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1. 发明授权

US10870620B1 Radioactive carbon-14-labeled 2,2′-(((4-((4-14C chlorobenzyl)oxy)-3-methoxyphenyl)methylene)bis(2-hydroxyethyl)dithioacetal, preparation method and applications there of 有权
公开(公告)号：US10870620B1
公开(公告)日：2020-12-22
申请号：US16935727
申请日：2020-07-22
申请人： Zhejiang University
发明人： Wang Haiyan , Lu Yuhui , Ye Qingfu
IPC分类号： C07C323/16 , C07B59/00 , C07C29/147 , C07C319/20 , G01T5/00 , C07C17/16 , C07C323/64
CPC分类号： C07C323/16 , C07B59/001 , C07C17/16 , C07C29/147 , C07C319/20 , C07C323/64 , G01T5/00 , C07B2200/05 , C07C319/20 , C07C323/64 , C07C29/147 , C07C33/46 , C07C17/16 , C07C25/02
摘要： The present disclosure provides a radioactive carbon-14 labeled XCLSBM in the structure of Formula 4 and its preparation method and applications. A 14C labeled raw material is used to synthesize a 14C-labeled XCLSBM, and a method for synthesizing a trace 14C-labeled marker of 14C-labeled XCLSBM is established, which avoids high-temperature, high-pressure reactions and the production process is safe with a low synthesis cost. The radioactive carbon-14 labeled XCLSBM can be used to trace the migration and transformation, metabolic degradation, absorption and enrichment of XCLSBM in environment and living bodies, for providing technical supports for comprehensive evaluation of the ecological safety of XCLSBM.

2. 发明授权

US10654032B2 Recyclable catalysts for chlorination of organic acids and alcohols 有权
公开(公告)号：US10654032B2
公开(公告)日：2020-05-19
申请号：US15463722
申请日：2017-03-20
申请人： GALAXY SURFACTANTS LTD.
发明人： Nirmal Koshti , Bhagyesh Jagannath Sawant , Arpit Wankhade , Pritesh Mhatre
IPC分类号： B01J31/06 , C07C51/60 , C08F8/30 , C07C17/16 , C08F8/32
摘要： The present invention discloses recyclable polymeric catalyst of Formula I, for chlorination of organic acids and alcohols using chlorinating agents such as carbonyl chloride, oxalyl chloride or thionyl chloride, wherein, ‘m’ on the pendent groups on polystyrene backbone can have values from 1 to 5 and R is the alkyl group ranging from C1 to C5.

3. 发明授权

US10392325B2 Method for producing fluorinated alkane, method for separating and recovering amidine base, and method for using recovered amidine base 有权
公开(公告)号：US10392325B2
公开(公告)日：2019-08-27
申请号：US15561456
申请日：2016-03-29
申请人： Kanto Denka Kogyo Co., Ltd. , ZEON CORPORATION
发明人： Kazuki Kurihara , Tatsuya Sugimoto
IPC分类号： C07D471/04 , C07C17/16 , C07C19/08 , B01D1/22 , B01D3/10 , B01D3/36
摘要： The present invention provides: a method for producing a fluorinated alkane represented by the formula (2): R2—F, wherein an alcohol having 3 to 5 carbon atoms is fluorinated by a fluorinating agent represented by the formula (1): R1SO2F in the absence of a solvent, and in the presence of an amidine base. In the formula, R1 represents a methyl group, an ethyl group or an aromatic group, R2 represents an alkyl group having 3 to 5 carbon atoms, and n is 0 or 2.

