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1. 发明授权

US10864461B2 Organic gel or liquid chromatography method 有权
公开(公告)号：US10864461B2
公开(公告)日：2020-12-15
申请号：US15515082
申请日：2015-09-29
申请人： Francois Parmentier
发明人： Francois Parmentier
IPC分类号： B01D15/22 , B01J20/291 , B01J20/292 , B01J20/28 , B01J20/285 , B01D53/02
CPC分类号： B01D15/22 , B01J20/2805 , B01J20/285 , B01J20/28042 , B01J20/28047 , B01J20/28078 , B01J20/291 , B01J20/292 , B01D53/025 , B01D2253/202 , B01D2253/308 , B01D2253/31 , B01J2220/84
摘要： The invention relates to a chromatography method in which a gaseous, liquid or supercritical mobile phase containing species to be separated is circulated through a packing, said packing comprising: —a plurality of capillary ducts extending in the packing between an upstream face through which the mobile phase enters the packing and a downstream face through which the mobile phase leaves the packing, and —a continuous medium permeable to molecular diffusion extending between said ducts, comprising a porous organic gel or an organic liquid and including at least one network of connected pores, the size of which is greater than two times the molecular diameter of at least one species to be separated and opening to the ducts, so as to give said at least one species a diffusive path between said ducts. The invention also relates to a packing for the implementation of such a method and a method for manufacturing such a packing.

2. 发明授权

US09005526B2 Narrow bore porous layer open tube capillary column and uses thereof 有权
标题翻译：窄孔多孔层开管毛细管柱及其用途
公开(公告)号：US09005526B2
公开(公告)日：2015-04-14
申请号：US14048378
申请日：2013-10-08
申请人： Northeastern University
发明人： Barry L. Karger , Jian Zhang
IPC分类号： G01N30/02 , G01N30/60 , B01J20/28 , B01J20/285 , B01J20/289 , B01J20/32 , G01N30/72 , G01N30/52
CPC分类号： G01N30/60 , B01J20/28085 , B01J20/285 , B01J20/289 , B01J20/327 , B01J20/3282 , B01J2220/54 , B01J2220/84 , B01J2220/86 , G01N30/6073 , G01N30/7266 , G01N2030/528 , Y10T436/11 , Y10T436/117497
摘要： A polymer-based PLOT capillary column prepared by in situ copolymerization of a functional monomer and a crosslinking monomer, which enhances the strength of the polymer matrix, is disclosed. Also disclosed is a system comprising the polymer-based PLOT column coupled to a mass flow or concentration sensitive detector, for carrying out a chemical analysis method on samples separated by liquid chromatography using the column, and a process for using the system. Columns of the invention can be prepared in a robust fashion with a very narrow i.d., e.g., 5-15 μm. Thus, they are suitable for commercial use in ultratrace LC/MS proteomic analysis. Columns according to the invention are characterized by high resolving power and high column-to-column reproducibility. When these columns are coupled on-line with, e.g., ESI-MS detection, the resulting systems are capable of detecting the component parts of complex proteomic samples down to the low attomole to sub-attomole level.
摘要翻译：公开了通过功能单体和交联单体的原位共聚制备的聚合物基PLOT毛细管柱，其增强聚合物基质的强度。还公开了一种系统，其包含与质量流量或浓度敏感检测器相连的基于聚合物的PLOT柱，用于对通过使用该柱的液相色谱分离的样品进行化学分析方法，以及使用该系统的方法。可以以非常窄的i.d.例如5-15μm的稳健方式制备本发明的色谱柱。因此，它们适用于超临界LC / MS蛋白质组学分析中的商业用途。根据本发明的色谱柱的特征在于高分辨能力和高柱色谱重现性。当这些柱在线与例如ESI-MS检测偶联时，所得到的系统能够检测复合蛋白质组样品的组分部分，直至低阿托莫尔至亚阿托莫尔水平。

