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1. 发明申请

US20130142695A1 OXYGENATOR WITH INTEGRATED ARTERIAL FILTER INCLUDING FILTER FRAME 有权
标题翻译：带有集成过滤器的过滤器，包括过滤器框架
公开(公告)号：US20130142695A1
公开(公告)日：2013-06-06
申请号：US13750531
申请日：2013-01-25
申请人： Sorin Group Italia S.r.l. , Politecnico di Milano
发明人： Stefano Reggiani , Claudio Silvestri , Alberto Giri , Alberto Redaelli , Gianfranco Beniamino Fiore
IPC分类号： A61M1/16
CPC分类号： A61M1/1698 , A61M1/322 , A61M1/3627
摘要： An oxygenator combines, in a single structure, a heat exchanger, a gas exchanger, an arterial filter, and a filter frame. Such an oxygenator permits fewer fluid connections and thus may simplify an extracorporeal blood circuit, including a heart-lung machine and a blood reservoir, in which it is used. In some embodiments, the oxygenator may be configured to include multiple purge ports for purging bubbles both before and after filtering the blood.
摘要翻译：氧合器在单个结构中结合了热交换器，气体交换器，动脉过滤器和过滤器框架。这种氧合器允许更少的流体连接，并且因此可以简化体外血液回路，包括使用它的心肺机器和血液储存器。在一些实施例中，氧合器可以被配置为包括用于在过滤血液之前和之后净化气泡的多个吹扫端口。

2. 发明申请

US20060167400A1 Blood perfusion system 有权
公开(公告)号：US20060167400A1
公开(公告)日：2006-07-27
申请号：US11333671
申请日：2006-01-17
申请人： Bruce Ellingboe , William Dalke , J Ingebrigtsen , John Kappus , Bruce Lawrence , Mike Schwab , Cary Carson , Kevin Kollar
发明人： Bruce Ellingboe , William Dalke , J Ingebrigtsen , John Kappus , Bruce Lawrence , Mike Schwab , Cary Carson , Kevin Kollar
IPC分类号： A61M37/00
CPC分类号： A61M1/32 , A61M1/322 , A61M1/3621 , A61M1/3624 , A61M1/3626 , A61M1/3632 , A61M1/3639 , A61M1/3641 , A61M1/3643 , A61M1/3644 , A61M1/3663 , A61M1/3664 , A61M1/3666 , A61M1/3667 , A61M2205/123 , A61M2205/128 , A61M2205/3389 , A61M2205/505 , A61M2205/705 , A61M2205/707 , A61M2209/082 , G06F19/00
摘要： An extracorporeal blood perfusion system includes a disposable assembly and a control unit having a control interface region. The interface region includes pump assemblies for selective pumping of venous blood, arterial blood, cardioplegia solution, suctioned blood and blood removed from the left ventricle. Valve assemblies control the flow of fluids through the assembly and to/from the patient and sensors monitor various fluid parameters including temperature and pressure within the various fluid circuits. The user interface is a functional screen interface for effecting the operation of the control unit and valve assemblies. The screen interface may be a touch screen having objects that corresponds to the component interface region. The display may be selectively controlled to provide graphic depictions of disposable assembly components with corresponding narrative instructions.

3. 发明申请

US20030135152A1 Disposable cartridge for a blood perfusion system 审中-公开
标题翻译：用于血液灌注系统的一次性药筒
公开(公告)号：US20030135152A1
公开(公告)日：2003-07-17
申请号：US09963793
申请日：2001-09-26
发明人： Kevin J. Kollar , Bruce S. Ellingboe , John J. Kappus , Gary A. Carson
IPC分类号： A61M001/00
CPC分类号： A61M1/32 , A61M1/322 , A61M1/3621 , A61M1/3624 , A61M1/3626 , A61M1/3632 , A61M1/3639 , A61M1/3641 , A61M1/3643 , A61M1/3644 , A61M1/3663 , A61M1/3664 , A61M1/3666 , A61M1/3667 , A61M2205/123 , A61M2205/128 , A61M2205/3389 , A61M2205/505 , A61M2205/705 , A61M2205/707 , A61M2209/082
摘要： A disposable cartridge for use in extracorporeal blood perfusions systems that have a control unit for controlling the flow of fluids. The cartridge has a housing defining a plurality of internal passageways that connect to a cardiopulmonary circuit, a cardioplegia circuit and a suction circuit. The cartridge may be fitted with one or more of a bubble trap, a filter, and a valve.
摘要翻译：用于体外血液灌注系统的一次性药筒，其具有用于控制流体流动的控制单元。药筒具有限定连接到心肺电路，心麻痹电路和吸入电路的多个内部通道的壳体。墨盒可以装配一个或多个气泡阱，过滤器和阀。

