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1. 发明授权

US09797908B2 Unnatural reactive amino acid genetic code additions 有权
公开(公告)号：US09797908B2
公开(公告)日：2017-10-24
申请号：US14338113
申请日：2014-07-22
申请人： The Scripps Research Institute
发明人： Alexander Deiters , T. Ashton Cropp , Jason W. Chin , J. Christopher Anderson , Peter G. Schultz
IPC分类号： C12P21/00 , G01N33/58 , C07C227/22 , C07C229/36 , C07C269/06 , C07C311/41 , C07K1/107 , C07K1/13 , C07K14/00 , C09B11/08 , C09B57/00 , C12N9/00 , C12N15/67 , C12P17/04 , C12P21/02 , G01N33/532 , C07K16/18
CPC分类号： G01N33/583 , C07C227/22 , C07C229/36 , C07C269/06 , C07C311/41 , C07K1/1072 , C07K1/13 , C07K14/001 , C07K16/18 , C09B11/08 , C09B57/00 , C12N9/93 , C12N15/67 , C12N2510/02 , C12P17/04 , C12P21/02 , G01N33/532 , G01N33/582 , C07C271/22
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.

2. 发明申请

US20170121389A1 Aldehyde Tags, Uses Thereof in Site-Specific Protein Modification 审中-公开
公开(公告)号：US20170121389A1
公开(公告)日：2017-05-04
申请号：US15238158
申请日：2016-08-16
申请人： The Regents of the University of California
发明人： Isaac S. Carrico , Brian L. Carlson , Peng Wu , Carolyn Ruth Bertozzi
IPC分类号： C07K16/00 , A61K38/18 , A61K38/21 , A61K39/00 , A61K38/45 , A61K38/37
CPC分类号： C07K16/00 , A61K38/1825 , A61K38/215 , A61K38/37 , A61K38/45 , A61K39/00 , C07K1/006 , C07K1/1072 , C07K1/13 , C07K14/00 , C07K14/35 , C07K14/565 , C07K16/46 , C07K2317/24 , C07K2317/40 , C07K2317/52 , C07K2317/622 , C12N9/13 , C12N9/96 , C12P21/00 , C12P21/005 , C12Y208/02
摘要： The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.

3. 发明申请

US20170081360A1 Chemically Modifying Peptides 审中-公开
公开(公告)号：US20170081360A1
公开(公告)日：2017-03-23
申请号：US15312502
申请日：2015-05-28
申请人： The University of Durham
发明人： Steven Cobb , Christopher Coxon , Graham Sandford
IPC分类号： C07K1/107 , C07K1/113 , C07K1/02 , C07K1/08
CPC分类号： C07K1/1077 , C07K1/02 , C07K1/084 , C07K1/088 , C07K1/1072 , C07K1/113
摘要： A method for chemically modifying a peptide, derivative or analogue thereof is described. The method comprises contacting a peptide, derivative or analogue thereof with a fluoro-heteroaromatic compound to activate the peptide, derivative or analogue thereof. The activated peptide, derivative or analogue thereof is then contacted with a nucleophile or base to create a chemically modified peptide, derivative or analogue thereof.

4. 发明授权

US09447390B2 Aldehyde tags, uses thereof in site-specific protein modification 有权
公开(公告)号：US09447390B2
公开(公告)日：2016-09-20
申请号：US14464528
申请日：2014-08-20
申请人： The Regents of the University of California
发明人： Isaac S. Carrico , Brian L. Carlson , Peng Wu , Carolyn Bertozzi
IPC分类号： C12N9/10 , C07K1/00 , C07K1/13 , C07K1/107 , C07K14/00 , C07K16/46 , C12P21/00 , C07K14/35 , C07K14/565 , C07K16/00 , C12N9/96
CPC分类号： C07K16/00 , A61K38/1825 , A61K38/215 , A61K38/37 , A61K38/45 , A61K39/00 , C07K1/006 , C07K1/1072 , C07K1/13 , C07K14/00 , C07K14/35 , C07K14/565 , C07K16/46 , C07K2317/24 , C07K2317/40 , C07K2317/52 , C07K2317/622 , C12N9/13 , C12N9/96 , C12P21/00 , C12P21/005 , C12Y208/02
摘要： The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.

