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1. 发明申请

US20180202908A1 Automated Vault Module 审中-公开
公开(公告)号：US20180202908A1
公开(公告)日：2018-07-19
申请号：US15743222
申请日：2016-07-12
申请人： Brooks Automation, Inc.
发明人： Etienne Croquette , Matteo Salvetti , Rhett Affleck
IPC分类号： G01N1/42 , G01N35/00
CPC分类号： G01N1/42 , A01N1/0257 , G01N33/48 , G01N35/00 , G01N35/0099 , G01N35/02 , G01N35/04 , G01N2035/00326 , G01N2035/0418 , G01N2035/0425
摘要： Cryogenic storage system provides automated storage and retrieval of samples in a cryogenic environment, as well as automated transfer of individual samples between cryogenic environments. Stored samples are maintained under a cryogenic temperature threshold, while also enabling access to the samples. The samples may be organized and tracked by scanning a barcode of each sample. Embodiments may also comprise multiple storage vaults and provide for transfer of individual samples between the storage vaults, as well as between a storage vault and a removable cryogenic storage device.

2. 发明申请

US20180055042A1 Portable, insulated capsules for cryopreservation of biological materials 审中-公开
公开(公告)号：US20180055042A1
公开(公告)日：2018-03-01
申请号：US14756605
申请日：2015-09-24
申请人： Alberto Jose Sarmentero Ortiz
发明人： Alberto Jose Sarmentero Ortiz
IPC分类号： A01N1/02 , F25D11/04
CPC分类号： A01N1/0221 , A01N1/0257 , A01N1/0263 , A01N1/0268 , A23L3/375 , C12N1/04 , C12N5/0602 , F25D3/107 , F25D11/04 , F25D29/001 , F25D2700/123
摘要： This invention consists in portable cryostat capsules built in several materials, dimensions and configurations according to the size of the biological refrigeratable samples to be cryopreserved and its cold storage requirements of these biological materials including umbilical cord blood, cells, semen, oocytes, tissues and bigger biological units such as organs for transplantation, entire animals or plants, including human organs or entire bodies in the cryo-medical practice. These capsules are all built in a form of thermoplastic cryostat with a cold source that is in contact with a myogenic tank, a cryo-liquid generator, a cryo-coolant unit and/or an hybrid unit (combination of an external cryogen supply in continuous flow with a closed cycle unit) and includes an outer casing and an inner vessel covered by a thermal insulating material consisting of vacuum, perlite or similar thermal insulator to inhibit the transfer of heat for the correct vitrification of the biological materials.

3. 发明申请

US20170312852A1 Laser Ablation Machine for Labeling Cryogenically-Frozen Vials 审中-公开
公开(公告)号：US20170312852A1
公开(公告)日：2017-11-02
申请号：US15499127
申请日：2017-04-27
申请人： MERIAL INC.
发明人： Andy Brehm , Dennis Jerome Freeman , Ed Schindler , Julie Campbell
IPC分类号： B23K26/12 , B23K37/047 , B23K28/00 , B41M5/24 , B23K26/362
CPC分类号： B23K26/127 , A01N1/0236 , A01N1/0257 , A01N1/0268 , B23K26/361 , B23K26/362 , B23K28/00 , B23K37/047 , B41M5/24 , B41M5/26 , B41M5/262
摘要： The invention relates to a machine for labeling “blank-labeled” cryogenically-frozen vials or ampoules, which contain heat-labile biological materials, and to which a laser-light sensitive material had been applied prior to freezing. Accordingly, the machine has been designed to maintain the integrity of the biological materials throughout all phases of the labeling process. The machine generally comprises a master control system; a programmable user interface; a frame; cryogenic freezer assemblies, for keeping the vials at the required low temperatures; an infeed assembly, configured to receive and position blank-labeled cryogenic vials; a cryostatic labeling/quality control tunnel, wherein the vials are maintained at the required temperature, labeled by laser ablation, and checked for quality; and, an outfeed assembly. The machine further comprises a means for transporting the vials from the infeed assembly to the tunnel, and from the tunnel to the outfeed assembly. Vials labeled according to the instant disclosure are ultimately manually or automatically loaded into cryogenic shipping containers.

