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1. 发明授权

US07404948B2 Peptidic conjugates for alopecia prevention and treatment 有权
标题翻译：用于秃发预防和治疗的肽类共轭物
公开(公告)号：US07404948B2
公开(公告)日：2008-07-29
申请号：US10565009
申请日：2004-07-16
申请人： Anne-Marie Pinel , Michel Hocquaux
发明人： Anne-Marie Pinel , Michel Hocquaux
IPC分类号： A61K38/06 , A61K38/07 , A61K38/08 , A61K8/64
CPC分类号： C07K7/06 , A61K38/00 , C07K5/0815 , C07K5/1019 , C07K14/66
摘要： The invention relates to novel peptidic conjugates containing a Gly-His-Lys sequence and used for dermatology or cosmetology for stimulating hair growth or stopping hair fall.
摘要翻译：本发明涉及含有Gly-His-Lys序列并用于刺激毛发生长或阻止头发下垂的皮肤病学或美容学的新型肽缀合物。

2. 发明授权

US5593842A Method of measuring thymopoietin proteins in plasma and serum including acidification of the plasma and serum 失效
标题翻译：血浆和血清中胸腺生成素蛋白测定方法，包括血浆和血清的酸化
公开(公告)号：US5593842A
公开(公告)日：1997-01-14
申请号：US309419
申请日：1994-09-20
申请人： Gideon Goldstein , Michael D. Culler
发明人： Gideon Goldstein , Michael D. Culler
IPC分类号： C07K14/66 , G01N33/74 , G01N33/53 , G01N1/00 , G01N1/18
CPC分类号： C07K14/66 , G01N33/74 , Y10S435/962 , Y10S435/967 , Y10S435/975 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： Method for accurately measuring thymopoietin (TP) in human serum or plasma by dissociating TP from protein complexes, releasing bound TP in a unbound form, extracting TP, preparing it for assay, and measuring TP levels in a suitable assay.
摘要翻译：通过将TP从蛋白质复合物中解离出来，准确测定人血清或血浆中的胸腺生成素（TP）的方法，以未结合的形式释放结合的TP，提取TP，制备其用于测定，以及在合适的测定中测量TP水平。

3. 发明授权

US5457180A Methods for producing linear thiopeptides using an amino acid ortho amino thioanilide compound 失效
标题翻译：使用氨基酸邻氨基苯甲酰苯胺化合物生产线性硫代肽的方法
公开(公告)号：US5457180A
公开(公告)日：1995-10-10
申请号：US258402
申请日：1994-06-13
申请人： Boulos Zacharie
发明人： Boulos Zacharie
IPC分类号： A61K38/00 , C07D235/26 , C07D403/12 , C07K5/02 , C07K5/09 , C07K5/093 , C07K5/103 , C07K14/66 , H03M5/14 , C07K7/02 , C07K7/04 , C07K7/06 , C07K7/08 , C07K14/00
CPC分类号： C07D403/12 , C07D235/26 , C07K14/66 , C07K5/02 , C07K5/0815 , C07K5/0819 , C07K5/1013 , H03M5/145 , A61K38/00
摘要： The present invention provides methods for producing linear thiopeptides using an amino acid ortho amino thioanilide compound of formula (III) ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen or C.sub.1 -C.sub.4 branched or unbranched alkyl;R.sub.2 is selected from the group consisting of hydrogen, halo, amino, hydroxy, C.sub.1 -C.sub.4 branched or unbranched alkoxy, guanido, amido, acyl, carboxy, cyano, mercapto, nitro, azido, and C.sub.1 -C.sub.4 branched or unbranched alkyl optionally substituted by halo, amino, hydroxy, C.sub.1 -C.sub.4 branched or unbranched alkoxy, guanido, amido, acyl, carboxy, cyano, mercapto, nitro, azido;R.sub.3 is a decarboxylated amino acid residue or a decarboxylated amino acid chain comprising at least two amino acid residue.
摘要翻译：本发明提供使用式（III）的氨基酸邻氨基苯甲酰苯胺化合物（III）制备线性硫代肽的方法，其中R 1选自氢或C 1 -C 4支链或非支链烷基; R 2选自氢，卤素，氨基，羟基，C 1 -C 4支链或非支链烷氧基，胍基，酰氨基，酰基，羧基，氰基，巯基，硝基，叠氮基和任选取代的C 1 -C 4支链或非支链烷基氨基，羟基，C 1 -C 4支链或非支链烷氧基，胍基，酰氨基，酰基，羧基，氰基，巯基，硝基，叠氮基; R3是包含至少两个氨基酸残基的脱羧氨基酸残基或脱羧氨基酸链。

