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1. 发明申请

US20130288375A1 Tissue-Specific Extracellular Matrix With or Without Tissue Protein Components for Cell Culture 有权
标题翻译：具有或不具有用于细胞培养的组织蛋白质组分的组织特异性细胞外基质
公开(公告)号：US20130288375A1
公开(公告)日：2013-10-31
申请号：US13882429
申请日：2011-11-04
申请人： Yuanyuan Zhang , Shay Soker , Anthony Atala
发明人： Yuanyuan Zhang , Shay Soker , Anthony Atala
IPC分类号： C12N5/071
CPC分类号： C12N5/0671 , C12N5/0068 , C12N2513/00 , C12N2533/54 , C12N2533/80 , C12N2533/90
摘要： The present invention relates to compositions and methods for mimicking an in vivo environment for culturing cells in vitro. The in vivo mimicking environment is based on the generation of a tissue-specific extracellular matrix wherein the matrix provides a substrate for which the cultured cell originated from. The tissue-specific extracellular matrix can further comprise a component of a whole tissue-specific homogenate.
摘要翻译：本发明涉及用于模拟用于体外培养细胞的体内环境的组合物和方法。体内模拟环境基于组织特异性细胞外基质的产生，其中基质提供培养细胞来源的底物。组织特异性细胞外基质可进一步包含整个组织特异性匀浆的组分。

2. 发明授权

US09938502B2 Tissue-specific extracellular matrix with or without tissue protein components for cell culture 有权
公开(公告)号：US09938502B2
公开(公告)日：2018-04-10
申请号：US13882429
申请日：2011-11-04
申请人： Yuanyuan Zhang , Shay Soker , Anthony Atala , Aleksander Skardal
发明人： Yuanyuan Zhang , Shay Soker , Anthony Atala , Aleksander Skardal
IPC分类号： C12N5/00 , C12N5/071
CPC分类号： C12N5/0671 , C12N5/0068 , C12N2513/00 , C12N2533/54 , C12N2533/80 , C12N2533/90
摘要： The present invention relates to compositions and methods for mimicking an in vivo environment for culturing cells in vitro. The in vivo mimicking environment is based on the generation of a tissue-specific extracellular matrix wherein the matrix provides a substrate for which the cultured cell originated from. The tissue-specific extracellular matrix can further comprise a component of a whole tissue-specific homogenate.

3. 发明授权

US08491457B2 Tissue engineered blood vessels 有权
标题翻译：组织工程血管
公开(公告)号：US08491457B2
公开(公告)日：2013-07-23
申请号：US11372743
申请日：2006-03-10
申请人： Anthony Atala , Shay Soker , James Yoo
发明人： Anthony Atala , Shay Soker , James Yoo
IPC分类号： A61F2/06
CPC分类号： A61L27/3604 , A61F2/06 , A61F2/062 , A61K35/44 , A61L27/3808 , A61L27/50 , A61L27/507 , A61L2430/36 , B82Y5/00 , B82Y10/00
摘要： The invention is directed to methods for preparing artificial blood vessels by preconditioning a matrix seeded with endothelial cells to fluid flow conditions that mimic blood flow.
摘要翻译：本发明涉及通过将接种有内皮细胞的基质预处理以模拟血液流动的流体流动条件来制备人造血管的方法。

4. 发明授权

US07666393B2 Methods for assessing antiangiogenic agents 失效
标题翻译：评估抗血管生成剂的方法
公开(公告)号：US07666393B2
公开(公告)日：2010-02-23
申请号：US10142165
申请日：2002-05-09
申请人： Shay Soker , Anthony Atala , Gunter Schuch
发明人： Shay Soker , Anthony Atala , Gunter Schuch
IPC分类号： A61K49/00 , G01N33/574
CPC分类号： A61K49/0004 , G01N33/5011
摘要： We have discovered that endothelial progenitor cells (EPC) are particularly suitable for use in a sensitive assay for antiangiogenic factors. We have found that EPC mobilization and differentiation is greatly inhibited by antiangiogenic factors as evidenced in vivo by VEGF inducing a massive mobilization of EPC into the blood circulation which effect is significantly inhibited by endostatin treatment, and, in vitro, human blood-derived EPC forming adherent colonies, which colonies, in the presence of angiogenic factors, give rise to differentiated EC, and which differentiation is disrupted and cell growth is inhibited in the presence of angiostatin and endostatin.
摘要翻译：我们已经发现内皮祖细胞（EPC）特别适用于抗血管生成因子的敏感测定。我们已经发现，抗血管生成因子的EPC动员和分化受到很大的抑制，因为体内VEGF的诱导大量动员EPC进入血液循环，这种作用被内皮抑制素治疗显着抑制，而在体外，人血源性EPC形成在血管生成因子存在下，这些集落的粘附菌落产生分化的EC，并且在血管抑素和内皮抑制素的存在下，分化被破坏并且细胞生长被抑制。

