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1. 发明申请

US20180230143A1 INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION 审中-公开
公开(公告)号：US20180230143A1
公开(公告)日：2018-08-16
申请号：US15837235
申请日：2017-12-11
申请人： Heinrich-Heine-Universität Düsseldorf
发明人： Alexander Metz , Holger Gohlke , Julia Schanda , Christian Wichmann , Manuel Grez
IPC分类号： C07D471/04 , C07D209/42 , C07D317/60 , C07D239/22 , C07C59/68 , C07D493/04 , C07D207/337 , C07D307/68 , G01N27/447 , C07C59/70 , G01N33/50 , C07D235/28
CPC分类号： C07D471/04 , C07C59/68 , C07C59/70 , C07D207/337 , C07D209/42 , C07D235/28 , C07D239/22 , C07D307/68 , C07D317/60 , C07D493/04 , G01N27/447 , G01N33/5011 , G01N2333/47
摘要： The invention relates to inhibitors of the NHR2 tetramerization and their use as tumor therapeutics (e.g. against acute myeloid leukemia (AML)), cytostatics, and diagnostic agents.

2. 发明申请

US20180179139A1 GPBP inhibition using Q2 peptidomimetics 审中-公开
公开(公告)号：US20180179139A1
公开(公告)日：2018-06-28
申请号：US15892317
申请日：2018-02-08
申请人： FibroStatin, S.L.
发明人： Juan Saus , Santos Fustero , Juan F. Sanz-Cervera , Enrique Pérez-Payá , Raül Blasco , Francisco Revert-Ros , Fernando Revert
IPC分类号： C07C59/52 , C07D213/58 , C07D213/55 , C07D213/48 , C07D213/34 , C07D213/26 , C07C309/65 , C07C45/68 , C07C69/734 , C07C69/732 , C07C67/313 , C07C59/70 , C07C59/64 , C07C59/56 , C07C69/738
CPC分类号： C07C59/52 , C07C45/68 , C07C47/565 , C07C59/56 , C07C59/64 , C07C59/70 , C07C67/313 , C07C69/732 , C07C69/734 , C07C69/738 , C07C309/65 , C07D213/26 , C07D213/34 , C07D213/48 , C07D213/55 , C07D213/58
摘要： Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.

3. 发明授权

US09199936B2 GPBP inhibition using Q2 peptidomimetics 有权
标题翻译：使用Q2肽模拟物的GPBP抑制
公开(公告)号：US09199936B2
公开(公告)日：2015-12-01
申请号：US14063709
申请日：2013-10-25
申请人： FibroStatin, S.L.
发明人： Juan Saus , Santos Fustero , Juan F Sanz-Cervera , Enrique Pérez-Payá , Raül Blasco , Francisco Revert-Ros , Fernando Revert
IPC分类号： C07C43/23 , C07C59/90 , C07C43/225 , C07D213/58 , C07C45/68 , C07C47/565 , C07C59/52 , C07C59/56 , C07C59/64 , C07C59/70 , C07C69/732 , C07C69/734 , C07C69/738 , C07C309/65 , C07D213/26 , C07D213/34 , C07D213/48 , C07D213/55
CPC分类号： C07C59/52 , C07C45/68 , C07C47/565 , C07C59/56 , C07C59/64 , C07C59/70 , C07C67/313 , C07C69/732 , C07C69/734 , C07C69/738 , C07C309/65 , C07D213/26 , C07D213/34 , C07D213/48 , C07D213/55 , C07D213/58
摘要： Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
摘要翻译：公开的是下式的化合物：抑制GPBP活性，使其可用作抗体介导的病症，耐药性癌症，炎症，蛋白质错误折叠和ER应激介导的病症以及异常凋亡中的治疗剂。

