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1. 发明授权

US10279350B2 Method of generating droplets 有权
公开(公告)号：US10279350B2
公开(公告)日：2019-05-07
申请号：US15365894
申请日：2016-11-30
申请人： Bio-Rad Laboratories, Inc.
发明人： Benjamin J. Hindson , Kevin D. Ness , Billy W. Colston, Jr. , Fred P. Milanovich , Donald A. Masquelier
IPC分类号： B01L3/00 , B01F13/00 , B01F15/00 , B01L3/02 , B01L7/00 , B29C45/00 , C12Q1/686 , G01N21/3563 , G01N21/49 , G01N21/64 , B01F3/08 , B29L31/00
CPC分类号： B01L3/502784 , B01F3/0807 , B01F13/0062 , B01F15/00922 , B01F2003/0834 , B01F2003/0842 , B01F2215/0037 , B01L3/0241 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/0673 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/041 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0858 , B01L2300/0867 , B01L2300/1822 , B01L2400/0478 , B01L2400/0487 , B01L2400/049 , B01L2400/0622 , B29C45/0053 , B29C45/006 , B29C2045/0079 , B29L2031/752 , C12Q1/686 , G01N21/3563 , G01N21/49 , G01N21/6428 , G01N21/6486 , G01N2021/6439 , Y02A90/26
摘要： Methods of generating droplets. In an exemplary method, a device including a sample well, a carrier well, a droplet well, and a plurality of microfluidic channels is selected. The microfluidic channels include a first channel, a second channel, and a third channel. A discrete volume of sample-containing fluid is placed into the sample well, and a discrete volume of carrier fluid is placed into the carrier well. A pressure differential is created after placing the discrete volumes, to cause fluid flow. Sample-containing fluid flows from the sample well to a droplet-generation region of the device via the first channel. Carrier fluid flows from the carrier well to the droplet-generation region via the second channel. Sample-containing droplets and carrier fluid flow from the droplet-generation region to the droplet well via the third channel.

2. 发明申请

US20180244014A1 GLASS/RESIN COMPOSITE STRUCTURE AND METHOD FOR MANUFACTURING SAME 审中-公开
公开(公告)号：US20180244014A1
公开(公告)日：2018-08-30
申请号：US15968048
申请日：2018-05-01
申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION
发明人： Yusuke GOTO , Masao KAMAHORI , Hiroshi SASAKI , Kiyotoshi MORI , Hideyuki AKIYAMA
IPC分类号： B32B1/08 , G01N21/05 , B32B17/06 , B01L3/00 , B29C65/46 , B29C65/48 , B32B7/12 , B32B27/28 , B32B27/34 , B32B27/36 , C09J5/06 , B29K71/00 , B29L31/00 , B29L23/00
CPC分类号： B32B1/08 , B01L3/561 , B01L2300/12 , B29C65/46 , B29C65/4895 , B29C66/73117 , B29C66/7465 , B29K2071/00 , B29K2995/0026 , B29K2995/0058 , B29K2995/0077 , B29L2023/22 , B29L2031/752 , B32B7/12 , B32B17/064 , B32B27/281 , B32B27/285 , B32B27/286 , B32B27/288 , B32B27/34 , B32B27/365 , B32B2255/20 , B32B2597/00 , C09J5/06 , C09J2400/143 , C09J2400/226 , G01N21/05 , Y10T428/1321
摘要： A composite structure with high pressure resistance that is suitable for a flow channel is produced by reducing the number of components while maintaining the excellent chemical resistance and high stress tolerance inherent to a glass substrate and a resin substrate. A glass substrate surface is modified with a hydrolyzable silicon compound, and the glass substrate is brought into contact with the resin substrate. Subsequently, the contact surface between the glass substrate and the resin substrate is heated to a temperature from the glass transition temperature to the pyrolysis temperature of the resin substrate, eliminating gaps between the glass substrate and the resin substrate to bring them into close contact with each other, and causing chemical binding or anchor effects between the glass substrate and the resin substrate via the hydrolyzable silicon compound. Thus, the glass substrate and the resin substrate are firmly fixed to each other.

3. 发明申请

US20180229240A1 REAGENT VESSEL FOR STORING A LIQUID REAGENT, APPARATUS FOR MANUFACTURING A LOWER PART OF A REAGENT VESSEL AND A METHOD FOR MANUFACTURING A LOWER PART OF A REAGENT VESSEL 审中-公开
公开(公告)号：US20180229240A1
公开(公告)日：2018-08-16
申请号：US15950620
申请日：2018-04-11
申请人： Roche Diagnostics Operations, Inc.
发明人： Reinhold Kraemer , Stephan Sattler
IPC分类号： B01L3/00 , B29C45/44 , B29C45/33
CPC分类号： B01L3/523 , B01L3/52 , B01L2300/0809 , B01L2300/0848 , B01L2300/0851 , B01L2300/0858 , B29C45/2624 , B29C45/332 , B29C45/4421 , B29K2023/06 , B29K2023/12 , B29L2031/752 , G01N2035/0405
摘要： A reagent vessel, an apparatus and a method for manufacturing a lower part of a reagent vessel for an analytical instrument are disclosed. The reagent vessel is configured to store a liquid reagent. The reagent vessel comprises a cover and a lower part. The lower part comprises a bottom wall, a front wall, a rear wall, two opposing side walls and at least one connection wall. The cover, bottom wall, front wall, rear wall and two opposing side walls define at least one internal volume for storing at least one liquid reagent. The two opposing side walls are at least partially connected to one another by the at least one connection wall located within the at least one internal volume. The connection wall is spaced apart from the bottom wall. The connection wall and at least the two opposing side walls can be injection-molded and are monolithically formed.

