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1. 发明授权

US09174790B2 Storage cassette for laboratory objects 有权
标题翻译：实验室物体的储存盒
公开(公告)号：US09174790B2
公开(公告)日：2015-11-03
申请号：US14103255
申请日：2013-12-11
申请人： LICONIC AG
发明人： Cosmas Malin
IPC分类号： B65D81/38 , F25D3/10 , A01N1/02 , G01N35/00
CPC分类号： B65D81/38 , A01N1/0257 , F25D3/102 , G01N2035/00435
摘要： A storage system (1) has a chamber (3). In the chamber (3), multiple storage tanks (5) are arranged, and a picking and placing device (8) is arranged above these tanks. Carrousels (8) are arranged in the storage tanks. These carrousels are suspended from a top pivot bearing (35) and laterally guided by a bottom pivot bearing (44). The top pivot bearing (35) is located outside the insulation (12) of the storage tanks and is thus protected from extreme temperatures. In the carrousel (18), storage cassettes (20) are arranged which are laterally held by guide elements (31).
摘要翻译：存储系统（1）具有室（3）。在室（3）中，设置有多个储罐（5），并且在这些罐之上布置有拾取和放置装置（8）。转盘（8）布置在储罐中。这些转盘从顶部枢转轴承（35）悬挂并由底部枢转轴承（44）横向引导。顶部枢转轴承（35）位于储罐的绝缘体（12）的外部，因此被保护免受极端温度的影响。在转盘（18）中，布置有由引导元件（31）横向保持的存储盒（20）。

2. 发明授权

US08794012B2 Method and system for controlled rate freezing of biological material 有权
标题翻译：生物材料控制速率冷冻的方法和系统
公开(公告)号：US08794012B2
公开(公告)日：2014-08-05
申请号：US12266760
申请日：2008-11-07
申请人： Alan Cheng
发明人： Alan Cheng
IPC分类号： F25D25/00 , B01D8/00 , F17C7/02 , F25D3/10 , A01N1/02
CPC分类号： F25D3/102 , A01N1/0252 , F25D29/001
摘要： A method and system for controlled rate freezing of biological materials is provided. The presently disclosed system and method provides the ability to rapidly cool the biological materials contained in vials or other containers within a cooling unit via forced convective cooling using a laminar and uniform flow of cryogen in proximity to the plurality of vials disposed within the cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogen being introduced to the system as a function of time.
摘要翻译：提供了生物材料控制速率冷冻的方法和系统。本公开的系统和方法提供了通过强制对流冷却来快速冷却包含在冷却单元内的小瓶或其他容器中的生物材料的能力，其中使用层流和均匀流动的冷冻剂在设置在冷却单元内的多个小瓶附近。生物材料的快速冷却是通过精确地控制和调节作为时间的函数引入到系统中的冷冻剂的温度来实现的。

3. 发明申请

US20140075968A1 METHOD FOR FREEZING A PLURALITY OF CONDITIONING TUBES EACH FILLED WITH A PREDETERMINED VOLUME OF BIOLOGICAL SUBSTANCE AND SYSTEM FOR THE IMPLEMENTATION OF SUCH A METHOD 有权
标题翻译：用于冷却具有预测的生物物质体积的多个调节管的方法和用于实施这种方法的系统
公开(公告)号：US20140075968A1
公开(公告)日：2014-03-20
申请号：US13623677
申请日：2012-09-20
申请人： IMV TECHNOLOGIES
发明人： Christian BEAU , Agnes CAMUS , Eric SCHMITT
IPC分类号： F25D31/00
CPC分类号： F25D3/102 , A01N1/0252 , A01N1/0284 , F25D25/005 , F25D2400/30
摘要： A method for freezing a plurality of conditioning tubes is provided, each tube filled with a predetermined volume of biological substance, including arranging each conditioning tube directly into a conditioning unit placed in a cooling enclosure then causing the enclosure to be passed through by a flow of cooling agent and simultaneously driving the conditioning unit (6) in rotation, and providing the unit (6) with a greater capacity than the plurality of tubes; wherein the step of arranging each tube directly in a unit is carried out by placing the plurality of tubes into the unit, and the step of driving the unit in rotation is implemented by setting each tube in motion with respect to the unit and with respect to the other tubes.
摘要翻译：提供了一种用于冷冻多个调节管的方法，每个管填充有预定体积的生物物质，包括将每个调节管直接放置在放置在冷却外壳中的调节单元中，然后使外壳通过同时驱动调节单元（6）旋转，并为单元（6）提供比多个管更大的容量; 其中通过将所述多个管放置在所述单元中来执行将每个管直接布置在单元中的步骤，并且通过将每个管相对于所述单元运动并且相对于其他管。