4. 发明授权

US09063416B2 Resist composition, method of forming resist pattern and compound 有权
标题翻译：抗蚀剂组合物，抗蚀剂图案和化合物的形成方法
公开(公告)号：US09063416B2
公开(公告)日：2015-06-23
申请号：US13706771
申请日：2012-12-06
申请人： Tokyo Ohka Kogyo Co., Ltd.
发明人： Yoshitaka Komuro , Yoshiyuki Utsumi , Akiya Kawaue , Toshiaki Hato
IPC分类号： G03F7/004 , C07C59/125 , G03F7/027 , G03F7/039 , C07D313/10 , C07D327/04 , C07D333/46 , C07D333/54 , C07D333/76 , C07D335/02 , C07D335/16 , C07C323/52 , C07C381/12 , C07D493/18 , C07D307/00 , C07D307/33 , C07C25/18 , C07C69/14 , C07C69/63 , C07C69/753 , C07C69/78 , C07C59/13 , C07C59/66 , C07C59/70 , C07C62/04 , C07D493/08
CPC分类号： G03F7/027 , C07C25/18 , C07C59/125 , C07C59/13 , C07C59/66 , C07C59/70 , C07C62/04 , C07C69/14 , C07C69/63 , C07C69/753 , C07C69/78 , C07C323/52 , C07C381/12 , C07C2601/08 , C07C2603/74 , C07D307/00 , C07D307/33 , C07D313/10 , C07D327/04 , C07D333/46 , C07D333/54 , C07D333/76 , C07D335/02 , C07D335/16 , C07D493/08 , C07D493/18 , G03F7/0045 , G03F7/0397
摘要： A resist composition comprising: a base component (A) that exhibits changed solubility in a developing solution by the action of acid; a photoreactive quencher (C); and an acid-generator component (B) that generates acid upon exposure, wherein the photoreactive quencher (C) contains a compound represented by general formula (c1) shown below. In the formula, R1 represents a hydrogen atom or a hydrocarbon group of 1 to 20 carbon atoms which may have a substituent; each of R2 and R3 independently represents a hydrogen atom or a hydrocarbon group of 1 to 20 carbon atoms which may have a substituent; at least two of R1 to R3 may be mutually bonded to form a ring; X represents an oxygen atom or a sulfur atom; n represents 0 or 1; and Z+ represents an organic cation.
摘要翻译：一种抗蚀剂组合物，其包含：通过酸作用而在显影液中显示改变的溶解度的碱成分（A）光反应猝灭剂（C）; 以及曝光时产生酸的酸发生剂成分（B），其中，所述光反应性猝灭剂（C）含有下述通式（c1）表示的化合物。在该式中，R 1表示氢原子或可以具有取代基的1〜20个碳原子的烃基; R 2和R 3各自独立地表示氢原子或可以具有取代基的1〜20个碳原子的烃基; R 1至R 3中的至少两个可以相互键合形成环; X表示氧原子或硫原子; n表示0或1; Z +表示有机阳离子。

5. 发明申请

US20050124698A1 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs 有权
标题翻译： 4 - （（苯氧基烷基）硫代） - 苯氧基乙酸和类似物
公开(公告)号：US20050124698A1
公开(公告)日：2005-06-09
申请号：US10942478
申请日：2004-09-16
申请人： Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis
发明人： Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis
IPC分类号： A61K31/192 , C07C59/68 , C07C59/70 , C07C317/22 , C07C323/20 , C07C323/22 , C07C323/60 , C07C323/62 , C07D333/16 , C07D333/28
CPC分类号： A61K31/277 , A61K31/192 , C07C59/68 , C07C59/70 , C07C317/22 , C07C323/20 , C07C323/60 , C07C323/62 , C07D333/16 , C07D333/28
摘要： The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.
摘要翻译：本发明具有4 - （（苯氧基烷基）硫基） - 苯氧基乙酸及其类似物，含有它们的组合物，以及使用它们作为PPARδ调节剂治疗或抑制例如血脂异常进展的方法。

