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1. 发明授权

US09221768B2 Affinity adsorbents for fibrinogen 有权
标题翻译：纤维蛋白原亲和吸附剂
公开(公告)号：US09221768B2
公开(公告)日：2015-12-29
申请号：US13954237
申请日：2013-07-30
申请人： PROMETIC BIOSCIENCES LTD
发明人： Jason Richard Betley , James Christopher Pearson , Ben Martin Beacom , Tadeusz Antoni Podgorski , Robert William Pannell
IPC分类号： C07D251/00 , A61K31/5375 , C07K1/22 , G01N30/02 , C07D251/48 , B01J20/286 , B01J20/289 , C07K14/75 , G01N33/86 , B01J20/32
CPC分类号： C07D251/48 , B01J20/286 , B01J20/289 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J2220/54 , B01J2220/58 , C07K14/75 , G01N33/86
摘要： For the separation, removal, isolation, purification, characterisation, identification or quantification of fibrinogen or a protein that is a fibrinogen analogue, an affinity adsorbent is used that is a compound of formula II wherein one X is N and the other is N, C—CI or C—CN; Y is O, S or NR2; Z is O, S or NR3; R2 and R3 are each H, alkyl, hydroxyalkyl, benzyl or β-phenylethyl; n is 0 to 6; A is a support matrix, optionally linked to the triazine ring by a spacer; R7 is a group bearing a positive charge at neutral pH; W is an optional linker; V is an aromatic group; and R8 and R9 are each H, OH, alkyl, alkoxy, amino, NH2, acyloxy, acylamino, CO2H, sulphonic acid, carbamoyl, sulphamoyl, alkylsulphonyl or halogen or a cyclic structure such as a morpholino group, or R8 and R9 are linked to form such a cyclic structure.
摘要翻译：为了纤维蛋白原或纤维蛋白原类似物的蛋白质的分离，去除，分离，纯化，表征，鉴定或定量，使用亲和吸附剂，其为一种式II化合物，其中一个X为N，另一个为N，C -CI或C-CN; Y是O，S或NR2; Z是O，S或NR 3; R 2和R 3各自为H，烷基，羟基烷基，苄基或苯乙基; n为0〜6; A是支持基质，任选地通过间隔基与三嗪环连接; R7是在中性pH下带正电荷的基团; W是可选的接头; V是芳族基团; 并且R 8和R 9各自为H，OH，烷基，烷氧基，氨基，NH 2，酰氧基，酰基氨基，CO 2 H，磺酸，氨基甲酰基，氨磺酰基，烷基磺酰基或卤素或环状结构如吗啉代基或R8和R9 形成这样的循环结构。

2. 发明申请

US20130217645A1 Compounds and Compositions for the Treatment of Cancer 有权
标题翻译：用于治疗癌症的化合物和组合物
公开(公告)号：US20130217645A1
公开(公告)日：2013-08-22
申请号：US13882355
申请日：2011-10-26
申请人： Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Pierre Laurin , Christopher Penney , Boulos Zacharie
发明人： Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Pierre Laurin , Christopher Penney , Boulos Zacharie
IPC分类号： A61K31/192 , C07C57/48 , C07C59/54 , C07C229/42 , A61K31/196 , A61K31/675 , C07C229/18 , C07C323/52 , C07C62/20 , A61K31/7068 , A61K31/513 , C07C57/46 , C07C59/84
CPC分类号： A61K31/192 , A61K31/196 , A61K31/22 , A61K31/513 , A61K31/675 , A61K31/7068 , C07C57/46 , C07C57/48 , C07C59/54 , C07C59/84 , C07C62/20 , C07C229/18 , C07C229/42 , C07C323/52
摘要： New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC and Formula II and their pharmaceutical acceptable salts for the treatment of cancer. The use of a combination of two of these compounds is described and the use of the combination of one of these compounds with an anticancer agent such as decarbazine, doxorubicin, daunorubicin, cyclophosphamide, busulfex, busulfan, vinblastine, vincristine, bleomycin, etoposide, topotecan, irinotecan, taxotere, taxol, 5-fluorouracil, methotrexate, gemcitabine, cisplatin, carboplatin and chlorambucil.
摘要翻译：苯甲酮羧酸酯化合物和式I，式I.1，式I.2，式IA，式IB，式IC和式II的取代芳族化合物及其用于治疗癌症的药学上可接受的盐的新用途。描述了这些化合物中的两种的组合的使用，并且使用这些化合物之一与抗癌剂如脱巴嗪，多柔比星，柔红霉素，环磷酰胺，总胆固醇，白消安，长春花碱，长春新碱，博来霉素，依托泊苷，拓扑替康，伊立替康，泰索帝，紫杉醇，5-氟尿嘧啶，甲氨蝶呤，吉西他滨，顺铂，卡铂和苯丁酸氮芥。