4. 发明授权

US10246412B2 Chemical film on substrate and method of forming the same, method of forming paracyclophane containing functional ground with disulfide bond 有权
公开(公告)号：US10246412B2
公开(公告)日：2019-04-02
申请号：US15185003
申请日：2016-06-16
申请人： MAY-HWA ENTERPRISE CORPORATION
发明人： Hsien-Yeh Chen , Zhen-Yu Guan , Chih-Yu Wu
IPC分类号： C07C319/22 , C07C17/16 , C07C29/14 , C07C45/30 , C07C209/08 , C09D165/04 , C07C45/45 , C07C22/04
摘要： The present invention provides a method of forming paracyclyophane containing disulfide functional group. The paracyclophane is prepared by adding 3,3′-dithiodipropionic acid (DPDPA) and N-ethyl-N′-(3-(dimethylamino)propyl)carbodiimide (EDC) into 4-aminomethyl [2,2] paracyclophane. The present invention further provides a chemical film and a method of forming the same. The chemical film contains poly-p-xylylene with disulfide functional group and is formed on a substrate by a chemical vapor deposition process.

5. 发明授权

US10179735B2 Method for purifying contaminated gaseous hydrogen chloride 有权
公开(公告)号：US10179735B2
公开(公告)日：2019-01-15
申请号：US15527141
申请日：2016-01-26
申请人： Wacker Chemie AG
发明人： Konrad Mautner
IPC分类号： C01B7/07 , C08G77/32 , C08G77/06 , C08G77/34 , C08G77/36 , C07C17/16
摘要： Impure gaseous hydrogen chloride from organochlorosilane hydrolysis is freed of impurities by first scrubbing with an organochlorosilane, which may be the same or different from the organochlorosilane(s) hydrolyzed, and then further scrubbing with chloromethane. The purified gaseous hydrogen chloride is preferably used in chlorosilane synthesis.

6. 发明授权

US09550753B2 Mono quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors 有权
标题翻译：单季铵盐和调节神经元烟碱乙酰胆碱受体的方法
公开(公告)号：US09550753B2
公开(公告)日：2017-01-24
申请号：US14470715
申请日：2014-08-27
申请人： University of Kentucky Research Foundation
发明人： Peter Crooks , Linda P. Dwoskin , Guangrong Zheng , Sangeetha Sumithran , Zhenfa Zhang
IPC分类号： C07D211/92 , C07D401/14 , C07C17/16 , C07D213/20 , C07D213/30 , C07D215/10 , C07D217/10 , C07D401/06
CPC分类号： C07D401/14 , C07C17/16 , C07D213/20 , C07D213/30 , C07D215/10 , C07D217/10 , C07D401/06 , C07C22/04
摘要： Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and gastrointestinal tract disorders.
摘要翻译：提供作为烟碱乙酰胆碱受体调节剂的单季铵化合物。还提供了使用化合物调节烟碱乙酰胆碱受体的功能以及用于预防和/或治疗中枢神经系统疾病，物质使用和/或滥用以及胃肠道疾病的方法。

7. 发明授权

US09475757B2 Synthesis of anti-Parkinson agent 有权
标题翻译：合成抗帕金森病药
公开(公告)号：US09475757B2
公开(公告)日：2016-10-25
申请号：US14888697
申请日：2014-05-02
申请人： Council of Scientific & Industrial Research
发明人： Murugan Muthukrishnan , Mohammad Mujahid
IPC分类号： C07C231/12 , C07C237/06 , C07C41/01 , C07C41/18 , C07C303/40 , C07C247/04 , C07C17/16 , C07C231/02
CPC分类号： C07C231/12 , C07C17/16 , C07C41/01 , C07C41/18 , C07C231/02 , C07C237/06 , C07C247/04 , C07C303/40
摘要： The present invention relates to an improved process for synthesis of anti-Parkinson compound of formula (I) from commercially available (R)-benzyl glycidyl ether, wherein the compound obtained has enantiopurity greater than >98%. Formula (I) wherein R1 and R2 are each independently selected from hydrogen or halogen.