6. 发明授权

US5739374A Processes of preparing diphenylheteroalkyl derivatives 失效
标题翻译：制备二苯基杂烷基衍生物的方法
公开(公告)号：US5739374A
公开(公告)日：1998-04-14
申请号：US800623
申请日：1997-02-14
申请人： Bernd Janssen , Hans-Heiner Wuest
发明人： Bernd Janssen , Hans-Heiner Wuest
IPC分类号： A61K8/33 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/67 , A61K31/195 , A61Q19/00 , C07C37/11 , C07C39/17 , C07C43/20 , C07C43/205 , C07C43/21 , C07C43/23 , C07C45/44 , C07C47/575 , C07C51/367 , C07C59/70 , C07C65/21 , C07C65/24 , C07C65/26 , C07C69/76 , C07C69/92 , C07C205/06 , C07C205/34 , C07C205/35 , C07C205/37 , C07C211/60 , C07C217/48 , C07C217/58 , C07C217/76 , C07C217/86 , C07C223/06 , C07C229/38 , C07C229/60 , C07C233/18 , C07C233/25 , C07C233/43 , C07C233/47 , C07C233/48 , C07C233/75 , C07C235/42 , C07C255/51 , C07C255/54 , C07C259/10 , C07C309/42 , C07C317/22 , C07C317/32 , C07C317/44 , C07C323/16 , C07C323/19 , C07C323/20 , C07C323/32 , C07C323/34 , C07C323/36 , C07C323/41 , C07C323/56 , C07C323/62 , C07C327/30 , C07D263/58 , C07D311/72 , C07F9/38 , C07F9/40 , C07C255/49 , C07C69/02
CPC分类号： A61K8/46 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/411 , A61K8/42 , A61K8/445 , A61K8/671 , A61Q19/00 , C07C205/06 , C07C205/34 , C07C205/35 , C07C205/37 , C07C211/60 , C07C217/48 , C07C217/58 , C07C217/76 , C07C217/86 , C07C223/06 , C07C229/38 , C07C229/60 , C07C233/18 , C07C233/25 , C07C233/43 , C07C233/47 , C07C233/48 , C07C233/75 , C07C235/42 , C07C255/54 , C07C259/10 , C07C309/42 , C07C317/22 , C07C317/32 , C07C317/44 , C07C323/16 , C07C323/19 , C07C323/20 , C07C323/32 , C07C323/34 , C07C323/36 , C07C323/41 , C07C323/56 , C07C323/62 , C07C327/30 , C07C37/18 , C07C39/17 , C07C41/26 , C07C43/202 , C07C43/2055 , C07C43/21 , C07C43/23 , C07C45/44 , C07C47/575 , C07C51/367 , C07C65/24 , C07C65/26 , C07C69/76 , C07C69/92 , C07D263/58 , C07D311/58 , C07D311/70 , C07D311/72 , C07D317/22 , C07F9/3834 , C07F9/4021 , C07C2102/10
摘要： Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R.sup.1 -R.sup.6 have the meanings specified in the description, and the preparation thereof are described. The substances are suitable for controlling diseases and as cosmetic agents.
摘要翻译：描述了其中A和R 1 -R 6具有说明书中规定的含义的式I的（I）的二苯基杂烷基衍生物及其制备。该物质适用于控制疾病和化妆品。