5. 发明授权

US07531503B2 Cell scaffold matrices with incorporated therapeutic agents 有权
标题翻译：具有掺入治疗剂的细胞支架基质
公开(公告)号：US07531503B2
公开(公告)日：2009-05-12
申请号：US11084350
申请日：2005-03-18
申请人： Anthony Atala , James Yoo , Grace Lim , Richard Czerw , Shay Soker , Joel Stitzel
发明人： Anthony Atala , James Yoo , Grace Lim , Richard Czerw , Shay Soker , Joel Stitzel
IPC分类号： A61K38/00 , A61K31/70 , A61K33/00 , A61K33/36 , A61K33/32 , A61K33/04
CPC分类号： A61K49/18 , A61K38/00 , A61K41/0042 , A61K47/6923 , A61L27/26 , A61L27/507 , A61L27/54 , A61L2400/12 , B82Y5/00 , B82Y10/00 , Y10S977/906 , C08L67/04
摘要： The invention is directed to methods and compositions for preparing matrices for controlled delivery of at least one therapeutic or biological agent to a target site in a subject. This is accomplished using nanoparticles coupled to the therapeutic or biological agent that are incorporated within the matrix or reacted on the surface of the matrix.
摘要翻译：本发明涉及用于制备用于受控递送至少一种治疗或生物剂到受试者的靶位点的基质的方法和组合物。这是使用与治疗或生物试剂偶联的纳米颗粒完成的，所述纳米颗粒结合到基质中或在基质的表面上反应。

6. 发明申请

US20060204539A1 Electrospun cell matrices 审中-公开
公开(公告)号：US20060204539A1
公开(公告)日：2006-09-14
申请号：US11083853
申请日：2005-03-18
申请人： Anthony Atala , James Yoo , Grace Lim , Richard Czerw , Shay Soker , Joel Stitzel
发明人： Anthony Atala , James Yoo , Grace Lim , Richard Czerw , Shay Soker , Joel Stitzel
IPC分类号： A61F2/02
CPC分类号： D01D5/0007 , C12N5/0691 , C12N2533/40 , C12N2533/54 , D01F4/00 , D01F6/92
摘要： The invention is directed to compositions and methods for preparing electrospun matrices comprising at least one natural biological material component and at least one synthetic polymer material. The natural component makes the matrices highly biocompatible while the molecular weight polymer component can impart additional strength mechanical strength to the scaffold and/or improve ease of manufacture by increasing viscosity and spinning characteristics of the solution during electrospining.

7. 发明申请

US20060204445A1 Cell scaffold matrices with image contrast agents 审中-公开
标题翻译：具有图像造影剂的细胞支架基质
公开(公告)号：US20060204445A1
公开(公告)日：2006-09-14
申请号：US11083602
申请日：2005-03-18
申请人： Anthony Atala , Shay Soker , James Yoo , Joel Stitzel , Richard Czerw , Grace Lim
发明人： Anthony Atala , Shay Soker , James Yoo , Joel Stitzel , Richard Czerw , Grace Lim
IPC分类号： A61K49/10 , A61F2/02
CPC分类号： A61L27/54 , A61K41/0042 , A61K47/6923 , A61K49/18 , A61L27/047 , A61L27/26 , A61L27/50 , A61L27/507 , A61L2300/44 , C08L89/06
摘要： The invention is directed to methods and compositions for monitoring remodeling of an artificial tissue construct using image or contrast enhancing agents. The invention allows the growth, development, and remodeling of the artificial tissue to be monitored.
摘要翻译：本发明涉及使用图像或对比度增强剂监测人造组织构建体的重塑的方法和组合物。本发明允许监测人造组织的生长，发育和重塑。

