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1. 发明申请

US20190247537A1 Method of Hemostasis 审中-公开
公开(公告)号：US20190247537A1
公开(公告)日：2019-08-15
申请号：US16396561
申请日：2019-04-26
申请人： NATIONAL INSTITUTE FOR MATERIALS SCIENCE
发明人： Tetsushi TAGUCHI
IPC分类号： A61L24/10 , A61L24/00
CPC分类号： A61L24/104 , A61L15/32 , A61L24/0005 , A61L24/10 , A61L31/04
摘要： A method of hemostasis includes the step of applying a hemostatic agent to an affected site of a subject, the hemostatic agent consisting of a first agent comprising a gelatin derivative having a hydrophobic group bonded to the gelatin via an imino group, wherein the gelatin derivative has (a) a weight average molecular weight of from 10,000 to 50,000, (b) the hydrophobic group, which is an alkyl group having 6 to 18 carbon atoms; and (c) a molar ratio of imino group/amino group of the gelatin derivative ranging from 1/99 to 30/70; and a second agent including a crosslinking agent for the gelatin derivative.

2. 发明授权

US09913927B2 In situ solidifying complex coacervates and methods of making and using thereof 有权
公开(公告)号：US09913927B2
公开(公告)日：2018-03-13
申请号：US15325885
申请日：2015-07-14
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION
发明人： Russell J. Stewart
IPC分类号： A61L24/10 , A61L24/04 , A61L24/00 , A61L24/02 , A61K49/00 , C09D5/16
CPC分类号： A61L24/046 , A61K49/0043 , A61K49/0054 , A61K49/0073 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/02 , A61L24/043 , A61L24/10 , A61L24/104 , A61L2300/416 , A61L2300/44 , A61L2430/02 , A61L2430/36 , C09D5/1668 , C08L89/00
摘要： Described herein are fluid complex coacervates that produce solid adhesives in situ. Oppositely charged polyelectrolytes were designed to form fluid adhesive complex coacervates at ionic strengths higher than the ionic strength of the application site, but an insoluble adhesive solid or gel at the application site. When the fluid, high ionic strength adhesive complex coacervates are introduced into the lower ionic strength application site, the fluid complex coacervate is converted to a an adhesive solid or gel as the salt concentration in the complex coacervate equilibrates to the application site salt concentration. In one embodiment, the fluid complex coacervates are designed to solidify in situ at physiological ionic strength and have numerous medical applications. In other aspects, the fluid complex coacervates can be used in aqueous environment for non-medical applications.

3. 发明申请

US20160287659A1 BIOGEL 审中-公开
公开(公告)号：US20160287659A1
公开(公告)日：2016-10-06
申请号：US15098028
申请日：2016-04-13
申请人： Haemostatix Limited
发明人： Greg Walker
IPC分类号： A61K38/07 , A61L24/06 , A61L24/10 , A61K9/00 , A61L24/00
CPC分类号： A61K38/07 , A61K9/0014 , A61L24/0015 , A61L24/0031 , A61L24/06 , A61L24/10 , A61L24/106 , A61L2400/04
摘要： A biogel, and kits, agents, and methods for formation of the biogel are described. The biogel can be used for a variety of applications, including haemostasis, wound sealing, tissue engineering or localised drug delivery.
摘要翻译：描述了生物凝胶，以及用于形成生物凝胶的试剂盒，试剂和方法。生物凝胶可用于各种应用，包括止血，伤口密封，组织工程或局部药物递送。

4. 发明申请

US20160270895A1 Compositions, Devices, Kits and Methods for Attaching Surgical Meshes to Tissue 审中-公开
标题翻译：组合，装置，套件和方法将外科手术网附着在组织上
公开(公告)号：US20160270895A1
公开(公告)日：2016-09-22
申请号：US15063138
申请日：2016-03-07
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： Jonathan Zoll , Peter J. Pereira
IPC分类号： A61F2/00 , A61B18/18
CPC分类号： A61F2/0063 , A61B1/303 , A61B17/42 , A61B18/14 , A61B18/18 , A61B18/1815 , A61B18/20 , A61B2017/00513 , A61B2018/00559 , A61B2018/00619 , A61B2018/00642 , A61B2018/00702 , A61B2018/00791 , A61B2018/1807 , A61F2/0045 , A61F2002/0086 , A61F2220/0008 , A61F2230/006 , A61F2250/0001 , A61L24/08 , A61L24/10 , A61L31/10 , A61L31/18 , A61L2400/12 , C08L89/00 , C08L5/08
摘要： The present disclosure is directed to methods, compositions, devices and kits which pertain to the attachment of surgical meshes to tissue by application of an energy source to the meshes and tissue in the presence of a bonding material.
摘要翻译：本公开涉及涉及通过在存在粘合材料的情况下将能量源施加到网状物和组织而将外科手术网连接到组织的方法，组合物，装置和试剂盒。

