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1. 发明授权

US10017460B2 Compounds for promoting liposomal and cellular adhesion and compositions and methods of use thereof 有权
公开(公告)号：US10017460B2
公开(公告)日：2018-07-10
申请号：US14896069
申请日：2014-06-11
申请人： Muhammad Naveed Yousaf
发明人： Muhammad Naveed Yousaf
IPC分类号： A61K9/127 , C07C235/20 , C12N5/00 , C07F9/50 , C07C43/14 , C07C217/08 , C07C323/12 , C07C239/20 , C07C243/14 , C07C247/04 , C07D495/04 , C07D207/46 , C07C50/28 , C07D307/60 , C07F9/40 , C07C43/172 , C07C49/175 , C12N15/88
CPC分类号： C07C235/20 , A61K9/127 , C07C43/14 , C07C43/172 , C07C49/175 , C07C50/28 , C07C217/08 , C07C239/20 , C07C243/14 , C07C247/04 , C07C323/12 , C07C2601/10 , C07D207/46 , C07D307/60 , C07D495/04 , C07F9/4084 , C07F9/5022 , C12N5/0006 , C12N15/88
摘要： The present application describes amphiphatic compounds like compound IIa below, compositions and methods for incorporating chemoselective and bio-orthogonal complementary functional groups into liposomes. Such compounds are incorporated in greater numbers in liposome and fused cell surfaces, leading to greater adhesion and conjugation efficiency. The present application also describes various uses of these modified liposomes including for tethering the chemoselective and bioorthogonal complementary functional groups from cell surfaces by liposome delivery toward the goal of rewiring the cell surface.

2. 发明授权

US09802880B2 Cannabigerol derivatives 有权
公开(公告)号：US09802880B2
公开(公告)日：2017-10-31
申请号：US15122160
申请日：2015-02-12
申请人： VIVACELL BIOTECHNOLOGY ESPAÑA S.L.
发明人： Giovanni Appendino , María Luz Bellido Cabello De Alba , Eduardo Muñoz Blanco
IPC分类号： C07C50/28 , A61K31/122 , A61K31/13 , A61K31/215 , C07C69/757 , C07C225/28
CPC分类号： C07C50/28 , A61K31/122 , A61K31/13 , A61K31/215 , C07C69/757 , C07C69/95 , C07C225/28 , C07C2601/14 , C07C2601/16
摘要： The present invention relates to novel cannabigerol quinone derivatives of formula (I) wherein R is the carbon atom of a linear or branched group, represented by: aryl, alkenyl, alkynyl or alcoxycarbonil groups; or wherein R is the nitrogen atom of a linear or branched group, represented by: alkylamino, arylamino, alkenylamino or alkynylamino groups; or, alternatively, R represents a bond between 2 molecules of formula (I) forming a dimer. The invention also relates to the use of any of the compounds of formula (I) as medicaments in therapy, particularly for treating PPARg-related diseases due to their high PPARg agonistic effect lacking electrophilic (Nrf2 activation) and cytotoxic activities. This invention also provides pharmaceutical compositions comprising said compounds and method of treating diseases with said compounds.

3. 发明申请

US20170037023A1 PROCESS FOR THE PRODUCTION OF ALPHA-TOCOTRIENOL AND DERIVATIVES 审中-公开
标题翻译：生产阿托伐他汀和衍生物的方法
公开(公告)号：US20170037023A1
公开(公告)日：2017-02-09
申请号：US15068452
申请日：2016-03-11
申请人： EDISON PHARMACEUTICALS, INC.
发明人： Kieron W. Wesson , Andrew W. Hinman , Orion D. Jankowski
IPC分类号： C07D311/72 , C07C46/02
CPC分类号： C07D311/72 , C07C46/02 , C07C50/28
摘要： The invention discloses novel processes for production, enrichment and/or isolation of alpha-tocotrienol from source material comprising at least one non-alpha-tocotrienol, such as natural extracts comprising mixed tocotrienols.
摘要翻译：本发明公开了从源材料生产，富集和/或分离α-生育三烯酚的新方法，其包含至少一种非α-生育三烯酚，例如包含混合的生育三烯酚的天然提取物。