8. 发明申请

US20060204441A1 Cell scaffold matrices with incorporated therapeutic agents 有权
公开(公告)号：US20060204441A1
公开(公告)日：2006-09-14
申请号：US11084350
申请日：2005-03-18
申请人： Anthony Atala , James Yoo , Grace Lim , Richard Czerw , Shay Soker , Joel Stitzel
发明人： Anthony Atala , James Yoo , Grace Lim , Richard Czerw , Shay Soker , Joel Stitzel
IPC分类号： A61K49/00 , A61K38/19 , A61K38/18 , A61K31/727
CPC分类号： A61K49/18 , A61K38/00 , A61K41/0042 , A61K47/6923 , A61L27/26 , A61L27/507 , A61L27/54 , A61L2400/12 , B82Y5/00 , B82Y10/00 , Y10S977/906 , C08L67/04
摘要： The invention is directed to methods and compositions for preparing matrices for controlled delivery of at least one therapeutic or biological agent to a target site in a subject. This is accomplished using nanoparticles coupled to the therapeutic or biological agent that are incorporated within the matrix or reacted on the surface of the matrix.

9. 发明授权

US08940292B2 Enhancement of angiogenesis to grafts using cells engineered to produce growth factors 有权
标题翻译：使用工程化生产生长因子的细胞增强移植物的血管生成
公开(公告)号：US08940292B2
公开(公告)日：2015-01-27
申请号：US10766642
申请日：2004-01-28
申请人： Anthony Atala , Shay Soker
发明人： Anthony Atala , Shay Soker
IPC分类号： A61L27/38 , A61K48/00 , C12N5/077 , C12N5/071 , A61K38/18 , A61K35/34 , A61K35/44 , A61K35/12
CPC分类号： A61L27/3886 , A61K35/12 , A61K35/34 , A61K35/44 , A61K38/1866 , A61K48/00 , A61L27/3808 , A61L27/3834 , C12N5/0658 , C12N5/0686 , C12N5/0697 , C12N2501/165 , C12N2502/1347 , C12N2502/253 , C12N2502/28 , C12N2502/99 , C12N2533/32 , C12N2533/52 , C12N2533/54 , C12N2533/72 , C12N2533/90
摘要： The present invention provides methods and compositions of engineered cells for use in the continuous or transient delivery of growth factors and angiogenesis modulating agents, such as vascular endothelial growth factor (VEGF), in conjunction with constructs for replacing or augmenting organ functions. In one aspect of the invention, the genetically engineered cells can be immature cells that are capable of differentiating and assimilating into the target region. The methods of the present invention can be used to enhance vascularization locally at a target site in need of repair, growth, or implantation through the incorporation of autologous cells which have been genetically engineered to secrete a growth factor or angiogenesis modulating agent.
摘要翻译：本发明提供了用于连续或瞬时递送生长因子和血管生成调节剂（例如血管内皮生长因子（VEGF））的工程细胞的方法和组合，以及用于替代或增加器官功能的构建体。在本发明的一个方面，基因工程细胞可以是能够分化和同化到靶区域中的未成熟细胞。本发明的方法可用于在需要修复，生长或植入的靶位点局部增强血管化，这是通过掺入已被遗传工程化以分泌生长因子或血管生成调节剂的自体细胞。

10. 发明申请

US20070031384A1 Regeneration of pancreatic islets by amniotic fluid stem cell therapy 有权
标题翻译：通过羊水干细胞治疗胰岛再生
公开(公告)号：US20070031384A1
公开(公告)日：2007-02-08
申请号：US11327074
申请日：2006-01-06
申请人： Anthony Atala , Anna Milanesi , Shay Soker
发明人： Anthony Atala , Anna Milanesi , Shay Soker
IPC分类号： A61K35/39
CPC分类号： A61K35/39 , A61K9/0019 , A61K35/12 , A61K35/50 , A61K38/00 , A61K38/1709 , C12N5/0605 , C12N5/0607 , C12N5/0676 , C12N2501/60 , C12N2506/02 , C12N2506/03 , C12N2510/00
摘要： A method of treating diabetes in a mammalian subject is carried out by: (a) providing mammalian amniotic fluid stem cells, and then (b) administering the cells to the subject in an amount effective to treat diabetes. Optionally, the cells may be differentiated into pancreatic-like cells or at least treated to initiate subsequent differentiation into-pancreatic-like cells, prior to administration.
摘要翻译：通过以下方式进行哺乳动物受试者中的糖尿病治疗的方法：（a）提供哺乳动物羊水干细胞，然后（b）以有效治疗糖尿病的量向对象施用细胞。任选地，在施用前，细胞可以分化为胰腺样细胞或至少被处理以引发随后的分化成胰腺样细胞。

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