7. 发明授权

US5712226A Optically active D-pyridyloxy phenoxy propionate herbicides 失效
标题翻译：光学活性D-吡啶氧基苯氧基丙酸酯除草剂
公开(公告)号：US5712226A
公开(公告)日：1998-01-27
申请号：US465889
申请日：1995-06-06
申请人： Hans Jurgen Nestler , Gerhard Horlein , Reinhard Handte , Hermann Bieringer , Friedhelm Schwerdtle , Peter Langeluddeke , Peter Frisch
发明人： Hans Jurgen Nestler , Gerhard Horlein , Reinhard Handte , Hermann Bieringer , Friedhelm Schwerdtle , Peter Langeluddeke , Peter Frisch
IPC分类号： C07C69/712 , A01N31/08 , A01N37/36 , A01N37/42 , A01N39/02 , A01N43/08 , A01N43/20 , A01N43/40 , A01N43/52 , A01N43/72 , A01N43/74 , A01N43/76 , A01N43/78 , A01N47/12 , A01N47/16 , A01N47/18 , A01N47/20 , A01N47/22 , A01N47/24 , A01P13/00 , A61K31/41 , C07C41/00 , C07C41/26 , C07C43/29 , C07C43/295 , C07C51/00 , C07C51/367 , C07C59/08 , C07C59/125 , C07C59/13 , C07C59/58 , C07C59/68 , C07C59/70 , C07C67/00 , C07C67/343 , C07C69/003 , C07C69/67 , C07C69/68 , C07C201/00 , C07C205/38 , C07C219/06 , C07C231/00 , C07C231/12 , C07C233/00 , C07C235/20 , C07C235/22 , C07C235/24 , C07C241/00 , C07C243/28 , C07C253/00 , C07C255/16 , C07C255/37 , C07C313/00 , C07C323/12 , C07C325/00 , C07C327/22 , C07C327/42 , C07D213/64 , C07D213/643 , C07D213/647 , C07D235/26 , C07D263/54 , C07D263/58 , C07D277/66 , C07D277/68 , C07D303/48 , C07D307/12 , C07D307/42 , C07D413/12
CPC分类号： A01N39/02 , A01N43/08 , A01N43/20 , A01N43/40 , A01N43/52 , A01N43/74 , A01N43/76 , A01N43/78 , A01N47/12 , A01N47/16 , A01N47/18 , A01N47/20 , C07C243/00 , C07C323/00 , C07C327/00 , C07C41/26 , C07C59/68 , C07C67/31 , C07C69/736 , C07D213/643 , C07D213/647 , C07D235/26 , C07D263/58 , C07D277/68 , C07D307/12 , C07B2200/07 , C07C2101/08 , C07C2101/14
摘要： Opticalls active enantiomers of the formula I ##STR1## where R is a group of the formulae ##STR2## R.sub.1 and R.sub.2, among others, are halogen or CF.sub.3 and Z is a carboxyl, carboxylate, carboxylic acid ester, thioester, carbonamide, carboxylic acid anilide, carbohydrazide or thioamide group, are interesting herbicides the effect of which is considerably superior to that of the optically inactive racemates.
摘要翻译：（I）其中R是下式的基团的光学活性对映异构体：其中R是下式的基团：其中R是下式的基团：（VI））R1和R2等是卤素或CF 3，Z是羧基，羧酸酯，羧酸酯，硫酯，碳酰胺，羧酸酰苯胺，碳酰肼或硫代酰胺基，是有意义的除草剂，其效果明显优于光学无活性的外消旋体。

8. 发明授权

US5657156A Polymeric optical amplifier doped with lanthanide 失效
标题翻译：掺杂镧系元素的聚合光学放大器
公开(公告)号：US5657156A
公开(公告)日：1997-08-12
申请号：US615482
申请日：1996-03-15
申请人： Franciscus Cornelis Jacobus Maria van Veggel , Gustaaf Ronald Mohlmann
发明人： Franciscus Cornelis Jacobus Maria van Veggel , Gustaaf Ronald Mohlmann
IPC分类号： C07C59/70 , C07D273/00 , C07D323/00 , H01S3/067 , H01S3/16 , H01S3/17 , H01S3/00 , C07D321/00
CPC分类号： C07D273/00 , C07C59/70 , C07D323/00 , H01S3/06708 , H01S3/1603 , H01S3/178
摘要： The invention relates to a polymeric optical amplifier doped with lanthanide ions, which are present in the amplifier in the form of a complex.The invention also relates to novel electrically neutral lanthanide complexes which can be applied with advantage in the above-described polymeric optical amplifiers. These complexes comprise host molecules which readily complex with the lanthanide and fully encapsulate it.
摘要翻译：本发明涉及掺杂有镧系元素离子的聚合物光学放大器，其以络合物的形式存在于放大器中。本发明还涉及可以在上述聚合物光学放大器中有利地应用的新的电中性镧系元素络合物。这些复合物包含与镧系元素容易复合并完全封装的主体分子。