3. 发明申请

US20100286269A1 Medium-Chain Length Fatty Acids and Glycerides as Nephroprotection Agents 有权
标题翻译：中链长度脂肪酸和甘油酯作为肾保护剂
公开(公告)号：US20100286269A1
公开(公告)日：2010-11-11
申请号：US12740700
申请日：2008-11-03
申请人： Vincent Pichette , Francois Leblond , Mouna Lagraoui , Lyne Gagnon
发明人： Vincent Pichette , Francois Leblond , Mouna Lagraoui , Lyne Gagnon
IPC分类号： A61K31/23 , A61K31/20 , A61P35/00 , A61P13/12 , A61P3/10 , A61P37/00 , A61P9/00 , A61P29/00
CPC分类号： A61K31/20 , A61K31/23 , A61K45/06 , A61K2300/00
摘要： Use of medium-chain length fatty acids such as capric acid, caprylic acid or lauric acid and their salts or mono- or di- or triglycerides as nephroprotection agents to protect against renal failure progression in chronic kidney diseases This includes the treatment of kidney diseases associated with nephrectomy, renal fibrosis, glomerular scelrosis and end-stage renal disease Also includes the protection of the kidney against cytotoxic agent used in chemotherapy or autoimmune diseases or transplantation Further includes the treatment of renal failure progression associated with hypertension, infarct, tumour, diabetes mellitus, autoimmunity or inflammation.
摘要翻译：使用中链长度脂肪酸如癸酸，辛酸或月桂酸及其盐或单 - 或二 - 或甘油三酸酯作为肾保护剂，以防止慢性肾脏疾病中的肾衰竭进展这包括治疗肾脏疾病相关肾切除术，肾纤维化，肾小球结肠炎和终末期肾脏疾病还包括对化疗或自身免疫性疾病或移植中使用的细胞毒性剂的肾脏保护进一步包括治疗与高血压，梗塞，肿瘤，糖尿病相关的肾衰竭进展，自身免疫或炎症。

4. 发明授权

US09114118B2 Compounds and compositions for the treatment of cancer 有权
标题翻译：用于治疗癌症的化合物和组合物
公开(公告)号：US09114118B2
公开(公告)日：2015-08-25
申请号：US13882355
申请日：2011-10-26
申请人： Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Pierre Laurin , Christopher Penney , Boulos Zacharie
发明人： Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Pierre Laurin , Christopher Penney , Boulos Zacharie
IPC分类号： A01N27/00 , A61K31/015 , A61K31/192 , A61K31/196 , A61K31/22 , A61K31/513 , A61K31/675 , A61K31/7068 , C07C57/46 , C07C57/48 , C07C59/54 , C07C59/84 , C07C62/20 , C07C229/18 , C07C229/42 , C07C323/52
CPC分类号： A61K31/192 , A61K31/196 , A61K31/22 , A61K31/513 , A61K31/675 , A61K31/7068 , C07C57/46 , C07C57/48 , C07C59/54 , C07C59/84 , C07C62/20 , C07C229/18 , C07C229/42 , C07C323/52
摘要： New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC and Formula II and their pharmaceutical acceptable salts for the treatment of cancer. The use of a combination of two of these compounds is described and the use of the combination of one of these compounds with an anticancer agent such as decarbazine, doxorubicin, daunorubicin, cyclophosphamide, busulfex, busulfan, vinblastine, vincristine, bleomycin, etoposide, topotecan, irinotecan, taxotere, taxol, 5-fluorouracil, methotrexate, gemcitabine, cisplatin, carboplatin and chlorambucil.
摘要翻译：苯甲酮羧酸酯化合物和式I，式I.1，式I.2，式IA，式IB，式IC和式II的取代芳族化合物及其用于治疗癌症的药学上可接受的盐的新用途。描述了这些化合物中的两种的组合的使用，并且使用这些化合物之一与抗癌剂如脱巴嗪，多柔比星，柔红霉素，环磷酰胺，总胆固醇，白消安，长春花碱，长春新碱，博来霉素，依托泊苷，拓扑替康，伊立替康，泰索帝，紫杉醇，5-氟尿嘧啶，甲氨蝶呤，吉西他滨，顺铂，卡铂和苯丁酸氮芥。