4. 发明授权

US09903836B2 Microfluidic devices and methods for fabricating microfluidic devices 有权
公开(公告)号：US09903836B2
公开(公告)日：2018-02-27
申请号：US14309307
申请日：2014-06-19
申请人： Saint Louis University
发明人： Robert Scott Martin , Asmira Selmovic Alagic , Alicia Johnson Hoover
IPC分类号： C02F1/40 , B01L3/00 , G01N27/447 , B29K63/00 , B29L31/00 , B29C35/02
CPC分类号： G01N27/44791 , B01L3/502707 , B01L3/502715 , B01L2300/0816 , B01L2300/0838 , B01L2300/088 , B01L2400/0421 , B29C35/02 , B29K2063/00 , B29L2031/752
摘要： The present disclosure relates generally to microfluidic devices and methods for fabricating the devices. More particularly, the present disclosure relates to microfluidic devices having encapsulated fluidic tubing and encapsulated electrodes, microfluidic devices having encapsulated fluidic tubing, encapsulated capillary loops and encapsulated electrodes, and methods of fabricating devices having encapsulated fluidic tubing, encapsulated capillary loops and encapsulated electrodes resulting in reduced dead volume interconnects between the fluidic tubing and capillary loops and associated microchannels and aligned fluidic tubing openings, capillary loop openings, electrodes and other device features.

5. 发明授权

US09726484B2 Level device 有权
公开(公告)号：US09726484B2
公开(公告)日：2017-08-08
申请号：US14688145
申请日：2015-04-16
申请人： SOLA-Messwerkzeuge GmbH
发明人： Lukas Zwing , Wolfgang Scheyer
IPC分类号： G01C9/28 , B29C45/16 , G01C9/32 , G01C9/34 , B29L9/00 , B29L31/00
CPC分类号： G01C9/28 , B29C45/16 , B29L2009/00 , B29L2031/752 , G01C9/32 , G01C9/34
摘要： A level device for a spirit level includes a level device body, and a substantially cylindrical cavity formed by an inside wall of the level device body. The cavity has a longitudinal axis and serves to accommodate a liquid, and the level device body is arranged in a carrier body. The carrier body includes two transparent covers for closing the carrier body and preferably includes a casing body which is preferably in the form of a circular ring. An outside wall of the level device body has a curved region with a curvature in the longitudinal direction relative to the longitudinal axis of the cavity, by which a magnifying glass effect can be achieved when viewing a marker body which can be arranged in the cavity.

6. 发明申请

US20170221593A1 USING ADDITIVE MANUFACTURING TO PRODUCE SHIELDING OR MODULATING MATERIAL FOR NUCLEAR DETECTORS 审中-公开
公开(公告)号：US20170221593A1
公开(公告)日：2017-08-03
申请号：US15013560
申请日：2016-02-02
申请人： Edgar R. Alvarez
发明人： Edgar R. Alvarez
IPC分类号： G21F5/015 , B29C67/00 , G01V5/04 , B22F3/105 , G21F5/06 , G21F1/00
CPC分类号： G21F5/015 , B22F3/1055 , B29C64/112 , B29K2101/12 , B29L2031/752 , B33Y10/00 , B33Y80/00 , G21F1/00 , G21F3/00 , Y02P10/295
摘要： An apparatus for a nuclear detector of a downhole tool and method of manufacturing the apparatus is disclosed. The apparatus includes a single multi-metallic component manufactured using additive manufacturing, wherein the component includes at least a first material having a first density and a second material having a second density. The method includes using additive manufacturing to form the component so that the component includes at least a first material having a first density and a second material having a second density and the first material and the second material form the single multi-metallic component.

7. 发明申请

US20170171999A1 APPLYING PRESSURE TO ADHESIVE USING CTE MISMATCH BETWEEN COMPONENTS 审中-公开
公开(公告)号：US20170171999A1
公开(公告)日：2017-06-15
申请号：US15193556
申请日：2016-06-27
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION
发明人： Michael J. FISHER , David C. LONG , Donald MERTE , Robert WEISS , Thomas WEISS
IPC分类号： H05K5/02 , H05K5/06 , B29C65/02 , H05K5/00
CPC分类号： H05K5/0208 , B29C65/02 , B29L2031/752 , H05K5/0013 , H05K5/064
摘要： Assembly apparatuses and processes are provided which include a pressure cure fixture. The pressure cure fixture is sized to reside within a container, such as an electronic enclosure, and facilitate applying pressure to an adhesive disposed over an inner surface of the container. The pressure cure fixture is formed of a material with a higher coefficient of thermal expansion (CTE) than the container, and is sized to correspond, at least in part, to an inner space of the container while allowing for the adhesive and a surface-mount element to be disposed between the pressure cure fixture and the inner surface of the container. When heated, the pressure cure fixture expands greater than the container and imparts the pressure to the surface-mount element and the adhesive to facilitate securing the surface-mount element to the inner surface of the container.

