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1. 发明申请

US20190201562A1 Compositions And Methods For In Vivo Imaging 审中-公开
公开(公告)号：US20190201562A1
公开(公告)日：2019-07-04
申请号：US16147370
申请日：2018-09-28
申请人： The General Hospital Corporation
发明人： Thomas Reiner , Edmund J. Keliher , Ralph Weissleder
IPC分类号： A61K51/04 , A61K49/00 , A61K51/12
CPC分类号： A61K51/0459 , A61K49/0021 , A61K51/1251
摘要： This document relates to compounds useful for targeting PARP1. Also provided herein are methods for using such compounds to detect and image cancer cells.

2. 发明申请

US20180055955A1 SCANDIUM NANO-RADIOPHARMACEUTICAL 审中-公开
公开(公告)号：US20180055955A1
公开(公告)日：2018-03-01
申请号：US15796775
申请日：2017-10-28
申请人： Navideh Aghaei Amirkhizi , Leila Moghaddam-Banaem , Mitra Athari Allaf , Sodeh Sajadi , Fariba Johari Daha
发明人： Navideh Aghaei Amirkhizi , Leila Moghaddam-Banaem , Mitra Athari Allaf , Sodeh Sajadi , Fariba Johari Daha
IPC分类号： A61K51/12 , A61K51/06 , G21G1/06
CPC分类号： A61K51/1251 , A61K51/06 , A61K51/065 , A61P35/00 , G21G1/001 , G21G1/06 , G21Y2002/104
摘要： Disclosed herein is a method for preparing a scandium nano-radiopharmaceutical. The method comprises forming a plurality of scandium-encapsulated dendrimers by encapsulating scandium in polyamidoamine (PAMAM) dendrimers with amine surface groups, and forming a scandium nano-radiopharmaceutical by irradiating the plurality of scandium-encapsulated dendrimers by bombarding neutrons toward the scandium-encapsulated dendrimers.

3. 发明授权

US09718929B2 Chelating amphiphilic polymers 有权
公开(公告)号：US09718929B2
公开(公告)日：2017-08-01
申请号：US14713256
申请日：2015-05-15
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Holger Gruell , Anke De Vries , Sander Langereis , Johan Lub , Erica Maria Gerarda Aussems-Custers
IPC分类号： C08G81/02 , A61K9/107 , A61K9/51 , A61K49/12 , A61K49/18 , A61K51/06 , A61K51/12 , A61K9/127 , A61K49/04
CPC分类号： C08G81/025 , A61K9/107 , A61K9/1075 , A61K9/1273 , A61K9/5146 , A61K49/0414 , A61K49/126 , A61K49/1806 , A61K49/1812 , A61K49/1818 , A61K51/06 , A61K51/065 , A61K51/1217 , A61K51/1237 , A61K51/1251
摘要： Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T1/T2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.

4. 发明申请

US20170189569A1 BIODEGRADABLE MICROSPHERES INCORPORATING RADIONUCLIDES TECHNICAL FIELD 审中-公开
公开(公告)号：US20170189569A1
公开(公告)日：2017-07-06
申请号：US15460708
申请日：2017-03-16
申请人： Omid Souresrafil , Ehson Souresrafil , Nazmi Peyman
发明人： Omid Souresrafil , Ehson Souresrafil , Nazmi Peyman
IPC分类号： A61K51/12 , B01J13/08 , A61K51/06
CPC分类号： A61K51/1251 , B01J13/06 , B01J13/08 , B01J13/14 , B01J13/206
摘要： A crosslinked NATURAL POLYMER POLYMER/NATURAL POLYMER POLYMER microsphere comprising a stably incorporated radionuclide. The microsphere can be prepared by droplet microfluidics and used in a method for radiation treatment comprising the administration of microspheres with incorporated radionuclide.

