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1. 发明授权

US08476470B2 Process for production of bicyclo[2.2.2]octylamine derivative 失效
标题翻译：二环[2.2.2]辛胺衍生物的制备方法
公开(公告)号：US08476470B2
公开(公告)日：2013-07-02
申请号：US13057879
申请日：2009-08-07
申请人： Tomohiro Akeboshi , Yusuke Iriyama , Hirotaka Kawanami
发明人： Tomohiro Akeboshi , Yusuke Iriyama , Hirotaka Kawanami
IPC分类号： C07C62/20
CPC分类号： C07C229/50 , C07C227/16 , C07C227/22 , C07C249/02 , C07C251/20 , C07C303/28 , C07C309/66 , C07C2602/44
摘要： The present invention herein provides a process for production of a bicyclo[2.2.2]octylamine derivative which may be used as an intermediate for preparation of medical and pharmaceutical products. The process is quite efficient and can produce the derivative in a large-scale while using mild reaction conditions.The process for producing a bicyclo[2.2.2]octylamine derivative comprises the steps of subjecting, to ring-formation, a compound represented by the following general formula (1): [wherein R1 represents an alkyl group having 1 to 6 carbon atoms, which may have a substituent; an arylmethyl group which may have a substituent; or an arylethyl group which may have a substituent], and a compound represented by the following general formula (2): R2—NH2 (2) [wherein R2 represents an alkyl group having 1 to 6 carbon atoms, which may have a substituent; an aralkyl group which may have a substituent; a hydroxyl group; an alkyloxy group having 1 to 6 carbon atoms, which may have a substituent; or an aralkyloxy group which may have a substituent], and then reducing the resulting product.
摘要翻译：本发明提供了可用作制备医药产品的中间体的双环[2.2.2]辛胺衍生物的制备方法。该方法是非常有效的，并且可以在使用温和的反应条件的情况下大量产生衍生物。制备双环[2.2.2]辛胺衍生物的方法包括以下步骤：使由下列通式（1）表示的化合物进行成环：其中R 1表示具有1至6个碳原子的烷基，其可以具有取代基; 可以具有取代基的芳基甲基; 或可以具有取代基的芳基乙基）和由以下通式（2）表示的化合物：R2-NH2（2）[其中R2表示可以具有取代基的碳原子数1〜6的烷基] 可以具有取代基的芳烷基; 羟基; 可以具有取代基的碳原子数1〜6的烷氧基; 或可具有取代基的芳烷氧基），然后还原所得产物。

2. 发明授权

US4283420A Pharmaceutically active cyclohexyl compounds and their preparation 失效
标题翻译：药物活性环己基化合物及其制备方法
公开(公告)号：US4283420A
公开(公告)日：1981-08-11
申请号：US31165
申请日：1979-04-18
申请人： Charles Pigerol , Jean-Claude Vernieres , Pierre Eymard , Jacques Simiand , Madeleine Broll , Jean-Yves Lacolle
发明人： Charles Pigerol , Jean-Claude Vernieres , Pierre Eymard , Jacques Simiand , Madeleine Broll , Jean-Yves Lacolle
IPC分类号： A61K31/16 , A61K31/165 , A61K31/19 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/28 , C07C51/00 , C07C51/08 , C07C51/09 , C07C51/27 , C07C51/353 , C07C51/367 , C07C51/377 , C07C51/41 , C07C51/60 , C07C61/08 , C07C61/10 , C07C61/15 , C07C61/16 , C07C61/20 , C07C61/22 , C07C61/35 , C07C61/39 , C07C61/40 , C07C62/04 , C07C62/10 , C07C62/20 , C07C62/34 , C07C67/00 , C07C231/00 , C07C233/00 , C07C233/58 , C07C235/40 , C07C235/82
CPC分类号： C07C62/34 , C07C51/08 , C07C51/09 , C07C51/27 , C07C51/353 , C07C51/367 , C07C51/377 , C07C51/412 , C07C51/60 , C07C61/08 , C07C61/15 , C07C61/35 , C07C61/39 , C07C61/40 , C07C62/04 , C07C62/10 , C07C62/20
摘要： The chemical compounds of the invention are useful as the active compound in drugs because of their anticonvulsant and/or antianoxic activity. They have the general formula ##STR1## wherein Z is a hydroxyl group; a group--OM wherein M is an alkali metal atom or an equivalent atom fraction of an alkaline-earth metal or an amino group such as --NH.sub.2, and R is a linear or branched alkyl group containing from 1 to 9 carbon atoms, and optionally substituted by one or more halogen atoms; a linear or branched alkenyl or alkynyl, alkoxyalkyl, or acylalkyl group containing from 2 to 9 carbon atoms and optionally substituted by one or more halogen atoms; an aryl or arylalkyl or aryloxyalkyl group comprising at least one aromatic radical and an alkyl chain having from 1 to 4 carbon atoms.
摘要翻译：本发明的化合物由于其抗惊厥和/或抗氧化活性而可用作药物中的活性化合物。它们具有通式，其中Z是羟基; 基团-M OM，其中M是碱金属原子或碱土金属或氨基的等价原子级分，例如-NH 2，R是含有1至9个碳原子的直链或支链烷基，并且任选地被一个或多个卤素原子取代; 含有2至9个碳原子并且任选被一个或多个卤素原子取代的直链或支链烯基或炔基，烷氧基烷基或酰基烷基; 包含至少一个芳族基团和具有1至4个碳原子的烷基链的芳基或芳基烷基或芳氧基烷基。

