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1. 发明申请

US20130131797A1 RETINAL IMPLANT AND VISUAL PROSTHESIS INCORPORATING SUCH AN IMPLANT 审中-公开
标题翻译：放置植入物和植入物的视觉遗传
公开(公告)号：US20130131797A1
公开(公告)日：2013-05-23
申请号：US13638523
申请日：2010-04-01
申请人： Tom Klaver , Marcus Dapper , Hans-Jurgen Tiedtke
发明人： Tom Klaver , Marcus Dapper , Hans-Jurgen Tiedtke
IPC分类号： A61F2/14
CPC分类号： A61F2/141 , A61F2/14 , A61N1/36046
摘要： A system for generating artificial vision in a subject, comprising: an image capture means for capturing an image from a surrounding environment; an image processing means for processing the image and converting the image into an image signal; and a retinal implant or stimulation device (10) configured to be implanted within an eye of a patient and positioned on or adjacent the retina. The implant or stimulation device (10) comprises a substrate (11) and a plurality of light sources (12) arranged in an array on the substrate (11) for stimulating nerve cells of the retina, wherein each of the plurality of light sources (12) is configured to emit infrared radiation to stimulate one or more nerve cells in response to a respective stimulation signal derived from the image signal.
摘要翻译：一种用于在对象中产生人造视觉的系统，包括：用于从周围环境捕获图像的图像捕获装置; 图像处理装置，用于处理图像并将图像转换为图像信号; 以及视网膜植入物或刺激装置（10），其被配置为植入患者的眼睛内并定位在视网膜上或邻近视网膜。植入物或刺激装置（10）包括基板（11）和阵列上布置在基板（11）上的多个光源（12），用于刺激视网膜的神经细胞，其中多个光源（ 12）被配置为发射红外辐射以响应于从图像信号导出的相应刺激信号来刺激一个或多个神经细胞。

2. 发明授权

US08437858B2 Visual prosthesis system for displaying video image and text data 有权
标题翻译：用于显示视频图像和文本数据的视觉假体系统
公开(公告)号：US08437858B2
公开(公告)日：2013-05-07
申请号：US12921714
申请日：2008-03-18
申请人： Marcus Dapper , Christian Martin Kopka
发明人： Marcus Dapper , Christian Martin Kopka
IPC分类号： A61N1/00
CPC分类号： A61N1/36046 , A61N1/025 , A61N1/37217
摘要： A visual prosthesis system comprises a retina implant at least partly located in the interior of a patient's eye. The retina implant comprises an array of micro-contacts adapted for contacting ganglia of the patient's retinal tissue. The visual prosthesis system further comprises a data processing unit with an additional interface for receiving an external signal from an external signal source, the data processing unit being adapted for converting the external signal into corresponding stimulation data for the retina implant, and a wireless transmission unit adapted for transmitting the stimulation data to the retina implant via wireless transmission. The retina implant is adapted for receiving the stimulation data and for stimulating the micro-contacts according to the stimulation data.
摘要翻译：视觉假体系统包括至少部分地位于患者眼睛内部的视网膜植入物。视网膜植入物包括适于接触患者视网膜组织的神经节的微接触阵列。视觉假体系统还包括具有用于从外部信号源接收外部信号的附加接口的数据处理单元，所述数据处理单元适于将外部信号转换成用于视网膜植入物的相应刺激数据，以及无线传输单元适于经由无线传输将刺激数据发送到视网膜植入物。视网膜植入物适于接收刺激数据并根据刺激数据刺激微接触。