3. 发明申请

US20140033804A1 NARROW BORE POROUS LAYER OPEN TUBE CAPILLARY COLUMN AND USES THEREOF 有权
标题翻译： NARROW BORE POROUS LAYER OPEN TUBE CAPILLARY COLUMN及其用途
公开(公告)号：US20140033804A1
公开(公告)日：2014-02-06
申请号：US14048378
申请日：2013-10-08
申请人： Northeastern University
发明人： Barry L. Karger , Jian Zhang
IPC分类号： G01N30/60
CPC分类号： G01N30/60 , B01J20/28085 , B01J20/285 , B01J20/289 , B01J20/327 , B01J20/3282 , B01J2220/54 , B01J2220/84 , B01J2220/86 , G01N30/6073 , G01N30/7266 , G01N2030/528 , Y10T436/11 , Y10T436/117497
摘要： A polymer-based PLOT capillary column prepared by in situ copolymerization of a functional monomer and a crosslinking monomer, which enhances the strength of the polymer matrix, is disclosed. Also disclosed is a system comprising the polymer-based PLOT column coupled to a mass flow or concentration sensitive detector, for carrying out a chemical analysis method on samples separated by liquid chromatography using the column, and a process for using the system. Columns of the invention can be prepared in a robust fashion with a very narrow i.d., e.g., 5-15 μm. Thus, they are suitable for commercial use in ultratrace LC/MS proteomic analysis. Columns according to the invention are characterized by high resolving power and high column-to-column reproducibility. When these columns are coupled on-line with, e.g., ESI-MS detection, the resulting systems are capable of detecting the component parts of complex proteomic samples down to the low attomole to sub-attomole level.
摘要翻译：公开了通过功能单体和交联单体的原位共聚制备的聚合物基PLOT毛细管柱，其增强聚合物基质的强度。还公开了一种系统，其包含与质量流量或浓度敏感检测器相连的基于聚合物的PLOT柱，用于对通过使用该柱的液相色谱分离的样品进行化学分析方法，以及使用该系统的方法。可以以非常窄的i.d.例如5-15mum的稳健方式制备本发明的色谱柱。因此，它们适用于超临界LC / MS蛋白质组学分析中的商业用途。根据本发明的色谱柱的特征在于高分辨能力和高柱色谱重现性。当这些柱在线与例如ESI-MS检测偶联时，所得到的系统能够检测复合蛋白质组样品的组分部分，直至低阿托莫尔至亚阿托莫尔水平。

4. 发明授权

US08580570B2 Narrow bore porous layer open tube capillary column and uses thereof 失效
标题翻译：窄孔多孔层开管毛细管柱及其用途
公开(公告)号：US08580570B2
公开(公告)日：2013-11-12
申请号：US13184075
申请日：2011-07-15
申请人： Barry L. Karger , Jian Zhang
发明人： Barry L. Karger , Jian Zhang
IPC分类号： G01N30/00 , G01N30/02
CPC分类号： G01N30/60 , B01J20/28085 , B01J20/285 , B01J20/289 , B01J20/327 , B01J20/3282 , B01J2220/54 , B01J2220/84 , B01J2220/86 , G01N30/6073 , G01N30/7266 , G01N2030/528 , Y10T436/11 , Y10T436/117497
摘要： A polymer-based PLOT capillary column prepared by in situ copolymerization of a functional monomer, which usually contains the retentive chemistries, and a crosslinking monomer, which enhances the strength of the polymer matrix, is disclosed. Also disclosed is a system comprising the polymer-based PLOT column coupled to a mass flow or concentration sensitive detector, for carrying out a chemical analysis method on samples separated by liquid chromatography using the column, and a process for using the system. Columns of the invention can be prepared in a robust fashion with a very narrow i.d., e.g., 5-15 μm. Thus, they are suitable for commercial use in ultratrace LC/MS proteomic analysis. Columns according to the invention are characterized by high resolving power and high column-to-column reproducibility. When these columns are coupled on-line with, e.g., ESI-MS detection, the resulting systems are capable of detecting the component parts of complex proteomic samples down to the low attomole to sub-attomole level.
摘要翻译：公开了通过含有保持性化学物质的官能单体的原位共聚制备的聚合物基PLOT毛细管柱和增强聚合物基质的强度的交联单体。还公开了一种系统，其包含与质量流量或浓度敏感检测器相连的基于聚合物的PLOT柱，用于对通过使用该柱的液相色谱分离的样品进行化学分析方法，以及使用该系统的方法。可以以非常窄的i.d.例如5-15mum的稳健方式制备本发明的色谱柱。因此，它们适用于超临界LC / MS蛋白质组学分析中的商业用途。根据本发明的色谱柱的特征在于高分辨能力和高柱色谱重现性。当这些柱在线与例如ESI-MS检测偶联时，所得到的系统能够检测复合蛋白质组样品的组分部分，直至低阿托莫尔至亚阿托莫尔水平。

