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1. 发明申请

US20180230116A1 PROCESS FOR THE PREPARATION OF VORTIOXETINE AND SALTS THEREOF 审中-公开
公开(公告)号：US20180230116A1
公开(公告)日：2018-08-16
申请号：US15896193
申请日：2018-02-14
申请人： PIRAMAL ENTERPRISES LIMITED
发明人： Milind Gharpure , Sanjay Kumar Sharma , Nainesh Kansagara
IPC分类号： C07D295/096 , C07C211/46 , C07B43/04
CPC分类号： C07D295/096 , C07B43/04 , C07C211/46
摘要： The present invention provides an improved process for preparation of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine; commonly known as vortioxetine (referred to as the compound (I)) and pharmaceutically acceptable salts thereof; wherein the process comprises reaction of 2-((2,4-dimethylphenyl)thio)aniline (II) with bis(2-alkyl)amine (IIIa) or its salt in the presence of a cyclic amide solvent.

2. 发明申请

US20160089657A1 CATALYSIS BY METAL NANOPARTICLES DISPERSED WITHIN A HIERARCHICALLY POROUS CARBON MATERIAL 有权
标题翻译：金属纳米粒子在高分子多孔碳材料中的分解催化
公开(公告)号：US20160089657A1
公开(公告)日：2016-03-31
申请号：US14962342
申请日：2015-12-08
申请人： Board of Trustees of The University of Alabama
发明人： Martin G. Bakker , Franchessa Maddox Sayler , Kevin Shaughnessy
IPC分类号： B01J21/18 , B01J23/44 , B01J23/46 , B01J35/10 , C07C41/30 , B01J37/16 , C07C2/86 , C07C67/343 , C07C253/30 , B01J23/42 , B01J35/08
CPC分类号： B01J21/18 , B01J21/185 , B01J23/42 , B01J23/44 , B01J23/462 , B01J23/464 , B01J23/72 , B01J23/755 , B01J35/0013 , B01J35/002 , B01J35/0053 , B01J35/006 , B01J35/08 , B01J35/1061 , B01J35/1066 , B01J35/1071 , B01J35/1076 , B01J35/109 , B01J35/1095 , B01J37/0018 , B01J37/0201 , B01J37/0207 , B01J37/06 , B01J37/08 , B01J37/084 , B01J37/088 , B01J37/16 , B01J37/18 , B82Y30/00 , C04B38/0032 , C07C2/861 , C07C41/30 , C07C67/343 , C07C209/36 , C07C253/30 , C07C2521/18 , C07C2523/44 , C07C211/46 , C07C255/57 , C07C255/50 , C07C15/52 , C07C69/618 , C04B35/52 , C04B38/0054 , C04B38/0058 , C04B38/0064 , C04B38/045 , C04B38/0615
摘要： Disclosed are hierarchically porous carbon materials with a plurality of discreet nanoparticles dispersed on their carbon phase. The materials possess a continuous network of pores that spans the porous material, permitting the flow of fluids into and through the material. The porous materials can be used as heterogeneous catalysts.
摘要翻译：公开了具有分散在其碳相上的多个分散纳米颗粒的层状多孔碳材料。这些材料具有跨越多孔材料的连续孔隙网络，允许流体流入材料和通过材料。多孔材料可用作非均相催化剂。