3. 发明申请

US20130217645A1 Compounds and Compositions for the Treatment of Cancer 有权
标题翻译：用于治疗癌症的化合物和组合物
公开(公告)号：US20130217645A1
公开(公告)日：2013-08-22
申请号：US13882355
申请日：2011-10-26
申请人： Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Pierre Laurin , Christopher Penney , Boulos Zacharie
发明人： Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Pierre Laurin , Christopher Penney , Boulos Zacharie
IPC分类号： A61K31/192 , C07C57/48 , C07C59/54 , C07C229/42 , A61K31/196 , A61K31/675 , C07C229/18 , C07C323/52 , C07C62/20 , A61K31/7068 , A61K31/513 , C07C57/46 , C07C59/84
CPC分类号： A61K31/192 , A61K31/196 , A61K31/22 , A61K31/513 , A61K31/675 , A61K31/7068 , C07C57/46 , C07C57/48 , C07C59/54 , C07C59/84 , C07C62/20 , C07C229/18 , C07C229/42 , C07C323/52
摘要： New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC and Formula II and their pharmaceutical acceptable salts for the treatment of cancer. The use of a combination of two of these compounds is described and the use of the combination of one of these compounds with an anticancer agent such as decarbazine, doxorubicin, daunorubicin, cyclophosphamide, busulfex, busulfan, vinblastine, vincristine, bleomycin, etoposide, topotecan, irinotecan, taxotere, taxol, 5-fluorouracil, methotrexate, gemcitabine, cisplatin, carboplatin and chlorambucil.
摘要翻译：苯甲酮羧酸酯化合物和式I，式I.1，式I.2，式IA，式IB，式IC和式II的取代芳族化合物及其用于治疗癌症的药学上可接受的盐的新用途。描述了这些化合物中的两种的组合的使用，并且使用这些化合物之一与抗癌剂如脱巴嗪，多柔比星，柔红霉素，环磷酰胺，总胆固醇，白消安，长春花碱，长春新碱，博来霉素，依托泊苷，拓扑替康，伊立替康，泰索帝，紫杉醇，5-氟尿嘧啶，甲氨蝶呤，吉西他滨，顺铂，卡铂和苯丁酸氮芥。

