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1. 发明申请

US20190024037A1 METHOD FOR PRODUCING CELL CONCENTRATE, AND CELL SUSPENSION TREATMENT SYSTEM 审中-公开
公开(公告)号：US20190024037A1
公开(公告)日：2019-01-24
申请号：US16142857
申请日：2018-09-26
申请人： KANEKA CORPORATION
发明人： Shuhei TANIGUCHI , Nobuyoshi UMEDA , Takaaki SAKASHITA , Hiroshi SAKURAI
IPC分类号： C12M1/34 , C12M1/00 , A61M1/02 , C12M1/26 , C12M1/02 , C12M1/36 , A61M1/34 , A61M1/36
CPC分类号： C12M41/46 , A61M1/0218 , A61M1/0281 , A61M1/34 , A61M1/3403 , A61M1/3406 , A61M1/3496 , A61M1/3603 , A61M1/3621 , A61M1/3626 , A61M1/3643 , A61M1/3644 , A61M1/3692 , A61M2205/3389 , A61M2205/3393 , C12M27/00 , C12M33/04 , C12M41/44 , C12M41/48 , C12M47/02
摘要： In a method for producing a cell concentrate using a cell suspension treatment system including a storage container of a cell suspension, which has a solution inlet port, a circulation outlet port, and a circulation inlet port, a cell suspension treatment device for concentrating the cell suspension by separating liquid from the cell suspension by filtration, the device including a container having a cell suspension introduction port, a cell suspension lead-out port, and a filtrate outlet, which is filled with a hollow fiber separation membrane, a circulation circuit for concentrating the cell suspension while circulating the cell suspension between the storage container and the cell suspension treatment device, a collection container of a cell concentrate obtained by concentration, a collection path for feeding the cell concentrate to the collection container, an injection path for injecting a solution into the solution inlet port of the storage container, and a detecting unit.

2. 发明授权

US09782707B2 Biological fluid filters having flexible walls and methods for making such filters 有权
公开(公告)号：US09782707B2
公开(公告)日：2017-10-10
申请号：US14223511
申请日：2014-03-24
申请人： Fenwal, Inc.
发明人： Daniel Lynn , Scott Day , Paolo Verri
IPC分类号： B01D35/30 , B01D29/50 , B01D39/16 , A61M1/36 , B01D39/08 , B01D39/10 , A61M1/02 , A61M1/34
CPC分类号： B01D35/30 , A61M1/0218 , A61M1/0281 , A61M1/34 , A61M1/3403 , A61M1/3406 , A61M1/3633 , A61M1/3636 , B01D29/50 , B01D39/083 , B01D39/086 , B01D39/10 , B01D39/1623 , B01D2201/306 , B01D2239/1258
摘要： Flexible housing filters for filtration of fluids and methods of making such filters are disclosed. The filters may include one or more peripheral seals in the flexible housing.

3. 发明授权

US09707326B2 Mobile system for separating donor blood by means of gravitational force 有权
公开(公告)号：US09707326B2
公开(公告)日：2017-07-18
申请号：US14417429
申请日：2013-07-18
申请人： 3M Innovative Properties Company
发明人： Roland Müller , Bodo Von Harten
IPC分类号： A61M1/02 , A61M1/34 , B01D63/02
CPC分类号： A61M1/0209 , A61M1/0218 , A61M1/0272 , A61M1/3496 , B01D63/02 , B01D2319/04
摘要： A mobile system for separating donor blood by gravitational force into erythrocyte concentrate and plasma. The system includes a first bag serving as a reservoir for the blood to be separated and at least a second and third bag for respectively receiving the erythrocyte concentrate and plasma, and also multiple tubes for connecting the flexible bags to a separator module having a separating membrane in the form of a bundle of hollow fibers. This system is divided into at least one first and one second sterilely packaged, individual subsystem. The first subsystem includes the individual bags and associated connection tubes and the second subsystem includes the separator module, and male/female connectors.

