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1. 发明申请

US20130288375A1 Tissue-Specific Extracellular Matrix With or Without Tissue Protein Components for Cell Culture 有权
标题翻译：具有或不具有用于细胞培养的组织蛋白质组分的组织特异性细胞外基质
公开(公告)号：US20130288375A1
公开(公告)日：2013-10-31
申请号：US13882429
申请日：2011-11-04
申请人： Yuanyuan Zhang , Shay Soker , Anthony Atala
发明人： Yuanyuan Zhang , Shay Soker , Anthony Atala
IPC分类号： C12N5/071
CPC分类号： C12N5/0671 , C12N5/0068 , C12N2513/00 , C12N2533/54 , C12N2533/80 , C12N2533/90
摘要： The present invention relates to compositions and methods for mimicking an in vivo environment for culturing cells in vitro. The in vivo mimicking environment is based on the generation of a tissue-specific extracellular matrix wherein the matrix provides a substrate for which the cultured cell originated from. The tissue-specific extracellular matrix can further comprise a component of a whole tissue-specific homogenate.
摘要翻译：本发明涉及用于模拟用于体外培养细胞的体内环境的组合物和方法。体内模拟环境基于组织特异性细胞外基质的产生，其中基质提供培养细胞来源的底物。组织特异性细胞外基质可进一步包含整个组织特异性匀浆的组分。

2. 发明授权

US09938502B2 Tissue-specific extracellular matrix with or without tissue protein components for cell culture 有权
公开(公告)号：US09938502B2
公开(公告)日：2018-04-10
申请号：US13882429
申请日：2011-11-04
申请人： Yuanyuan Zhang , Shay Soker , Anthony Atala , Aleksander Skardal
发明人： Yuanyuan Zhang , Shay Soker , Anthony Atala , Aleksander Skardal
IPC分类号： C12N5/00 , C12N5/071
CPC分类号： C12N5/0671 , C12N5/0068 , C12N2513/00 , C12N2533/54 , C12N2533/80 , C12N2533/90
摘要： The present invention relates to compositions and methods for mimicking an in vivo environment for culturing cells in vitro. The in vivo mimicking environment is based on the generation of a tissue-specific extracellular matrix wherein the matrix provides a substrate for which the cultured cell originated from. The tissue-specific extracellular matrix can further comprise a component of a whole tissue-specific homogenate.

3. 发明申请

US20100111914A1 STEM CELLS FROM URINE AND METHODS FOR USING THE SAME 审中-公开
标题翻译：来自尿液的干细胞和使用它的方法
公开(公告)号：US20100111914A1
公开(公告)日：2010-05-06
申请号：US12614901
申请日：2009-11-09
申请人： Yuanyuan Zhang , Anthony Atala
发明人： Yuanyuan Zhang , Anthony Atala
IPC分类号： A61K35/12 , C12N5/00 , A61P13/02
CPC分类号： A61K35/22 , C12N5/0668 , C12N5/0684
摘要： Provided herein are stem cells and methods for producing a culture of stem cells from urine. The stem cells may be differentiated into an osteogenic, chondrogenic, adipogenic, endothelial, neurogenic or myogenic lineage. Methods of use of the cells are provided, including methods of treating a subject in need of a cell based therapy.
摘要翻译：本文提供的是干细胞和从尿中产生干细胞培养的方法。干细胞可以分化为成骨，软骨形成，脂肪形成，内皮，神经源性或肌原性谱系。提供了使用细胞的方法，包括治疗需要基于细胞的疗法的受试者的方法。

4. 发明授权

US10398804B2 Progenitor cells from urine and methods for using the same 有权
公开(公告)号：US10398804B2
公开(公告)日：2019-09-03
申请号：US12601028
申请日：2008-05-20
申请人： Yuanyuan Zhang , Anthony Atala
发明人： Yuanyuan Zhang , Anthony Atala
IPC分类号： A61F2/00 , A01N65/00 , C12N5/00 , C12N5/02 , A61L27/38 , C12N5/071 , A61K35/12
摘要： Provided herein are urine progenitor cells and methods for producing a culture of urine progenitor cells from a urine sample. The cells may be selected based upon the use of a selective cell medium, based upon morphology, and/or by selecting cell-specific markers. Also provided is an isolated urine progenitor cell that is c-kit positive and can differentiate into urothelium, smooth muscle, endothelium or interstitial cells. Methods of use of urine progenitor cells are provided, wherein cell are seeded onto a tissue scaffold are provided. Methods of treating a subject in need thereof are also provided, including providing a bladder tissue substrate that includes differentiated UPCs and transplanting the substrate into the patient. Finally, kits are provided that include a container suitable for the transport of a urine sample; media; one or more antibiotics; a package for holding said container, media, and antibiotics; and optionally, instructions for use.