4. 发明授权

US09554572B2 Portable device and method for cryopreservation of cells encapsulated in immunoisolating devices 有权
标题翻译：用于冷冻保存免疫隔离装置中的细胞的便携式装置和方法
公开(公告)号：US09554572B2
公开(公告)日：2017-01-31
申请号：US14557420
申请日：2014-12-01
申请人： Celltronix
发明人： Igor Katkov , Vladimir Fedorovich Bolyukh , Pamela Itkin-Ansari
IPC分类号： A01N1/00 , C12M3/00 , A01N1/02
CPC分类号： A01N1/0257
摘要： Embodiments of a cryopreservation device and method of use are described that allow cryopreserved samples to be transferred from one location to another. In one embodiment, a cryopreservation device comprises two, telescoping tubes; one for plunging biological material into a reservoir of cryogenic liquid refrigerant, and the other for capturing the biological material along with some of the liquid refrigerant, for transferring the biological material to another location.
摘要翻译：描述了冷冻保存装置和使用方法的实施例，其允许将冷冻保存的样品从一个位置转移到另一个位置。在一个实施例中，冷冻保存装置包括两个伸缩管; 一个用于将生物材料插入低温液体制冷剂的储存器中，另一个用于与一些液体制冷剂一起捕获生物材料，用于将生物材料转移到另一位置。

5. 发明授权

US09297499B2 Cryogenic storage container, storage device, and methods of using the same 有权
标题翻译：低温储存容器，储存装置及其使用方法
公开(公告)号：US09297499B2
公开(公告)日：2016-03-29
申请号：US14097357
申请日：2013-12-05
申请人： Cook Medical Technologies LLC
发明人： Jorge L. Jimenez-Rios , Bryan D. Woodard , Shawn Nichols , Scott K. Philhower , Barry B. Hoult
IPC分类号： F25D25/00 , F17C13/00 , F25D3/10 , A01N1/02 , B01L7/00 , B01L9/06
CPC分类号： F17C13/001 , A01N1/0257 , A01N1/0268 , B01L7/50 , B01L9/06 , B01L2200/147 , B01L2300/1883 , F25D3/10
摘要： A device for the cryopreservation and/or vitrification of a biological sample in a freezing medium is described. The device preferably comprises a bath for receiving a vessel containing a biological sample in liquid-phase nitrogen. In one example, the bath includes a first member extending generally vertically from a bottom wall portion which divides the interior chamber of the bath into a first sub-chamber adapted for receiving a volume of cryogenic freezing medium and a second or overflow sub-chamber adapted to receive freezing medium from the first sub-chamber. A second member extends generally horizontally between the sidewall portions of the bath and includes at least one opening for receiving a biological sample-containing vessel(s). A kit including a cryogenic storage device and a vessel is also described.
摘要翻译：描述了用于冷冻介质中生物样品的冷冻保存和/或玻璃化的装置。该装置优选地包括用于接收含有液相氮中的生物样品的容器的浴。在一个示例中，浴包括从底壁部分大致垂直延伸的第一构件，该底壁部分将浴室的内部腔分成适于接收一定体积的低温冷冻介质的第一子室，以及适于以从第一子室接收冷冻介质。第二构件在浴的侧壁部分之间大致水平地延伸，并且包括用于接收含生物样品的容器的至少一个开口。还描述了包括低温存储装置和容器的试剂盒。

6. 发明授权

US08820097B2 Method and system for regulating the mixture of cryogen liquid and warm gas for a controlled rate cryogenic chiller or freezing system 有权
标题翻译：用于调节低温冷冻机或冷冻系统的冷冻液和暖气混合物的方法和系统
公开(公告)号：US08820097B2
公开(公告)日：2014-09-02
申请号：US13097763
申请日：2011-04-29
申请人： Alan T. Cheng , Yeu-Chuan Simon Ho , Ying Zhou
发明人： Alan T. Cheng , Yeu-Chuan Simon Ho , Ying Zhou
IPC分类号： F25D25/00 , G01N1/22 , C12M3/00 , A01N1/02 , F25D3/10 , F25D29/00
CPC分类号： A01N1/0257 , A01N1/0284 , A01N1/0289 , F25D3/102 , F25D29/001
摘要： A method and system for controlled rate freezing and nucleation of materials is provided. The presently disclosed system and method provides the ability to rapidly cool the materials contained in vials or other containers within a cooling unit via forced convective cooling using a laminar and uniform flow of cryogen in proximity to the plurality of vials disposed within the cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogen being introduced to the system as a function of time. The presently disclosed methods to systems also provide nucleation control via temperature quench and depressurized nucleation control.
摘要翻译：提供了控制速率冷冻和成核的方法和系统。本公开的系统和方法提供了通过强制对流冷却来快速冷却包含在冷却单元内的小瓶或其他容器中的材料的能力，其中使用层流和均匀流动的冷冻剂靠近设置在冷却单元内的多个小瓶。生物材料的快速冷却是通过精确地控制和调节作为时间的函数引入到系统中的冷冻剂的温度来实现的。目前公开的系统方法还通过温度骤冷和减压成核控制提供成核控制。