4. 发明申请

US20170128643A1 BLOOD BAG SYSTEM AND BLOOD TREATMENT METHOD 审中-公开
公开(公告)号：US20170128643A1
公开(公告)日：2017-05-11
申请号：US15409959
申请日：2017-01-19
申请人： TERUMO KABUSHIKI KAISHA
发明人： Makoto HIRABUKI , Masayoshi HIGASHI
IPC分类号： A61M1/02 , A61M1/36
CPC分类号： A61M1/029 , A61M1/0218 , A61M1/0236 , A61M1/3693
摘要： A blood bag system includes: a first bag in which blood containing multiple components is stored; a second bag in which a relative medium-density component is stored; a third bag in which a relative low-density component is stored; a first tube through which the relative low-density component and the relative medium-density component are transported from the first bag to the second bag; and a second tube through which the relative low-density component is transported from the first bag to the third bag. A blood treatment method involves: centrifuging blood containing multiple components in a first bag, transporting a low-density component from the first bag to a third bag through a first tube and transporting a relative medium-density component from the first bag to the second bag through the first tube.

5. 发明申请

US20170072339A1 Integrated Leukocyte, Oxygen and/or CO2 Depletion, and Plasma Separation Filter Device 审中-公开
标题翻译：综合白细胞，氧气和/或二氧化碳消耗，和血浆分离过滤装置
公开(公告)号：US20170072339A1
公开(公告)日：2017-03-16
申请号：US15363687
申请日：2016-11-29
申请人： New Health Sciences, Inc.
发明人： Tatsuro YOSHIDA , Paul J. VERNUCCI
IPC分类号： B01D19/00 , A61M1/36 , B01D61/14 , A61M1/02
CPC分类号： B01D19/0031 , A61M1/0209 , A61M1/0213 , A61M1/0218 , A61M1/0272 , A61M1/0281 , A61M1/262 , A61M1/34 , A61M1/3403 , A61M1/3633 , A61M1/3679 , A61M1/38 , A61M2202/0208 , A61M2202/0225 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429 , A61M2202/0439 , B01D61/147
摘要： A blood filter device comprising: a housing comprising an outer wall and a first inlet, a first outlet and a second outlet; a membrane which is capable of separating plasma from the blood, wherein the membrane forms an inner chamber; a leukocyte and oxygen and/or carbon dioxide depletion media disposed wherein the inner chamber, the leukocyte and oxygen and/or carbon dioxide depletion media is capable of depleting leukocytes and oxygen and/or carbon dioxide from the blood; an outer chamber disposed between the outer wall and the membrane, wherein the plasma which permeates through the membrane enters the outer chamber and exits the filter device via the first outlet; whereby the blood which has been depleted of oxygen and/or carbon dioxide, leukocytes and plasma exists and filter device via the second outlet.
摘要翻译：一种血液过滤装置，包括：壳体，包括外壁和第一入口，第一出口和第二出口; 能够从血液中分离血浆的膜，其中所述膜形成内腔; 设置有白细胞和氧和/或二氧化碳耗尽介质，其中所述内室，所述白细胞和氧和/或二氧化碳消耗介质能够从血液中消耗白细胞和氧和/或二氧化碳; 设置在外壁和膜之间的外室，其中渗透通过膜的等离子体进入外室并经由第一出口离开过滤器装置; 由此已经耗尽氧气和/或二氧化碳，白细胞和等离子体的血液经由第二出口存在并过滤装置。

6. 发明授权

US09474845B2 Cell removal method, cell removal system, and white blood cell removal method 有权
标题翻译：细胞去除方法，细胞去除系统和白细胞去除方法
公开(公告)号：US09474845B2
公开(公告)日：2016-10-25
申请号：US13635194
申请日：2011-03-22
申请人： Shuichiro Inadome , Nobukazu Shimada , Tomohisa Yokomizo
发明人： Shuichiro Inadome , Nobukazu Shimada , Tomohisa Yokomizo
IPC分类号： A61M1/36 , A61M1/02 , A61M1/34
CPC分类号： A61M1/3696 , A61M1/0209 , A61M1/0218 , A61M1/34 , A61M1/341 , A61M1/3693 , A61M2202/0439 , B04B5/0442
摘要： In the removal of white blood cells from blood, the efficiency of white blood cell removal by a filter is improved. Centrifugal force is applied to blood placed in a blood bag by centrifugal separation to form a plurality of separation layers having a concentration gradient of white blood cells. The separation layers are passed through a filter in ascending order of white blood cell concentration to remove the white blood cells from the separation layers. The separation layers from which the white blood cells have been removed are received in a first blood component bag.
摘要翻译：在从血液中除去白血球时，通过过滤器去除白细胞的效率提高。通过离心分离将离心力施加到放置在血袋中的血液中，形成具有白细胞浓度梯度的多个分离层。分离层以白细胞浓度的升序通过过滤器，以从分离层去除白细胞。将白细胞从其中除去的分离层被接收在第一血液成分袋中。

