations thereby providing for patient comfort during imaging. The head (28) contains an integrated assembly of the optical and mechanical components of the microscope. The assembly includes a main chassis plate (82). The optical components are mounted principally on one side of the plate while a PC board (130) is mounted on the opposite side of the plate. The board (130) mounts the electronic components, including interfaces, a microprocessor (222), and drivers (206, 208, 210) for motors (105, 106, 108) which control scanning and may also control fine positioning of the locations being imaged. The head (28) is detachable from the arm for manual disposition which is useful when imaging, not only the skin but other tissues, especially for research in investigating living processes at the cellular level.
摘要翻译：共焦成像显微镜，特别是用于在选定位置处的皮肤的细胞成像，其在使用中是人体工程学的，紧凑的和可定位的，从而在成像期间提供患者的舒适度。头部（28）包含显微镜的光学和机械部件的集成组件。组件包括主底盘（82）。光学部件主要安装在板的一侧，而PC板（130）安装在板的相对侧上。板（130）安装包括接口的电子部件，微处理器（222）和用于控制扫描的电动机（105,106,108）的驱动器（206,208,210），并且还可以控制位置的精细定位成像。头部（28）可从手臂上拆卸，用于手动配置，这对于成像不仅皮肤而且其它组织尤其是用于调查细胞水平的生物过程的研究是有用的。

3. 发明申请

US20090097108A1 Confocal scanning microscope having optical and scanning systems which provide a handheld imaging head 有权
标题翻译：共焦扫描显微镜具有提供手持成像头的光学和扫描系统
公开(公告)号：US20090097108A1
公开(公告)日：2009-04-16
申请号：US11920195
申请日：2006-05-12
申请人： William J. Fox , Scott R. Grodevant , Christopher C. Distasio
发明人： William J. Fox , Scott R. Grodevant , Christopher C. Distasio
IPC分类号： G02B21/06
CPC分类号： A61B5/0068 , A61B5/0062 , A61B5/0064 , A61B5/445 , A61B90/20 , G02B5/3083 , G02B21/0008 , G02B21/0028 , G02B21/0048 , G02B21/0068 , G02B21/0072 , G02B21/008
摘要： A confocal microscope having a scanning head in the form of a hand piece (102) which may be placed at selected locations on the body of a patient. A laser beam is scanned in orthogonal (horizontal and vertical) directions by scanners (128, 130) which drive scan mirrors (128a, 130a), which are closely adjacent to each other The optics include an objective lens (138) and a single telescope lens (132, 134). The telescope provides sufficient magnification to overfill the entrance pupil of the objective lens (138) over the entire scan angle produced by the scan mirrors (128a, 130a). The telescope images (has a focus) in the beam path between the mirrors of the scanners, thereby limiting the distance over the entrance pupil of the objective as the beam executes the scan angle. Scanner (128) represents pulse driven resonant scanner (7) which is pulse driven. The pulse duration is controlled to vary the scan angle and obtain dynamic, electronic image zooming without changing the positional relationship of the telescope lenses.
摘要翻译：一种共焦显微镜，其具有手部形式的扫描头（102），该扫描头可放置在患者身体的选定位置。通过扫描器（128,130）沿正交（水平和垂直）方向扫描激光束，扫描器驱动彼此紧密相邻的扫描镜（128a，130a）。光学器件包括物镜（138）和单个望远镜透镜（132,134）。望远镜提供足够的放大倍率以在由扫描镜（128a，130a）产生的整个扫描角度上覆盖物镜（138）的入射光瞳。在扫描仪的反射镜之间的光束路径中的望远镜图像（具有焦点），从而当光束执行扫描角度时限制物镜入射光瞳上的距离。扫描器（128）表示脉冲驱动的脉冲驱动谐振扫描器（7）。控制脉冲持续时间以改变扫描角度并获得动态的电子图像变焦而不改变望远镜透镜的位置关系。