5. 发明申请

US20130225681A1 Phenylketone Carboxylate Compounds and Pharmaceutical Uses Thereof 有权
标题翻译：苯甲酮羧酸酯化合物及其药物用途
公开(公告)号：US20130225681A1
公开(公告)日：2013-08-29
申请号：US13882363
申请日：2011-10-26
申请人： Boulos Zacharie , Christopher Penney , Shaun Abbott , Lyne Gagnon , Brigette Grouix , Pierre Laurin
发明人： Boulos Zacharie , Christopher Penney , Shaun Abbott , Lyne Gagnon , Brigette Grouix , Pierre Laurin
IPC分类号： C07C59/90 , C07C229/18 , C07C59/84 , C07C69/92 , C07C59/68 , C07C62/38 , C07C323/52
CPC分类号： C07C59/90 , A61K31/192 , A61K31/196 , A61K31/222 , A61K31/235 , C07C59/68 , C07C59/84 , C07C62/38 , C07C65/32 , C07C69/92 , C07C217/84 , C07C225/22 , C07C229/18 , C07C323/20 , C07C323/52 , C07C323/62 , C07C2602/08
摘要： Phenylketone carboxylate compounds of Formula I, wherein n=2-6; R═C(0); —OC(O)— or —CH(OH)—; A is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when B is Ft B is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when A is Ft or A and B form a 5-7 membered cycloalkyl substituted with COOFt W=0, S or NFt Y=0,S,NH or CH2; m=0-2; p=1-7; have been prepared. These compounds and their pharmaceutically acceptable salts have beneficial therapeutic effects to prevent or treat a condition related to (l) blood disorders, (ii) inflammation related diseases, (iii) renal disorders and/or renal disorders complications, or (iv) fibrosis-related organ dysfunction.
摘要翻译：式I的苯甲酮羧酸酯化合物，其中n = 2-6; R = C（0）; -OC（O） - 或-CH（OH） - ; 当B是Ft B是（CH2）mCOOH，W（CH2）mCOOH或YCH（COOH）（（CH2）pCH3）时，A是（CH2）mCOOH，W（CH2）mCOOH或YCH 当A为Ft或A和B形成被COOFt W = 0取代的5-7元环烷基时，S或NFt Y = 0，S，NH或CH 2; m = 0-2; p = 1-7; 已经准备好了这些化合物及其药学上可接受的盐具有有益的治疗效果，以预防或治疗与（l）血液病症有关的病症，（ii）炎症相关疾病，（iii）肾脏疾病和/或肾脏疾病并发症，或（iv）纤维化 - 相关器官功能障碍。

6. 发明授权

US6046246A Process for making fluorinated polymer adsorbent particles 失效
标题翻译：制备氟化聚合物吸附剂颗粒的方法
公开(公告)号：US6046246A
公开(公告)日：2000-04-04
申请号：US329289
申请日：1999-06-10
申请人： Christopher Lowe , Julie Tucker
发明人： Christopher Lowe , Julie Tucker
IPC分类号： B01J20/285 , B01D15/08 , B01D15/32 , B01D15/34 , B01D15/36 , B01D15/38 , B01J20/26 , B01J20/281 , B01J20/286 , B01J20/287 , B01J20/30 , B01J20/32 , C08F2/18 , C08F2/44 , C08F20/20 , C08J9/26 , C08J9/36 , C12N15/10 , G01N30/88 , C08J9/22
CPC分类号： B01D15/325 , B01D15/1807 , B01D15/366 , B01D15/3804 , B01J20/26 , B01J20/286 , B01J20/287 , C12N15/1006 , C12N15/101 , B01D2215/021 , G01N2030/042 , Y10S435/803
摘要： Chemically resistant, strong fluorinated copolymer adsorbent particles for use in carrying out chromatographic separations are prepared by high shear, anaerobic reaction of a di-unsaturated crosslinking agent with a polyfluorinated monomer in the presence of poly(vinyl alcohol) and a porogen.
摘要翻译：通过在聚（乙烯醇）和致孔剂存在下，通过二不饱和交联剂与多氟化单体的高剪切，厌氧反应来制备用于进行色谱分离的化学抗性强的含氟共聚物吸附剂颗粒。