3. 发明授权

US09278905B2 Production method for compound comprising amino group and/or hydroxyl group 有权
标题翻译：包含氨基和/或羟基的化合物的制备方法
公开(公告)号：US09278905B2
公开(公告)日：2016-03-08
申请号：US14382455
申请日：2013-03-04
申请人： Takashi Ohshima , Hiroyuki Morimoto , Yuhei Shimizu
发明人： Takashi Ohshima , Hiroyuki Morimoto , Yuhei Shimizu
IPC分类号： C07C211/00 , C07C209/62 , C07D217/02 , C07B41/02 , C07B43/04 , C07B51/00 , C07C213/02 , C07C227/06 , C07D209/16 , C07F7/18 , C07C41/26 , C07C29/00 , C07C41/18 , C07C227/04 , C07D209/08 , C07D309/12 , C07D317/28
CPC分类号： C07C209/62 , C07B41/02 , C07B43/04 , C07B51/00 , C07C29/00 , C07C41/18 , C07C41/26 , C07C213/02 , C07C227/04 , C07C227/06 , C07D209/08 , C07D209/16 , C07D217/02 , C07D309/12 , C07D317/28 , C07F7/1804 , C07F7/1892 , C07C31/205 , C07C33/22 , C07C43/23 , C07C211/27 , C07C211/46 , C07C215/76 , C07C215/30 , C07C215/44 , C07C229/60 , C07C217/84 , C07C217/02 , C07C211/38
摘要： Disclosed is a method for producing a compound having an amino group and/or a hydroxyl group from a substrate compound having an atomic group containing CO or CS by eliminating such atomic group. The substrate compound, having an atomic group containing CO or CS (for example, an amide, a carbamate, or the like), is allowed to react with a compound expressed by formula (I) below, at a temperature of 120° C. or lower, preferably in the presence of an ammonium salt, to eliminate such atomic group containing CO or CS. In formula (I) A may not be present, and in a case where A is present, A represents an alkyl group having 1 to 6 carbon atoms. H2N-A-NH2 (I).
摘要翻译：公开了通过除去这种原子团，从具有含有CO或CS的原子团的底物化合物制备具有氨基和/或羟基的化合物的方法。使具有含有CO或CS的原子团（例如酰胺，氨基甲酸酯等）的底物化合物与下述式（I）表示的化合物在120℃的温度下反应。或更低，优选在铵盐存在下，以消除含有CO或CS的原子团。在式（I）中，A可以不存在，并且在存在A的情况下，A表示具有1至6个碳原子的烷基。 H2N-A-NH2（I）。

4. 发明申请

US20160023997A1 ABSORBABLE POLYURETHANES AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20160023997A1
公开(公告)日：2016-01-28
申请号：US14874387
申请日：2015-10-03
申请人： Bezwada Biomedical, LLC
发明人： Rao S. Bezwada
IPC分类号： C07C265/12 , C07C229/56 , C08G18/02 , C08G69/40 , A61L24/04 , C08G63/685 , A61K47/34 , A61L31/10 , A61L27/18 , A61L27/56 , C07C219/34 , C08G69/44
CPC分类号： C07C265/12 , A61K9/12 , A61K47/14 , A61K47/16 , A61K47/34 , A61L15/26 , A61L17/10 , A61L24/046 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/06 , A61L31/10 , A61L31/148 , C07C211/46 , C07C219/34 , C07C229/56 , C07C229/60 , C07C265/14 , C08G18/02 , C08G18/28 , C08G18/7657 , C08G63/685 , C08G69/40 , C08G69/44 , C08G2230/00 , C09D175/04 , C08L75/04 , C08L75/06 , C08L77/12 , C08L77/00
摘要： Disclosed are novel bioabsorbable and biodegradable monomer compounds, bioabsorbable and biodegradable polymers therefrom, and methods of making such monomers and polymers, which are useful in pharmaceutical delivery systems, tissue engineering applications, tissue adhesives products, implantable medical devices, foams and reticulated foams for wound healing and drug delivery, bone hemostats and bone void fillers, adhesion prevention barriers, meshes, filters, stents, medical device coatings, pharmaceutical drug formulations, consumer product and cosmetic and pharmaceutical packaging, apparel, infusion devices, blood collection tubes and devices, other medical tubes, skin care products, and transdermal drug delivery materials.