8. 发明授权

US09272966B2 Method for preparing optically active 1-bromo-1[3,5-bis(trifluoromethyl)phenyl]ethane 有权
标题翻译：光学活性1-溴-1 [3,5-双（三氟甲基）苯基]乙烷的制备方法
公开(公告)号：US09272966B2
公开(公告)日：2016-03-01
申请号：US13811651
申请日：2011-07-21
申请人： Taichi Kusakabe , Kennosuke Matsuda , Koichi Yamazaki , Tadaaki Ohgiya , Kimiyuki Shibuya
发明人： Taichi Kusakabe , Kennosuke Matsuda , Koichi Yamazaki , Tadaaki Ohgiya , Kimiyuki Shibuya
IPC分类号： C07C22/08 , C07C22/04 , C07C17/16 , C07C17/04 , C07B53/00
CPC分类号： C07C17/04 , C07B53/00 , C07B2200/07 , C07C17/16 , C07C22/08
摘要： A method for preparing optically active 1-bromo-1-[3,5-bis(trifluoromethyl)-phenyl]ethane having a high optical purity, which comprises the step of brominating optically active 1-[3,5-bis(trifluoromethyl)phenyl]ethanol by using, as a brominating agent, (a) a combination of a phosphorus halide and hydrogen bromide, (b) a combination of 1,2-dibromo-1,1,2,2-tetrachloroethane and an organic phosphorous compound represented by the general formula (I): P(R1)(R2)(R3) (in the formula, R1, R2, and R3 independently represent a C6-10 aryl group, a C6-10 aryloxy group, a C1-10 alkyl group, a C1-10 alkoxyl group, a C3-6 cycloalkyl group, or a C3-6 cycloalkoxy group), or (c) a combination of N-bromosuccinimide and a dialkyl sulfide.
摘要翻译：一种具有高光学纯度的光学活性1-溴-1- [3,5-双（三氟甲基） - 苯基]乙烷的制备方法，其包括将光学活性的1- [3,5-双（三氟甲基）苯基]乙醇通过使用溴化剂，（a）卤化磷和溴化氢的组合，（b）1,2-二溴-1,1,2,2-四氯乙烷与有机磷化合物的组合由通式（I）表示：P（R1）（R2）（R3）（在式中，R1，R2和R3独立地表示C6-10芳基，C6-10芳氧基，C1-10 烷基，C1-10烷氧基，C3-6环烷基或C3-6环烷氧基），或（c）N-溴代琥珀酰亚胺与二烷基硫醚的组合。

9. 发明授权

US09249084B2 Substituted n-pentanamide compounds, preparation method and the use thereof 有权
标题翻译：取代的正戊酰胺化合物，其制备方法及其用途
公开(公告)号：US09249084B2
公开(公告)日：2016-02-02
申请号：US13982733
申请日：2012-01-31
申请人： Qiang Zhang , Rongxia Zhang , Guanghui Tian , Jianfeng Li , Fuqiang Zhu , Xiangrui Jiang , Jingshan Shen
发明人： Qiang Zhang , Rongxia Zhang , Guanghui Tian , Jianfeng Li , Fuqiang Zhu , Xiangrui Jiang , Jingshan Shen
IPC分类号： C07C213/02 , C07C59/64 , C07C235/34 , C07C309/75 , C07C309/66 , C07C43/225 , C07D263/26 , C07C17/16 , C07C215/54 , C07C217/62 , C07C309/73 , C07D263/52 , C07C43/23 , C07C59/68 , C07C41/26
CPC分类号： C07C235/34 , C07C17/16 , C07C41/26 , C07C43/225 , C07C43/23 , C07C59/64 , C07C59/68 , C07C213/02 , C07C215/54 , C07C217/62 , C07C309/66 , C07C309/73 , C07C309/75 , C07D263/26 , C07D263/52 , Y02P20/582 , C07C22/04
摘要： The present invention relates to a (2R,3R)-3-(3-substituted phenyl)-2-methyl n-pentanamide compounds as shown in the formula I and the preparation method thereof, wherein, the substituents are as defined in the specification, the present invention further relates to a use of the above compounds for the preparation of tapentadol II or its pharmaceutically acceptable salt, and the intermediates involved in the preparation process.
摘要翻译：本发明涉及式I所示的（2R，3R）-3-（3-取代苯基）-2-甲基正戊酰胺化合物及其制备方法，其中取代基如本说明书中所定义，本发明还涉及上述化合物在制备他喷他多II或其药学上可接受的盐中的用途，以及参与制备方法的中间体。

