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1. 发明授权

US10040754B2 Cellulose acylate film, novel compound, polarizing plate and liquid crystal display device 有权
公开(公告)号：US10040754B2
公开(公告)日：2018-08-07
申请号：US14835165
申请日：2015-08-25
申请人： FUJIFILM Corporation
发明人： Hiroshi Inada , Naozumi Shiraiwa , Yingjie Xu , Aiko Yoshida , Masaki Noro , Yasukazu Kuwayama , Nobutaka Fukagawa
IPC分类号： C07C271/20 , C07C271/06 , C07C271/28 , C07C271/36 , C07C271/56 , C07D295/20 , C08J5/18 , C08K5/16 , G02B1/14 , G02B5/30
CPC分类号： C07C271/20 , B32B2457/202 , C07C271/06 , C07C271/28 , C07C271/36 , C07C271/56 , C07D295/20 , C08J5/18 , C08J2301/10 , C08J2301/12 , C08K5/16 , C08K5/205 , G02B1/14 , G02B5/30 , Y10T428/1041 , Y10T428/31971 , C08L1/10
摘要： A cellulose acylate film, which includes a compound denoted by general formula (I) below, the equivalent U of which, calculated as a value obtained by dividing the molecular weight of the compound by the number of divalent linking groups denoted by —O—C(═O)—NH— contained per molecule, is less than or equal to 515, wherein, in general formula (I), each of L11 and L21 independently denotes an optionally substituted alkylene group; each of L12 and L22 independently denotes a single bond, any one of or any combination of —O—, —NR1—, —S— and —C(═O)—; R1 denotes a hydrogen atom or a substituent; each of n1 and n2 independently denotes an integer of 0 to 20, with at least either n1 or n2 being an integer of greater than or equal to 1. Q1-(L12-L11)n1-O—C(═O)—NH-(L21-L22)n2-Q2 General formula (I)

2. 发明申请

US20170349691A1 COMPOSITION FOR MAGNETIC RECORDING MEDIUM AND MAGNETIC RECORDING MEDIUM 审中-公开
公开(公告)号：US20170349691A1
公开(公告)日：2017-12-07
申请号：US15685202
申请日：2017-08-24
申请人： FUJIFILM Corporation
发明人： Toshihide AOSHIMA , Kazutoshi KATAYAMA
IPC分类号： C08G18/32 , C08G18/75 , C08G18/72 , C08G18/76 , G11B5/702 , C08G18/80
CPC分类号： C08G18/3215 , C07C271/40 , C07C271/42 , C07C271/56 , C07C271/58 , C08G18/724 , C08G18/755 , C08G18/757 , C08G18/7621 , C08G18/7642 , C08G18/8016 , C08G18/8019 , C08G18/8025 , C08G18/8029 , G11B5/7021
摘要： An aspect of the present invention relates to a composition, which is a composition for a magnetic recording medium and comprises an isocyanate compound in the form of an adduct of a polyhydroxyl compound having one or more aromatic carbon rings and three or more hydroxyl groups per molecule with a polyisocyanate having two or more isocyanate groups per molecule.

3. 发明授权

US09249090B2 N-substituted carbamic acid ester production method and isocyanate production method using the N-substituted carbamic acid ester 有权
标题翻译： N-取代氨基甲酸酯的制造方法和使用N-取代氨基甲酸酯的异氰酸酯制造方法
公开(公告)号：US09249090B2
公开(公告)日：2016-02-02
申请号：US14490027
申请日：2014-09-18
申请人： Asahi Kasei Chemicals Corporation
发明人： Nobuhisa Miyake , Masaaki Shinohata , Atsushi Okubo
IPC分类号： C07C261/00 , C07C275/40 , C07C263/04 , C07C269/00 , C07C269/04 , C07C271/54 , C07C271/56 , C07C271/58
CPC分类号： C07C275/40 , C07C263/04 , C07C269/00 , C07C269/04 , C07C271/54 , C07C271/56 , C07C271/58 , C07C2601/14 , C07C265/14 , C07C271/52
摘要： The present invention provides a method for producing N-substituted carbamic acid-O-aryl ester derived from a compound having an ureido group, the method comprising the step of carrying out esterification or esterification and transesterification from the compound having the ureido group and a hydroxy composition containing one type or a plurality of types of hydroxy compounds.
摘要翻译：本发明提供一种由具有脲基的化合物衍生的N-取代氨基甲酸-O-芳基酯的方法，该方法包括从具有脲基的化合物和羟基进行酯化或酯化和酯交换的步骤含有一种或多种类型的羟基化合物的组合物。