4. 发明授权

US09055867B2 Confocal scanning microscope having optical and scanning systems which provide a handheld imaging head 有权
标题翻译：共焦扫描显微镜具有提供手持成像头的光学和扫描系统
公开(公告)号：US09055867B2
公开(公告)日：2015-06-16
申请号：US11920195
申请日：2006-05-12
申请人： William J. Fox , Scott R. Grodevant , Christopher C. Distasio
发明人： William J. Fox , Scott R. Grodevant , Christopher C. Distasio
IPC分类号： G01B9/02 , A61B5/00 , G02B21/00
CPC分类号： A61B5/0068 , A61B5/0062 , A61B5/0064 , A61B5/445 , A61B90/20 , G02B5/3083 , G02B21/0008 , G02B21/0028 , G02B21/0048 , G02B21/0068 , G02B21/0072 , G02B21/008
摘要： A confocal microscope having a scanning head in the form of a hand piece which may be placed at selected locations on the body of a patient. A laser beam is scanned in orthogonal (horizontal and vertical) directions by scanners which drive scan mirrors, which are closely adjacent to each other. The optics include an objective lens and a telescope lenses that image the objective lens entrance pupil between the scan mirrors. Scanner is a pulse driven resonant scanner which is feed back controlled to maintain scanning rate and can change the scan angle and obtain dynamic, electronic image zooming without changing the positional relationship of the telescope.
摘要翻译：一种共焦显微镜，其具有手部形式的扫描头，其可以放置在患者身体的选定位置。通过扫描器在正交（水平和垂直）方向上扫描激光束，扫描仪驱动彼此紧密相邻的扫描镜。光学元件包括物镜和在扫描镜之间对物镜入射光瞳进行成像的望远镜。扫描仪是一个脉冲驱动的谐振扫描器，其被反馈控制以保持扫描速率并且可以改变扫描角度并且获得动态的电子图像变焦而不改变望远镜的位置关系。

5. 发明申请

US20080239474A1 Confocal microscope for imaging of selected locations of the body of a patient 有权
标题翻译：共焦显微镜，用于对患者身体的选定位置进行成像
公开(公告)号：US20080239474A1
公开(公告)日：2008-10-02
申请号：US12154981
申请日：2008-05-29
申请人： William J. Fox , Christopher C. DiStasio , Scott R. Grodevant
发明人： William J. Fox , Christopher C. DiStasio , Scott R. Grodevant
IPC分类号： G02B21/00
CPC分类号： G02B21/0048 , A61B5/0064 , A61B5/0068 , A61B5/6835 , G02B21/0012 , G02B21/0028 , G02B21/008 , G02B21/362
摘要： A confocal imaging microscope, especially for the cellular imaging of the skin at selected locations, is ergonomic in use, compact, and positionable at the locations thereby providing for patient comfort during imaging. An imaging head (28) is gimble mounted on a multi-axis compound arm (34) to allow for precise placement of a confocal objective (116) extending from the head at selected locations against the skin of the patient while providing for patient comfort. The arm (34) attaches the head to an upright station (10) which may be movable along the floor on which the station is disposed. The station (10) has a platform (16) on which a keyboard (24) and a display (22) for monitoring the images is supported. The station (10) also supports a personal computer (PC) (26) for processing signals providing the images on the display and controlling the microscope. The head (28) contains an integrated assembly of the optical and mechanical components of the microscope. The assembly includes a main chassis plate (82). The optical components are mounted principally on one side of the plate while a PC board (130) is mounted on the opposite side of the plate. The board (130) mounts the electronic components, including interfaces, a microprocessor (222), and drivers (206, 208, 210) for motors (105, 106, 108) which control scanning and may also control fine positioning of the locations being imaged. Controls (50) for the fine positioning and focusing are on the head (28) for ease of use. The head (28) is detachable from the arm for manual disposition which is useful when imaging, not only the skin but other tissues, especially for research in investigating living processes at the cellular level.
摘要翻译：共焦成像显微镜，特别是用于在选定位置处的皮肤的细胞成像，其在使用中是人体工程学的，紧凑的和可定位的，从而在成像期间提供患者的舒适度。成像头（28）被安装在多轴复合臂（34）上，以允许在选定位置处从选定位置延伸的聚焦物镜（116）精确地放置在患者皮肤上，同时提供患者舒适度。臂（34）将头部附接到直立站（10），其可以沿着设置站的地板移动。站（10）具有平台（16），支撑用于监视图像的键盘（24）和显示器（22）。站（10）还支持个人计算机（PC）（26），用于处理在显示器上提供图像并控制显微镜的信号。头部（28）包含显微镜的光学和机械部件的集成组件。组件包括主底板（82）。光学部件主要安装在板的一侧，而PC板（130）安装在板的相对侧上。板（130）安装包括接口的电子部件，微处理器（222）和用于控制扫描的电动机（105,106,108）的驱动器（206,208,210），并且还可以控制位置的精细定位成像。用于精细定位和聚焦的控制器（50）位于头部（28）上以便于使用。头部（28）可从手臂上拆卸，用于手动配置，这对于成像不仅皮肤而且其它组织尤其是用于调查细胞水平的生物过程的研究是有用的。

