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1. 发明申请

US20180303091A1 SINGLE PHASE LIQUIDS OF ALKANOLAMINE SALTS OF DICAMBA 审中-公开
公开(公告)号：US20180303091A1
公开(公告)日：2018-10-25
申请号：US15957013
申请日：2018-04-19
申请人： Taminco BVBA
发明人： Jim Van Durme , Michael Schmidt , Karen Mollet , Kristof Moonen , Peter Roose
IPC分类号： A01N37/40 , A01N25/02 , C07C213/08 , C07C215/08 , C07C217/08 , C07C215/10 , C07C65/21 , C07C51/41 , C07F9/38 , A01N57/20 , C07C59/70 , A01N39/04 , C07C209/68 , C07C211/11 , C07C255/30 , C07C253/30
CPC分类号： A01N37/40 , A01N25/02 , A01N39/04 , A01N57/20 , C07C51/412 , C07C59/70 , C07C65/21 , C07C209/68 , C07C211/11 , C07C213/08 , C07C215/08 , C07C215/10 , C07C217/08 , C07C253/30 , C07C255/30 , C07F9/3808 , C07F9/3813
摘要： The invention is a herbicidal composition containing an alkanolamine salt of an dicamba capable of remaining as a single phase liquid over a period of at least 1 week and containing low amounts of water and high loadings of the salt. Such herbicidal compositions are capable of remaining liquid in the absence of high amounts of water, thereby enhancing their capacity to remain liquid over an extended period of time when exposed to environmental conditions to improve their effectiveness to transport the active salt through a leafy substrate and can reduce transportation costs by increasing the salt loading without compromising the stability of the composition.

2. 发明申请

US20180243300A1 FUNGICIDAL AGENT 审中-公开
公开(公告)号：US20180243300A1
公开(公告)日：2018-08-30
申请号：US15868719
申请日：2018-01-11
申请人： Viktor Veniaminovich Tets , Georgy Viktorovich Tets
发明人： Viktor Veniaminovich Tets , Georgy Viktorovich Tets , Viktor Iosifovich Krutikov
IPC分类号： A61K31/513 , C07C215/10 , C07D239/545 , A01N33/08 , A61K31/133 , A01N43/54
CPC分类号： A61K31/513 , A01N33/08 , A01N43/54 , A61K31/133 , C07C215/10 , C07D239/10 , C07D239/545 , A01N25/12
摘要： The invention relates to a novel fungicidal agent in the form of a salt associate having the structural formula shown. The agent can be used for treating diseases caused by fungi, and also for preventing fungal damage to various materials and agricultural products. The present fungicidal agent is an associate of 5-[3,5-dichloro-2-hydroxy benzylidene)amino]-4-hydroxy-1H-pyrimidine-2-on with 1,2,3,4,5-pentahydroxy-6-methylaminohexane and has the formula (I). This fungicidal agent exhibits a broad range of activity and high solubility, which increases the effectiveness of the use thereof in the form of solutions. Compounds were obtained in a crystalline form, and the structure thereof was established by means of magnetic resonance spectra in dimethyl sulfoxide.

3. 发明申请

US20180116939A1 PHYTOSPINGOSINE DERIVATIVE AND COMPOSITION CONTAINING SAME 审中-公开
公开(公告)号：US20180116939A1
公开(公告)日：2018-05-03
申请号：US15560879
申请日：2016-03-14
申请人： AMOREPACIFIC CORPORATION
发明人： Jae Won YOU , Tae Hun PARK , Yong-Jin KIM , Jon Hwan LEE
IPC分类号： A61K8/68 , A61K8/60 , A61Q19/00 , A61K31/133 , A61P17/10 , A61P31/04 , C07H15/04 , C07C215/10
CPC分类号： A61K8/68 , A61K8/60 , A61K31/133 , A61P17/10 , A61P31/04 , A61Q19/00 , C07C215/10 , C07H15/04 , C07H15/12
摘要： The present invention relates to a phytospingosine derivative generated by a condensation reaction of phytospingosine and maltose or lactose, which is an aldose-based disaccharide, and to a composition containing the same. The phytospingosine derivative of the present invention has high solubility in water compared with phytospingosine, is easy to formulate since the stabilization problem in a solution is solved, and maintains or further enhances the antibacterial effect of phytospingosine.