5. 发明申请

US20150376248A1 PHOTOACTIVE SILK PROTEIN AND FABRICATION OF SILK PROTEIN STRUCTURES USING PHOTOLITHOGRAPHY 有权
标题翻译：光学丝素蛋白和使用光刻技术制备丝素蛋白结构
公开(公告)号：US20150376248A1
公开(公告)日：2015-12-31
申请号：US14765016
申请日：2014-01-31
申请人： VIRGINIA COMMONWEALTH UNIVERSITY
发明人： Nicholas E. Kurland , Vamsi K. Yadavalli
IPC分类号： C07K14/435 , G03F7/20 , G03F7/26 , C07K1/107
CPC分类号： C07K14/43586 , C07K1/1072 , C07K1/1077 , G03F7/038 , G03F7/0388 , G03F7/20 , G03F7/26
摘要： A natural protein, specifically silk fibroin or sericin, is chemically modified such that it can be rendered photoactive, but which otherwise has similar structure and attributes as silk fibroin or sericin. This chemically modified silk conjugate can be patterned using radiant energy to produce patterned silk materials which may be used for a wide variety of applications such as making micro and nanoparticles of different shapes and functionalities for drug delivery, creating new forms of intricate 3D scaffolds for tissue engineering, and forming substrates for flexible bio-electronics.
摘要翻译：化学修饰天然蛋白质，特别是丝素蛋白或丝胶蛋白，使其能够呈现光活性，但其具有与丝素蛋白或丝胶蛋白相似的结构和属性。这种化学改性的丝绸缀合物可以使用辐射能图案化以产生图案化丝材料，其可用于各种应用，例如制备用于药物递送的不同形状和功能的微型和纳米颗粒，为组织创造复杂的3D支架的新形式工程和形成柔性生物电子基材。

6. 发明申请

US20140213758A1 VERSATILE NATIVE CHEMICAL LIGATION TECHNOLOGIES 有权
标题翻译：多功能化学化学技术
公开(公告)号：US20140213758A1
公开(公告)日：2014-07-31
申请号：US14211176
申请日：2014-03-14
申请人： Washington State University
发明人： Philip Garner
IPC分类号： C07K1/107 , C07H13/00
CPC分类号： C07K1/1077 , C07H13/04 , C07K1/107 , C07K1/1072 , C07K5/00 , C07K5/04 , C07K5/08 , C07K5/0802 , C07K5/0804 , C07K5/0808 , Y02P20/55
摘要： Novel methods of native chemical ligation are provided. The methods involve reacting a thioacid (e.g. a peptide thioacid) with an aziridinyl compound (e.g. an aziridinyl peptide) or glycosylamine under mild conditions without the use of protecting groups, and without requiring that a cysteine residue be present in the ligation product. Initial coupling of the thioacid and the aziridinyl compound yields a ligation product containing an aziridinyl ring. Optional subsequent opening of the aziridinyl ring (e.g. via a nucleophilic attack) produces a linearized and modified ligation product. Coupling of a peptide thioacid and glycosylamine yields a glycosylated peptide.
摘要翻译：提供了本土化学连接的新方法。所述方法包括在温和条件下使硫代酸（例如肽硫代酸）与氮丙啶基化合物（例如氮丙啶基肽）或糖胺反应而不使用保护基团，并且不要求连接产物中存在半胱氨酸残基。硫代酸和氮丙啶基化合物的初始偶联产生含有氮丙啶基环的连接产物。可选地随后打开氮丙啶基环（例如通过亲核攻击）产生线性化和修饰的连接产物。肽硫代酸和糖胺的偶联产生糖基化肽。

7. 发明申请

US20140051828A1 METHODS FOR PREPARING INTERNALLY CONSTRAINED PEPTIDES AND PEPTIDOMIMETICS 有权
标题翻译：用于制备内部受限制肽和细胞因子的方法
公开(公告)号：US20140051828A1
公开(公告)日：2014-02-20
申请号：US13868959
申请日：2013-04-23
申请人： New York University
发明人： Paramjit Arora , Ross Chapman
IPC分类号： C07K5/02
CPC分类号： C07K5/0215 , A61K38/00 , C07K1/1072 , C07K1/113 , C07K5/08 , C07K5/12 , C07K7/56
摘要： The present invention relates to a method for preparing a peptide having a stable, internally constrained alpha-helical, beta-sheet/beta-turn, 310-helical, or pi-helical region and a method of stabilizing an alpha-helical, beta-sheet/beta-turn, 310-helical, or pi-helical region within a peptide structure. The resulting peptides and methods of using them are also disclosed.
摘要翻译：本发明涉及一种制备具有稳定的内部约束的α-螺旋，β-折叠，310-螺旋或π-螺旋区域的肽的方法和一种稳定α-螺旋，β- 肽结构内的片/β-匝，310-螺旋或π-螺旋区域。还公开了所得肽及其使用方法。