5. 发明申请

US20160250375A1 REINFORCED ADHESIVE COMPLEX COACERVATES AND METHODS OF MAKING AND USING THEREOF 有权
标题翻译：增强粘合复合材料及其制备和使用方法
公开(公告)号：US20160250375A1
公开(公告)日：2016-09-01
申请号：US15131583
申请日：2016-04-18
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION
发明人： Russell J. STEWART
IPC分类号： A61L24/04 , A61L24/06 , A61L24/02 , A61L24/10
CPC分类号： A61L24/046 , A61L24/0015 , A61L24/02 , A61L24/043 , A61L24/06 , A61L24/10 , A61L27/26 , A61L27/54 , A61L2300/62 , A61L2430/16 , C08F8/00 , C08F8/06 , C08L89/00
摘要： Described herein is the synthesis of reinforced adhesive complex coacervates and their use thereof. The reinforced adhesive complex coacervates are composed of (a) at least one polycation, (b) at least one polyanion, and (c) a reinforcing component. The adhesive complex coacervates described herein can be subsequently cured to produce strong, cohesive adhesives. The reinforced adhesive complex coacervates have several desirable features when compared to conventional adhesives. The reinforced adhesive complex coacervates are effective in wet or underwater applications. The reinforced adhesive complex coacervates described herein, being phase separated from water, can be applied underwater without dissolving or dispersing into the water. The reinforced adhesive complex coacervates have numerous biological applications as bioadhesives and bioactive delivery devices. In particular, the reinforced adhesive complex coacervates described herein are particularly useful in underwater applications and situations where water is present such as, for example, wet tissues in physiological conditions.
摘要翻译：本文描述的是增强粘合剂复合凝聚层的合成及其用途。增强粘合剂复合物凝聚层由（a）至少一种聚阳离子，（b）至少一种聚阴离子和（c）增强组分组成。随后可以固化本文所述的粘合剂复合物凝聚层以产生强的粘结粘合剂。当与常规粘合剂相比时，增强粘合剂复合物凝聚层具有几个期望的特征。增强粘合剂复合物凝聚层在湿法或水下应用中是有效的。本文所述的与水相分离的增强粘合剂复合物凝聚层可以在水中施加而不溶解或分散在水中。增强粘合剂复合物凝聚层具有生物粘合剂和生物活性递送装置的许多生物应用。特别地，本文所述的增强粘合剂复合物凝聚层在水下应用和存在水的情况下特别有用，例如生理条件下的湿纸巾。

6. 发明授权

US09339584B2 Biogel 有权
标题翻译：生物凝胶
公开(公告)号：US09339584B2
公开(公告)日：2016-05-17
申请号：US12515721
申请日：2007-11-27
申请人： Greg Walker
发明人： Greg Walker
IPC分类号： A61K38/36 , C12N5/07 , A61P17/02 , A61L24/10
CPC分类号： A61K38/07 , A61K9/0014 , A61L24/0015 , A61L24/0031 , A61L24/06 , A61L24/10 , A61L24/106 , A61L2400/04
摘要： A biogel, and kits, agents, and methods for formation of the biogel are described. The biogel can be used for a variety of applications, including haemostasis, wound sealing, tissue engineering or localized drug delivery.
摘要翻译：描述了生物凝胶，以及用于形成生物凝胶的试剂盒，试剂和方法。生物凝胶可用于各种应用，包括止血，伤口密封，组织工程或局部药物递送。

7. 发明申请

US20160114075A1 PHOTOACTIVATED CROSSLINKING OF A PROTEIN OR PEPTIDE 审中-公开
标题翻译：蛋白质或肽的光合交联
公开(公告)号：US20160114075A1
公开(公告)日：2016-04-28
申请号：US14941814
申请日：2015-11-16
申请人： Cook Medical Technologies LLC
发明人： Alan George Brownlee , Christopher Malcolm Elvin , Jerome Anthony Werkmeister , John Alan Maurice Ramshaw , Charles Mark Lindall
IPC分类号： A61L24/10 , A61L24/00
CPC分类号： A61L24/10 , A61L24/001 , A61L24/0026 , A61L24/102 , A61L24/106 , A61L24/108 , A61L26/0028 , A61L26/0061 , A61L26/0076 , A61L27/22 , A61L27/50 , C08H1/00 , C09J189/00
摘要： A method of crosslinking a protein or peptide for use as a biomaterial, the method comprising the step of irradiating a photoactivatable metal-ligand complex and an electron acceptor in the presence of the protein or peptide, thereby initiating a cross-linking reaction to form a 3-dimensional matrix of the biomaterial.
摘要翻译：交联用作生物材料的蛋白质或肽的方法，所述方法包括在蛋白质或肽存在下照射可光活化的金属 - 配体复合物和电子受体的步骤，由此引发交联反应以形成生物材料的3维矩阵。