6. 发明授权

US5834750A Bar code scanning system for automatically maintaining constant the amplitude of light reflected from a bar code 失效
标题翻译：条码扫描系统，用于自动保持从条形码反射的光的幅度恒定
公开(公告)号：US5834750A
公开(公告)日：1998-11-10
申请号：US524075
申请日：1995-09-06
申请人： Edward P. Coleman , Scott R. Grodevant
发明人： Edward P. Coleman , Scott R. Grodevant
IPC分类号： G06K7/10
CPC分类号： G06K7/10851 , G06K2207/1018
摘要： A system for bar code reading and scanning is provided having automatic bar code signal size control. In the first embodiment of the system, a processor selects on successive scans of a bar code one of a plurality of different optical power levels from a laser diode which provides a light beam illuminating the bar code. This selection is responsive to the size of the signal from a photo-detector which receives returned light from the bar code during scanning. The signal size is detected by a signal size detecting circuit, and is measured by the processor during scanning. In a second embodiment of the system, the processor calculates an optical power level after every two consecutive scans across the bar code. The laser power level is calculated differently for alternative scans occurring in different orders (even or odd counting from the first scan). For even scans, the power is calculated based upon signal size and power level on one of the prior two scans of the bar code, while for odd numbered scans (except the first scan), the power level is in a proportionately opposite relationship to the power level on the prior scan about an average power level. In a third embodiment of the system, the processor calculates the power for the next scan after each scan across the symbol. This calculation is responsive to the power level and the detected signal size of the preceding scan. In both the second and third embodiments, the laser is set to a starting power level on the first scan of the bar code.
摘要翻译：提供了一种用于条形码读取和扫描的系统，其具有自动条形码信号尺寸控制。在系统的第一实施例中，处理器从提供照射条形码的光束的激光二极管连续扫描多个不同光功率电平中的一个的条形码。该选择响应于来自光电检测器的信号的大小，光电检测器在扫描期间从条形码接收返回的光。信号尺寸由信号尺寸检测电路检测，在扫描期间由处理器测量。在该系统的第二实施例中，处理器在跨条形码的每两次连续扫描之后计算光功率水平。对于以不同顺序发生的替代扫描（从第一次扫描的偶数或奇数计数），激光功率电平的计算方式不同。对于偶数扫描，根据信号大小和条形码的先前两次扫描之间的功率电平计算功率，而对于奇数扫描（除第一次扫描之外），功率电平与关于平均功率水平的先前扫描的功率水平。在系统的第三实施例中，处理器在穿过符号的每次扫描之后计算下次扫描的功率。该计算响应于先前扫描的功率电平和检测到的信号大小。在第二和第三实施例中，激光器在条形码的第一扫描上被设置为起始功率电平。