4. 发明申请

US20180037847A1 AMINOALCOHOL SALTS OF ALKYLBENZENE SULFONIC ACIDS AND THEIR USE IN DETERGENT FORMULATIONS 审中-公开
公开(公告)号：US20180037847A1
公开(公告)日：2018-02-08
申请号：US15548426
申请日：2016-03-17
申请人： Dow Global Technologies LLC
发明人： Vikram Prasad
IPC分类号： C11D1/22 , C07C215/08 , C07C309/31 , C07C215/10 , C11D17/04 , C11D3/30
CPC分类号： C11D1/22 , C07C215/08 , C07C215/10 , C07C309/31 , C11D3/30 , C11D10/04 , C11D17/042
摘要： Provided are amine-neutralized anionic surfactants and their use in detergent formulations. The amine-neutralized an ionic surfactants are of the formula I, as described herein.

5. 发明申请

US20170320823A1 SYNERGISTIC COMPOSITIONS 有权
公开(公告)号：US20170320823A1
公开(公告)日：2017-11-09
申请号：US15594795
申请日：2017-05-15
申请人： Cadila Healthcare Limited
发明人： Mukul R. Jain , Suresh Giri , Himanshu M. Kothari , Kaushik Banerjee , Rashmikant Kachhiya
IPC分类号： C07D207/333 , C07D233/58 , A61K31/155 , C07C279/14 , C07C229/26 , C07C217/60 , C07C215/40 , C07C215/12 , C07C215/10 , C07C211/51 , C07C211/35 , C07C211/30 , C07C211/27 , C07C211/11 , A61K45/06 , A61K38/26 , A61K31/64 , A61K31/505 , A61K31/4985 , A61K31/4015 , A61K31/40 , C07D295/027 , C07C2601/14
CPC分类号： C07D207/333 , A61K31/155 , A61K31/40 , A61K31/4015 , A61K31/4985 , A61K31/505 , A61K31/64 , A61K38/26 , A61K45/06 , A61K2300/00 , C07C211/11 , C07C211/27 , C07C211/30 , C07C211/35 , C07C211/51 , C07C215/10 , C07C215/12 , C07C215/40 , C07C217/60 , C07C229/26 , C07C279/14 , C07C2601/14 , C07D233/58 , C07D295/027
摘要： The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or more biguanide antihyperglycaemic agent and a PPAR agonist of formula (1a) for the treatment of diabetes, especially non-insulin dependent diabetes or Type 2 diabetes and conditions associated with diabetes mellitus and to compositions suitable for use in such method. The invention also describes the preparation of such compositions. The present invention also relates to certain novel salts of the PPAR agonist of formula (I), processes for the preparation of: these novel salts and use thereof.