7. 发明申请

US20140234956A1 LIVING CELL CRYOPRESERVATION TOOL 有权
标题翻译：生活细胞CRYOPRESERVATION工具
公开(公告)号：US20140234956A1
公开(公告)日：2014-08-21
申请号：US14349208
申请日：2012-10-01
申请人： Kitazato BioPharma Co., Ltd.
发明人： Futoshi Inoue
IPC分类号： A01N1/02
CPC分类号： A01N1/0257 , A01N1/0268 , A61D19/024
摘要： A living cell cryopreservation tool has a living cell holding member having a body part and a living cell holding part and a tubular accommodation member, closed at one end thereof, which is capable of accommodating the living cell holding member. The living cell holding part has a long and narrow living cell attaching and holding portion. The living cell attaching and holding portion has heat conductors extended in a longitudinal direction thereof and projected from a distal end thereof. The tubular accommodation member has a heat conductive member accommodated inside a distal portion thereof. When the living cell holding member is inserted into the tubular accommodation member from a distal side of each heat conductor thereof, a distal portion of each heat conductor contacts the heat conductive member of the tubular accommodation member.
摘要翻译：活细胞冷冻保存工具具有活体细胞保持部件，该活体细胞保持部件具有主体部分和活体单元保持部以及能够容纳活细胞保持部件的一端封闭的管状容纳部件。活细胞保持部具有长而窄的活细胞附着保持部。活细胞安装保持部具有沿其长度方向延伸并从其远端突出的导热体。管状容纳构件具有容纳在其远端部分内的导热构件。当活体单元保持构件从其每个导热体的远侧插入到管状容纳构件中时，每个导热体的远端部分与管状容纳构件的导热构件接触。

8. 发明申请

US20140157798A1 Cryogenic Storage Container, Storage Device, and Methods of Using the Same 有权
标题翻译：低温储存容器，储存装置及其使用方法
公开(公告)号：US20140157798A1
公开(公告)日：2014-06-12
申请号：US14097357
申请日：2013-12-05
申请人： Cook Medical Technologies LLC
发明人： Jorge L. Jimenez-Rios , Bryan D. Woodard , Shawn Nichols , Scott K. Philhower , Barry B. Hoult
IPC分类号： F17C13/00 , F25D3/10
CPC分类号： F17C13/001 , A01N1/0257 , A01N1/0268 , B01L7/50 , B01L9/06 , B01L2200/147 , B01L2300/1883 , F25D3/10
摘要： A device for the cryopreservation and/or vitrification of a biological sample in a freezing medium is described. The device preferably comprises a bath for receiving a vessel containing a biological sample in liquid-phase nitrogen. In one example, the bath includes a first member extending generally vertically from a bottom wall portion which divides the interior chamber of the bath into a first sub-chamber adapted for receiving a volume of cryogenic freezing medium and a second or overflow sub-chamber adapted to receive freezing medium from the first sub-chamber. A second member extends generally horizontally between the sidewall portions of the bath and includes at least one opening for receiving a biological sample-containing vessel(s). A kit including a cryogenic storage device and a vessel is also described.
摘要翻译：描述了用于冷冻介质中生物样品的冷冻保存和/或玻璃化的装置。该装置优选地包括用于接收含有液相氮中的生物样品的容器的浴。在一个示例中，浴包括从底壁部分大致垂直延伸的第一构件，该底壁部分将浴室的内部腔分成适于接收一定体积的低温冷冻介质的第一子室，以及适于以从第一子室接收冷冻介质。第二构件在浴的侧壁部分之间大致水平地延伸，并且包括用于接收含生物样品的容器的至少一个开口。还描述了包括低温存储装置和容器的试剂盒。