4. 发明申请

US20120102977A1 METHOD AND SYSTEM FOR GAS TEMPERATURE REGULATION 有权
标题翻译：气温调节方法与系统
公开(公告)号：US20120102977A1
公开(公告)日：2012-05-03
申请号：US13097763
申请日：2011-04-29
申请人： Alan T. Cheng , Yeu-Chuan Simon Ho , Ying Zhou
发明人： Alan T. Cheng , Yeu-Chuan Simon Ho , Ying Zhou
IPC分类号： F17C5/02
CPC分类号： A01N1/0257 , A01N1/0284 , A01N1/0289 , F25D3/102 , F25D29/001
摘要： A method and system for controlled rate freezing and nucleation of materials is provided. The presently disclosed system and method provides the ability to rapidly cool the materials contained in vials or other containers within a cooling unit via forced convective cooling using a laminar and uniform flow of cryogen in proximity to the plurality of vials disposed within the cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogen being introduced to the system as a function of time. The presently disclosed methods to systems also provide nucleation control via temperature quench and depressurized nucleation control.
摘要翻译：提供了控制速率冷冻和成核的方法和系统。本公开的系统和方法提供了通过强制对流冷却来快速冷却包含在冷却单元内的小瓶或其他容器中的材料的能力，其中使用层流和均匀流动的冷冻剂靠近设置在冷却单元内的多个小瓶。生物材料的快速冷却是通过精确控制和调节作为时间的函数引入到系统中的冷冻剂的温度来实现的。目前公开的系统方法还通过温度骤冷和减压成核控制提供成核控制。

5. 发明申请

US20110039009A1 Method and system for flash freezing tea-flavored liquid and making tea-based beverages 审中-公开
标题翻译：快速冷冻茶味液体和茶基饮料的方法和系统
公开(公告)号：US20110039009A1
公开(公告)日：2011-02-17
申请号：US12806397
申请日：2010-08-11
申请人： Curt Jones , Robert Lynn
发明人： Curt Jones , Robert Lynn
IPC分类号： A23F3/00 , A23F3/40 , A47J31/44 , F25C1/00
CPC分类号： A23F3/26 , A23F3/163 , F25D3/102
摘要： An apparatus and method of flash freezing a tea-based liquid into small beads and then packaging the beads for consumers is disclosed. The beads are stored in a conventional freezer until desired and then reconstituted into a tea beverage base as needed. In particular, a warm or cold tea-based beverage may be easily and affordably created using the frozen beads.
摘要翻译：公开了将茶基液体快速冷冻成小珠粒，然后将消费者包装珠粒的装置和方法。将珠子储存在常规冷冻器中直到需要，然后根据需要重新配制成茶饮料基料。特别地，使用冷冻珠子可以容易且经济地制造温或冷的茶基饮料。

6. 发明申请

US20090133411A1 METHOD AND SYSTEM FOR CONTROLLED RATE FREEZING OF BIOLOGICAL MATERIAL 有权
标题翻译：生物材料控制速率冻结的方法与系统
公开(公告)号：US20090133411A1
公开(公告)日：2009-05-28
申请号：US12266760
申请日：2008-11-07
申请人： Alan Cheng
发明人： Alan Cheng
IPC分类号： F25D25/00 , B01D8/00
CPC分类号： F25D3/102 , A01N1/0252 , F25D29/001
摘要： A method and system for controlled rate freezing of biological materials is provided. The presently disclosed system and method provides the ability to rapidly cool the biological materials contained in vials or other containers within a cooling unit via forced convective cooling using a laminar and uniform flow of cryogen in proximity to the plurality of vials disposed within the cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogen being introduced to the system as a function of time.
摘要翻译：提供了生物材料控制速率冷冻的方法和系统。本公开的系统和方法提供了通过强制对流冷却来快速冷却包含在冷却单元内的小瓶或其他容器中的生物材料的能力，其中使用层流和均匀流动的冷冻剂在设置在冷却单元内的多个小瓶附近。生物材料的快速冷却是通过精确地控制和调节作为时间的函数引入到系统中的冷冻剂的温度来实现的。