6. 发明申请

US20170233386A1 Compounds Which Have a Protective Activity with Respect to the Action of Toxins and of Viruses with an Intracellular Mode of Action 审中-公开
公开(公告)号：US20170233386A1
公开(公告)日：2017-08-17
申请号：US15494798
申请日：2017-04-24
申请人： Commissariat a l'Energie Atomique et aux Energies Alternatives
发明人： Roman Lopez , Séverine Hebbe , Daniel Gillet , Julien Barbier
IPC分类号： C07D453/02 , C07C211/38 , C07C217/58 , C07C233/58 , C07C317/14 , C07D215/12 , C07D209/14 , C07D451/02 , C07C229/14 , C07C271/56 , C07C251/24 , C07D317/46 , C07D213/38 , C07D233/64 , C07C275/28 , C07C335/02 , C07D243/12 , C07D243/24 , C07D333/20 , C07D307/52
CPC分类号： C07D453/02 , A61K31/167 , A61K31/341 , A61K31/5513 , C07C211/27 , C07C211/38 , C07C215/10 , C07C215/42 , C07C215/44 , C07C217/16 , C07C217/58 , C07C229/14 , C07C229/22 , C07C229/38 , C07C229/48 , C07C233/06 , C07C233/58 , C07C233/65 , C07C237/40 , C07C251/24 , C07C271/56 , C07C275/28 , C07C317/14 , C07C335/02 , C07C2601/08 , C07C2602/46 , C07C2603/74 , C07D209/14 , C07D213/38 , C07D215/12 , C07D233/10 , C07D233/58 , C07D233/61 , C07D233/64 , C07D235/08 , C07D243/12 , C07D243/24 , C07D245/06 , C07D249/06 , C07D307/42 , C07D307/52 , C07D317/46 , C07D317/58 , C07D317/62 , C07D317/66 , C07D333/20 , C07D401/04 , C07D451/02 , C07D471/08 , C07D487/04 , Y02A50/471 , Y02A50/473
摘要： The subject matter of the present invention is novel families of compounds which are aromatic amine, imine, aminoadamantane and benzodiazepine derivatives, medicaments comprising same and the use thereof as inhibitors of the toxic effects of toxins with intracellular activity, such as, for example, ricin, and of viruses that use the internalization pathway for infecting cells.

7. 发明申请

US20170022145A1 MINIMIZING WATER CONTENT IN ETHANOLAMINE PRODUCT STREAMS 审中-公开
标题翻译：最小化乙醇胺产品流中的水含量
公开(公告)号：US20170022145A1
公开(公告)日：2017-01-26
申请号：US15302600
申请日：2015-04-06
申请人： SABIC GLOBAL TECHNOLOGIES B.V.
发明人： Naeem Al-Hazmi
IPC分类号： C07C213/04 , B01D3/14 , B01D3/32 , C07C213/10
CPC分类号： C07C213/04 , B01D3/143 , B01D3/322 , C07C213/10 , Y02P20/127 , C07C215/08 , C07C215/10
摘要： Systems and method are provided for reducing the water content in ethanolamine product streams from approximately 0.15%-0.19% by weight of water to approximately 0.02 to approximately 0.04 by weight of water. The reduced water content can be achieved by increasing the processing conditions at the monoethanolamine column by approximately 5% to approximately 20%, more preferably to approximately 10%, and by adding a dummy stream to the monoethanolamine column, which can be recycled to the reactor. The increased processing conditions and dummy stream at the monoethanolamine column can result in the following to achieve said water content: (i) the bottom stream flow rate increase by up to approximately 18.9%; the reboiler duty can be increased by up to 47.9%; and (iii) the condenser duty can be increased by up to approximately 52.5%.
摘要翻译：提供的系统和方法用于将乙醇胺产物流中的水含量从约0.15％-0.19％（重量）的水减少至约0.02至约0.04重量％的水。降低的水含量可以通过将单乙醇胺柱的加工条件增加约5％至约20％，更优选至约10％，并通过向单乙醇胺塔中加入虚拟物流来实现，其可循环至反应器。在单乙醇胺塔处加工条件和虚拟物流的增加可能导致以下因素达到所述含水量：（i）底部流量增加高达约18.9％; 再沸器的使用税可以增加47.9％。和（iii）冷凝器功能可以增加高达约52.5％。

8. 发明申请

US20160214954A1 ALPHA-TEA SALT FORMS: COMPOSITIONS AND USES FOR TREATING DISEASE 审中-公开
标题翻译： ALPHA-TEA盐形式：用于治疗疾病的组合物和用途
公开(公告)号：US20160214954A1
公开(公告)日：2016-07-28
申请号：US14916271
申请日：2014-09-05
申请人： RESEARCH DEVELOPMENT FOUNDATION
发明人： Michael O'NEILL , Barbara KIDON , Thomas ADKINS , Hongqiao WU , Emmanuel T. AKPORIAYE
IPC分类号： C07D311/72 , C07C229/26 , C07C215/10 , A61K35/17 , A61K31/355 , A61K45/06 , C07K16/32 , A61K39/395 , C07C279/14 , C07C215/08
CPC分类号： C07D311/72 , A61K31/355 , A61K35/17 , A61K39/39558 , A61K45/06 , C07C215/08 , C07C215/10 , C07C229/26 , C07C279/14 , C07K16/32 , C07K2317/24
摘要： The present disclosure relates to salts of the compound (I), polymorphic forms thereof, methods for preparation and use thereof, and pharmaceutical compositions thereof.
摘要翻译：本公开涉及化合物（I）的盐，其多晶型物，其制备方法和用途及其药物组合物。