4. 发明授权

US4298523A Methods and compositions for preparation of H-ARG-X-Z-Y-TYR-R 失效
标题翻译：制备H-ARG-X-Z-Y-TYR-R的方法和组合物
公开(公告)号：US4298523A
公开(公告)日：1981-11-03
申请号：US160241
申请日：1980-06-17
申请人： George Heavner
发明人： George Heavner
IPC分类号： C07K5/10 , A61K38/00 , C07C20060101 , C07F9/24 , C07K20060101 , C07K1/02 , C07K1/06 , C07K5/02 , C07K5/04 , C07K5/06 , C07K5/072 , C07K5/093 , C07K7/02 , C07K7/06 , C07K14/66 , C07C103/52
CPC分类号： C07K5/0819 , C07K14/66 , C07K5/06026 , C07K5/06095 , C07K7/06 , A61K38/00 , Y02P20/55
摘要： Solution phase methods and compositions for preparing H-ARG-X-Z-Y-TYR-R wherein X is LYS and Y is VAL or X and Y are both SAR, Z is ASP or GLU, and R is NH.sub.2 or OH.
摘要翻译：制备H-ARG-X-Z-Y-TYR-R的溶液相方法和组合物，其中X为LYS，Y为VAL或X和Y均为SAR，Z为ASP或GLU，R为NH2或OH。

5. 发明申请

US20150044235A1 CARRIER IMMUNOGLOBULINS 有权
公开(公告)号：US20150044235A1
公开(公告)日：2015-02-12
申请号：US14285576
申请日：2014-05-22
申请人： Amgen Inc.
发明人： Kenneth W. WALKER , Yue-Sheng LI , Thomas Charles BOONE , George DOELLGAST (DECEASED) , HoSung MIN , Jane TALVENHEIMO , Taruna ARORA , Frederick W. JACOBSEN
IPC分类号： C07K16/44 , C07K14/575 , C07K14/605 , C07K16/24 , C07K14/435 , C07K16/18
CPC分类号： C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
摘要： Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.

6. 发明授权

US06372889B1 Soluble protein ZTMPO-1 失效
标题翻译：可溶性蛋白质ZTMPO-1
公开(公告)号：US06372889B1
公开(公告)日：2002-04-16
申请号：US09294531
申请日：1999-04-19
申请人： Paul O. Sheppard , Darrell C. Conklin , Theresa M. Farrah , Mark F. Maurer , Angelika Grossmann
发明人： Paul O. Sheppard , Darrell C. Conklin , Theresa M. Farrah , Mark F. Maurer , Angelika Grossmann
IPC分类号： C07K1447
CPC分类号： C07K14/47 , C07K14/66
摘要： The present invention relates to polynucleotide and polypeptide molecules for ZTMPO-1, a novel soluble protein with homology to emerin and the thymopoietins. The polypeptides, and polynucleotides encoding them are useful for modulating cellular proliferation and differentiation and may be used for diagnostic purposes. The present invention also includes antibodies to the ZTMPO-1 polypeptides.
摘要翻译：本发明涉及用于ZTMPO-1的多核苷酸和多肽分子，其与emerin和胸腺细胞生成素具有同源性的新型可溶性蛋白质。多肽和编码它们的多核苷酸可用于调节细胞增殖和分化，并可用于诊断目的。本发明还包括针对ZTMPO-1多肽的抗体。