7. 发明授权

US5796222A System for driving and controlling the motion of an oscillatory electromechanical system especially suitable for use in an optical scanner 失效
标题翻译：用于驱动和控制特别适用于光学扫描仪的振荡机电系统的运动的系统
公开(公告)号：US5796222A
公开(公告)日：1998-08-18
申请号：US699223
申请日：1996-08-09
申请人： Scott R. Grodevant
发明人： Scott R. Grodevant
IPC分类号： G06K7/10 , H02K29/08
CPC分类号： G06K7/10851 , G06K7/10643 , G06K2207/1016
摘要： A computerized control system for driving an rotor which can carry a laser or a beam deflecting mirror and is actuated by a coil thereon electromagnetically coupled to a fixed magnet or a stepper motor coil. The rotor can be part of an electromechanical oscillatory system supported by flexures or the stepper motor can be electrically biased to produce, electrodynamically a restoring force. The back EMF of the coil is sensed, translated into successive digital signals which are processed in accordance with programs in firmware of the computer to generate driving pulses which are applied to the coil to obtain desired displacement motion of oscillation suitable for scanning the beam.
摘要翻译：一种用于驱动转子的计算机化控制系统，该转子可携带激光或光束偏转镜并由其上电磁耦合到固定磁体或步进电动机线圈上的线圈致动。转子可以是由挠曲件支撑的机电振荡系统的一部分，或者步进电机可以被电偏置以电动地产生恢复力。线圈的反电动势被感测，转换为根据计算机的固件中的程序处理的连续的数字信号，以产生施加到线圈的驱动脉冲，以获得适于扫描光束的期望的振荡位移运动。

8. 发明授权

US5666045A Laser drive and control systems useful for laser diode protection 失效
标题翻译：用于激光二极管保护的激光驱动和控制系统
公开(公告)号：US5666045A
公开(公告)日：1997-09-09
申请号：US353421
申请日：1994-12-09
申请人： Scott R. Grodevant
发明人： Scott R. Grodevant
IPC分类号： H01S5/042 , H01S5/068 , G05F1/40 , H01S3/00
CPC分类号： H01S5/042 , H01S5/06825
摘要： A laser drive and control system which provides protection for a laser diode by preventing excess current from a power source, that normally supplies power to the laser diode, from destroying the laser diode when the voltage supplied by the power source to the laser diode decreases below a certain voltage which causes excess current. The system is implemented in CMOS circuitry for miniaturization into an integrated circuit chip.
摘要翻译：一种激光驱动和控制系统，其通过防止来自电源的过剩电流（通常为激光二极管供电），从而在由电源向激光二极管提供的电压降低时破坏激光二极管，为激光二极管提供保护导致过电流的一定电压。该系统在CMOS电路中实现，用于小型化成集成电路芯片。