4. 发明授权

US09187413B2 Peripherally restricted FAAH inhibitors 有权
标题翻译：外周限制的FAAH抑制剂
公开(公告)号：US09187413B2
公开(公告)日：2015-11-17
申请号：US13812777
申请日：2011-07-22
申请人： Daniele Piomelli , Jason R. Clapper , Guillermo Moreno-Sanz , Andrea Duranti , Giovanna Guiducci , Marco Mor , Giorgio Tarzia
发明人： Daniele Piomelli , Jason R. Clapper , Guillermo Moreno-Sanz , Andrea Duranti , Andrea Tontini , Marco Mor , Giorgio Tarzia
IPC分类号： C07C233/00 , A61K31/265 , A61K31/16 , A61K31/165 , C07C271/56
CPC分类号： C07C271/56 , C07C2601/14
摘要： Peripherally restricted inhibitors of fatty acid amide hydrolase (FAAH) are provided. The compounds can suppress FAAH activity and increases anandamide levels outside the central nervous system (CNS). Despite their relative inability to access brain and spinal cord, the compounds attenuate behavioral responses indicative of persistent pain in rodent models of inflammation and peripheral nerve injury, and suppresses noxious stimulus-evoked neuronal activation in spinal cord regions implicated in nociceptive processing. CBi receptor blockade prevents these effects. Accordingly, the invention also provides methods, and pharmaceutical compositions for treating conditions in which the inhibition of peripheral FAAH would be of benefit. The compounds of the invention are according to the formula (I): in which R1 is a polar group. In some embodiments, R1 is selected from the group consisting of hydroxy and the physiologically hydro lysable esters thereof. R2 and R3 are independently selected from the group consisting of hydrogen and substituted or unsubstituted hydrocarbyl; each R4 is independently selected from the group consisting of halogen and substituted or unsubstituted hydrocarbyl and n is an integer from 0 to 4; each R5 is independently selected from the group consisting of halo and substituted or unsubstituted hydrocarbyl and m is an integer from 0 to 3; and R6 is substituted or unsubstituted cyclohexyl; and the pharmaceutically acceptable salts thereof.
摘要翻译：提供脂肪酸酰胺水解酶（FAAH）的外周限制性抑制剂。该化合物可以抑制FAAH活性，并增加中枢神经系统（CNS）外的氨基酰胺水平。尽管它们相对不能进入脑和脊髓，但化合物减弱了指示炎症和周围神经损伤的啮齿动物模型中的持续疼痛的行为反应，并且抑制了与伤害性处理相关的脊髓区域中的有害刺激诱发的神经元激活。 CBi受体阻断防止这些影响。因此，本发明还提供了用于治疗其中外周FAAH的抑制将是有益的病症的方法和药物组合物。本发明的化合物根据式（I）：其中R1是极性基团。在一些实施方案中，R 1选自羟基及其生理上可水解的酯。 R2和R3独立地选自氢和取代或未取代的烃基; 每个R 4独立地选自卤素和取代或未取代的烃基，n是0至4的整数; 每个R 5独立地选自卤素和取代或未取代的烃基，m是0-3的整数; 并且R 6是取代或未取代的环己基; 及其药学上可接受的盐。

5. 发明授权

US09145358B2 N-substituted carbamic acid ester production method, isocyanate production method using such N-substituted carbamic acid ester, and composition for transfer and storage of N-substituted carbamic acid ester comprising N-substituted carbamic acid ester and aromatic hydroxy compound 有权
公开(公告)号：US09145358B2
公开(公告)日：2015-09-29
申请号：US14151213
申请日：2014-01-09
申请人： Asahi Kasei Chemicals Corporation
发明人： Masaaki Shinohata , Nobuhisa Miyake
IPC分类号： C07C271/06 , C07C275/40 , C07C263/04 , C07C269/00 , C07C269/04 , C07C271/54 , C07C271/56 , C07C271/58
CPC分类号： C07C275/40 , C07C263/04 , C07C269/00 , C07C269/04 , C07C271/54 , C07C271/56 , C07C271/58 , C07C2601/14 , C07C265/14 , C07C271/52
摘要： The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (—C(═O)—) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.