5. 发明申请

US20150284529A1 STABILIZED MONOMER DISPERSION CONTAINING INORGANIC OXIDE NANOPARTICLES WITH HIGH REFRACTIVE INDEX AND ITS PREPARATION 审中-公开
标题翻译：含有高反应性指数的无机氧化物纳米粒子的稳定单体分散体及其制备
公开(公告)号：US20150284529A1
公开(公告)日：2015-10-08
申请号：US14735491
申请日：2015-06-10
申请人： National Taiwan University
发明人： Wen-Yen CHIU , I-Ann LEI , Dai-Fu LAI , Wen-Chang CHEN , Yang-Yen YU , Guey-Sheng LIOU , Trong-Ming DON
IPC分类号： C08K3/22 , C08K5/56 , C07C31/20 , C07C69/54 , C07D303/16 , C07C211/46 , C08K5/09 , C07C15/02
CPC分类号： C08K3/22 , B82Y30/00 , C01P2002/88 , C01P2004/52 , C01P2004/64 , C07C15/02 , C07C31/202 , C07C69/54 , C07C211/46 , C07D303/16 , C08F20/14 , C08K5/09 , C08K5/56 , C08K2003/2213 , C08K2003/2241 , C08K2003/2244 , C09C1/3676 , C09C3/10 , G02B2006/12071 , H01B1/124
摘要： The present invention relates to a stabilized monomer dispersion containing inorganic oxide nanoparticles with high refractive index in which the refractive index of the inorganic oxide nanoparticles is greater than 1.65 and the average particle size of the high refractive inorganic oxide nanoparticles ranges from 1 to 100 nm and its content is in a range of from 1.0% by weight to 10.0% by weight based on the total weight of the monomer dispersion. The present invention also relates to a process for preparing the stabilized monomer dispersion containing high refractive inorganic oxide nanoparticles.
摘要翻译：本发明涉及含有无机氧化物纳米粒子的折射率大于1.65且高折射率无机氧化物纳米粒子的平均粒径为1〜100nm的折射率高的无机氧化物纳米粒子的稳定化单体分散体，其含量基于单体分散体的总重量为1.0重量％至10.0重量％。本发明还涉及制备含有高折射率无机氧化物纳米粒子的稳定单体分散体的方法。