9. 发明授权

US5235092A Phenoxyacetic acid derivatives and plant growth regulating agents containing them as active ingredients 失效
标题翻译：苯氧乙酸衍生物和含有它们作为活性成分的植物生长调节剂
公开(公告)号：US5235092A
公开(公告)日：1993-08-10
申请号：US799986
申请日：1991-11-29
申请人： Takumi Yoshimura , Tetsuo Takematsu , Makoto Konnai
发明人： Takumi Yoshimura , Tetsuo Takematsu , Makoto Konnai
IPC分类号： A01N39/04 , C07C59/70 , C07C69/712 , C07C235/20 , C07C243/28 , C07C259/06
CPC分类号： C07C59/70 , A01N39/04 , C07C69/712
摘要： A phenoxycetic acid derivative of the formula: ##STR1## wherein R is a hydroxyl group, an alkoxy group, a group of the formula OM wherein M is an alkali metal ion, an alkaline earth metal ion, a transition metal ion, an ammonium ion or an organic ammonium ion, or a group of the formula NHR.sub.1 wherein R.sub.1 is a hydrogen atom, a hydroxyl group, an amino group, an allyloxy group or an ethoxycarboxylmethoxy group.
摘要翻译：下式的苯氧基酸衍生物：其中R是羟基，烷氧基，式OM基团，其中M是碱金属离子，碱土金属离子，过渡金属离子，铵离子或有机铵离子，或式NHR1的基团，其中R1是氢原子，羟基，氨基，烯丙氧基或乙氧基羧基甲氧基。

10. 发明授权

US5145674A Biologically-active compounds comprising a biologically-active anionic portion and a water-insoluble, inorganic cationic portion 失效
标题翻译：包含生物活性阴离子部分和水不溶性无机阳离子部分的生物活性化合物
公开(公告)号：US5145674A
公开(公告)日：1992-09-08
申请号：US693838
申请日：1991-04-30
申请人： George A. Lane , Harold E. Rossow
发明人： George A. Lane , Harold E. Rossow
IPC分类号： A61K31/28 , A61K31/375 , A61K31/60 , C07C57/30 , C07C59/42 , C07C59/70 , C07F5/06 , C07F7/00
CPC分类号： A61K31/60 , A61K31/28 , A61K31/375 , C07C57/30 , C07C59/42 , C07C59/70 , C07F5/069 , C07F7/006
摘要： A biologically-active compound which includes an inorganic mixed metal cationic portion having anion exchange properties and an anionic portion containing a biologically-active anion. The mixed metal cationic portion can be an oxide, hydroxide, or both, and can be fully hydrated, partially hydrated, or not hydrated. The biologically-active anion can be, e.g., an antibiotic, an analgesic, an antimicrobial, a pharmaceutical, an antioxidant, or an agricultural chemical such as a herbicide or a pesticide. These biologically-active compounds can have controlled-release properties and can be produced by relatively simple processes, using for the cationic portion relatively common starting materials. These biologically-active compounds are useful, for example, in compositions to form pharmaceuticals, antioxidants, or herbicides, and can be incorporated into a polymeric material to form a shaped body, such as a plastic film which can be utilized to form bags for food storage or transportation. Also included are processes for making the biologically-active compounds.
摘要翻译：一种生物活性化合物，其包括具有阴离子交换性质的无机混合金属阳离子部分和含有生物活性阴离子的阴离子部分。混合金属阳离子部分可以是氧化物，氢氧化物或两者，并且可以完全水合，部分水合或不水合。生物活性阴离子可以是例如抗生素，止痛剂，抗微生物剂，药物，抗氧化剂或农药如除草剂或农药。这些生物活性化合物可以具有控制释放性质，并且可以通过相对简单的方法制备，使用阳离子部分相对常见的起始材料。这些生物活性化合物可用于例如形成药物，抗氧化剂或除草剂的组合物中，并且可以并入聚合物材料中以形成成型体，例如可用于形成食品袋的塑料膜存储或运输。还包括制备生物活性化合物的方法。

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