6. 发明授权

US09145357B2 N-substituted carbamic acid ester production method, isocyanate production method using such N-substituted carbamic acid ester, and composition for transfer and storage of N-substituted carbamic acid ester comprising N-substituted carbamic acid ester and aromatic hydroxy compound 有权
标题翻译： N-取代氨基甲酸酯的制造方法，使用这种N-取代氨基甲酸酯的异氰酸酯的制造方法以及N-取代氨基甲酸酯和芳香族羟基化合物的N-取代氨基甲酸酯的转移和储存组合物
公开(公告)号：US09145357B2
公开(公告)日：2015-09-29
申请号：US14151178
申请日：2014-01-09
申请人： Asahi Kasei Chemicals Corporation
发明人： Masaaki Shinohata , Nobuhisa Miyake
IPC分类号： C07C263/00 , C07C263/04 , C07C275/40 , C07C269/00 , C07C269/04 , C07C271/54 , C07C271/56 , C07C271/58
CPC分类号： C07C275/40 , C07C263/04 , C07C269/00 , C07C269/04 , C07C271/54 , C07C271/56 , C07C271/58 , C07C2601/14 , C07C265/14 , C07C271/52
摘要： The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (—C(═O)—) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.
摘要翻译：本发明是从有机胺，碳酸衍生物和含有一种以上羟基化合物的羟基组合物生产由有机胺衍生的N-取代氨基甲酸酯的方法，其中有机胺，碳酸衍生物和羟基组合物使用设置有冷凝器，含有羟基组合物的气体，具有衍生自碳酸衍生物的羰基的化合物和在反应中作为副产物形成的氨的氨基甲酸酯制备反应容器进行反应被引入聚氨酯生产反应容器中的冷凝器中，羟基组合物和衍生自碳酸衍生物的具有羰基的化合物被缩合，其中在缩合羟基组合物中包含的羟基化合物的化学计量比与具有衍生自碳酸衍生物的羰基的缩合化合物为1以上，由碳酸衍生物衍生的具有羰基的化合物中所含的羰基数（-C（= O） - ））与作为气体回收的氨中氨分子数的比例冷凝器为1或更小。

7. 发明申请

US20150064500A1 COMPOSITION FOR MAGNETIC RECORDING MEDIUM AND MAGNETIC RECORDING MEDIUM 审中-公开
标题翻译：磁记录介质和磁记录介质的组成
公开(公告)号：US20150064500A1
公开(公告)日：2015-03-05
申请号：US14472663
申请日：2014-08-29
申请人： FUJIFILM Corporation
发明人： Toshihide AOSHIMA , Kazutoshi KATAYAMA
IPC分类号： G11B5/702 , C08G18/76 , C08G18/32 , C08G18/75
CPC分类号： C08G18/3215 , C07C271/40 , C07C271/42 , C07C271/56 , C07C271/58 , C08G18/724 , C08G18/755 , C08G18/757 , C08G18/7621 , C08G18/7642 , C08G18/8016 , C08G18/8019 , C08G18/8025 , C08G18/8029 , G11B5/7021
摘要： An aspect of the present invention relates to a composition, which is a composition for a magnetic recording medium and comprises an isocyanate compound in the form of an adduct of a polyhydroxyl compound having one or more aromatic carbon rings and three or more hydroxyl groups per molecule with a polyisocyanate having two or more isocyanate groups per molecule.
摘要翻译：本发明的一个方面涉及一种组合物，其是用于磁记录介质的组合物，并且包含每分子具有一个或多个芳族碳环和三个或更多个羟基的多羟基化合物的加合物形式的异氰酸酯化合物与每个分子具有两个或更多个异氰酸酯基团的多异氰酸酯。

8. 发明授权

US08884047B2 N-substituted carbamic acid ester production method and isocyanate production method using the N-substituted carbamic acid ester 有权
标题翻译： N-取代氨基甲酸酯的制造方法和使用N-取代氨基甲酸酯的异氰酸酯制造方法
公开(公告)号：US08884047B2
公开(公告)日：2014-11-11
申请号：US13001238
申请日：2009-09-29
申请人： Nobuhisa Miyake , Masaaki Shinohata , Atsushi Okubo
发明人： Nobuhisa Miyake , Masaaki Shinohata , Atsushi Okubo
IPC分类号： C07C261/00 , C07C269/00 , C07C271/00 , C07C269/04 , C07C263/04
CPC分类号： C07C275/40 , C07C263/04 , C07C269/00 , C07C269/04 , C07C271/54 , C07C271/56 , C07C271/58 , C07C2601/14 , C07C265/14 , C07C271/52
摘要： The present invention provides a method for producing N-substituted carbamic acid-O-aryl ester derived from a compound having an ureido group, the method comprising the step of carrying out esterification or esterification and transesterification from the compound having the ureido group and a hydroxy composition containing one type or a plurality of types of hydroxy compounds.
摘要翻译：本发明提供一种由具有脲基的化合物衍生的N-取代氨基甲酸-O-芳基酯的方法，该方法包括从具有脲基的化合物和羟基进行酯化或酯化和酯交换的步骤含有一种或多种类型的羟基化合物的组合物。