3. 发明申请

US20120101550A1 VISUAL PROSTHESIS AND RETINA STIMULATION DEVICE FOR SAME 有权
标题翻译：可视化预防和反射刺激装置
公开(公告)号：US20120101550A1
公开(公告)日：2012-04-26
申请号：US13203710
申请日：2009-02-27
申请人： Hans-Jürgen Tiedtke
发明人： Hans-Jürgen Tiedtke
IPC分类号： A61F9/08 , A61N1/36
CPC分类号： A61N1/36046 , A61N1/0543
摘要： The present invention provides a visual prosthesis comprising: image capture means for capturing an image from a surrounding environment; image processing means for processing the image and converting the image into a transmissible image signal; signal processing means for processing and converting the image signal into a stimulation signal; and a retina stimulation device (10) adapted to stimulate the retina of both left and right eyes in accordance with the stimulation signal. The retina stimulation device (10) comprises a left-side stimulation unit (11) having an electrode array (12) for stimulating the retina of the left eye, and a right-side stimulation unit (11′) having an electrode array (12′) for stimulating the retina of the right eye, with the left-side stimulation unit (11) having a configuration which is reversed with respect to a configuration of the right-side stimulation unit (11′). Furthermore, the electrode array (12) has a plurality of individual electrodes (15) distributed in a predetermined pattern across a substrate (16) of the electrode array for stimulating the nerve cells of the retina. The electrode array substrate (16) is elongate in a lateral or transverse direction, namely in a medial-lateral direction with respect to an implantation orientation, such that the electrode array has a height-to-width ratio of less than 1, preferably less than 0.8, more preferably in the range of 0.6 to 0.2, and most preferably in the range of about 0.5 to about 0.3.
摘要翻译：本发明提供了一种视觉假体，包括：用于从周围环境拍摄图像的图像捕获装置; 图像处理装置，用于处理图像并将图像转换成可传输图像信号; 信号处理装置，用于处理和转换图像信号为刺激信号; 以及适于根据刺激信号刺激左眼和右眼的视网膜的视网膜刺激装置（10）。视网膜刺激装置（10）包括具有用于刺激左眼视网膜的电极阵列（12）的左侧刺激单元（11）和具有电极阵列（12'）的右侧刺激单元（11'）， '），用于刺激右眼的视网膜，左侧刺激单元（11）具有相对于右侧刺激单元（11'）的构造反转的构造。此外，电极阵列（12）具有分布在电极阵列的基板（16）上的预定图案的多个单独电极（15），用于刺激视网膜的神经细胞。电极阵列基板（16）在横向或横向方向上是细长的，即相对于注入取向在内侧方向上延伸，使得电极阵列的高度 - 宽度比小于1，优选较小优选为0.8，更优选为0.6〜0.2，最优选为0.5〜0.3左右。

4. 发明申请

US20110152969A1 EXTRAOCULAR EPIRETINAL IMPLANT 有权
标题翻译：特发性EPIRETINAL IMPLANT
公开(公告)号：US20110152969A1
公开(公告)日：2011-06-23
申请号：US11988634
申请日：2006-06-02
申请人： Thomas Zehnder , Hans-Jurgen Tiedtke
发明人： Thomas Zehnder , Hans-Jurgen Tiedtke
IPC分类号： A61F9/08 , A61N1/36
CPC分类号： A61N1/36046 , A61F9/08 , A61N1/025 , A61N1/0543 , A61N1/37223 , A61N1/37229 , A61N1/3787 , G02B27/017
摘要： The object of providing a visual prosthesis in the form of a retinal implant, which is distinguished by the least possible space requirement inside the eye, is achieved according to the present invention by a visual prosthesis having an intraocular implant and an extraocular implant, which supplies the intraocular implant with energy and controls it. The visual prosthesis according to the invention therefore offers the advantage that virtually all the electronic components, which do not necessarily need to be accommodated with the intraocular implant inside the eye, can be arranged outside the eyeball, for example on the sclera. In this way, the space requirement of the stimulation system inside the eye is reduced and the operative intervention for implanting the stimulation system inside the eye is kept as small as possible. The present invention furthermore discloses a bidirectional inductive interface between an extracorporeal part of the visual prosthesis and an intracorporeal part, comprising the intraocular and extraocular implants, via which an current supply and bidirectional data transmission can be carried out.
摘要翻译：根据本发明，通过具有眼内植入物和眼外植入物的视觉假体来实现以视网膜植入物形式提供视网膜植入物的目的，其目的是通过眼睛内部尽可能少的空间需求来区分，眼内植入物具有能量并控制它。因此，根据本发明的视觉假体提供的优点在于，实际上，不一定需要将眼内植入物容纳在眼睛内部的所有电子部件可以布置在眼球的外部，例如在巩膜上。以这种方式，眼睛内刺激系统的空间需求减少，并且用于将刺激系统植入眼睛内的手术干预尽可能地保持尽可能小。本发明还公开了一种在视觉假体的体外部分和体内部分之间的双向感应界面，其包括眼内和眼外植入物，通过该双眼感应界面可以进行电流供应和双向数据传输。