5. 发明授权

US08465669B2 Monolith separation medium for chromatography and process for producing the same 有权
标题翻译：用于色谱的单片分离介质及其制备方法
公开(公告)号：US08465669B2
公开(公告)日：2013-06-18
申请号：US13197747
申请日：2011-08-03
申请人： Ken Hosoya
发明人： Ken Hosoya
IPC分类号： C01B31/16 , C09K3/00 , G01N30/02 , G01N30/90 , G01N1/22 , G01N33/497 , G01N37/00 , B32B3/26 , C08G18/00 , B29C65/00 , B29C44/34 , C08J9/00
CPC分类号： B01J20/285 , B01J20/26 , B01J20/265 , B01J20/28042 , B01J20/291 , B01J20/305 , B01J20/3242 , B01J20/3244 , B01J2220/82 , B01J2220/84 , G01N2030/528 , Y10T428/249953 , Y10T428/249994 , Y10T428/249995
摘要： To obtain a non-particle-aggregation-type organic polymer monolith separation medium, there is provided a monolith separation medium comprising a skeletal phase and pores being continuous in the form of three-dimensional network, which skeletal phase on its surface has a functional group permitting introduction of a new functional group. The skeletal phase has a non-particle-aggregation-type co-continuous structure having an average diameter of submicron to micrometer size, and is constituted of an addition polymer from an epoxy compound of bi- or higher functionality and an amine compound of bi- or higher functionality. Further, the skeletal phase is enriched in organic matter and does not contain any carbon atoms derived from aromatic series.
摘要翻译：为了获得非颗粒聚集型有机聚合物整料分离介质，提供了一种整体分离介质，其包含骨架相和以三维网络形式连续的孔，其表面上的骨架相具有官能团允许引入一个新的功能组。骨架相具有平均直径为亚微米至微米尺寸的非颗粒聚集型共连续结构，并且由来自双官能度或更高官能度的环氧化合物的加成聚合物和双官能团的胺化合物构成，或更高的功能。此外，骨架相富含有机物质，并且不含有衍生自芳香族系列的任何碳原子。

6. 发明授权

US07887754B2 Polymeric solid supports for chromatography nanocolumns 有权
标题翻译：用于色谱纳米柱的聚合物固体支持物
公开(公告)号：US07887754B2
公开(公告)日：2011-02-15
申请号：US10544883
申请日：2004-02-06
申请人： Jennifer H. Granger , Robert Plumb
发明人： Jennifer H. Granger , Robert Plumb
IPC分类号： G01N33/00
CPC分类号： B01J19/0093 , B01J20/28026 , B01J20/28057 , B01J20/28069 , B01J20/28083 , B01J20/281 , B01J20/282 , B01J20/283 , B01J20/284 , B01J20/285 , B01J20/286 , B01J2220/54 , B01J2220/84 , G01N30/603 , G01N30/6095 , Y10T436/255
摘要： Nanocolumn chromatography devices useful, e.g., in CEC and nanoLC are disclosed. An exemplary chromatography device of the invention includes a nanocolumn, e.g., a capillary, packed with a particulate stationary phase material and a solid support. The solid support, or in situ frit, is adjacent to and integral with the stationary phase material. An in situ frit of the invention may be a mixture of the stationary phase material and a polymeric network of cross-linked poly(diorganosiloxane), e.g., poly(dimethylsiloxane), which may optionally be sintered. The invention also provides methods of making and using such devices.
摘要翻译：公开了可用于例如CEC和nanoLC的纳米柱色谱装置。本发明的示例性色谱装置包括填充有颗粒固定相材料和固体支持物的纳米柱，例如毛细管。固体支撑体或原位玻璃料与固定相材料相邻并且与固定相材料成一体。本发明的原位玻璃料可以是固定相材料和可以任选烧结的交联聚（二有机硅氧烷）例如聚（二甲基硅氧烷）的聚合物网络的混合物。本发明还提供了制造和使用这些装置的方法。