9. 发明授权

US08609732B2 Inhibitors of the Shiga toxins trafficking through the retrograde pathway 失效
标题翻译：滋贺毒素抑制剂通过逆行途径传播
公开(公告)号：US08609732B2
公开(公告)日：2013-12-17
申请号：US12999749
申请日：2009-06-17
申请人： Daniel Gillet , Julien Barbier , Ludger Johannes , Bahne Stechmann , Siau-Kun Bai
发明人： Daniel Gillet , Julien Barbier , Ludger Johannes , Bahne Stechmann , Siau-Kun Bai
IPC分类号： A61K31/65
CPC分类号： C07D453/02 , A61K31/167 , A61K31/341 , A61K31/5513 , C07C211/27 , C07C211/38 , C07C215/10 , C07C215/42 , C07C215/44 , C07C217/16 , C07C217/58 , C07C229/14 , C07C229/22 , C07C229/38 , C07C229/48 , C07C233/06 , C07C233/58 , C07C233/65 , C07C237/40 , C07C251/24 , C07C271/56 , C07C275/28 , C07C317/14 , C07C335/02 , C07C2601/08 , C07C2602/46 , C07C2603/74 , C07D209/14 , C07D213/38 , C07D215/12 , C07D233/10 , C07D233/58 , C07D233/61 , C07D233/64 , C07D235/08 , C07D243/12 , C07D243/24 , C07D245/06 , C07D249/06 , C07D307/42 , C07D307/52 , C07D317/46 , C07D317/58 , C07D317/62 , C07D317/66 , C07D333/20 , C07D401/04 , C07D451/02 , C07D471/08 , C07D487/04 , Y02A50/471 , Y02A50/473
摘要： The present invention relates to the use of compounds of general formula (I) and (II) for the preparation of a drug for preventing and/or treating disorders caused by Shiga toxins and related toxins.
摘要翻译：本发明涉及通式（I）和（II）的化合物在制备用于预防和/或治疗志贺毒素和相关毒素引起的疾病的药物中的应用。

10. 发明申请

US20130217764A1 PERIPHERALLY RESTRICTED FAAH INHIBITORS 有权
标题翻译：外用限制性FAAH抑制剂
公开(公告)号：US20130217764A1
公开(公告)日：2013-08-22
申请号：US13812777
申请日：2011-07-22
申请人： Daniele Piomelli , Jason R. Clapper , Guillermo Moreno-Sanz , Andrea Duranti , Andrea Tontini , Marco Mor , Giorgio Tarzia , Todd A. Ostomel
发明人： Daniele Piomelli , Jason R. Clapper , Guillermo Moreno-Sanz , Andrea Duranti , Andrea Tontini , Marco Mor , Giorgio Tarzia , Todd A. Ostomel
IPC分类号： C07C271/56
CPC分类号： C07C271/56 , C07C2601/14
摘要： Peripherally restricted inhibitors of fatty acid amide hydrolase (FAAH) are provided. The compounds can suppress FAAH activity and increases anandamide levels outside the central nervous system (CNS). Despite their relative inability to access brain and spinal cord, the compounds attenuate behavioral responses indicative of persistent pain in rodent models of inflammation and peripheral nerve injury, and suppresses noxious stimulus-evoked neuronal activation in spinal cord regions implicated in nociceptive processing. CBi receptor blockade prevents these effects. Accordingly, the invention also provides methods, and pharmaceutical compositions for treating conditions in which the inhibition of peripheral FAAH would be of benefit. The compounds of the invention are according to the formula (I): in which R1 is a polar group. In some embodiments, R1 is selected from the group consisting of hydroxy and the physiologically hydro lysable esters thereof. R2 and R3 are independently selected from the group consisting of hydrogen and substituted or unsubstituted hydrocarbyl; each R4 is independently selected from the group consisting of halogen and substituted or unsubstituted hydrocarbyl and n is an integer from 0 to 4; each R5 is independently selected from the group consisting of halo and substituted or unsubstituted hydrocarbyl and m is an integer from 0 to 3; and R6 is substituted or unsubstituted cyclohexyl; and the pharmaceutically acceptable salts thereof.
摘要翻译：提供脂肪酸酰胺水解酶（FAAH）的外周限制性抑制剂。该化合物可以抑制FAAH活性，并增加中枢神经系统（CNS）外的氨基酰胺水平。尽管它们相对不能进入脑和脊髓，但化合物减弱了指示炎症和周围神经损伤的啮齿动物模型中的持续疼痛的行为反应，并且抑制了与伤害性处理相关的脊髓区域中的有害刺激诱发的神经元激活。 CBi受体阻断防止这些影响。因此，本发明还提供了用于治疗其中外周FAAH的抑制将是有益的病症的方法和药物组合物。本发明的化合物根据式（I）：其中R1是极性基团。在一些实施方案中，R 1选自羟基及其生理上可水解的酯。 R2和R3独立地选自氢和取代或未取代的烃基; 每个R 4独立地选自卤素和取代或未取代的烃基，n是0至4的整数; 每个R 5独立地选自卤素和取代或未取代的烃基，m是0-3的整数; 并且R 6是取代或未取代的环己基; 及其药学上可接受的盐。

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