5. 发明申请

US20110071627A1 DEVICE FOR REVERSIBLY ATTACHING AN IMPLANT IN AN EYE 有权
标题翻译：用于直接连接眼睛中的植入物的装置
公开(公告)号：US20110071627A1
公开(公告)日：2011-03-24
申请号：US12293788
申请日：2007-01-26
申请人： Hans-Jürgen Tiedtke , Alexander Meyer
发明人： Hans-Jürgen Tiedtke , Alexander Meyer
IPC分类号： A61F2/14 , A61F9/00
CPC分类号： A61F2/148 , A61F2/14 , A61F9/007 , A61F2220/0008 , A61F2220/0016 , A61N1/0543
摘要： The object of providing a device for reversibly attaching an implant to an eye, with which the implant can be attached in a simple way to the eye and can if necessary be detached or removed from the eye, is achieved according to the present invention by means of a device for attaching an implant by means of a pin that comprises a substantially elongated shaft, wherein the implant includes an implant film for contacting living tissue or nerves in the visual system of the eye and the implant film has an opening through which the shaft of the pin can be at least partially inserted, characterised in that the device includes a holding element that can be arranged on the shaft of the pin so that the holding element engages on the shaft of the pin and is fixed in an attachment position to the pin. By means of the device according to the invention the implant is on the one hand reliably attached, but can if necessary be detached from the retina by removing the holding element or retainer, wherein the pin anchored in the eye does not have to be removed at the same time, but can be re-used. Damage or injury to the tissue of the eye that would otherwise be associated with the removal of the pin can thereby also be avoided.
摘要翻译：提供用于将植入物可逆地附接到眼睛的装置的目的是通过手段来实现根据本发明的植入物可以以简单的方式附接到眼睛并且如果必要的话可以从眼睛移除用于通过包括基本上细长的轴的销附接植入物的装置，其中所述植入物包括用于接触眼睛的视觉系统中的生物组织或神经的植入膜，并且所述植入物膜具有开口，所述轴通过所述开口销的至少一部分可以至少部分地插入，其特征在于，所述装置包括可以设置在销的轴上的保持元件，使得保持元件接合在销的轴上并且被固定在附接位置销。通过根据本发明的装置，植入物一方面可靠地附接，但是如果需要，可以通过移除保持元件或保持器从视网膜脱离，其中锚定在眼睛中的销钉不必在同时，但可以重复使用。因此，也可以避免对于否则与去除针相关联的眼睛组织的损伤或损伤。

6. 发明授权

US08306626B2 Artificial retina device with stimulating and ground return electrodes disposed on opposite sides of the neuroretina and method of attachment 有权
标题翻译：具有设置在神经视网膜的相对侧上的刺激和接地返回电极的人造视网膜装置和附着方法
公开(公告)号：US08306626B2
公开(公告)日：2012-11-06
申请号：US13153062
申请日：2011-06-03
申请人： Alan Y. Chow , Vincent Y. Chow
发明人： Alan Y. Chow , Vincent Y. Chow
IPC分类号： A61F9/08
CPC分类号： A61N1/0543 , A61F9/08 , A61N1/36046
摘要： An artificial retina device to electrically stimulate a neuroretina of an eye to produce artificial vision, the artificial retina device comprising: an electrical source; at least one stimulating electrode connected with the electrical source; and at least one ground return electrode connected with the electrical source, wherein the stimulating electrode and ground return electrode are configured to be disposed within the eye on opposite sides of the neuroretina.
摘要翻译：一种人造视网膜装置，用于电刺激眼睛的神经视网膜以产生人造视觉，所述人造视网膜装置包括：电源; 至少一个与电源连接的刺激电极; 以及与电源连接的至少一个接地返回电极，其中所述刺激电极和接地返回电极被配置为设置在所述眼睛内的所述神经视网膜的相对侧上。