6. 发明申请

US20150284417A1 NOVEL RUTHENIUM COMPLEXES AND THEIR USES IN PROCESSES FOR FORMATION AND/OR HYDROGENATION OF ESTERS, AMIDES AND DERIVATIVES THEREOF 审中-公开
标题翻译：新型氢氧化钠复合物及其用于形成和/或加氢酯，氨基和衍生物的方法中的用途
公开(公告)号：US20150284417A1
公开(公告)日：2015-10-08
申请号：US14702641
申请日：2015-05-01
申请人： YEDA RESEARCH AND DEVELOPMENT CO., LTD.
发明人： David MILSTEIN , Ekambaram BALARAMAN , Chidambaram GUNANATHAN , Boopathy GNANAPRAKASAM , Jing ZHANG
IPC分类号： C07F15/00 , C07D305/06 , C07D307/44 , C07D295/023 , C07K5/12 , C07C29/149 , C07C213/02 , C07C67/00 , C07C231/10 , C07D307/52 , C07D295/185 , C07C51/00 , C07D309/30 , C07D307/33 , C07D307/83 , C07D241/12 , C07K1/00 , C07B41/08 , C07B41/02 , C07B41/12 , C07B43/06 , C07B43/04 , B01J31/24 , C07C209/62
CPC分类号： C07K5/12 , B01J31/18 , B01J31/189 , B01J31/2404 , B01J31/2409 , B01J31/248 , B01J31/2485 , B01J2231/40 , B01J2231/49 , B01J2231/643 , B01J2231/763 , B01J2531/0244 , B01J2531/821 , C07B41/02 , C07B41/08 , C07B41/12 , C07B43/04 , C07B43/06 , C07C29/136 , C07C29/149 , C07C29/177 , C07C41/16 , C07C41/26 , C07C45/002 , C07C45/006 , C07C51/00 , C07C51/02 , C07C51/23 , C07C51/295 , C07C67/00 , C07C67/03 , C07C67/297 , C07C209/00 , C07C209/62 , C07C213/00 , C07C213/02 , C07C231/02 , C07C231/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D207/06 , C07D207/08 , C07D211/12 , C07D213/38 , C07D241/08 , C07D241/12 , C07D295/023 , C07D295/027 , C07D295/185 , C07D305/06 , C07D307/14 , C07D307/33 , C07D307/44 , C07D307/52 , C07D307/83 , C07D309/30 , C07D487/14 , C07F9/58 , C07F9/65583 , C07F15/0046 , C07F15/0053 , C07K1/00 , C08G69/00 , Y02P20/52 , C07C233/05 , C07C235/06 , C07C233/07 , C07C235/16 , C07C235/14 , C07C235/10 , C07C211/27 , C07C211/07 , C07C211/35 , C07C211/46 , C07C211/10 , C07C215/28 , C07C217/58 , C07C69/14 , C07C69/24 , C07C31/125 , C07C31/12 , C07C49/78 , C07C49/04 , C07C49/10 , C07C49/08 , C07C49/403 , C07C31/205 , C07C31/202 , C07C31/04 , C07C31/08 , C07C33/20 , C07C33/22 , C07C31/1355 , C07C31/10 , C07C43/13 , C07C69/78 , C07C69/75 , C07C53/124 , C07C53/126 , C07C59/125 , C07C57/32 , C07C61/08 , C07C57/30 , C07C65/21 , C07C63/08 , C07C63/06
摘要： The present invention relates to novel Ruthenium complexes and related borohydride complexes, and their use for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including preparing polyamides (e.g., polypeptides) by reacting dialcohols and diamines or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones), cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta-amino alcohols to form pyrazines. The present invention further relates to novel uses of certain pyridine Ruthenium complexes.
摘要翻译：本发明涉及新型钌络合物和相关硼氢化物配合物及其用于（1）将酰胺（包括聚酰胺）氢化成醇和胺的用途; （2）由醇与胺（包括通过使二元醇和二胺反应制备聚酰胺（如多肽）或通过氨基醇的聚合）制备酰胺; （3）将酯氢化成醇（包括环酯（内酯）的加氢，环状二酯（二内酯）或聚酯））; （4）有机碳酸酯（包括聚碳酸酯）对醇和氨基甲酸酯（包括聚氨基甲酸酯）或脲衍生物氢化成醇和胺; （5）醇与酯的脱氢偶联; （6）将仲醇醇化成酮类; （7）酯的酰胺化（由酯和胺合成酰胺）; （8）使用酯酰化醇; （9）将醇与水偶联以形成羧酸; 和（10）β-氨基醇脱氢形成吡嗪。本发明还涉及某些吡啶钌络合物的新用途。