5. 发明申请

US20170106105A1 NANOSTRUCTURES AND APPLICATIONS THEREOF 有权
公开(公告)号：US20170106105A1
公开(公告)日：2017-04-20
申请号：US15129229
申请日：2015-03-27
申请人： SPAGO NANOMEDICAL AB
发明人： Oskar AXELSSON , Sania BÄCKSTRÖM , Rodrigo PETORAL, JR.
IPC分类号： A61K51/06 , C08G77/30 , A61K51/12
CPC分类号： A61K51/065 , A61K51/1251 , C08G77/30
摘要： Disclosed herein are globular nanostructures having a hydrodynamic diameter (Dh) of 8-100 nm comprising a central part and a peripheral part, wherein said central part has a calculated diameter (Dc) of 6-90 nm and said peripheral part has an estimated thickness (Tp) so that Dh=Dc+2Tp, wherein said central part comprises: (i) a crosslinked polymeric framework comprising monomer residues wherein at least 30% by number of the monomer residues have crosslinked thereby forming the crosslinked polymeric framework and/or (ii) a branched polymeric framework comprising monomer residues wherein the number of branch points is at least 30% of the number of monomer residues, wherein said central part comprises chelating groups of which at least 4 allow chelation of at least one multiply charged cation, wherein said chelating groups are independently selected from the group consisting of —COOR1, —P═O(OR1)(OR2), and —S(═O)2OR1, wherein R1 and R2 are independently selected from the group consisting of a negative charge, H, and lower alkyls, and wherein said peripheral part comprises a synthetic polymer material covalently attached to the central part, wherein the synthetic polymer material is hydrophilic and bioinert, and electrically neutral or zwitterionic. Also disclosed are compositions comprising such nanoparticles, and optionally also a radionuclide, use of such compositions, kits containing such compositions and methods for obtaining such compositions.

6. 发明申请

US20160331853A1 COMPOSITIONS FOR RADIOTHERAPY AND USES THEREOF 审中-公开
标题翻译：放射治疗组合物及其用途
公开(公告)号：US20160331853A1
公开(公告)日：2016-11-17
申请号：US15112589
申请日：2015-01-21
申请人： The Trustees of Columbia University in the City of New York
发明人： Robert N. Taub
IPC分类号： A61K51/04 , A61K47/02 , A61K47/26 , A61K47/10 , A61K47/24 , A61K47/22 , A61K47/18 , A61K51/08
CPC分类号： A61K51/0495 , A61K47/02 , A61K47/10 , A61K47/183 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/6921 , A61K47/6923 , A61K47/6929 , A61K51/0497 , A61K51/088 , A61K51/1241 , A61K51/1251 , C12Y111/01007
摘要： Provided herein are compositions and methods for treatment of a disease, disorder, or condition, such as a proliferative disease, disorder, or condition. One aspect provides a kit including a first composition including a bare ligand or a ligand coupled to a molecule or substrate; and a second composition including a receptor coupled to a radioisotope. Another aspect provides methods for treating a disease, disorder, or condition.
摘要翻译：本文提供了用于治疗疾病，病症或病症如增殖性疾病，病症或病症的组合物和方法。一方面提供一种试剂盒，其包括第一组合物，其包含裸配体或与分子或底物偶联的配体; 以及包含与放射性同位素偶联的受体的第二组合物。另一方面提供了治疗疾病，病症或病症的方法。

7. 发明授权

US09446156B2 Gas-filled microvesicles with polymer-modified lipids 有权
标题翻译：具有聚合物改性脂质的充气微泡
公开(公告)号：US09446156B2
公开(公告)日：2016-09-20
申请号：US12440009
申请日：2007-09-04
申请人： Stephane Gorgerat , Christian Guillot , Feng Yan
发明人： Stephane Gorgerat , Christian Guillot , Feng Yan
IPC分类号： A61K49/22 , A61K49/18 , A61K51/12
CPC分类号： A61K49/223 , A61K49/1818 , A61K51/1251
摘要： Image enhancing contrast agents for use in diagnostic and/or therapeutic methods, particularly in the form of gas-filled microvesicles, with enhanced stability. The gas-filled microvesicles are stabilized by a layer of amphiphilic material and comprise from 0.15% to 1.0% by moles of a lipid bearing a hydrophilic polymer. The lipid bearing a hydrophilic polymer is preferably a phospholipid linked to polyethyleneglycol.
摘要翻译：用于诊断和/或治疗方法的图像增强造影剂，特别是以气体填充的微泡的形式，具有增强的稳定性。气体填充的微泡由一层两亲性材料稳定，并含有0.15％至1.0％（摩尔）含有亲水性聚合物的脂质。含有亲水性聚合物的脂质优选为与聚乙二醇连接的磷脂。