7. 发明申请

US20120065670A1 DEVICE FOR SEALING AN INCISION 审中-公开
标题翻译：密封隐患的手段
公开(公告)号：US20120065670A1
公开(公告)日：2012-03-15
申请号：US13255880
申请日：2009-03-10
申请人： Hans-Jürgen Tiedtke , Ralf Hornig , Gisbert Richard
发明人： Hans-Jürgen Tiedtke , Ralf Hornig , Gisbert Richard
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B17/3423 , A61F9/0017 , A61F9/007
摘要： The present invention provides a plug device or grommet (1) for sealing an incision in tissue of a human or animal body, such as an incision in the tissue of the sclera (S) made during a surgical intervention for the implantation of a visual prosthesis. The device (1) comprises: a cover part (10) for covering the incision and an area of the tissue (S) around the incision; and an insertion part (20) extending from the cover part (10) for insertion into the incision through the tissue (S). The insertion part (20) defines a sealable passage (30) which is adapted to extend through the incision, and the insertion part (20) is preferably flexible and resiliency deformable to open and close the sealable passage (30) there-through. The sealable passage (30) extends through the incision to provide communication between an outer side (S0) of the tissue and an inner side (Si) of the tissue. The passage (30) may accommodate a component which provides a connection or interconnection through the tissue (S).
摘要翻译：本发明提供一种用于密封人体或动物体的组织中的切口的塞子装置或护环（1），例如在用于植入视觉假体的外科手术期间制造的巩膜组织中的切口（S）。所述装置（1）包括：覆盖所述切口的覆盖部分（10）和所述切口周围的所述组织（S）的区域; 以及从所述盖部（10）延伸以插入穿过所述组织（S）的切口的插入部（20）。所述插入部分（20）限定适于延伸通过所述切口的可密封通道（30），并且所述插入部分（20）优选是柔性的并且可弹性变形以在其上打开和关闭所述可密封通道（30）。可密封通道（30）延伸穿过切口以提供组织的外侧（S0）和组织的内侧（Si）之间的连通。通道（30）可以容纳通过组织（S）提供连接或互连的部件。

8. 发明申请

US20110257716A1 ELECTRODE ARRAY AND METHOD OF MANUFACTURING SAME 有权
标题翻译：电极阵列及其制造方法
公开(公告)号：US20110257716A1
公开(公告)日：2011-10-20
申请号：US13120749
申请日：2008-09-26
申请人： Hans-Jürgen Tiedtke
发明人： Hans-Jürgen Tiedtke
IPC分类号： A61F9/08 , B32B37/02
CPC分类号： A61N1/0543 , A61N1/05 , Y10T156/10
摘要： The present invention provides an electrode array for a medical implant device, comprising a substrate supporting a plurality of electrodes, the substrate comprising at least two layers of material including a first layer and a second layer, wherein the first layer of material and the second layer of material have different coefficients of thermal expansion. The plurality of electrodes may be supported on the first layer of material, and are preferably incorporated in and/or project from the second layer of material. The second layer of material may itself have a layered structure comprising multiple material layers, with the plurality of electrodes incorporated within the said multiple material layers. The first layer of material preferably has a higher coefficient of thermal expansion than the second layer of material. The invention furthermore provides a medical implant device including an electrode array according to the invention, and a method of manufacturing such an electrode array.
摘要翻译：本发明提供了一种用于医疗植入装置的电极阵列，包括支撑多个电极的基底，所述基底包括至少两层包括第一层和第二层的材料，其中第一层材料和第二层的材料具有不同的热膨胀系数。多个电极可以被支撑在第一材料层上，并且优选地并入第二层材料和/或从第二层材料突出。第二层材料本身可以具有包括多个材料层的分层结构，其中多个电极并入所述多个材料层内。第一层材料优选具有比第二层材料更高的热膨胀系数。本发明还提供了包括根据本发明的电极阵列的医疗植入装置和制造这种电极阵列的方法。