4. 发明申请

US20160244392A1 SIDE-CHAIN VARIANTS OF REDOX-ACTIVE THERAPEUTICS FOR TREATMENT OF MITOCHONDRIAL DISEASES AND OTHER CONDITIONS AND MODULATION OF ENERGY BIOMARKERS 有权
标题翻译：用于治疗麻醉病毒和其他条件和能量生物标志物调节的氧化还原活性治疗剂的侧链变量
公开(公告)号：US20160244392A1
公开(公告)日：2016-08-25
申请号：US14983330
申请日：2015-12-29
申请人： Edison Pharmaceuticals, Inc.
发明人： Guy M. Miller , Sidney M. Hecht , Orion D. Jankowski , Kieron E. Wesson , Paul Mollard
IPC分类号： C07C50/04 , C07C43/225 , C07C50/24 , C07C50/06 , C07C69/608 , C07C233/27 , C07C233/32 , C07C47/277 , C07C43/23 , C07C69/618 , C07C50/28 , C07C255/37
CPC分类号： C07C50/04 , A61K31/05 , A61K31/355 , C07C39/08 , C07C39/11 , C07C39/19 , C07C39/245 , C07C43/225 , C07C43/23 , C07C47/277 , C07C50/02 , C07C50/06 , C07C50/24 , C07C50/28 , C07C69/608 , C07C69/618 , C07C215/56 , C07C233/27 , C07C233/32 , C07C255/37 , C07C403/04 , C07C403/08 , C07C403/18 , C07C2601/16
摘要： Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), or Kearns-Sayre Syndrome (KSS) are disclosed, as well as compounds useful in the methods of the invention. Methods and compounds useful in treating other disorders are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.
摘要翻译：公开了治疗或抑制线粒体疾病如弗里德里希共济失调（FRDA），莱伯氏遗传性视神经病变（LHON），线粒体肌病，脑病，乳酸脱落症，中风（MELAS）或Kearns-Sayre综合征（KSS）的方法，以及可用于本发明方法的化合物。还公开了可用于治疗其它疾病的方法和化合物。还公开了可用于评估受试者的代谢状态和治疗功效的能量生物标志物。还公开了调节，归一化或增强能量生物标志物的方法以及可用于这些方法的化合物。

5. 发明授权

US09295656B2 Composition containing reduced coenzyme Q10 and production method thereof 有权
标题翻译：含有还原型辅酶Q10的组合物及其制备方法
公开(公告)号：US09295656B2
公开(公告)日：2016-03-29
申请号：US11812887
申请日：2007-06-22
申请人： Takashi Ueda , Shinsuke Akao , Shiro Kitamura , Hideyuki Kishida , Takahiro Ueda
发明人： Takashi Ueda , Shinsuke Akao , Shiro Kitamura , Hideyuki Kishida , Takahiro Ueda
IPC分类号： A61K31/122 , A61K9/00 , A61K9/16 , A61K9/20 , A61K9/48 , A61K9/107
CPC分类号： C07C50/28 , A61K9/0056 , A61K9/107 , A61K9/1652 , A61K9/1664 , A61K9/2018 , A61K9/4858 , A61K9/4875 , A61K31/122
摘要： The present invention provides a particulate composition wherein an oil component containing reduced coenzyme Q10 is polydispersed forming a domain in a matrix containing a water-soluble excipient, which simultaneously shows high oxidative stability and high oral absorbability, a production method thereof, and a stabilizing method thereof. It also provides a food, food with nutrient function claims, food for specified health uses, dietary supplement, nutritional product, animal drug, drink, feed, pet food, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like, which contain the composition.
摘要翻译：本发明提供了一种颗粒组合物，其中含有还原型辅酶Q10的油成分是多分散的，在含有水溶性赋形剂的基质中形成一个结构域，其同时表现出高氧化稳定性和高口服吸收性，其制备方法和稳定化方法其中。它还提供食物，具有营养功能的食物，特定健康用途的食物，膳食补充剂，营养产品，动物药物，饮料，饲料，宠物食品，化妆品，药物，治疗药物，预防药物等，其含有组成。