9. 发明授权

US09340488B2 Synthetic analogs of sphingolipids 有权
公开(公告)号：US09340488B2
公开(公告)日：2016-05-17
申请号：US14540621
申请日：2014-11-13
申请人： HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
发明人： Arie Dagan , Shimon Slavin , Shimon Gatt , Jeremy Zahavy
IPC分类号： A61K31/133 , C07C215/12 , C07C215/10 , A61K31/4745 , A61K31/513
CPC分类号： C07C215/12 , A61K31/133 , A61K31/4745 , A61K31/513 , C07C215/10 , Y02A50/409 , Y02A50/411
摘要： The present invention provides new ceramide analogs indicated as the compounds of formula (II). These novel analogs exhibit a significant anti cancerous effect and are therefore provided as a pharmaceutical composition for treating cell proliferative diseases, neurodegenerative disorders, metabolism-associated conditions, infectious diseases, and immune-related disorders. The invention further provides combined compositions and kits combining the novel ceramide analogs of formula (II) with an additional therapeutic agent.

10. 发明申请

US20160083355A1 COMPOUNDS WHICH HAVE A PROTECTIVE ACTIVITY WITH RESPECT TO THE ACTION OF TOXINS AND OF VIRUSES WITH AN INTRACELLULAR MODE OF ACTION 审中-公开
标题翻译：具有针对动作模式的毒素和病毒的保护活性的化合物
公开(公告)号：US20160083355A1
公开(公告)日：2016-03-24
申请号：US14810342
申请日：2015-07-27
申请人： Commissariat A L'Energie Atomique Et Aux Energies Alternatives
发明人： Roman Lopez , Severine Hebbe , Daniel Gillet , Julien Barbier
IPC分类号： C07D245/06
CPC分类号： C07D453/02 , A61K31/167 , A61K31/341 , A61K31/5513 , C07C211/27 , C07C211/38 , C07C215/10 , C07C215/42 , C07C215/44 , C07C217/16 , C07C217/58 , C07C229/14 , C07C229/22 , C07C229/38 , C07C229/48 , C07C233/06 , C07C233/58 , C07C233/65 , C07C237/40 , C07C251/24 , C07C271/56 , C07C275/28 , C07C317/14 , C07C335/02 , C07C2601/08 , C07C2602/46 , C07C2603/74 , C07D209/14 , C07D213/38 , C07D215/12 , C07D233/10 , C07D233/58 , C07D233/61 , C07D233/64 , C07D235/08 , C07D243/12 , C07D243/24 , C07D245/06 , C07D249/06 , C07D307/42 , C07D307/52 , C07D317/46 , C07D317/58 , C07D317/62 , C07D317/66 , C07D333/20 , C07D401/04 , C07D451/02 , C07D471/08 , C07D487/04 , Y02A50/471 , Y02A50/473
摘要： The subject matter of the present invention is novel families of compounds which are aromatic amine, imine, aminoadamantane and benzodiazepine derivatives, medicaments comprising same and the use thereof as inhibitors of the toxic effects of toxins with intracellular activity, such as, for example, ricin, and of viruses that use the internalization pathway for infecting cells.
摘要翻译：本发明的主题是芳族胺，亚胺，氨基金刚烷和苯并二氮杂衍生物的化合物的新型家族，包含其的药物及其作为具有细胞内活性的毒素的毒性作用的抑制剂的用途，例如蓖麻毒素以及使用内源化途径感染细胞的病毒。

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