8. 发明申请

US20120253012A1 METHOD FOR PREPARING LIPOPEPTIDE COMPOUND 有权
标题翻译：制备肝磷脂化合物的方法
公开(公告)号：US20120253012A1
公开(公告)日：2012-10-04
申请号：US13394243
申请日：2010-09-07
申请人： Nobuyuki Kakiuchi , Takeaki Shoji , Kazuki Hirasada , Keigo Matsumoto , Hiroki Yamaguchi
发明人： Nobuyuki Kakiuchi , Takeaki Shoji , Kazuki Hirasada , Keigo Matsumoto , Hiroki Yamaguchi
IPC分类号： C07K1/02
CPC分类号： A61K47/48046 , A61K38/05 , A61K47/543 , C07K1/026 , C07K1/107 , C07K1/1072 , C07K1/1075 , C07K5/06 , C07K5/06026 , C07K5/06043 , C07K5/06052
摘要： There is provided a practical method for preparing lipopeptide compounds, which method is capable of inexpensive mass production without requiring complicated operations. The lipopeptide compound of formula (3): is produced by reacting an ester compound of formula (1): with an α-amino acid compound of formula (2): in the presence of a base and within a solvent containing a nonpolar organic solvent.
摘要翻译：提供了一种制备脂肽化合物的实用方法，该方法能够廉价地批量生产而不需要复杂的操作。式（3）的脂肽化合物：通过使式（1）的酯化合物与式（2）的α-氨基酸化合物在碱的存在下和含有非极性有机溶剂的溶剂。

9. 发明授权

US08101375B2 Compositions and methods for detecting phosphomonoester 有权
标题翻译：用于检测磷酸单酯的组合物和方法
公开(公告)号：US08101375B2
公开(公告)日：2012-01-24
申请号：US12868524
申请日：2010-08-25
申请人： Igor Kozlov , Peter Melnyk , Chanfeng Zhao
发明人： Igor Kozlov , Peter Melnyk , Chanfeng Zhao
IPC分类号： C12Q1/48
CPC分类号： G01N33/5308 , C07K1/1072 , C07K1/13
摘要： The invention provides a method of modifying a phosphomonoester moiety of a target compound. The method can include the steps of (a) providing a target compound having an electrophilic moiety and a phosphomonoester moiety; (b) contacting the target compound with a first carbodiimide compound under conditions for preferential addition of the first carbodiimide compound to the electrophilic moiety over the phosphomonoester moiety, thereby forming an electrophile-protected target compound; and (c) contacting the electrophile-protected target compound with a second carbodiimide compound and a nucleophilic compound under conditions for addition of the nucleophilic compound to the phosphomonoester.
摘要翻译：本发明提供了修饰目标化合物的磷酸单酯部分的方法。该方法可以包括以下步骤：（a）提供具有亲电子部分和磷酸酯部分的目标化合物; （b）在优先将第一碳二亚胺化合物添加到磷酸单酯部分上的亲电子部分的条件下，使目标化合物与第一碳二亚胺化合物接触，由此形成亲电试剂保护的目标化合物; 和（c）在向磷酸单酯添加亲核性化合物的条件下，将亲电试剂保护的目标化合物与第二碳二亚胺化合物和亲核化合物接触。

10. 发明授权

US08071541B2 Methods for preparing internally constrained peptides and peptidomimetics 有权
标题翻译：内部约束肽和肽模拟物的制备方法
公开(公告)号：US08071541B2
公开(公告)日：2011-12-06
申请号：US12712089
申请日：2010-02-24
申请人： Paramjit Arora , Ross Chapman
发明人： Paramjit Arora , Ross Chapman
IPC分类号： A61K38/04
CPC分类号： C07K5/0215 , A61K38/00 , C07K1/1072 , C07K1/113 , C07K5/08 , C07K5/12 , C07K7/56
摘要： The present invention relates to a method for preparing a peptide having a stable, internally constrained alpha-helical, beta-sheet/beta-turn, 310-helical, or pi-helical region and a method of stabilizing an alpha-helical, beta-sheet/beta-turn, 310-helical, or pi-helical region within a peptide structure. The resulting peptides and methods of using them are also disclosed.
摘要翻译：本发明涉及一种制备具有稳定的内部约束的α-螺旋，β-折叠，310-螺旋或π-螺旋区域的肽的方法和一种稳定α-螺旋，β- 肽结构内的片/β-匝，310-螺旋或π-螺旋区域。还公开了所得肽及其使用方法。

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