6. 发明申请

US20150166449A1 Deuterated Idebenone 审中-公开
标题翻译：氘代艾地苯醌
公开(公告)号：US20150166449A1
公开(公告)日：2015-06-18
申请号：US14414039
申请日：2013-07-12
申请人： Concert Pharmaceuticals, Inc.
发明人： Roger D. Tung
IPC分类号： C07C50/28 , C07B59/00
CPC分类号： C07C50/28 , C07B59/001 , C07B2200/05
摘要： The present invention in one embodiment provides a compound of Formula I:(I), or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula I are as defined in the specification.
摘要翻译：本发明在一个实施方案中提供式I化合物：（I）或其药学上可接受的盐，其中式I所示的变量如说明书中所定义。

7. 发明申请

US20140249332A1 METHODS FOR SELECTIVE OXIDATION OF ALPHA TOCOTRIENOL IN THE PRESENCE OF NON-ALPHA TOCOTRIENOLS 有权
标题翻译：在非ALPHA TOCOTRIENOLS存在下选择性氧化阿托伐他汀的方法
公开(公告)号：US20140249332A1
公开(公告)日：2014-09-04
申请号：US14233734
申请日：2012-07-19
申请人： Paul Mollard
发明人： Paul Mollard
IPC分类号： C07C46/06
CPC分类号： C07C46/06 , C07C403/08 , C07C2601/16 , C07D311/72 , C07C50/28
摘要： A method of producing alpha-tocotrienol quinone or a stereoisomer thereof, the method comprising selective opening of alpha-tocotrienol chroman to alpha-tocotrienol quinone in the presence of non-alpha tocotrienol chromans by oxidizing alpha-tocotrienol with a metal salt oxidizing agent, wherein the stoichiometric ratio of metal salt oxidizing agent/alpha-tocotrienol is at least 4:1 and wherein said metal oxidizing agent is added in sequential additions, in order to reduce oxidation of any amounts of non-alpha tocotrienol chromans that might have been present in the starting alpha-tocotrienol chroman material. This process uses conditions favoring oxidation rates of the alpha tocotrienol chroman vs the non-alpha tocotrienol chromans.
摘要翻译：一种生产α-生育三烯酚醌或其立体异构体的方法，所述方法包括通过用金属盐氧化剂氧化α-生育三烯酚，在非α-生育三烯酚染料色素存在下选择性地将α-生育三烯酚苯并二氢吡喃酮打开至α-生育三烯酚醌金属盐氧化剂/α-生育三烯酚的化学计量比为至少4:1，并且其中所述金属氧化剂按顺序加入添加，以减少可能存在于任何量的非α-生育三烯酚黑色素的氧化起始的α-生育三烯酚色满物质。该方法使用有利于α-生育三烯酚苯并二氢吡喃酮与非α-生育三烯酚染料色素的氧化速率的条件。

8. 发明申请

US20130158126A1 CANNABINOID QUINONE DERIVATIVES 有权
标题翻译： CANNABINOID QUINONE衍生物
公开(公告)号：US20130158126A1
公开(公告)日：2013-06-20
申请号：US13636214
申请日：2010-03-26
申请人： Eduardo Muñoz Blanco , Giovanni Appendino , María Luz Bellido Cabello De Alba
发明人： Eduardo Muñoz Blanco , Giovanni Appendino , María Luz Bellido Cabello De Alba
IPC分类号： C07C50/28
CPC分类号： C07C50/28 , C07C50/38
摘要： Cannabinoid quinone derivatives. The present invention refers to cannabinoid quinone derivatives to be used as medicaments, particularly as PPAR gamma (PPARg) agonists for treating diseases which etiology is based on an impaired PPARg function as transcription factor i.e. PPARg-related diseases.
摘要翻译：大麻酚醌衍生物。本发明涉及用作药物的大麻素醌衍生物，特别是作为用于治疗疾病的PPARγ（PPARg）激动剂，其病因为受损的PPARg功能为转录因子即PPARg相关疾病。