7. 发明申请

US20040000151A1 Preserving system 失效
标题翻译：保存系统
公开(公告)号：US20040000151A1
公开(公告)日：2004-01-01
申请号：US10602515
申请日：2003-06-24
申请人： Sanyo Electric Co., Ltd. , Sanyo Electric Biomedical Co., Ltd.
发明人： Kazuo Takemasa
IPC分类号： F25B009/00 , F17C003/10 , F25D017/02
CPC分类号： F17C3/085 , F17C3/10 , F17C13/021 , F17C13/025 , F17C2205/0326 , F17C2205/0332 , F17C2221/014 , F17C2223/0161 , F17C2223/033 , F17C2250/0408 , F17C2250/043 , F17C2270/02 , F25B9/14 , F25B2500/06 , F25D3/102 , F25D16/00
摘要： To provide a preserving system capable of re-using vaporized nitrogen, and moreover, capable of always cooling the specimens at a predetermined temperature or lower. The preserving system comprising a cylinder and the preserving vessel which is supplied with liquid nitrogen from this cylinder, is provided with a Stirling refrigerator and a condensing chamber arranged outside of said preserving vessel, and the gas phase part of this condensing chamber is made to communicate with that of said preserving vessel and also the liquid phase part is made to communicate with that of said preserving vessel, and further the cooling part of said Stirling refrigerator is arranged in said condensing chamber, therefore, the nitrogen vaporized in the preserving vessel is cooled by the cooling part of the Stirling refrigerator in the condensing chamber and liquefied again, and so this liquid nitrogen can be reused for cooling the preserving vessel. Moreover, since the preserving vessel can be cooled by the liquid nitrogen when performing maintenance on the Stirling refrigerator, the specimens in the preserving vessel can always be cooled at a predetermined temperature or lower.
摘要翻译：为了提供能够重新使用蒸发的氮气的保存系统，此外，能够在预定温度或更低的温度下始终冷却样品。该保存系统包括一个气缸和从该气缸供给液氮的保存容器，设置有一个布置在所述保存容器外部的斯特林制冷机和一个冷凝室，该冷凝室的气相部分被连通与所述保存容器的液相部分相通，并使液相部分与所述保存容器连通，并且所述斯特林制冷机的冷却部分进一步设置在所述冷凝室中，因此将保存容器中蒸发的氮气冷却通过冷凝室中的斯特林冰箱的冷却部分再次液化，因此这种液氮可以重新用于冷却保存容器。此外，由于当在斯特林制冷机上进行维护时保存容器可以被液氮冷却，所以保存容器中的试样可以总是在预定温度或更低温度下冷却。

8. 发明申请

US20020194853A1 Freezer and plant gas system 失效
标题翻译：冷冻和植物气体系统
公开(公告)号：US20020194853A1
公开(公告)日：2002-12-26
申请号：US10171347
申请日：2002-06-12
发明人： Michael D. Cashin
IPC分类号： F25D025/00
CPC分类号： C21D6/04 , F25D3/102 , F25D29/001
摘要： An improved freezer and plant gas system that harnesses the cooling properties of the plant gas evaporator to facilitate energy and cryogen savings, as well as the automation and optimization of a plant thermal processing system. The freezer preferably includes an internally mounted evaporator sized to meet the gas requirements of the plant processes requiring inert gas. By evaporating the plant gas in the freezer, the freezer can be remotely located from the liquid cryogen source while still making liquid cryogen available when called for during a cryogenic treatment process metal or other materials. In addition, by evaporating in the freezer the freezer is able to harness the cooling properties of the evaporator to pre-cool the freezer and material prior to use of liquid in the cooling cycle. Alternatively, a liquid load basket is adapted to economically thermally treat materials in a deep cryogenic treatment.
摘要翻译：改进的冷冻和植物气体系统，利用植物气体蒸发器的冷却特性，以便节省能源和冷冻剂，以及工厂热处理系统的自动化和优化。冷冻器优选地包括内部安装的蒸发器，其尺寸适于满足需要惰性气体的设备工艺的气体需求。通过蒸发冷冻机中的植物气体，冷冻器可以远离液体冷冻剂源，同时在低温处理过程金属或其他材料期间要求液态冷冻剂可用。此外，通过在冷冻机中蒸发，冷冻机能够利用蒸发器的冷却特性来在冷却循环中使用液体之前对冷冻器和材料进行预冷却。或者，液体负载篮适于在深低温处理中经济地热处理材料。