8. 发明申请

US20170144116A1 METHOD OF MAKING A DEVICE FOR GENERATING DROPLETS 审中-公开
公开(公告)号：US20170144116A1
公开(公告)日：2017-05-25
申请号：US15365888
申请日：2016-11-30
申请人： Bio-Rad Laboratories, Inc.
发明人： Kevin D. Ness , Benjamin J. Hindson , Billy W. Colston, JR. , Donald A. Masquelier
IPC分类号： B01F3/08 , B01F15/00 , B29C45/00 , G01N21/49 , B01L3/00 , B01L7/00 , G01N21/64 , B01F13/00 , C12Q1/68
CPC分类号： B01L3/502784 , B01F3/0807 , B01F13/0062 , B01F15/00922 , B01F2003/0834 , B01F2003/0842 , B01F2215/0037 , B01L3/0241 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/0673 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/041 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0858 , B01L2300/0867 , B01L2300/1822 , B01L2400/0478 , B01L2400/0487 , B01L2400/049 , B01L2400/0622 , B29C45/0053 , B29C45/006 , B29C2045/0079 , B29L2031/752 , C12Q1/686 , G01N21/3563 , G01N21/49 , G01N21/6428 , G01N21/6486 , G01N2021/6439 , G06F19/00 , Y02A90/26
摘要： Methods of making a droplet-generating device. In an exemplary method, an upper member is injection molded. The upper member includes a bottom surface and also includes a first microfluidic channel, a second microfluidic channel, and a third microfluidic channel each formed in the bottom surface. The upper member has a plurality of openings each extending completely through the upper member from the bottom surface and creating a side wall region of a sample well, a carrier well, and a droplet well. A cover layer is attached to the bottom surface of the upper member, such that the cover layer seals a bottom side of each microfluidic channel. The microfluidic channels meet one another to create a droplet-generation region. The sample well, the carrier well, and the droplet well are connected to the droplet-generation region via the first, second, and third microfluidic channels, respectively.

9. 发明申请

US20160209288A1 Polymer Composite Vacuum Components 审中-公开
标题翻译：聚合物复合真空组件
公开(公告)号：US20160209288A1
公开(公告)日：2016-07-21
申请号：US14994969
申请日：2016-01-13
申请人： MKS Instruments, Inc.
发明人： Brandon J. Kelly , Clinton L. Percy , Scott C. Heinbuch , Gerardo A. Brucker , Timothy C. Swinney , Timothy R. Piwonka-Corle
IPC分类号： G01L21/34 , B29C45/14
CPC分类号： G01L21/34 , B29C45/14065 , B29K2023/12 , B29K2069/00 , B29K2071/00 , B29L2031/752 , G01L19/0084 , G01L21/30
摘要： A gauge having a housing formed of a polymer material and one or more electrical feedthrough pins disposed in the housing. The electrical feedthrough pins can be oriented substantially perpendicular to each other and have complex shapes.
摘要翻译：具有由聚合物材料形成的壳体和设置在壳体中的一个或多个电馈通销的量规。电馈通引脚可以基本上彼此垂直定向并且具有复杂的形状。

10. 发明申请

US20150308821A1 LEVEL DEVICE 有权
标题翻译：水平装置
公开(公告)号：US20150308821A1
公开(公告)日：2015-10-29
申请号：US14688145
申请日：2015-04-16
申请人： SOLA-Messwerkzeuge GmbH
发明人： Lukas ZWING , Wolfgang SCHEYER
IPC分类号： G01C9/28 , G01C9/34 , B29C45/16 , G01C9/32
CPC分类号： G01C9/28 , B29C45/16 , B29L2009/00 , B29L2031/752 , G01C9/32 , G01C9/34
摘要： A level device for a spirit level includes a level device body, and a substantially cylindrical cavity formed by an inside wall of the level device body. The cavity has a longitudinal axis and serves to accommodate a liquid, and the level device body is arranged in a carrier body. The carrier body includes two transparent covers for closing the carrier body and preferably includes a casing body which is preferably in the form of a circular ring. An outside wall of the level device body has a curved region with a curvature in the longitudinal direction relative to the longitudinal axis of the cavity, by which a magnifying glass effect can be achieved when viewing a marker body which can be arranged in the cavity.
摘要翻译：用于液位的液位装置包括液位装置主体和由液位装置主体的内壁形成的大致圆柱形腔。空腔具有纵向轴线并用于容纳液体，并且液位装置主体被布置在载体主体中。载体主体包括用于封闭载体主体的两个透明盖，并且优选地包括优选为圆形形状的壳体。水平装置主体的外壁具有相对于空腔的纵向轴线在纵向方向上具有曲率的弯曲区域，当观察可设置在空腔中的标记体时，可以实现放大镜效果。

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