7. 发明申请

US20100112208A1 Titania-Based Coating for Capillary Microextraction 审中-公开
标题翻译：用于毛细管微萃取的二氧化钛基涂层
公开(公告)号：US20100112208A1
公开(公告)日：2010-05-06
申请号：US12605095
申请日：2009-10-23
申请人： Abdul Malik , Tae-Young Kim
发明人： Abdul Malik , Tae-Young Kim
IPC分类号： B05D7/22 , B05D3/02
CPC分类号： B01J20/0211 , B01J20/103 , B01J20/262 , B01J20/265 , B01J20/286 , B01J20/291 , B01J20/3071 , B01J20/3078 , B01J20/3085 , B01J20/3092 , B01J20/3204 , B01J20/3217 , B01J20/3234 , B01J20/3272 , B01J2220/54 , B01J2220/84 , B01J2220/86 , C08G77/58 , C09D183/14 , G01N2030/009 , G01N2030/085 , G01N2030/207 , Y10T428/1393 , Y10T428/31663
摘要： A method is presented describing in situ preparation of the titania-based sol-gel PDMS coating and its immobilization on the inner surface of a fused silica microextraction capillary. Sol-gel titania-poly (dimethylsiloxane) (TiO2-PDMS) coating was developed for capillary microextraction (CME) to perform on-line preconcentration and HPLC analysis of trace impurities in aqueous samples. The sol-gel titania-based coatings demonstrated strong pH stability and enhanced extraction capability over other commercially available GC coatings. Extraction characteristics of a sol-gel titania-PDMS capillary remained practically unchanged after continuous rinsing with a 0.1 M NaOH solution (pH=13) for 12 hours.
摘要翻译：介绍了一种描述二氧化钛基溶胶 - 凝胶PDMS涂层的原位制备及其固定在熔融二氧化硅微萃取毛细管内表面上的方法。开发了用于毛细管微萃取（CME）的溶胶 - 凝胶二氧化钛 - 聚（二甲基硅氧烷）（TiO 2 -PDMS）涂层，以对含水样品中的微量杂质进行在线预浓缩和HPLC分析。溶胶 - 凝胶二氧化钛基涂层显示出强大的pH稳定性和提高的萃取能力超过其他市售的GC涂料。在用0.1M NaOH溶液（pH = 13）连续冲洗12小时后，溶胶 - 凝胶二氧化钛-PDMS毛细管的提取特性保持几乎不变。

8. 发明授权

US07666336B2 Process for the production of monolithic mouldings 有权
标题翻译：整体模制品生产工艺
公开(公告)号：US07666336B2
公开(公告)日：2010-02-23
申请号：US10578193
申请日：2004-10-15
申请人： Karin Cabrera , Peter Knoell
发明人： Karin Cabrera , Peter Knoell
IPC分类号： C04B35/624
CPC分类号： B01J20/3007 , B01J20/28014 , B01J20/28023 , B01J20/28042 , B01J20/28047 , B01J20/282 , B01J20/30 , B01J2220/82 , B01J2220/84
摘要： The invention relates to a method for producing monolithic molded elements e.g. as sorbents for chromatographic columns or capillary vessels. The aim of the invention is for said molded elements to be able to remain directly in the gel mold thereof following the production process. Said aim is achieved by the inventive method, according to which the surface of the gel mold is activated by etching, increasing the surface, or chemically modifying the surface before the gelling mold is filled with the monomer sol.
摘要翻译：本发明涉及一种用于制造单块模制元件的方法，例如作为色谱柱或毛细血管的吸附剂。本发明的目的是使所述模制元件能够在制造过程之后直接保留在其凝胶模具中。所述目的通过本发明的方法实现，根据该方法，凝胶模具的表面通过蚀刻活化，增加表面，或者在胶凝模具填充单体溶胶之前化学改性表面。