7. 发明授权

US08071580B2 Medium-chain length fatty alcohols as stimulators of hematopoiesis 有权
标题翻译：中链长脂肪醇作为造血刺激物
公开(公告)号：US08071580B2
公开(公告)日：2011-12-06
申请号：US11663888
申请日：2005-09-29
申请人： Christopher Penney , Lyne Gagnon , Jean Barabé
发明人： Christopher Penney , Lyne Gagnon , Jean Barabé
IPC分类号： A61K31/33 , A61K31/045
CPC分类号： A61K31/045
摘要： Medium-chain length fatty alcohols such as octanol, decanol, dodecanol, or analogues thereof can be used as a stimulator of hematopoiesis, hematopoietic stem cell proliferation, and/or proliferation of one or more of the progenitors of red or white blood cells (e.g., erythrocyte, leukocyte, neutrophil, granulocyte, megakaryocyte, or any combination thereof). It also relates to the treatment of myelosuppression; in particular, this includes the treatment of anemia and/or neutropenia associated with chemotherapy and/or radiotherapy. Moreover, anemia arising from chronic renal failure or treatment of HIV-infected patients with AZT (zidovudine), or other inhibitors of reverse transcriptase, can be treated. Furthermore, neutropenia arising from infections, hematologic diseases, or nutritional deficiencies can be treated. It also relates to reducing drug toxicity and enhancing drug efficiency.
摘要翻译：中链长度脂肪醇如辛醇，癸醇，十二烷醇或其类似物可用作红细胞或白细胞的一种或多种祖细胞造血干细胞增殖和/或增殖的刺激物（例如，，红细胞，白细胞，嗜中性粒细胞，粒细胞，巨核细胞或其任何组合）。它还涉及骨髓抑制的治疗; 特别地，这包括治疗与化学疗法和/或放射疗法相关的贫血和/或中性白细胞减少症。此外，可以治疗由慢性肾衰竭引起的贫血或治疗感染AZT（齐多夫定）的HIV感染患者或其他逆转录酶抑制剂的贫血。此外，可以治疗由感染，血液病或营养缺乏引起的中性粒细胞减少症。它还涉及降低药物毒性和提高药物效率。

8. 发明授权

US07745488B2 Medium-chain length fatty acids, glycerides and analogues as neutrophil survival and activation factors 有权
标题翻译：中链长度脂肪酸，甘油酯和类似物作为嗜中性粒细胞存活和激活因子
公开(公告)号：US07745488B2
公开(公告)日：2010-06-29
申请号：US10475266
申请日：2002-04-18
申请人： Lyne Gagnon , Jean Barabe , Pierre Laurin , Christopher Penney , Boulos Zacharie
发明人： Lyne Gagnon , Jean Barabe , Pierre Laurin , Christopher Penney , Boulos Zacharie
IPC分类号： A61K31/255 , A61K31/225
CPC分类号： C07C237/22 , A61K31/18 , A61K31/194 , A61K31/20 , A61K31/23 , A61K31/255 , A61K31/7024 , A61K38/193 , A61K38/2013 , A61K38/2086 , A61K45/06 , C07B2200/11 , C07C233/18 , C07C233/47 , C07C235/06 , C07C235/08 , C11C3/003 , C11C3/02 , C40B40/00 , Y02A50/387 , Y02A50/483 , A61K2300/00
摘要： A composition and method for promoting neutrophil survival and activation such as the treatment of neutropenia arising as an undesirable side effect of chemotherapy and radiation therapy. A composition containing medium-chain fatty acids, such as Capri acid or caprylic acid, or salts or triglycerides thereof, or mono- or diglycerides or other analogues thereof or medium-chain triglycerides (MCT) is administered to a human or animal needing treatment in an amount sufficient to reduce or eliminate neutropenia. The composition is administered in an amount effective to treat the disorder. The methods are also useful in the management of bone narrow transplantation and in the treatment of various neutropenic diseases.
摘要翻译：用于促进嗜中性粒细胞存活和激活的组合物和方法，例如治疗作为化疗和放射治疗的不良副作用引起的中性粒细胞减少。将含有中链脂肪酸的组合物，例如Capri酸或辛酸，或其盐或甘油三酯，或甘油单酯或甘油二酯或其它类似物或中链甘油三酸酯（MCT）给予需要治疗的人或动物足以减少或消除中性粒细胞减少的量。组合物以有效治疗病症的量给药。该方法也可用于骨狭窄移植的治疗和各种嗜中性粒细胞减少症的治疗。