8. 发明申请

US20150367022A1 PROCESS FOR MAKING DRY AND STABLE HEMOSTATIC COMPOSITIONS 审中-公开
标题翻译：制备干燥和稳定的HEMOSTATIC组合物的方法
公开(公告)号：US20150367022A1
公开(公告)日：2015-12-24
申请号：US14804084
申请日：2015-07-20
申请人： Baxter International Inc. , Baxter Healthcare S.A.
发明人： Andreas Goessl , Atsushi Edward Osawa , Cary J. Reich
IPC分类号： A61L24/04 , A61K38/39 , B65B55/02 , A61K9/19 , B65B3/00 , B65B5/12 , A61K38/48 , A61L24/00
CPC分类号： A61L24/043 , A61K9/0014 , A61K9/1658 , A61K9/19 , A61K38/39 , A61K38/4833 , A61L24/0015 , A61L24/10 , A61L24/106 , A61L2300/418 , A61L2300/802 , A61L2400/04 , A61L2400/06 , B65B3/003 , B65B5/12 , B65B55/02 , C12Y304/21005 , Y10T428/13
摘要： Described is a process for making a dry and stable hemostatic composition, said process comprising a) providing a first component comprising a dry preparation of a coagulation inducing agent, b) providing a second component comprising a dry preparation of a biocompatible polymer suitable for use in hemostasis, c) providing said first component and said second component in a combined form in a final container, c1) either by filling said first component and said second component into said final container so as to obtain a dry mixture in said final container, c2) or by providing said first component or said second component in said final container and adding said second component or said first component so as to obtain a combination of said first component with said second component in said final container, d) finishing the final container to a storable pharmaceutical device containing said first component and said second component in a combined form as a dry and stable hemostatic composition.
摘要翻译：描述了制备干燥和稳定的止血组合物的方法，所述方法包括a）提供包含凝结诱导剂的干制剂的第一组分，b）提供第二组分，其包含适于用于止血，c）以最终容器中的组合形式提供所述第一组分和所述第二组分，c1）通过将所述第一组分和所述第二组分填充到所述最终容器中以在所述最终容器中获得干混合物，c2 ）或通过在所述最终容器中提供所述第一组分或所述第二组分并加入所述第二组分或所述第一组分以获得所述第一组分与所述最终容器中的所述第二组分的组合，d）将最终容器整理成一种包含所述第一组分和所述第二组分的可储存药物装置，其为组合形式，为干和稳定的止血组合物。

9. 发明授权

US09216235B2 Photoactivated crosslinking of a protein or peptide 有权
标题翻译：蛋白质或肽的光活化交联
公开(公告)号：US09216235B2
公开(公告)日：2015-12-22
申请号：US12673400
申请日：2008-08-14
申请人： Alan George Brownlee , Christopher Malcolm Elvin , Jerome Anthony Werkmeister , John Alan Maurice Ramshaw , Charles Mark Lindall
发明人： Alan George Brownlee , Christopher Malcolm Elvin , Jerome Anthony Werkmeister , John Alan Maurice Ramshaw , Charles Mark Lindall
IPC分类号： A61L24/10 , A61L24/00 , A61L26/00 , A61L27/22 , A61L27/50 , C08H1/00 , C09J189/00
CPC分类号： A61L24/10 , A61L24/001 , A61L24/0026 , A61L24/102 , A61L24/106 , A61L24/108 , A61L26/0028 , A61L26/0061 , A61L26/0076 , A61L27/22 , A61L27/50 , C08H1/00 , C09J189/00
摘要： A method of crosslinking a protein or peptide for use as a biomaterial, the method comprising the step of irradiating a photoactivatable metal-ligand complex and an electron acceptor in the presence of the protein or peptide, thereby initiating a crosslinking reaction to form a 3-dimensional matrix of the biomaterial.
摘要翻译：交联用作生物材料的蛋白质或肽的方法，所述方法包括在蛋白质或肽存在下照射可光活化的金属 - 配体复合物和电子受体的步骤，由此引发交联反应以形成3- 生物材料的三维矩阵。

10. 发明授权

US09211359B2 Cohesive osteogenic putty comprising bone morphogenic protein, insoluble collagen and biphasic calcium phosphate 有权
标题翻译：包括骨形态发生蛋白，不溶性胶原蛋白和双相磷酸钙的粘性成骨腻子
公开(公告)号：US09211359B2
公开(公告)日：2015-12-15
申请号：US14286720
申请日：2014-05-23
申请人： WARSAW ORTHOPEDIC, INC.
发明人： William F. McKay , Steven Marquis Peckham , Jeffrey L. Seifert
IPC分类号： A61F2/28 , A61L27/24 , A61K9/00 , A61L27/32 , A61L24/00 , A61L24/10 , A61L27/46 , A61L27/50 , A61L27/54
CPC分类号： A61L27/24 , A61K9/0024 , A61L24/0084 , A61L24/10 , A61L27/32 , A61L27/46 , A61L27/50 , A61L27/54 , A61L2300/414 , A61L2400/16 , A61L2430/02 , Y10S977/753 , Y10S977/776 , Y10S977/931
摘要： Described is an implantable medical material comprising a malleable, cohesive, shape-retaining putty including mineral particles, insoluble collagen fibers and soluble collagen. The medical material can be used in conjunction with biologically active factors such as osteogenic proteins to treat bone or other tissue defects in patients.
摘要翻译：描述了一种植入式医疗材料，其包括可延展的，内聚的形状保持油灰，其包括矿物颗粒，不溶性胶原纤维和可溶性胶原蛋白。医学材料可以与生物活性因子如成骨蛋白结合使用以治疗患者的骨或其他组织缺陷。

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