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1. 发明授权

US07754760B2 Epicatechin and vasodilation 失效
标题翻译：表儿茶素和血管舒张
公开(公告)号：US07754760B2
公开(公告)日：2010-07-13
申请号：US11977683
申请日：2007-10-25
申请人： Leo J. Romanczyk, Jr. , Harold H. Schmitz
发明人： Leo J. Romanczyk, Jr. , Harold H. Schmitz
IPC分类号： A61K31/353
CPC分类号： C07H17/06 , A23G1/32 , A23G3/36 , A23K20/111 , A23K50/40 , A61K9/2018 , A61K9/2068 , A61K9/4858 , A61K31/353 , A61K31/7048 , A61K36/185 , A61K45/06 , C07D311/32 , C07D311/62 , C07D311/64 , C11B5/0035 , A61K2300/00
摘要： This invention relates to compositions comprising epicatechin and method of use of such compositions for inducing vasodilation of blood vessels in humans and veterinary animals.
摘要翻译：本发明涉及包含表儿茶素的组合物及其用于诱导人体和兽医动物血管血管扩张的方法。

2. 发明申请

US20090182133A1 BENZOPYRANONE DERIVATIVES AND THEIR USE AS ANTI-VIRAL AGENTS 审中-公开
标题翻译：苯并噻吩衍生物及其用作反病毒剂
公开(公告)号：US20090182133A1
公开(公告)日：2009-07-16
申请号：US12159570
申请日：2006-12-15
申请人： Chum Mok Puah , Weiliang Zhu , Jian Li , Lili Chen , Cheng Luo , Gang Chen , Zhili Zuo , Xiaomin Luo , Xu Shen , Kaixian Chen , Hualiang Jiang
发明人： Chum Mok Puah , Weiliang Zhu , Jian Li , Lili Chen , Cheng Luo , Gang Chen , Zhili Zuo , Xiaomin Luo , Xu Shen , Kaixian Chen , Hualiang Jiang
IPC分类号： C07H17/06 , C07D319/08
CPC分类号： A61K31/35 , C07D311/30 , C07D407/04 , C07H17/06
摘要： The invention relates to pharmaceutical compositions comprising benzopyranone derivatives for the treatment of Severe Acute Respiratory Syndrome (SARS).
摘要翻译：本发明涉及包含用于治疗严重急性呼吸综合征（SARS）的苯并吡喃酮衍生物的药物组合物。

3. 发明授权

US07122574B2 Treatment of hypertension 有权
标题翻译：治疗高血压
公开(公告)号：US07122574B2
公开(公告)日：2006-10-17
申请号：US10795552
申请日：2004-03-08
申请人： Leo J. Romanczyk, Jr. , Harold H. Schmitz
发明人： Leo J. Romanczyk, Jr. , Harold H. Schmitz
IPC分类号： A61K31/352 , C07D311/62
CPC分类号： C07H17/06 , A23G1/32 , A23G3/36 , A23K20/111 , A23K50/40 , A61K9/2018 , A61K9/2068 , A61K9/4858 , A61K31/353 , A61K31/7048 , A61K36/185 , A61K45/06 , C07D311/32 , C07D311/62 , C07D311/64 , C11B5/0035 , A61K2300/00
摘要： Polyphenol-containing compositions, for example procyanidins and derivatives thereof, and their use for treating hypertension are disclosed. Compositions may be used for human and veterinary use, and may be, for example, in a form of a food, a dietary supplement or a pharmaceutical.
摘要翻译：公开了含多酚的组合物，例如原花青素及其衍生物及其用于治疗高血压的用途。组合物可以用于人类和兽医用途，并且可以是例如食物，膳食补充剂或药物的形式。