9. 发明授权

US08466326B2 Production method for ubiquinone powder for use in preparations and product thereof 有权
标题翻译：用于制剂及其制品的泛醌粉的制备方法
公开(公告)号：US08466326B2
公开(公告)日：2013-06-18
申请号：US13260147
申请日：2010-03-29
申请人： Takafumi Yoshimura , Rieko Nakano , Masayuki Furutani , Takeshi Uchiho
发明人： Takafumi Yoshimura , Rieko Nakano , Masayuki Furutani , Takeshi Uchiho
IPC分类号： C07C43/23 , C07C49/84 , B28B17/00 , A61K38/43
CPC分类号： A61K47/22 , C07C46/10 , C07C2601/16 , C07C50/28
摘要： Disclosed are a production method for a ubiquinone powder for use in preparations, including Step 1 of compression molding a ubiquinone crystal powder at a linear molding pressure of from 0.6 to 2.5 tons/cm to obtain a compressed fragment; and Step 2 of grinding the compressed fragment obtained in Step 1 to obtain a powder; and a ubiquinone powder for use in preparations, which is obtained by the subject production method. According to the subject production method, it becomes possible to provide a ubiquinone powder for use in preparations for medicines and health foods, which has a high bulk density, a small angle of repose and excellent handling properties and fluidity, without using an additive such as an excipient, a binder and the like.
摘要翻译：公开了用于制备的泛醌粉末的制备方法，包括在0.6-2.5吨/厘米的线性成型压力下压制成型泛醌晶体粉末的步骤1，得到压片; 和步骤2，研磨步骤1中得到的压片，得到粉末; 和用于制备的泛醌粉末，其通过目标制备方法获得。根据本发明的制备方法，可以提供一种用于药物和保健食品制剂的泛醌粉末，其具有高体积密度，小的休止角和优异的操作性能和流动性，而不使用添加剂如赋形剂，粘合剂等。

10. 发明申请

US20110263720A1 SYNTHESIS OF ALPHA-TOCOPHEROLQUINONE DERIVATIVES, AND METHODS OF USING THE SAME 审中-公开
标题翻译： ALPHA-TOCOPHEROLQUINONE衍生物的合成及其使用方法
公开(公告)号：US20110263720A1
公开(公告)日：2011-10-27
申请号：US13044056
申请日：2011-03-09
申请人： Steven D. PAISLEY , Jason M. LePree , Amale Hawi , Michael Eckhoff
发明人： Steven D. PAISLEY , Jason M. LePree , Amale Hawi , Michael Eckhoff
IPC分类号： A61K31/122 , C07C49/497 , A61P25/00 , A61P3/10 , A61P25/28 , A61P25/18 , A61P35/00 , C07C45/60 , A61P25/08
CPC分类号： C07D311/72 , C07C46/06 , C07C50/28
摘要： The present invention is directed to a method of synthesizing a compound of Formula I: the method comprising oxidizing alpha-tocopherol with a metal salt oxidizing agent to form the compound of Formula I, wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/alpha-tocopherol is 1.6 to 4. The invention is also directed to a method of synthesizing a compound of Formula I, the method comprising (a) hydrolyzing alpha-tocopheryl acetate in the presence of a base; (b) neutralizing the hydrolyzing of (a), thereby forming alpha-tocopherol; and (c) oxidizing the alpha-tocopherol of (b) with a metal salt oxidizing agent to form the compound of Formula I, wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/alpha-tocopherol is 1.6 to 4.
摘要翻译：本发明涉及一种合成式I化合物的方法：包括用金属盐氧化剂氧化α-生育酚以形成式I化合物的方法，其中金属盐氧化的化学计量比（mol / mol）药物/α-生育酚为1.6至4.本发明还涉及一种合成式I化合物的方法，该方法包括（a）在碱存在下水解α-生育酚乙酸酯; （b）中和（a）的水解，从而形成α-生育酚; 和（c）用金属盐氧化剂氧化（b）的α-生育酚以形成式I化合物，其中金属盐氧化剂/α-生育酚的化学计量比（mol / mol）为1.6至4。

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