7. 发明授权

US09150494B2 Process using microchannel technology for conducting alkylation or acylation reaction 有权
标题翻译：使用微通道技术进行烷基化或酰化反应的方法
公开(公告)号：US09150494B2
公开(公告)日：2015-10-06
申请号：US11271154
申请日：2005-11-11
申请人： Anna Lee Tonkovich , Steven T. Perry , Timothy J. LaPlante , Kai Tod Paul Jarosch , Thomas P. Hickey , Sean Patrick Fitzgerald , Dongming Qiu , Ravi Arora , Timothy J. Sullivan , Paul Neagle
发明人： Anna Lee Tonkovich , Steven T. Perry , Timothy J. LaPlante , Kai Tod Paul Jarosch , Thomas P. Hickey , Sean Patrick Fitzgerald , Dongming Qiu , Ravi Arora , Timothy J. Sullivan , Paul Neagle
IPC分类号： C07C2/56 , C07C209/68 , B01F5/04 , B01F13/00 , B01J19/00 , C07C2/66 , C07C2/70 , C07C37/14 , B01J29/40 , B01J37/02 , B01J38/10
CPC分类号： C07C209/68 , B01F5/0475 , B01F13/0059 , B01J19/0093 , B01J29/40 , B01J37/0225 , B01J38/10 , B01J2219/00783 , B01J2219/00822 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00837 , B01J2219/00844 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00905 , C07C2/66 , C07C2/70 , C07C37/14 , C07C2529/40 , Y02P20/582 , Y02P20/584 , C07C15/073 , C07C211/46 , C07C211/47 , C07C211/50 , C07C211/51 , C07C39/06 , C07C39/07
摘要： The disclosed invention relates to a process, comprising: flowing a first reactant feed stream comprising a reactant substrate and a second reactant feed stream comprising an alkylating agent, an acylating agent or a mixture thereof, in a process microchannel in contact with each other to form a product comprising at least one alkylation product, at least one acylation product, or a mixture thereof; transferring heat from the process microchannel to a heat sink; and removing the product from the process microchannel.
摘要翻译：所公开的发明涉及一种方法，其包括：将包含反应物底物的第一反应物进料流和包含烷基化试剂，酰化剂或其混合物的第二反应物进料流在彼此接触的工艺微通道中流动以形成包含至少一种烷基化产物，至少一种酰化产物或其混合物的产品; 将热量从工艺微通道转移到散热器; 并从工艺微通道中除去产品。

8. 发明申请

US20150251988A1 PROMOTION OF IMINE FORMATIN VIA CATIONIC RESIN CATALYST 有权
标题翻译：通过阳离子树脂催化剂促进内酯
公开(公告)号：US20150251988A1
公开(公告)日：2015-09-10
申请号：US14632265
申请日：2015-02-26
申请人： KELLOGG BROWN & ROOT LLC
发明人： Theodor Wilks , Eric Wing-Tak Wong , Matthew R. Ulrich
IPC分类号： C07C209/84 , B01J19/24
CPC分类号： C07C209/84 , B01J19/24 , B01J2219/24 , C07C209/36 , C07C211/46
摘要： Methods and systems for purifying a crude aniline. The method can include contacting a crude aniline that can include aniline, water, and cyclohexanone with a cation exchange resin to produce a cyclohexanone-lean product that contains less cyclohexanone than the crude aniline. The cation exchange resin can be a solid, a semi-solid, or a combination thereof.
摘要翻译：用于纯化粗苯胺的方法和系统。该方法可以包括使可以包括苯胺，水和环己酮的粗苯胺与阳离子交换树脂接触以产生比粗苯胺含有较少环己酮的环己酮贫产品。阳离子交换树脂可以是固体，半固体或其组合。