4. 发明申请

US20040220392A1 Compositions for, and methods of, treating atherosclerosis 有权
标题翻译：治疗动脉粥样硬化的组合物和方法
公开(公告)号：US20040220392A1
公开(公告)日：2004-11-04
申请号：US10770969
申请日：2004-05-06
发明人： Leo J. Romanczyk, JR. , Harold H. Schmitz
IPC分类号： C07H017/00 , C07D311/74
CPC分类号： C07H17/06 , A23G1/32 , A23G3/36 , A23K20/111 , A23K50/40 , A61K9/2018 , A61K9/2068 , A61K9/4858 , A61K31/353 , A61K31/7048 , A61K36/185 , A61K45/06 , C07D311/32 , C07D311/62 , C07D311/64 , C11B5/0035 , A61K2300/00
摘要： Disclosed and claimed are cocoa extracts, compounds, combinations thereof and compositions containing the same, such as polyphenols or procyanidins, methods for preparing such extracts, compounds and compositions, as well as uses for them, especially a polymeric compound of the formula An, wherein A is a monomer of the formula: 1 wherein n is an integer from 2 to 18, such that there is at least one terminal monomeric unit A, and one or a plurality of additional monomeric units; R is 3-(null)-OH, 3-(null)-OH, 3-(null)-o-sugar, or 3-(null)-O-sugar; bonding between adjacent monomers takes place at positions 4, 6 or 8; a bond of an additional monomeric unit in position 4 has alpha or beta stereochemistry; X, Y and Z are selected from the group consisting of monomeric unit A, hydrogen, and a sugar, with the provisos that as to the at least one terminal monomeric unit, bonding of the additional monomeric unit thereto (the bonding of the additional monomeric unit adjacent to the terminal monomeric unit) is at position 4 and optionally YnullZnullhydrogen; the sugar is optionally substituted with a phenolic moiety, at any position on the sugar, for instance via an ester bond, and pharmaceutically acceptable salts or derivatives thereof (including oxidation products).
摘要翻译：公开和要求保护的是可可提取物，化合物，其组合和含有它们的组合物，例如多酚或原花青素，制备此类提取物，化合物和组合物的方法，以及它们的用途，特别是式An的聚合化合物，其中 A是下式的单体：其中n是2至18的整数，使得存在至少一个末端单体单元A和一个或多个另外的单体单元; R是3-（α）-OH，3-（β）-OH，3-（α） - 糖或3-（β）-O-糖; 相邻单体之间的结合发生在位置4,6或8; 位置4的附加单体单元的键具有α或β立体化学; X，Y和Z选自单体单元A，氢和糖，条件是对于至少一个末端单体单元，附加单体单元与其结合（附加单体单元的键合邻近末端单体单元的单元）在位置4且任选地Y = Z =氢; 糖任选被酚部分取代，在糖上的任何位置，例如通过酯键，及其药学上可接受的盐或衍生物（包括氧化产物）。

5. 发明申请

US20020128493A1 Synthetic methods for polyphenols 失效
标题翻译：多酚的合成方法
公开(公告)号：US20020128493A1
公开(公告)日：2002-09-12
申请号：US10017812
申请日：2001-12-14
申请人： Mars, Incorporated
发明人： Leo J. Romanczyk JR. , Alan P. Kozikowski , Werner Tueckmantel , Marc E. Lippman
IPC分类号： C07D311/26
CPC分类号： C07H17/06 , A61K31/35 , C07D311/32 , C07D311/60 , C07D311/62
摘要： A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphenol monomer. The protected polyphenol may be a protected polyphenol monomer or a protected polyphenol oligomer having 2-17 monomeric units. Advantageously, polyphenol monomeric units forming the polyphenol oligomers may be the same or different flavanoid compounds.
摘要翻译：公开了用于生产具有多酚单体单元的多酚低聚物的方法，n为2-18的整数。该方法包括将被保护的酚羟基的被保护的多酚与C-4官能化的多酚单体的偶联。受保护的多酚可以是受保护的多酚单体或具有2-17单体单元的被保护的多酚低聚物。有利地，形成多酚低聚物的多酚单体单元可以是相同或不同的类黄酮化合物。

6. 发明授权

US06420572B1 Synthetic methods for preparation of protected proanthocyanidin(s) 失效
标题翻译：用于制备被保护的原花色素的合成方法
公开(公告)号：US06420572B1
公开(公告)日：2002-07-16
申请号：US09169554
申请日：1998-10-09
申请人： Leo J. Romanczyk, Jr. , Alan P. Kozikowski , Werner Tueckmantel , Marc E. Lippman
发明人： Leo J. Romanczyk, Jr. , Alan P. Kozikowski , Werner Tueckmantel , Marc E. Lippman
IPC分类号： C07D31160
CPC分类号： C07H17/06 , A61K31/35 , C07D311/32 , C07D311/60 , C07D311/62
摘要： A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphenol monomer. The protected polyphenol may be a protected polyphenol monomer or a protected polyphenol oligomer having 2-17 monomeric units. Advantageously, polyphenol monomeric units forming the polyphenol oligomers may be the same or different flavanoid compounds.
摘要翻译：公开了用于生产具有多酚单体单元的多酚低聚物的方法，n为2-18的整数。该方法包括将被保护的酚羟基的被保护的多酚与C-4官能化的多酚单体的偶联。受保护的多酚可以是受保护的多酚单体或具有2-17单体单元的被保护的多酚低聚物。有利地，形成多酚低聚物的多酚单体单元可以是相同或不同的类黄酮化合物。