5. 发明申请

US20100158977A1 PROGENITOR CELLS FROM URINE AND METHODS FOR USING THE SAME 审中-公开
标题翻译：来自尿素的致癌细胞及其使用方法
公开(公告)号：US20100158977A1
公开(公告)日：2010-06-24
申请号：US12601028
申请日：2008-05-20
申请人： Yuanyuan Zhang , Anthony Atala
发明人： Yuanyuan Zhang , Anthony Atala
IPC分类号： A61F2/00 , C12N5/07 , A61K35/12 , A61P19/04
CPC分类号： A61L27/3882 , A61K35/12 , A61L27/3804 , A61L2430/22 , C12N5/0685 , C12N2500/40 , C12N2501/01 , C12N2501/11 , C12N2501/39 , C12N2501/395
摘要： Provided herein are urine progenitor cells and methods for producing a culture of urine progenitor cells from a urine sample. The cells may be selected based upon the use of a selective cell medium, based upon morphology, and/or by selecting cell-specific markers. Also provided is an isolated urine progenitor cell that is c-kit positive and can differentiate into urothelium, smooth muscle, endothelium or interstitial cells. Methods of use of urine progenitor cells are provided, wherein cell are seeded onto a tissue scaffold are provided. Methods of treating a subject in need thereof are also provided, including providing a bladder tissue substrate that includes differentiated UPCs and transplanting the substrate into the patient. Finally, kits are provided that include a container suitable for the transport of a urine sample; media; one or more antibiotics; a package for holding said container, media, and antibiotics; and optionally, instructions for use.
摘要翻译：本文提供了尿祖细胞和从尿液样品中产生尿祖细胞培养的方法。可以基于基于形态学的选择性细胞培养基的使用和/或通过选择细胞特异性标记来选择细胞。还提供了分离的尿祖细胞，其是c-kit阳性的并且可以分化成尿路上皮，平滑肌，内皮或间质细胞。提供使用尿祖细胞的方法，其中将细胞接种到组织支架上。还提供了治疗有需要的受试者的方法，包括提供包括分化的UPC并将基质移植到患者体内的膀胱组织底物。最后，提供了包括适合于运输尿样的容器的试剂盒; 媒体; 一种或多种抗生素; 用于容纳所述容器，介质和抗生素的包装; 以及可选的使用说明书。

6. 发明申请

US20150153267A1 Method for Analyzing Interaction force between Molecules 审中-公开
标题翻译：分析分子间相互作用力的方法
公开(公告)号：US20150153267A1
公开(公告)日：2015-06-04
申请号：US14397591
申请日：2013-07-09
申请人： Shunxin Zhang , Yuanyuan Zhang
发明人： Shunxin Zhang , Yuanyuan Zhang
IPC分类号： G01N19/04
CPC分类号： G01N19/04 , G01N2203/0089 , G01N2203/0298 , G09B23/08
摘要： A method for analyzing interaction force between molecules, comprising: it's based on Equilibrium Condition Objects, through the one ideal experiment now regarded as no air pressure between the contact surfaces and making experimental analysis on the change of stress on the object of study in a vacuumizing process, obtaining the macro demonstrated size of the molecular force as well display effect of elasticity and friction, verifying the qualitative relationship between the micro demonstrated molecular force and distance, and finally deducing the relationship between existing molecular force and distance.
摘要翻译：一种用于分析分子之间的相互作用力的方法，包括：它基于平衡条件对象，通过现在被认为在接触表面之间没有空气压力的一个理想实验，并且在抽真空中对研究对象上的应力变化进行实验分析过程，获得宏观分析的尺寸以及弹性和摩擦的显示效果，验证微观分子力与距离之间的定性关系，最终推导出现有分子力与距离之间的关系。

7. 发明授权

US08726315B2 Method and server side and terminal for finding interactive electric service guide 有权
标题翻译：方法和服务器端和终端查找交互式电气服务指南
公开(公告)号：US08726315B2
公开(公告)日：2014-05-13
申请号：US12403843
申请日：2009-03-13
申请人： Chuxiong Zhang , Teng Shi , Jie Zhang , Yuanyuan Zhang
发明人： Chuxiong Zhang , Teng Shi , Jie Zhang , Yuanyuan Zhang
IPC分类号： H04N7/025 , H04N7/10 , H04N7/173 , H04N5/445 , H04W4/00 , H04N21/00 , H04N21/61
CPC分类号： H04N21/00 , H04H20/38 , H04H20/57 , H04H20/93 , H04H60/72 , H04N7/17318 , H04N21/26283 , H04N21/4821 , H04N21/6125
摘要： A method and a service side and a terminal for finding an interactive electronic service guide. Said method comprises: the server side down-issuing the information corresponding to the finding interactive ESG service to the terminal through the broadcast channel, and the terminal acquires the information for finding the interactive ESG service in the broadcast channel. Said server side comprises a sending module of the related information for finding interactive ESG service and a down-issue module for the ESG supplier list. The terminal comprises a receiving module of the related information for finding the interactive ESG service and a receiving module for the ESG supplier list.
摘要翻译：一种用于查找交互式电子服务指南的方法和服务端以及终端。所述方法包括：服务器端通过广播信道向终端发送与发现的交互式ESG业务相对应的信息，并且终端获取用于在广播信道中查找交互式ESG业务的信息。所述服务器侧包括用于发现交互式ESG服务的相关信息的发送模块和用于ESG供应商列表的下发模块。终端包括用于查找交互式ESG服务的相关信息的接收模块和用于ESG供应商列表的接收模块。