4. 发明授权

US5344845A Compound and use of the same as medicine 失效
标题翻译：复合和使用与药物相同
公开(公告)号：US5344845A
公开(公告)日：1994-09-06
申请号：US938170
申请日：1992-12-04
申请人： Akihide Koda , Koji Waragai , Yutaka Ono , Hideyuki Ozawa , Hideki Kawamura , Masao Maruno , Takeshi Wakamatsu
发明人： Akihide Koda , Koji Waragai , Yutaka Ono , Hideyuki Ozawa , Hideki Kawamura , Masao Maruno , Takeshi Wakamatsu
IPC分类号： A61K31/12 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/357 , A61K31/36 , A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/4468 , A61K31/454 , A61P37/08 , C07C62/04 , C07C62/20 , C07C62/24 , C07C62/30 , C07C62/34 , C07C62/36 , C07C62/38 , C07C69/734 , C07C233/09 , C07C233/40 , C07C233/78 , C07C235/34 , C07C235/36 , C07C235/54 , C07C237/20 , C07C237/22 , C07C271/22 , C07C323/25 , C07D211/16 , C07D211/58 , C07D211/62 , C07D233/54 , C07D233/60 , C07D233/70 , C07D233/88 , C07D235/06 , C07D295/092 , C07D295/185 , C07D295/22 , C07D309/12 , C07D317/60 , C07D401/12 , C07D405/12 , C07D407/12 , C07D493/08 , C07D521/00 , A61K31/495 , C07D213/75 , C07C103/82
CPC分类号： C07D233/56 , C07C233/40 , C07C233/78 , C07C235/34 , C07C235/36 , C07C235/54 , C07C237/20 , C07C237/22 , C07C271/22 , C07C323/25 , C07C62/04 , C07C62/20 , C07C62/24 , C07C62/30 , C07C62/34 , C07C62/36 , C07C62/38 , C07C69/734 , C07D211/58 , C07D211/62 , C07D231/12 , C07D249/08 , C07D295/088 , C07D295/185 , C07D309/12 , C07D317/60 , C07D493/08 , C07C2101/08 , C07C2101/14 , C07C2102/22
摘要： Disclosed herein is a specific cinnamic acid derivative such as methyl 4-(4-acetoxy-3-methoxycinnamanide)-1-cyclohexanecarboxylate, or a pharmaceutically acceptable salt thereof. These compounds are useful as IV-type allergic reaction-suppressive drugs.
摘要翻译： PCT No.PCT / JP92 / 00451 Sec。 371日期1992年12月4日第 102（e）日期1992年12月4日PCT提交1992年4月10日PCT公布。 WO92 / 18463 PCT出版物 1992年10月29日的日期。本文公开了特定的肉桂酸衍生物，例如4-（4-乙酰氧基-3-甲氧基肉桂酸）-1-环己烷羧酸甲酯或其药学上可接受的盐。这些化合物可用作IV型过敏反应抑制药物。

5. 发明授权

US09114118B2 Compounds and compositions for the treatment of cancer 有权
标题翻译：用于治疗癌症的化合物和组合物
公开(公告)号：US09114118B2
公开(公告)日：2015-08-25
申请号：US13882355
申请日：2011-10-26
申请人： Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Pierre Laurin , Christopher Penney , Boulos Zacharie
发明人： Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Pierre Laurin , Christopher Penney , Boulos Zacharie
IPC分类号： A01N27/00 , A61K31/015 , A61K31/192 , A61K31/196 , A61K31/22 , A61K31/513 , A61K31/675 , A61K31/7068 , C07C57/46 , C07C57/48 , C07C59/54 , C07C59/84 , C07C62/20 , C07C229/18 , C07C229/42 , C07C323/52
CPC分类号： A61K31/192 , A61K31/196 , A61K31/22 , A61K31/513 , A61K31/675 , A61K31/7068 , C07C57/46 , C07C57/48 , C07C59/54 , C07C59/84 , C07C62/20 , C07C229/18 , C07C229/42 , C07C323/52
摘要： New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC and Formula II and their pharmaceutical acceptable salts for the treatment of cancer. The use of a combination of two of these compounds is described and the use of the combination of one of these compounds with an anticancer agent such as decarbazine, doxorubicin, daunorubicin, cyclophosphamide, busulfex, busulfan, vinblastine, vincristine, bleomycin, etoposide, topotecan, irinotecan, taxotere, taxol, 5-fluorouracil, methotrexate, gemcitabine, cisplatin, carboplatin and chlorambucil.
摘要翻译：苯甲酮羧酸酯化合物和式I，式I.1，式I.2，式IA，式IB，式IC和式II的取代芳族化合物及其用于治疗癌症的药学上可接受的盐的新用途。描述了这些化合物中的两种的组合的使用，并且使用这些化合物之一与抗癌剂如脱巴嗪，多柔比星，柔红霉素，环磷酰胺，总胆固醇，白消安，长春花碱，长春新碱，博来霉素，依托泊苷，拓扑替康，伊立替康，泰索帝，紫杉醇，5-氟尿嘧啶，甲氨蝶呤，吉西他滨，顺铂，卡铂和苯丁酸氮芥。