8. 发明授权

US09409776B2 Strontium phosphate microparticle for radiological imaging and therapy 有权
标题翻译：用于放射成像和治疗的磷酸锶微粒
公开(公告)号：US09409776B2
公开(公告)日：2016-08-09
申请号：US14519587
申请日：2014-10-21
申请人： MO-SCI Corporation
发明人： Delbert E. Day , Yiyong He
IPC分类号： A61K51/02 , A61K51/12 , C01B25/45 , C01B25/32
CPC分类号： C01B25/45 , A61K51/02 , A61K51/1251 , C01B25/32 , C01P2004/60 , C01P2004/61 , C01P2006/12 , C01P2006/44 , Y10T428/2982
摘要： This invention relates to a method for making strontium-phosphate microparticles that incorporate radioisotopes for radiation therapy and imaging.
摘要翻译：本发明涉及一种制备用于放射治疗和成像的放射性同位素的磷酸锶微粒的制造方法。

9. 发明授权

US09376690B2 Templated nanoconjugates 有权
标题翻译：模板纳米结合体
公开(公告)号：US09376690B2
公开(公告)日：2016-06-28
申请号：US13504842
申请日：2010-11-01
申请人： Chad A. Mirkin , David A. Giljohann , Weston L. Daniel , Joshua I. Cutler , Ke Zhang , Dan Zheng
发明人： Chad A. Mirkin , David A. Giljohann , Weston L. Daniel , Joshua I. Cutler , Ke Zhang , Dan Zheng
IPC分类号： A61K9/14 , C12N15/88 , A61K47/48 , A61K49/00 , B82Y5/00 , B82Y15/00 , G01N33/58
CPC分类号： A61K47/6923 , A61K47/6933 , A61K49/0002 , A61K49/0093 , A61K51/1251 , B82Y5/00 , B82Y15/00 , C12N15/88 , C12Q1/6876 , G01N33/588
摘要： The present disclosure is directed to compositions comprising templated nanoconjugates and methods of their use.
摘要翻译：本公开涉及包含模板纳米缀合物的组合物及其使用方法。

10. 发明授权

US09358310B2 EGCG stabilized gold nanoparticles and method for making same 有权
标题翻译： EGCG稳定金纳米颗粒及其制备方法
公开(公告)号：US09358310B2
公开(公告)日：2016-06-07
申请号：US13668916
申请日：2012-11-05
申请人： The Curators of the University of Missouri
发明人： Kattesh V. Katti , Raghuraman Kannan , Kativa K. Katti , Satish Kumar Nune , Cathy S. Cutler , Charles Caldwell , Ravi Shukla , Nripen Chanda , Ajit Zambre , Anandhi Upendran
IPC分类号： A61K9/14 , A61K9/16 , A61K51/00 , A61K51/12 , A61K33/24 , A61K41/00
CPC分类号： A61K51/1244 , A61K9/148 , A61K31/353 , A61K33/24 , A61K41/00 , A61K51/1251
摘要： The invention provides stabilized, biocompatible gold nanoparticles that are stabilized with material from epigallocatechin Gallate (EGCg), which is a polyphenols- or flavonoids-rich plant material that can be obtained from green tea. The EGCg is an antioxidant reducing agent derived from green tea. The gold nanoparticles of the invention can be radioactive or non radioactive and are formed via a simple room temperature fabrication method. In preferred embodiment method of making, an aqueous solution containing gold salts is provided. The aqueous solution is mixed with EGCg in a buffer, such as deionized water. The gold salts react to form biocompatible gold nanoparticles that are stabilized with a coating of EGCg. The thermodynamically feasible redox couple of AuCl4-/EGCg leading to the reduction of AuCl4- by EGCg to form gold nanoparticles. In another embodiment, pre-cooled gold salt and EGCg solutions form multi-layered EGCg coated particles.
摘要翻译：本发明提供了稳定的生物相容性金纳米颗粒，其由来自表儿茶酸乙酸酯镓酸盐（EGCg）的材料稳定，其是可以从绿茶中获得的多酚或类黄酮的植物材料。 EGCg是来自绿茶的抗氧化剂还原剂。本发明的金纳米颗粒可以是放射性的或非放射性的，并且通过简单的室温制造方法形成。在优选的实施方案中，提供含有金盐的水溶液。将水溶液与EGCg混合在缓冲液中，例如去离子水。金盐反应形成用EGCg涂层稳定的生物相容性金纳米颗粒。 AuCl4- / EGCg的热力学可行的氧化还原对导致由EGCg还原AuCl4以形成金纳米颗粒。在另一个实施方案中，预冷金盐和EGCg溶液形成多层EGCg涂覆的颗粒。

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