4. 发明授权

US3807958A A bubble oxygenerator including a blood foam return exchanger device 失效
标题翻译：一种包括血液回收交换器装置的泡沫氧化剂
公开(公告)号：US3807958A
公开(公告)日：1974-04-30
申请号：US25971372
申请日：1972-06-05
申请人： HARVEY RES CORP WILLIAM
发明人： BRUMFIELD R , SIMMONS E
IPC分类号： A61M1/32 , A61M1/36 , A61M1/03
CPC分类号： A61M1/32 , A61M1/322 , A61M1/369 , B01D63/06 , Y10S128/03
摘要： A blood foam return exchanger device provides multiple fluid flow guidance channels disposed around the exterior of a bloodoxygen fluid exchanger having multiple oxygenator tubes. The guidance channels, formed by multiple fins disposed parallel to the tubular axis of symmetry of the fluid exchanger, provide additional residence time in the fluid flow channels for the gaseous exchange of the oxygen gas-blood two-phase mixture while descending the channels. The return shell has a return cap terminus disposed a spaced holding chamber volume above the top header plate of the exchanger, turning the blood foam flow downward 180* after ascending the oxygenator tubes. The multiple fins can provide heat exchange surfaces for further precise temperature control of the blood foam. The blood foam exiting from the return exchanger device flows through the surrounding defoamer filter, separating foam into blood and exchanged gases. A relatively short fluid exchanger utilizes the additional blood foam residence time provided by the guidance channels. Still another blood foam return exchanger device has an integral 180* U-bend return loop extension on each oxygenator tube of the fluid exchanger, and an oxygenator tube return length interiorly extending adjacently down the internal perimeter of the heat exchanger boundary case. Each exit terminus of an oxygenator tube return length extends through the exchanger boundary case, providing an exit for the blood foam into and through the surrounding annular defoamer filter.
摘要翻译：血液回流换热器装置提供多个流体引导通道，其设置在具有多个氧合器管的血 - 氧流体交换器的外部周围。引导通道由平行于流体交换器的管状对称轴线的多个翅片形成，在流体流动通道中提供额外的停留时间，用于氧气 - 血液两相混合物的气相交换，同时使通道下降。返回壳具有返回盖终端，其在交换器的顶部集管板上方设置间隔开的保持室容积，在加氧管上升之后将血液泡沫流动下降180°。多个翅片可以提供热交换表面以进一步精确地控制血液泡沫。从返回交换器装置排出的血液泡沫流过周围的消泡剂过滤器，将泡沫分离成血液和交换的气体。相对短的流体交换器利用由引导通道提供的额外的血液泡沫停留时间。另一种血液泡沫回流换热器装置在流体交换器的每个充氧器管上具有整体的180度U形弯曲返回环延伸部，以及在热交换器边界壳体的内部周边内部相邻延伸的氧合器管返回长度。氧合器管的返回长度的每个出口终端延伸穿过交换器边界箱，为血液泡沫提供并通过周围的环形消泡剂过滤器的出口。