6. 发明授权

US4788315A 2,5-substituted-cyclohexane-1,4-diones and a process for production thereof 失效
标题翻译： 2,5-取代 - 环己烷-1,4-二酮及其制备方法
公开(公告)号：US4788315A
公开(公告)日：1988-11-29
申请号：US91691
申请日：1987-09-01
申请人： Takeo Kawabata
发明人： Takeo Kawabata
IPC分类号： C07C59/353 , C07C51/373 , C07C59/82 , C07C67/00 , C07C69/716 , C07C253/00 , C07C255/31 , C07C121/46 , C07C62/20 , C07C69/608 , C07C103/19
CPC分类号： C07C255/00 , C07C59/82
摘要： A 2,5-substituted-cyclohexane-1,4-dione of the general formula ##STR1## wherein R.sup.1 and R.sup.2 each is hydrogen or methyl; X is --COOR.sup.3 (R.sup.3 .dbd.H or alkyl), --CONR.sup.4 R.sup.5 (R.sup.4 and R.sup.5 each is hydrogen or alkyl) or --CN and a process for production of the above compound.
摘要翻译：一种通式为“IMAGE”的2,5-取代的环己烷-1,4-二酮，其中R 1和R 2各自为氢或甲基; X是-COOR 3（R 3 = H或烷基），-CONR 4 R 5（R 4和R 5各自是氢或烷基）或-CN，以及上述化合物的制备方法。

7. 发明授权

US09439882B2 Compounds and compositions for the treatment of cancer 有权
公开(公告)号：US09439882B2
公开(公告)日：2016-09-13
申请号：US14797957
申请日：2015-07-13
申请人： PROMETIC BIOSCIENCES, INC.
发明人： Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Pierre Laurin , Christopher Penney , Boulos Zacharie
IPC分类号： A01N27/00 , A61K31/015 , A61K31/192 , A61K31/196 , A61K31/22 , A61K31/513 , A61K31/675 , A61K31/7068 , C07C57/46 , C07C57/48 , C07C59/54 , C07C59/84 , C07C62/20 , C07C229/18 , C07C229/42 , C07C323/52
CPC分类号： A61K31/192 , A61K31/196 , A61K31/22 , A61K31/513 , A61K31/675 , A61K31/7068 , C07C57/46 , C07C57/48 , C07C59/54 , C07C59/84 , C07C62/20 , C07C229/18 , C07C229/42 , C07C323/52
摘要： New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC and Formula II and their pharmaceutical acceptable salts for the treatment of cancer. The use of a combination of two of these compounds is described and the use of the combination of one of these compounds with an anticancer agent such as decarbazine, doxorubicin, daunorubicin, cyclophosphamide, busulfex, busulfan, vinblastine, vincristine, bleomycin, etoposide, topotecan, irinotecan, taxotere, taxol, 5-fluorouracil, methotrexate, gemcitabine, cisplatin, carboplatin and chlorambucil.

8. 发明授权

US3600406A Tetracarboxylic cycloalkyl ketones 失效
标题翻译：四羧基环烷基酮
公开(公告)号：US3600406A
公开(公告)日：1971-08-17
申请号：US3600406D
申请日：1969-02-14
申请人： UNIVERSAL OIL PROD CO
发明人： TOUVAL IRVING
IPC分类号： C07C62/20 , C07C61/06 , C07C61/08 , C07C61/10
CPC分类号： C07C62/20
摘要： BIS(CYCLOALKYLDICARBOXYLIC ACID)KETONES, THE CORRESPONDING ANHYDRIDES AND LOWER ALKYL ESTERS THEREOF ARE EXEMPLIFIED BY BIS(4-CYCLOHEXYL-1,2-DICARBOXYLIC ACID) KETONE. THE COMPOUNDS MAY BE PREPARED BY REACTING A CYCLOALKENE DICARBOXYLIC COMPOUND WITH CARBON MONOXIDE IN THE PRESENCE OF A METAL CARBONYL AND WATER UNDER HYDROXYLATION CONDITIONS, SAID COMPOUNDS BEING USEFUL AS REACTIVE COMPONENTS OF POLYESTERS, EPOXY CURING AGENTS, ETC.

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