9. 发明申请

US20150251153A1 HIGH SHEAR ROTARY FIXED BED REACTOR 审中-公开
标题翻译：高剪切旋转固定床反应器
公开(公告)号：US20150251153A1
公开(公告)日：2015-09-10
申请号：US14718579
申请日：2015-05-21
申请人： H R D Corporation
发明人： Abbas HASSAN , Rayford G. ANTHONY , Gregory BORSINGER , Aziz HASSAN , Ebrahim BAGHERZADEH
IPC分类号： B01J19/18 , B01J19/00
CPC分类号： B01J19/1806 , B01F7/00766 , B01F7/00791 , B01F13/1013 , B01F13/1016 , B01J8/20 , B01J8/22 , B01J10/007 , B01J14/005 , B01J19/008 , B01J2219/00105 , B01J2219/1941 , C07C29/04 , C07C29/106 , C07C45/34 , C07C45/39 , C07C51/265 , C07C67/08 , C07C209/36 , C07C2601/16 , C12C11/02 , C07C31/22 , C07C31/225 , C07C35/14 , C07C31/202 , C07C31/207 , C07C31/205 , C07C47/06 , C07C49/04 , C07C49/08 , C07C63/06 , C07C69/003 , C07C211/46 , C07C211/50 , C07C69/14
摘要： A reactor comprising at least one contact surface made from, coated with, or impregnated by a catalyst, wherein the contact surface comprises a sintered metal or a ceramic, and wherein the reactor is configured to subject a reactant stream to shear. A system for carrying out a heterogeneously catalyzed reaction, the system comprising a reactor as described above and a pump configured for delivering reactants to the at least one reactor. A method for carrying out a heterogeneously-catalyzed reaction by introducing reactants into a reactor comprising at least one contact surface made from, coated with, or impregnated by a catalyst under conditions which promote production of a desired product, wherein the contact surface comprises a sintered metal or a ceramic, and forming a dispersion of reactants within the reactor, wherein the dispersion comprises droplets or gas bubbles of reactant with an average diameter of less than about 5 μm.
摘要翻译：一种反应器，包括由催化剂制成，涂覆或浸渍的至少一个接触表面，其中所述接触表面包括烧结金属或陶瓷，并且其中所述反应器构造成使反应物流受到剪切。一种用于进行非均相催化反应的系统，该系统包括如上所述的反应器和构造成用于将反应物输送到至少一个反应器的泵。一种通过将反应物引入反应器中进行非均相催化反应的方法，所述反应器包括在促进所需产物生产的条件下由催化剂制备，涂覆或浸渍的至少一个接触表面，其中所述接触表面包括烧结金属或陶瓷，并且在反应器内形成反应物的分散体，其中分散体包含平均直径小于约5μm的反应物的液滴或气泡。

10. 发明授权

US09120036B2 Process for preparing an aromatic amine and apparatus therefor 有权
标题翻译：芳香胺的制备方法及其设备
公开(公告)号：US09120036B2
公开(公告)日：2015-09-01
申请号：US14276362
申请日：2014-05-13
申请人： BASF SE
发明人： Tilmann Steinmetz , Michael Nilles , Lucia Koenigsmann , Andreas Heussler , Nikolaus Zafred
IPC分类号： B01D11/04 , C07C209/86 , C07C209/00
CPC分类号： B01D11/043 , B01D3/141 , B01D3/40 , C07C209/86 , C07C211/46
摘要： The invention relates to a process for obtaining at least one aromatic amine from a liquid mixture comprising water and the at least one aromatic amine by extracting with at least one nitroaromatic in an extraction column (1) to form an essentially water-comprising raffinate stream and an extract stream comprising the at least one nitroaromatic and the aromatic amine. The extraction column (1) is divided by a dividing wall (3) into two regions (5, 7), and, in the case of an amount of liquid for separation which is less than a minimum cross sectional loading of the entire extraction column (1), the liquid mixture to be separated is fed only to one of the regions (5, 7) of the extraction column (1) divided by the dividing wall (3). The invention further relates to a process for preparing an aromatic amine and to an apparatus for separating a liquid mixture comprising water and at least one aromatic amine by extracting with at least one nitroaromatic, comprising an extraction column (1).
摘要翻译：本发明涉及一种从包含水和至少一种芳族胺的液体混合物中通过在提取塔（1）中用至少一种硝基芳族化合物萃取以形成基本上含水的萃余液流而获得至少一种芳族胺的方法，包含至少一种硝基芳族和芳族胺的提取物流。萃取塔（1）由分隔壁（3）分成两个区域（5,7），并且在分离液体的量小于整个萃取塔的最小横截面负荷的情况下（1）中，待分离的液体混合物仅被供给到由分隔壁（3）分隔的萃取塔（1）的区域（5,7）中的一个。本发明还涉及一种制备芳族胺的方法，以及用于通过用至少一种包含萃取塔（1）的硝基芳族化合物萃取来分离包含水和至少一种芳族胺的液体混合物的装置。

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