5. 发明授权

US3770384A Two-phase fluid flow guide for blood oxygenator 失效
标题翻译：用于血液氧化剂的两相流体流动指南
公开(公告)号：US3770384A
公开(公告)日：1973-11-06
申请号：US3770384D
申请日：1971-11-29
申请人： BRUMFIELD R
发明人： BRUMFIELD R
IPC分类号： A61M1/32 , A61M1/03
CPC分类号： A61M1/32 , A61M1/322 , Y10S128/03 , Y10S261/28
摘要： Blood flows in extra-corporeal blood circulation into a blood oxygenator. The oxygenating gas enters the blood streams through a means providing oxygenating gas injection, adjacent a means providing blood inlet. The pair of means co-react to provide twophase flow of blood and oxygenating gas bubbles for the two-phase fluid flow guide. The flow guide has a multiplicity of fluid guide, solid walls of equal length, one wall uniformly closely spaced to another wall. The spaced walls are held in a boundary case by wall securing means which provide a uniform base terminus position and a uniform top terminus position for the walls. The boundary case can have a case length at least equal to the fluid guide wall lengths and greater. The fluid guide solid wall can have multiple, uniform cross section flow control channels disposed in the wall, extending normally to the base terminus and the top terminus of the wall. The flow control channels stabilize the upward flow of the two-phase blood and oxygenating gas combination. The flow control channels stabilize the gas bubbleliquid interface flow geometry, and facilitate the rapid fixation of oxygen by the blood and the release of carbon dioxide into the gas phase exiting from the top terminus of the two-phase fluid flow guide.
摘要翻译：血液在体外血液循环中流入血液充氧器。氧化气体通过提供含氧气体注入的装置进入血流，邻近提供血液入口的装置。这对手段共同作用，为两相流体导流管提供血液和氧气气泡两相流。流动引导件具有多个流体引导件，相同长度的实心壁，一个壁与另一个壁均匀地间隔开。间隔开的墙壁通过壁固定装置保持在边界箱中，该固定装置为壁提供均匀的基座终点位置和均匀的顶端位置。边界箱可以具有至少等于流体导向壁长度的壳体长度和更大的外壳长度。流体引导实体壁可以具有多个均匀的横截面流动控制通道，其布置在壁中，正常延伸到壁的基端和顶端。流量控制通道稳定两相血液和充氧气体组合的向上流动。流动控制通道稳定气泡 - 液体界面流动几何形状，并促进氧气被血液快速固定，并且二氧化碳释放到从两相流体流动引导件顶端排出的气相中。

6. 发明授权

US08057419B2 Blood perfusion system 有权
标题翻译：血液灌注系统
公开(公告)号：US08057419B2
公开(公告)日：2011-11-15
申请号：US11333671
申请日：2006-01-17
申请人： Bruce S. Ellingboe , William D. Dalke , J. Steven Ingebrigtsen , John J. Kappus , Bruce E. Lawrence , Mike E. Schwab , Gary A. Carson , Kevin J. Kollar
发明人： Bruce S. Ellingboe , William D. Dalke , J. Steven Ingebrigtsen , John J. Kappus , Bruce E. Lawrence , Mike E. Schwab , Gary A. Carson , Kevin J. Kollar
IPC分类号： A61M37/00
CPC分类号： A61M1/32 , A61M1/322 , A61M1/3621 , A61M1/3624 , A61M1/3626 , A61M1/3632 , A61M1/3639 , A61M1/3641 , A61M1/3643 , A61M1/3644 , A61M1/3663 , A61M1/3664 , A61M1/3666 , A61M1/3667 , A61M2205/123 , A61M2205/128 , A61M2205/3389 , A61M2205/505 , A61M2205/705 , A61M2205/707 , A61M2209/082 , G06F19/00
摘要： An extracorporeal blood perfusion system includes a disposable assembly and a control unit having a control interface region. The interface region includes pump assemblies for selective pumping of venous blood, arterial blood, cardioplegia solution, suctioned blood and blood removed from the left ventricle. Valve assemblies control the flow of fluids through the assembly and to/from the patient and sensors monitor various fluid parameters including temperature and pressure within the various fluid circuits. The user interface is a functional screen interface for effecting the operation of the control unit and valve assemblies. The screen interface may be a touch screen having objects that corresponds to the component interface region. The display may be selectively controlled to provide graphic depictions of disposable assembly components with corresponding narrative instructions.
摘要翻译：体外血液灌注系统包括一次性组件和具有控制界面区域的控制单元。界面区域包括用于选择性泵送静脉血，动脉血，心麻痹液，从左心室移除的抽吸血液和血液的泵组件。阀组件控制通过组件和/或从患者流出的流体，并且传感器监测各种流体参数，包括各种流体回路内的温度和压力。用户界面是用于实现控制单元和阀组件操作的功能屏幕界面。屏幕界面可以是具有对应于组件接口区域的对象的触摸屏。可以选择性地控制显示器以提供具有相应的叙述指令的一次性组装部件的图形描绘。