10. 发明申请

US20160002369A1 CATALYSTS 有权
标题翻译：催化剂
公开(公告)号：US20160002369A1
公开(公告)日：2016-01-07
申请号：US14654409
申请日：2013-12-19
申请人： BOREALIS AG
发明人： Luigi RESCONI , Pascal CASTRO , Ville VIRKKUNEN , Vyatcheslav V. IZMER , Dmitry S. KONONOVICH , Pavel Sergeevich KULYABIN , Alexander Z. VOSKOBOYNIKOV
IPC分类号： C08F4/6592 , C07C1/32 , C07C51/00 , C07C45/00 , C07F7/08 , C07C17/16
CPC分类号： C08F4/65927 , C07C1/321 , C07C17/16 , C07C45/00 , C07C51/00 , C07F7/0803 , C07F7/081 , C07F17/00 , C08F210/06 , C08F10/06 , C08F4/65912 , C08F210/16 , C08F2500/03 , C08F2500/12
摘要： An asymmetric complex of formula (I) wherein M is zirconium or hafnium; each X is a sigma ligand; L is a divalent bridge selected from —R′2C—, —R′2C—CR′2—, —R′2Si—, —R′2Si—SiR′2—, —R′2Ge—, wherein each R′ is independently a hydrogen atom, C1-C20-alkyl, tri(C1-C20-alkyl)silyl, C6-C20-aryl, C7-C20-arylalkyl or C7-C20-alkylaryl; R2 and R2′ are each independently a C1-C20 hydrocarbyl radical; R5′ is a C1-20 hydrocarbyl group; R5 is hydrogen, or a C1-20 hydrocarbyl group; R6 is a non tertiary C1-10 alkyl group or C6-10-aryl group or C7-10 arylalkyl group or ZR3; R6′ is a tertiary C4-20 alkyl group; Z is O or S; R3 is a C1-20 hydrocarbyl group optionally substituted with halo; Ar is an aryl or heteroaryl group having up to 20 carbon atoms optionally substituted by one or more groups R1; Ar′ is an aryl or heteroaryl group having up to 20 carbon atoms optionally substituted by one or more groups R1; each R1 is a C1-20 hydrocarbyl group or two R1 groups on adjacent carbon atoms taken together can form a fused 5 or 6 membered ring with the Ar group, said ring being itself optionally substituted with one or more groups R4; and each R4 is a C1-20 hydrocarbyl group.
摘要翻译：式（I）的不对称配合物，其中M是锆或铪; 每个X是σ配体; L是选自-R'2C-，-R'2C-CR'2-，-R'2Si-，-R'2Si-SiR'2-，-R'2Ge-的二价桥，其中每个R' 独立地为氢原子，C 1 -C 20烷基，三（C 1 -C 20 - 烷基）甲硅烷基，C 6 -C 20 - 芳基，C 7 -C 20 - 芳基烷基或C 7 -C 20 - 烷基芳基; R2和R2'各自独立地为C1-C20烃基; R5'是C1-20烃基; R5是氢或C1-20烃基; R6是非叔C 1-10烷基或C 6-10 - 芳基或C 7-10芳基烷基或ZR 3; R6'是叔C4-20烷基; Z是O或S; R3是任选被卤素取代的C 1-20烃基; Ar是任选被一个或多个R 1基团取代的具有至多20个碳原子的芳基或杂芳基; Ar'是任选被一个或多个R 1基团取代的具有至多20个碳原子的芳基或杂芳基; 每个R 1是C 1-20烃基或相邻碳原子上的两个R 1基团可以与Ar基团形成稠合的5或6元环，所述环本身任选地被一个或多个基团R 4取代; 并且每个R 4是C 1-20烃基。

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