9. 发明授权

US5260554A System for automatically reading symbols, such as bar codes, on objects which are placed in the detection zone of a symbol reading unit, such as a bar code scanner 失效
标题翻译：用于在诸如条形码扫描器的符号读取单元的检测区域中的对象上自动读取诸如条形码的符号的系统
公开(公告)号：US5260554A
公开(公告)日：1993-11-09
申请号：US786147
申请日：1991-10-31
申请人： Scott R. Grodevant
发明人： Scott R. Grodevant
IPC分类号： G06K7/10
CPC分类号： G06K7/10881 , G06K7/10584 , G06K7/10594 , G06K7/109 , G06K2207/1012 , G06K2207/1016 , G06K2207/1018
摘要： A bar code label is read by automatically initiated scanning of the bar code symbol by a beam of light, as from a laser in a bar code scanner. Initially, the scanner is operated in a pulsed mode with low duty cycle (5%) pulses. These pulses are reflected from a reflective tape on one side of a detection zone or from an object carrying the label in the beam path. Then (because the beam is not scanning across the code) the reflected pulses (which are detected much like the bars and spaces of the code) are not detected. The ratio of the number of generated pulses to the reflected pulses is computed for a succession of pulses (ten pulses for example). If this ratio exceeds two (i.e., that the number of effective bars is less than the number of generated pulses during the succession), then the presence of the object is detected and the system, implemented in an application program in the microprocessor controller of the bar code scanner, initiates scanning of the bar code. Upon the detection of the code (a good read) or under conditions where the object is removed before a good read, or is not removed after a good read, the scanning mode is discontinued and the pulsing mode is again initiated. The pulsing mode is initiated continually to test for the presence of a object carrying a bar code label, when not scanning. The pulsing mode is used to detect the presence of a reflective tape or an object.
摘要翻译：通过条形码扫描器中的激光从光束自动启动扫描条形码符号来读取条形码标签。最初，扫描仪以低占空比（5％）脉冲的脉冲模式运行。这些脉冲从检测区域的一侧的反射带或者从光束路径中携带标签的物体反射。然后（因为光束没有扫描码），反射的脉冲（被检测得很像代码的条形和空格）被检测不到。针对一连串脉冲（例如十个脉冲）计算产生的脉冲数与反射脉冲的比率。如果该比例超过两个（即，有效条的数量小于在继承期间产生的脉冲数），则检测到对象的存在，并且系统在微处理器控制器中的应用程序中实现条形码扫描器，启动扫描条形码。在检测到代码（良好的读取）之后或在良好读取之前移除对象的条件下，或者在良好读取之后不被去除的情况下，扫描模式被停止并且再次启动脉冲模式。当不扫描时，连续启动脉冲模式以测试携带条形码标签的物体的存在。脉冲模式用于检测反射带或物体的存在。

10. 发明授权

US5258699A Motor control system especially for control of an optical scanner 失效
标题翻译：电机控制系统特别适用于光学扫描仪的控制
公开(公告)号：US5258699A
公开(公告)日：1993-11-02
申请号：US784331
申请日：1991-10-29
申请人： Scott R. Grodevant
发明人： Scott R. Grodevant
IPC分类号： G06K7/10 , H02P8/12 , H02K29/08
CPC分类号： G06K7/10851 , H02P8/12 , G06K2207/1016
摘要： A reflective deflector of a light beam which scans in opposite directions across a bar code is controlled in scan angle by monitoring the AC component of a current passing through a winding of a scanning motor which oscillates the deflector to scan the beam across the code over a scan angle. The inductance of the winding corresponds to the length of the scan angle and is measured in terms of the peak to peak value of the AC component during a scan period or frame which occurs over an interval corresponding to the reciprocal of the scan rate. During successive periods, successive trains of pulses are generated. The number of pulses or their duty cycle during each period is changed in accordance with an error signal corresponding to the difference between the desired scan angle and the peak to peak value of the AC component. The pulse trains are translated into trains of current pulses which are passed through another winding of the motor in opposite directions so as to drive the rotor of the motor which reciprocates the reflector in opposite directions over the desired scan angle. By modifying the desired scan angle in accordance with changes in temperature affecting the system, the system can be compensated for temperature changes. By modifying the error signal by processing it with a filter, the response of the system to changes in scan angle can be controlled.
摘要翻译：通过监视通过扫描电动机的绕组的电流的AC分量来监视通过条形码沿相反方向扫描的条形码的扫描角度的光束的反射偏转器被控制在扫描角度，该扫描电机的绕组振荡偏转器，以跨越码扫描角度。绕组的电感对应于扫描角度的长度，并且在与扫描速率的倒数相对应的间隔内发生的扫描周期或帧期间以AC分量的峰值测量。在连续的周期内，产生连续的脉冲串。根据与期望的扫描角度与AC分量的峰峰值之间的差对应的误差信号来改变每个周期期间的脉冲数或占空比。脉冲串被转换成电流脉冲串，其沿相反方向通过电动机的另一个绕组，以便驱动电动机的转子，使反射器在相反的方向上在期望的扫描角度上往复运动。通过根据影响系统的温度变化修改所需的扫描角度，系统可以补偿温度变化。通过使用滤波器处理误差信号进行修改，可以控制系统对扫描角度变化的响应。

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