9. 发明申请

US20140033739A1 COOLING APPARATUS USED FOR CRYONIC PRESERVATION, AND CORRESPONDING OPERATING METHOD 有权
标题翻译：用于保存的冷却装置及相应的操作方法
公开(公告)号：US20140033739A1
公开(公告)日：2014-02-06
申请号：US14047570
申请日：2013-10-07
申请人： Fraunhofer-Gesellschaft Zur Foerderung der angewandten Forschung, e.V.
发明人： Uwe SCHON , Heiko ZIMMERMANN , Guenter FUHR
IPC分类号： F25D3/10 , A01N1/02
CPC分类号： F25D3/10 , A01N1/02 , A01N1/0257 , B01L7/00 , F25D29/001 , F25D2700/12 , G01N1/42
摘要： The invention relates to a cooling apparatus, especially for cryogenically preserving biological samples, including a duct (5) for delivering a coolant (3) to a cooling chamber (1), a heater (6) that has an adjustable first heating performance (P2) for heating the coolant (3) delivered to the cooling chamber (1), a first temperature sensor (8-10) for measuring the temperature (T2-T4) in the cooling chamber (1), a second temperature sensor (7) for measuring the temperature (Ti) of the coolant (3) delivered to the cooling chamber (I), and a regulator (11) for regulating the temperature. The regulator (11) is embodied as a multiple regulator which detects several temperatures (T1-T4) as control variables and/or adjusts several heating performances (P1, P2) as manipulated variables. The invention further relates to a corresponding operating method.
摘要翻译：本发明涉及一种特别用于低温保存生物样品的冷却装置，包括用于将冷却剂（3）输送到冷却室（1）的管道（5），具有可调节的第一加热性能的加热器（6））用于加热输送到冷却室（1）的冷却剂（3），用于测量冷却室（1）中的温度（T2-T4）的第一温度传感器（8-10），第二温度传感器（7）用于测量输送到冷却室（I）的冷却剂（3）的温度（Ti）和用于调节温度的调节器（11）。调节器（11）被实施为多个调节器，其作为控制变量检测几个温度（T1-T4）和/或调节多个加热性能（P1，P2）作为操作变量。本发明还涉及相应的操作方法。

10. 发明申请

US20140011182A1 METHOD AND APPARATUS FOR PREVENTION OF THERMO-MECHANICAL FRACTURING IN VITRIFIED TISSUE USING RAPID COOLING AND WARMING BY PERSUFFLATION 有权
标题翻译：方法和装置，用于通过快速冷却和加热保护来修复维修组织中的热机械断裂
公开(公告)号：US20140011182A1
公开(公告)日：2014-01-09
申请号：US13936069
申请日：2013-07-05
申请人： Arigos Biomedical, Inc.
发明人： Stephen Van Sickle , Tanya Jones
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/021 , A01N1/0257 , A01N1/0284 , A01N1/0289
摘要： A method and apparatus are disclosed for avoiding fracturing, e.g., thermo-mechanical fracturing, in vitrified biological systems via rapid cooling and/or warming persufflation techniques, by reducing the domain size of fracturing and by reducing thermal gradients. Also disclosed is a system adapted to rapidly cool and warm vitrifiable vascular biological tissue by persufflation, significantly reducing cryoprotectant toxicity from that of surface cooled tissue, in which the system is constructed and configured to use one or more of helium gas, hydrogen gas, neon gas, argon gas, krypton gas, xenon gas, oxygen gas, or various gaseous compounds. The system can be operated under pressure to increase the density and heat capacity of the gas relative to its density and heat capacity at atmospheric pressure and to cool the gas by one or more of mechanical action and by the phase change of a material such as a cryogenic gas or solid.
摘要翻译：公开了一种方法和装置，用于通过快速冷却和/或升温渗透技术，通过减小压裂的畴尺寸和减少热梯度来避免玻璃化生物系统中的压裂，例如热机械压裂。还公开了一种适于通过透气快速冷却和温暖玻璃化血管生物组织的系统，显着降低来自表面冷却组织的冷冻保护剂毒性，其中系统被构造和配置为使用氦气，氢气，氖中的一种或多种气体，氩气，氪气，氙气，氧气或各种气态化合物。该系统可以在压力下操作，以增加气体的密度和热容量相对于其在大气压力下的密度和热容量，并通过一种或多种机械作用和诸如低温气体或固体。

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