7. 发明授权

US06297273B1 Use of cocoa solids having high cocoa polyphenol content in tabletting compositions and capsule filling compositions 失效
标题翻译：在压片组合物和胶囊填充组合物中使用具有高可可多元酚含量的可可固体
公开(公告)号：US06297273B1
公开(公告)日：2001-10-02
申请号：US08831245
申请日：1997-04-02
申请人： Leo J. Romanczyk, Jr.
发明人： Leo J. Romanczyk, Jr.
IPC分类号： A61K920
CPC分类号： C07H17/06 , A23G1/32 , A23G3/36 , A23K20/111 , A23K50/40 , A61K9/2018 , A61K9/2068 , A61K9/4858 , A61K31/353 , A61K31/7048 , A61K36/185 , A61K45/06 , C07D311/32 , C07D311/62 , C07D311/64 , C11B5/0035 , A61K2300/00
摘要： Disclosed and claimed are cocoa extracts, compounds, combinations thereof and compositions containing the same, such as polyphenols or procyanidins, methods for preparing such extracts, compounds and compositions, as well as uses for them, especially a polymeric compound of the formula An, wherein A is a monomer of the formula: wherein n is an integer from 2 to 18, such that there is at least one terminal monomeric unit A, and one or a plurality of additional monomeric units; R is 3-(&agr;)-OH, 3-(&bgr;)-OH, 3-(&agr;)-O-sugar, or 3-(&bgr;)-O-sugar; bonding between adjacent monomers takes place at positions 4, 6 or 8; a bond of an additional monomeric unit in position 4 has alpha or beta stereochemistry; X, Y and Z are selected from the group consisting of monomeric unit A, hydrogen, and a sugar, with the provisos that as to the at least one terminal monomeric unit, bonding of the additional monomeric unit thereto (the bonding of the additional monomeric unit adjacent to the terminal monomeric unit) is at position 4 and optionally Y=Z=hydrogen; the sugar is optionally substituted with a phenolic moiety, at any position on the sugar, for instance via an ester bond, and pharmaceutically acceptable salts or derivatives thereof (including oxidation products).
摘要翻译：公开和要求保护的是可可提取物，化合物，其组合和含有它们的组合物，例如多酚或原花青素，制备此类提取物，化合物和组合物的方法，以及它们的用途，特别是式An的聚合化合物，其中 A是下式的单体：其中n是2至18的整数，使得存在至少一个末端单体单元A和一个或多个另外的单体单元; R是3-（α）-OH， 3-（β）-OH，3-（α）-O-糖或3-（β）-O-糖;相邻单体之间的键合发生在位置4,6或8;附加单体单元的键位置4具有α或β立体化学; X，Y和Z选自单体单元A，氢和糖，条件是对于至少一个末端单体单元，附加单体单元单元（其中附加的单体单元与末端单体相邻）单元）位于第4位并且任选地Y = Z =氢;糖任选被酚部分取代，在糖上的任何位置，例如通过酯键，以及其药学上可接受的盐或其衍生物（包括氧化产物）。

8. 发明授权

US07960353B2 Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders 有权
标题翻译：新生霉素类似物作为神经保护剂和治疗自身免疫性疾病
公开(公告)号：US07960353B2
公开(公告)日：2011-06-14
申请号：US12577620
申请日：2009-10-12
申请人： Brian S. J. Blagg
发明人： Brian S. J. Blagg
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： C07H17/06
摘要： Novobiocin analogues and pharmaceutical composition containing such compounds useful for the treatment and/or prevention of neurodegenerative disorders and autoimmune disorders.
摘要翻译：含有可用于治疗和/或预防神经变性疾病和自身免疫性疾病的化合物的新生霉素类似物和药物组合物。

9. 发明申请

US20080318877A1 PURIFICATIONS OF POMEGRANATE ELLAGITANNINS AND THEIR USES THEREOF 有权
标题翻译：吡喃葡庚糖苷的纯化及其用途
公开(公告)号：US20080318877A1
公开(公告)日：2008-12-25
申请号：US12143657
申请日：2008-06-20
申请人： Navindra P. Seeram , David Heber
发明人： Navindra P. Seeram , David Heber
IPC分类号： A61K31/7048
CPC分类号： C07H17/08 , A61K31/352 , A61K31/357 , A61K31/7004 , C07H17/06 , A61K2300/00
摘要： Compositions of purified and biologically active ellagitannins are provided by separation from pomegranate husk using a method of extraction and purification using a solid polymeric adsorbent and the uses of the said compounds
摘要翻译：通过使用固体聚合物吸附剂的提取和纯化方法从石榴壳中分离提供纯化和生物活性鞣花素的组合物，以及所述化合物的用途

10. 发明授权

US07268240B2 Synthetic methods for polyphenols 失效
标题翻译：多酚的合成方法
公开(公告)号：US07268240B2
公开(公告)日：2007-09-11
申请号：US10858449
申请日：2004-05-28
申请人： Leo J. Romanczyk, Jr. , Alan P. Kozikowski , Werner Tueckmantel , Marc E. Lippman
发明人： Leo J. Romanczyk, Jr. , Alan P. Kozikowski , Werner Tueckmantel , Marc E. Lippman
IPC分类号： C07D311/62
CPC分类号： C07H17/06 , A61K31/35 , C07D311/32 , C07D311/60 , C07D311/62
摘要： A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphenol monomer. The protected polyphenol may be a protected polyphenol monomer or a protected polyphenol oligomer having 2-17 monomeric units. Advantageously, polyphenol monomeric units forming the polyphenol oligomers may be the same or different flavanoid compounds.
摘要翻译：公开了用于生产具有多酚单体单元的多酚低聚物的方法，n为2-18的整数。该方法包括将被保护的酚羟基的被保护的多酚与C-4官能化的多酚单体的偶联。受保护的多酚可以是受保护的多酚单体或具有2-17单体单元的被保护的多酚低聚物。有利地，形成多酚低聚物的多酚单体单元可以是相同或不同的类黄酮化合物。

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