8. 发明申请

US20120011549A1 Method, Terminal and Server for Finding Visited Service Provider 审中-公开
标题翻译：方法，终端和服务器查找访问服务提供商
公开(公告)号：US20120011549A1
公开(公告)日：2012-01-12
申请号：US13247496
申请日：2011-09-28
申请人： Feihu Jiang , Teng Shi , Yuanyuan Zhang , Peiyu Yue , Ruinan Sun , Jie Zhang
发明人： Feihu Jiang , Teng Shi , Yuanyuan Zhang , Peiyu Yue , Ruinan Sun , Jie Zhang
IPC分类号： H04N21/61
CPC分类号： H04W48/16 , H04H60/41 , H04L12/1818 , H04L12/189 , H04L67/16 , H04W4/00
摘要： A method for finding a visited Service Provider (SP) disclosed herein includes: after accessing a network, a terminal obtains current network information; and obtains the visited SP information through the home SP information preset on the terminal and the current network information. A method for finding a visited SP disclosed herein includes: after receiving a visited SP information request sent by a terminal, an SP server searches for the current network information, obtains the visited SP information, and sends the visited SP information to the terminal. Accordingly, a terminal for finding a visited SP and an SP server are disclosed. Through the present invention, a roaming terminal may find the visited SP conveniently.
摘要翻译：一种用于查找本文公开的访问服务提供商（SP）的方法，包括：在访问网络之后，终端获取当前网络信息; 并通过在终端上预先设定的本地SP信息和当前网络信息获取被访问的SP信息。用于发现本文所公开的访问SP的方法包括：在接收到由终端发送的访问SP信息请求之后，SP服务器搜索当前网络信息，获取所访问的SP信息，并将所访问的SP信息发送到终端。因此，公开了一种用于查找被访问的SP和SP服务器的终端。通过本发明，漫游终端可以方便地找到被访问的SP。

9. 发明授权

US07813148B2 Power converter having flux bias regulation method 有权
标题翻译：功率转换器具有通量偏置调节方式
公开(公告)号：US07813148B2
公开(公告)日：2010-10-12
申请号：US11834828
申请日：2007-08-07
申请人： Jianhong Zeng , Yuanyuan Zhang , Aibin Qiu , Kun Wei , Jianping Ying
发明人： Jianhong Zeng , Yuanyuan Zhang , Aibin Qiu , Kun Wei , Jianping Ying
IPC分类号： H02M3/335
CPC分类号： H02M3/3376 , H02M2007/4803
摘要： Provided is a flux regulation method for use in a power converter, wherein the method is carried out by a flux bias controller. The flux bias controller includes a current detector which is configured to detect the primary current of the transformer of the power converter in a predetermined switching cycle, a DC bias processor which is configured to obtain the duty ratio control signal according to the sampled primary current outputted from the current detector for a switching cycle later than the predetermined switching cycle, and a PWM controller which is configured to generate driving signals to control the on/off operations of the switching circuit of the power converter according to the duty ratio control signal, thereby suppressing the DC bias of the transformer by regulating the duty ratio of the switch circuit.
摘要翻译：提供了一种用于功率转换器的磁通调节方法，其中该方法由磁通偏压控制器执行。通量偏置控制器包括电流检测器，其被配置为在预定的开关周期内检测功率转换器的变压器的初级电流; DC偏置处理器，被配置为根据所输出的采样的一次电流获得占空比控制信号从电流检测器开始比预定开关周期晚的开关周期，以及PWM控制器，其被配置为产生驱动信号，以根据占空比控制信号来控制功率转换器的开关电路的接通/断开操作，由此通过调节开关电路的占空比来抑制变压器的直流偏压。

10. 发明授权

US08445889B2 Method of patterning of nanostructures 失效
标题翻译：纳米结构图案化方法
公开(公告)号：US08445889B2
公开(公告)日：2013-05-21
申请号：US12918842
申请日：2009-02-23
申请人： Kumar Bhupendra , Yuanyuan Zhang , Zongbin Wang , Lain-Jong Li , Subodh Gautam Mhaisalkar
发明人： Kumar Bhupendra , Yuanyuan Zhang , Zongbin Wang , Lain-Jong Li , Subodh Gautam Mhaisalkar
IPC分类号： H01L29/06
CPC分类号： G03F7/0002 , B41M3/006 , B81B2207/07 , B81C1/00031 , B81C2201/0184 , B81C2201/0191 , B82Y10/00 , B82Y40/00 , C09D11/52 , H01L51/0004 , H01L51/0005 , H01L51/0048 , H01L51/0541
摘要： A method of patterning nanostructures comprising printing an ink comprising the nanostructures onto a solvent-extracting first surface such that a pattern of nanostructures is formed on the first surface.
摘要翻译：一种图案化纳米结构的方法，包括将包含纳米结构的油墨印刷到溶剂萃取的第一表面上，使得在第一表面上形成纳米结构图案。

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