9. 发明授权

US07979134B2 Artificial retina device with stimulating and ground return electrodes disposed on opposite sides of the neuroretina and method of attachment 有权
标题翻译：具有设置在神经视网膜的相对侧上的刺激和接地返回电极的人造视网膜装置和附着方法
公开(公告)号：US07979134B2
公开(公告)日：2011-07-12
申请号：US11293871
申请日：2005-12-02
申请人： Alan Y. Chow , Vincent Y. Chow
发明人： Alan Y. Chow , Vincent Y. Chow
IPC分类号： A61F2/16
CPC分类号： A61N1/0543 , A61F9/08 , A61N1/36046
摘要： An artificial retinal device, implanted in the subretinal space of the eye in persons with certain types of retinal blindness, induces artificial vision by electrical stimulation of the remaining viable cells of the retina. The artificial retina device includes a stimulating electrode unit preferably placed in the subretinal space.
摘要翻译：人眼视网膜装置植入视网膜视网膜失明者中的视网膜视网膜中，通过电刺激视网膜的剩余活细胞诱导人工视觉。人造视网膜装置包括优选放置在视网膜下空间中的刺激电极单元。

10. 发明申请

US20090234425A1 METHOD FOR PRODUCING IMPLANT STRUCTURES FOR CONTACTING OR ELECTROSTIMULATION OF LIVING TISSUE CELLS OR NERVES 有权
标题翻译：生产用于生活组织细胞或神经细胞接触或电生理的植入物结构的方法
公开(公告)号：US20090234425A1
公开(公告)日：2009-09-17
申请号：US12296519
申请日：2007-01-26
申请人： Hans-Jurgen Tiedtke
发明人： Hans-Jurgen Tiedtke
IPC分类号： A61N1/05 , B05D3/00 , C23C14/34 , B32B15/00
CPC分类号： A61N1/05 , A61N1/0543 , A61N1/0551 , B81C99/008 , B81C2201/0107 , B81C2201/0181 , Y10T428/12493
摘要： The object, to create a method for producing multilayers or multilayer systems wherein the structures generated on a substrate can easily be jointly detached from the substrate and are preserved in a composite, is achieved by the present invention by means of a method for producing implant structures comprising generating a first metal layer on a substrate, generating a second metal layer above the first metal layer, producing a number of multilayered implant structures above the second metal layer, removing the first metal layer between the substrate and the second metal layer, and releasing the implant structures from the substrate in a coherent composite. With the method according to the invention, between the implant structures and the substrate a release layer is generated consisting of two or three metal layers which serve as sacrificial layer in the course of releasing the fully processed multilayers by means of an under-etching process. As a result, a uniform and reliable separation of the finished multilayers from the substrate in a composite is achieved, facilitating the subsequent technology for assembly and interconnection of the implant structures.
摘要翻译：本发明的目的是为了产生多层或多层体系的制造方法，其中在衬底上产生的结构可以容易地与衬底共同分离并且被保存在复合材料中，这通过本发明通过生产植入结构的方法来实现包括在衬底上产生第一金属层，在第一金属层上方产生第二金属层，在第二金属层之上产生多个多层植入结构，去除衬底和第二金属层之间的第一金属层，并释放在相干复合材料中来自基底的植入物结构。利用根据本发明的方法，在植入结构和衬底之间，产生剥离层，其由在蚀刻过程中释放完全处理的多层膜的过程中用作牺牲层的两个或三个金属层组成。结果，实现了在复合材料中完成的多层与基底的均匀可靠的分离，有助于随后的用于植入结构的组装和互连的技术。

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