9. 发明授权

US06332325B1 Apparatus and method for strengthening articles of manufacture through cryogenic thermal cycling 有权
标题翻译：通过低温热循环加强制品的装置和方法
公开(公告)号：US06332325B1
公开(公告)日：2001-12-25
申请号：US09641387
申请日：2000-08-17
申请人： Edward Monfort
发明人： Edward Monfort
IPC分类号： F25D2500
CPC分类号： F25D29/001 , C21D1/785 , C21D6/04 , F25D3/102
摘要： An apparatus for subjecting articles of manufacture to a cryogenic thermal cycling process includes a bottom portion and a lid. The bottom portion comprises an outer and inner tank separated by a plurality of insulation layers. The inner tank defines an inner cavity wherein the articles are subjected to the cryogenic process. A thermal break is provided between the lid and bottom portion so that the temperature of the inner cavity does not conduct to the outer tank of the apparatus bottom portion. The process conducted in the apparatus is controlled by a pre-programmed profile inputted by a key controller or PC. Liquid nitrogen is the preferred cryogenic material to be employed. The novel process subjects the article to extreme negative temperatures thereafter cycling the article between a set of negative temperatures for a number of cycles. The process is completed by heating the article to an extreme positive temperature and then allowed to cool to ambient room temperature. The novel cryogenic thermal cycling process strengthens the article by realigning its molecular structure to eliminate micro-cracking and other manufacturing deforming characteristics.
摘要翻译：用于使制品进行低温热循环过程的装置包括底部和盖。底部包括由多个绝缘层隔开的外槽和内箱。内罐限定了内部空腔，其中制品经受低温处理。在盖和底部之间设置热断裂，使得内腔的温度不会传导到设备底部的外槽。在设备中进行的处理由由键控制器或PC输入的预编程配置文件来控制。液氮是所用的优选低温材料。该新方法使物品处于极端的负温度，此后将物品在一组负温度之间循环多个循环。该过程通过将制品加热至极端正温度然后冷却至环境室温来完成。新型低温热循环工艺通过重新分配其分子结构来加强制品，消除微裂纹等制造变形特性。

10. 再颁专利

USRE33852E Chamber and process for thermal treatment comprising a cooling phase 失效
公开(公告)号：USRE33852E
公开(公告)日：1992-03-24
申请号：US507883
申请日：1990-04-12
申请人： Claude Gibot , Jean-Pierre Peyremorte , Richard Sojka
发明人： Claude Gibot , Jean-Pierre Peyremorte , Richard Sojka
IPC分类号： F25D3/10
CPC分类号： F25D3/102
摘要： A treatment chamber for a charge comprises at least oen door, internal walls delimiting a treatment space, passages for the recirculation of gas, and apparatus for circulating gases in the treatment space and the passages. The circulating apparatus extracts the gases from the treatment space (4) and sends them through the passages (9,9'). The chamber is provided with injectors (12) for cryogenic fluid and an outlet (16) for evacuation of gas. The injectors are at least one nozzle (12) to spray liquid nitrogen or carbon dioxide and are disposed adjacent the circulating apparatus, which is in the form of a fan (8), the injectors (12) being directed toward the inlet of this fan. In the corresponding treatment process, a cryogenic gas is circulated through the charge, a cryogenic fluid e.g. liquid carbon dioxide or liquid nitrogen is injected into the gas flow leaving the charge, and the cooled gas is recirculated so as to cause it to pass again through the charge in the same direction. All contact between the gas and the charge is prevented during its recirculation.

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