7. 发明申请

US20110268609A1 OXYGENATOR WITH INTEGRATED ARTERIAL FILTER INCLUDING FILTER FRAME 有权
标题翻译：带有集成过滤器的过滤器，包括过滤器框架
公开(公告)号：US20110268609A1
公开(公告)日：2011-11-03
申请号：US12899283
申请日：2010-10-06
申请人： Stefano Reggiani , Claudio Silvestri , Alberto Giri , Alberto Redaelli , Gianfranco Beniamino Fiore
发明人： Stefano Reggiani , Claudio Silvestri , Alberto Giri , Alberto Redaelli , Gianfranco Beniamino Fiore
IPC分类号： A61M1/32
CPC分类号： A61M1/1698 , A61M1/322 , A61M1/3627
摘要： An oxygenator combines, in a single structure, a heat exchanger, a gas exchanger, an arterial filter, and a filter frame. Such an oxygenator permits fewer fluid connections and thus may simplify an extracorporeal blood circuit, including a heart-lung machine and a blood reservoir, in which it is used. In some embodiments, the oxygenator may be configured to include multiple purge ports for purging bubbles both before and after filtering the blood.
摘要翻译：氧合器在单个结构中结合了热交换器，气体交换器，动脉过滤器和过滤器框架。这种氧合器允许更少的流体连接，并且因此可以简化体外血液回路，包括使用它的心肺机器和血液储存器。在一些实施例中，氧合器可以被配置为包括用于在过滤血液之前和之后净化气泡的多个吹扫端口。

8. 发明授权

US06482360B2 Antifoam compositions including lecithin and uses thereof 失效
标题翻译：消泡剂组合物，包括卵磷脂及其用途
公开(公告)号：US06482360B2
公开(公告)日：2002-11-19
申请号：US09850290
申请日：2001-05-07
申请人： Robert S. Friedman
发明人： Robert S. Friedman
IPC分类号： A61M114
CPC分类号： A61M1/3627 , A61L31/10 , A61M1/322 , B01D19/0404 , B01D19/0409 , B01D19/0418
摘要： A composition including lecithin which is useful for defoaming liquids, such as blood. In one aspect of the invention the composition includes inorganic particles. In another aspect of the invention the composition includes a silicone.
摘要翻译：包含卵磷脂的组合物，其可用于消泡液体如血液。在本发明的一个方面，组合物包括无机颗粒。在本发明的另一方面，组合物包括硅氧烷。

9. 发明授权

US3112746A Oxygenator 失效
公开(公告)号：US3112746A
公开(公告)日：1963-12-03
申请号：US61060556
申请日：1956-09-18
申请人： BAXTER LABORATORIES INC
发明人： GEWECKE THEODORE H , BROMAN CYRUS R
IPC分类号： A61M1/32
CPC分类号： A61M1/32 , A61M1/322 , Y10S128/03

10. 发明授权

US3043982A Device for the treatment of blood or the like 失效
标题翻译：用于治疗血液等的装置
公开(公告)号：US3043982A
公开(公告)日：1962-07-10
申请号：US63660357
申请日：1957-01-28
申请人： FEDERICO WEHRLI
发明人： FEDERICO WEHRLI
IPC分类号： A61L2/10 , A61M1/32 , A61M1/36 , H01J61/20
CPC分类号： H01J61/20 , A61L2/10 , A61M1/32 , A61M1/322 , A61M1/3681 , A61M1/3683 , A61M2202/0216 , A61M2205/053 , A61M2209/082 , A61M2209/084 , Y10S128/03

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