9. 发明申请

US20100129350A1 Triazine Derivatives, Compositions Containing Such Derivatives, and Methods of Treatment of Cancer and Autoimmune Diseases Using Such Derivatives 有权
标题翻译：三嗪衍生物，含有此类衍生物的组合物，以及使用此类衍生物治疗癌症和自身免疫性疾病的方法
公开(公告)号：US20100129350A1
公开(公告)日：2010-05-27
申请号：US12598273
申请日：2008-04-25
申请人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Shaun D. Abbott
发明人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Shaun D. Abbott
IPC分类号： A61K31/53 , C07D251/54 , A61K31/704 , A61K31/675 , A61K38/00 , A61K31/7048 , A61K31/7068 , A61K33/24 , A61K39/395 , A61P35/00 , A61P37/00
CPC分类号： C07D251/18 , C07D251/70
摘要： We describe compounds of the following general formula (I): wherein X is fluorine or chlorine; Y is oxygen, sulfur, or an amino group; R is an amino, hydroxyl, sulfonamide, or carboxamide group or an N-monomethyl or N-dimethyl analog thereof; m is an integer from 2 to 6, and n is an integer from 0 to 2. The compounds may be used for treating certain cancers and autoimmune diseases.
摘要翻译：我们描述以下通式（I）的化合物：其中X是氟或氯; Y是氧，硫或氨基; R是氨基，羟基，磺酰胺或羧酰胺基团或其N-甲基或N-二甲基类似物; m为2〜6的整数，n为0〜2的整数。化合物可用于治疗某些癌症和自身免疫性疾病。

10. 发明授权

US09475750B2 Phenylketone carboxylate compounds and pharmaceutical uses thereof 有权
标题翻译：苯甲酮羧酸酯化合物及其药物用途
公开(公告)号：US09475750B2
公开(公告)日：2016-10-25
申请号：US13882363
申请日：2011-10-26
申请人： Boulos Zacharie , Christopher Penney , Shaun Abbott , Lyne Gagnon , Brigitte Grouix , Pierre Laurin , Jean-François Bienvenu
发明人： Boulos Zacharie , Christopher Penney , Shaun Abbott , Lyne Gagnon , Brigitte Grouix , Pierre Laurin , Jean-François Bienvenu
IPC分类号： C07C59/90 , C07C62/38 , C07C65/32 , C07C69/92 , C07C217/84 , C07C225/22 , C07C229/18 , C07C323/20 , C07C323/52 , C07C323/62 , A61K31/192 , A61K31/196 , A61K31/222 , A61K31/235 , C07C59/68 , C07C59/84
CPC分类号： C07C59/90 , A61K31/192 , A61K31/196 , A61K31/222 , A61K31/235 , C07C59/68 , C07C59/84 , C07C62/38 , C07C65/32 , C07C69/92 , C07C217/84 , C07C225/22 , C07C229/18 , C07C323/20 , C07C323/52 , C07C323/62 , C07C2602/08
摘要： Phenylketone carboxylate compounds of Formula I, wherein n=2-6; R═C(0); —OC(O)— or —CH(OH)—; A is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when B is Ft B is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when A is Ft or A and B form a 5-7 membered cycloalkyl substituted with COOFt W=0, S or NFt Y=0,S,NH or CH2; m=0-2; p=1-7; have been prepared. These compounds and their pharmaceutically acceptable salts have beneficial therapeutic effects to prevent or treat a condition related to (l) blood disorders, (ii) inflammation related diseases, (iii) renal disorders and/or renal disorders complications, or (iv) fibrosis-related organ dysfunction.

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