7. 发明申请

US20150284682A1 BLOOD STORAGE BAG SYSTEM AND DEPLETION DEVICES WITH OXYGEN AND CARBON DIOXIDE DEPLETION CAPABILITIES 审中-公开
标题翻译：血液储存袋系统和具有氧气和二氧化碳排泄能力的装置
公开(公告)号：US20150284682A1
公开(公告)日：2015-10-08
申请号：US14746458
申请日：2015-06-22
申请人： NEW HEALTH SCIENCES, INC.
发明人： Tatsuro YOSHIDA , Paul J. VERNUCCI
IPC分类号： C12N5/078 , A61K35/18
CPC分类号： C12N5/0641 , A01N1/0221 , A01N1/0226 , A61K35/18 , A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M1/0272 , A61M1/342 , A61M2202/0208 , A61M2202/0225 , B01D19/0031 , B01D53/22
摘要： A blood storage system. The system has a collection bag for red blood cells; an oxygen/carbon dioxide depletion device; a storage bag for red blood cells; and tubing connecting the collection bag to the depletion device and the depletion device to the storage bag. The depletion device includes a receptacle of a solid material having an inlet and an outlet adapted to receiving and expelling a flushing gas; a plurality of hollow fibers or gas-permeable films extending within the receptacle from an entrance to an exit thereof. The hollow fibers or gas-permeable films are adapted to receiving and conveying red blood cells.
摘要翻译：血液储存系统。该系统具有红细胞收集袋; 氧/二氧化碳消耗装置; 红血球储存袋; 以及将收集袋连接到耗尽装置和将耗尽装置连接到存储袋的管道。耗尽装置包括固体材料的容器，其具有适于接收和排出冲洗气体的入口和出口; 多个中空纤维或气体可渗透膜，在容器内从入口到出口延伸。中空纤维或透气膜适于接收和输送红细胞。

8. 发明申请

US20150233803A1 HIGH-THROUGHPUT METHODS AND SYSTEMS FOR PROCESSING BIOLOGICAL MATERIALS 审中-公开
标题翻译：用于加工生物材料的高通量方法和系统
公开(公告)号：US20150233803A1
公开(公告)日：2015-08-20
申请号：US14702263
申请日：2015-05-01
申请人： General Electric Company
发明人： Weston Blaine Griffin , Jaydeep Roy , Phillip Alexander Shoemaker , William Patrick Waters
IPC分类号： G01N1/40
CPC分类号： A61M1/0209 , A61M1/0218 , A61M1/34 , A61M2205/3306 , A61M2205/3334 , B01D21/26 , B03D3/00
摘要： A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the vessel; a filtration device; a conduit through which one or more submaterials are transported between at least the vessel and the filtration device; and a first engagement structure; a processing unit comprising, a pumping device for moving one or more of the submaterials between at least the vessel and the filtration device via the conduit; a second engagement structure corresponding to the first engagement structure; a locking mechanism for at least temporarily holding the tray in a fixed position relative to the processing unit; a control device that automatically starts and stops the pumping device in response to one or more commands.
摘要翻译：一种用于处理生物材料的高通量系统，包括：托盘，其支撑功能封闭的流体路径子系统，包括：用于容纳和使所述生物材料分离成两个或更多个不同的子材料的容器; 从容器接收一个或多个子材料的一个或多个容器; 过滤装置; 导管，至少在所述容器和所述过滤装置之间运送一个或多个副材料; 和第一接合结构; 处理单元，包括：泵送装置，用于经由所述导管在至少所述容器和所述过滤装置之间移动所述副材料中的一种或多种; 对应于第一接合结构的第二接合结构; 用于至少临时将所述托盘相对于所述处理单元暂时保持在固定位置的锁定机构; 响应于一个或多个命令自动启动和停止泵送装置的控制装置。