9. 发明授权

US07622191B2 Titania-based coating for capillary microextraction 有权
标题翻译：用于毛细管微萃取的二氧化钛基涂层
公开(公告)号：US07622191B2
公开(公告)日：2009-11-24
申请号：US11161005
申请日：2005-07-19
申请人： Abdul Malik , Tae-Young Kim
发明人： Abdul Malik , Tae-Young Kim
IPC分类号： B32B15/00
CPC分类号： B01J20/0211 , B01J20/103 , B01J20/262 , B01J20/265 , B01J20/286 , B01J20/291 , B01J20/3071 , B01J20/3078 , B01J20/3085 , B01J20/3092 , B01J20/3204 , B01J20/3217 , B01J20/3234 , B01J20/3272 , B01J2220/54 , B01J2220/84 , B01J2220/86 , C08G77/58 , C09D183/14 , G01N2030/009 , G01N2030/085 , G01N2030/207 , Y10T428/1393 , Y10T428/31663
摘要： A method is presented describing in situ preparation of the titania-based sol-gel PDMS coating and its immobilization on the inner surface of a fused silica microextraction capillary. Sol-gel titania-poly (dimethylsiloxane) (TiO2-PDMS) coating was developed for capillary microextraction (CME) to perform on-line preconcentration and HPLC analysis of trace impurities in aqueous samples. The sol-gel titania-based coatings demonstrated strong pH stability and enhanced extraction capability over other commercially availble GC coatings. Extraction characteristics of a sol-gel titania-PDMS capillary remained practically unchanged after continuous rinsing with a 0.1 M NaOH solution (pH=13) for 12 hours.
摘要翻译：介绍了一种描述二氧化钛基溶胶 - 凝胶PDMS涂层的原位制备及其固定在熔融二氧化硅微萃取毛细管内表面上的方法。开发了用于毛细管微萃取（CME）的溶胶 - 凝胶二氧化钛 - 聚（二甲基硅氧烷）（TiO 2 -PDMS）涂层，以对含水样品中的微量杂质进行在线预浓缩和HPLC分析。溶胶 - 凝胶二氧化钛基涂层显示了强大的pH稳定性和提高的提取能力超过其他商业可用的GC涂层。在用0.1M NaOH溶液（pH = 13）连续冲洗12小时后，溶胶 - 凝胶二氧化钛-PDMS毛细管的提取特性保持几乎不变。

10. 发明申请

US20080116137A1 MONOLITHIC ORGANIC COPOLYMER 审中-公开
标题翻译：单晶有机共聚物
公开(公告)号：US20080116137A1
公开(公告)日：2008-05-22
申请号：US11562895
申请日：2006-11-22
申请人： Gunther Bonn , Said Lubbad , Clemens P. Bisjak
发明人： Gunther Bonn , Said Lubbad , Clemens P. Bisjak
IPC分类号： B01D15/08 , C08J3/09
CPC分类号： C08J3/09 , B01J20/26 , B01J20/261 , B01J20/267 , B01J20/285 , B01J2220/58 , B01J2220/82 , B01J2220/84 , C08J2333/08
摘要： Monolithic organic copolymer prepared by copolymerisation of a phenyl (meth)acrylate and a phenylene di(meth)acrylate in the presence of a porogen, wherein said copolymerisation is carried out at a temperature of at least 70° C. This polymer can be used as chromatographic material for separating biopolymers and small molecules.
摘要翻译：通过在致孔剂存在下使（甲基）丙烯酸苯酯与亚苯基二（甲基）丙烯酸酯共聚制备的单片有机共聚物，其中所述共聚在至少70℃的温度下进行。该聚合物可以用作用于分离生物聚合物和小分子的色谱材料。

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