9. 发明授权

US09102918B2 Methods for rejuvenating red blood cells 有权
标题翻译：振兴红细胞的方法
公开(公告)号：US09102918B2
公开(公告)日：2015-08-11
申请号：US13756116
申请日：2013-01-31
申请人： Biomet Biologics, LLC
发明人： Alan Gray
IPC分类号： A61K35/18 , C12N5/078 , G01N33/80 , A61M1/36 , A61M1/02 , A61K47/00
CPC分类号： A61K35/18 , A61K47/00 , A61M1/0209 , A61M1/0218 , A61M1/0272 , A61M1/0281 , A61M1/3621 , A61M1/3692 , A61M1/3693 , C12N5/0641 , C12N2501/999
摘要： Methods and a system for transfusing blood to a mammalian subject. The method includes obtaining a volume of donated red blood cells (RBCs), adding an enhancement composition to the RBCs to form a treated blood composition, incubating the treated blood composition to form an incubated blood composition, and administering the incubated blood composition to a patient. The system includes a functionally-closed, sterile Y-type tube set.
摘要翻译：用于向哺乳动物受试者输血的方法和系统。所述方法包括获得一定量的捐赠的红细胞（RBC），向RBC中加入增强组合物以形成治疗的血液组合物，孵育经处理的血液组合物以形成培养的血液组合物，以及将培养的血液组合物给予患者。该系统包括功能封闭的无菌Y型管组。

10. 发明授权

US09095663B2 Biological fluid filtration unit provided with an offset inlet and/or outlet member 有权
标题翻译：设置有偏移入口和/或出口构件的生物流体过滤单元
公开(公告)号：US09095663B2
公开(公告)日：2015-08-04
申请号：US12597276
申请日：2008-04-22
申请人： Robert Duhaut , Chryslain Sumian , David Godard
发明人： Robert Duhaut , Chryslain Sumian , David Godard
IPC分类号： A61M1/36 , A61M1/02 , B29C65/02 , B29C65/04 , B29C65/00 , B29L31/14 , B29L31/00
CPC分类号： A61M1/3633 , A61M1/0209 , A61M1/0218 , A61M1/3636 , A61M1/3686 , B29C65/02 , B29C65/04 , B29C66/1122 , B29C66/12443 , B29C66/133 , B29C66/24221 , B29C66/53262 , B29C66/53263 , B29C66/71 , B29C66/80 , B29C66/81423 , B29C66/81431 , B29C66/8322 , B29C66/83221 , B29C66/8432 , B29L2031/14 , B29L2031/7148 , B29K2027/06
摘要： A filtration unit intended to allow the selective elimination of target substances from a fluid such as flood or a blood component, has an outer envelope formed from two flexible sheets joined together over their periphery along a bond line so as to define an inner volume, the envelope containing a filtering medium which delimits, on both sides of the bond line, an inlet compartment of the fluid to be filtered and an outlet compartment of the filtrate, each of the compartments being provided with an element—respectively an inlet and outlet element—for bringing the compartment into communication with the outside, the elements being connected between the sheets and comprising a flow channel that passes through the bond line, the unit being characterized in that at least one channel is offset relative to the bond line towards the compartment with which the channel is in communication.
摘要翻译：用于允许从诸如洪水或血液成分的流体中选择性地清除目标物质的过滤单元具有由两个柔性片材形成的外部封套，该两个柔性片材沿其接合线连接在一起，以便限定内部容积，包含过滤介质的封套，其在接合线的两侧限定待过滤流体的入口隔室和滤液的出口室，每个隔室设有元件，分别为入口和出口元件，为了使隔室与外部连通，元件连接在片材之间，并且包括通过接合线的流动通道，该单元的特征在于至少一个通道相对于朝向隔室的接合线偏移，通道正在通信。

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