7. 发明授权

US4356119A Therapeutically active polypeptides or acid addition salts and a process for producing such compounds 失效
标题翻译：治疗活性多肽或酸加成盐及其制备方法
公开(公告)号：US4356119A
公开(公告)日：1982-10-26
申请号：US78424
申请日：1979-09-24
申请人： Hans Kofod
发明人： Hans Kofod
IPC分类号： C07K7/06 , A61K38/00 , A61K38/04 , A61P3/08 , A61P3/10 , C07C231/00 , C07K1/113 , C07K5/093 , C07K5/097 , C07K5/103 , C07K5/113 , C07K7/14 , C07K14/645 , C07K14/66 , C07C103/52 , A61K37/00
CPC分类号： C07K5/0825 , C07K14/645 , C07K14/66 , C07K5/0819 , C07K5/1005 , C07K5/1021 , C07K7/14 , A61K38/00 , Y02P20/55
摘要： Polypeptide derivatives of the formula:a--x--b--y--cwherein x represents an acidic amino acid, preferably glu or asp,y represents a basic amino acid, preferably arg, lys or his,z represents hydrogen or a small protective group for the .alpha.-amino group in x,b represents a bond, a single amino acid or a peptide having up to 10 amino acids in the chain, andc represents --NR.sup.1 R.sup.2, wherein R.sup.1 and R.sup.2 are selected from the group consisting of hydrogen, C.sub.1 -C.sub.6 alkyl and C.sub.3 -C.sub.8 cycloalkyl, or R.sup.1 and R.sup.2 together with the attached nitrogen atom form a heterocyclic group optionally containing an additional hetero atom, orc represents --OR.sup.3, wherein R.sup.3 is selected from the group consisting of C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.8 cycloalkyl, benzyl, phenacyl, phthalimidomethyl, .beta.-methylthioethyl, 4-picolyl or substituted benzyl, orc is a single amino acid, except leu, or an amino acid derivative --z--d with the proviso that --z cannot be leu, and d may be --NR.sup.1 R.sup.2 or OR.sup.3, wherein R.sup.1, R.sup.2, and R.sup.3 are as defined above,or acid addition salts of such peptides, may be produced by peptide synthesis methods known per se.The polypeptides inhibit the glucose stimulated secretion of insulin from Langerhans's islets without affecting the secretion of glucagon, and potentiate the effect of insulin on the metabolism of glucose in isolated fat cells and in vivo potentiate the metabolism of glucose.
摘要翻译：下式的多肽衍生物：axbyc其中x表示酸性氨基酸，优选glu或asp，y表示碱性氨基酸，优选arg，lys或his，z表示氢或x中的α-氨基的小保护基，b表示键，单个氨基酸或链中具有至多10个氨基酸的肽，c表示-NR1R2，其中R1和R2选自氢，C1-C6烷基和C3-C8 环烷基或R 1和R 2与连接的氮原子一起形成任选地含有另外的杂原子的杂环基，或c表示-OR 3，其中R 3选自C 1 -C 6烷基，C 3 -C 8环烷基，苄基，苯甲酰甲基，邻苯二甲酰亚氨基甲基，β-甲硫基乙基，4-吡啶甲基或取代的苄基，或c是除leu之外的单个氨基酸，或氨基酸衍生物，其条件是-z不能为leu，d可为-NR1R2或 OR3，其中R1，R2和R3如上定义，o 这种肽的R酸加成盐可以通过本身已知的肽合成方法产生。多肽抑制葡萄糖刺激的胰岛素从朗格汉斯岛分泌而不影响胰高血糖素的分泌，并且增强胰岛素对分离的脂肪细胞中葡萄糖代谢的作用并且体内增强葡萄糖的代谢。

8. 发明授权

US4190646A Polypeptide compositions and methods 失效
标题翻译：多肽组合物和方法
公开(公告)号：US4190646A
公开(公告)日：1980-02-26
申请号：US6893
申请日：1979-01-26
申请人： Gideon Goldstein , David H. Schlesinger
发明人： Gideon Goldstein , David H. Schlesinger
IPC分类号： A61K38/00 , C07K5/11 , C07K14/66 , A61K37/00 , C07C103/52 , C08L37/00
CPC分类号： C07K14/66 , C07K5/1019 , A61K38/00 , Y10S930/18
摘要： There are disclosed polypeptide compositions having the following amino acid sequence as the active site:ARG-LYS-ASP-VAL-TYRThese polypeptides have the capability of inducing the differentiation of T-lymphocytes but not of complement receptor (CR.sup.+) B-lymphocytes and thus are useful in a number of therapeutic areas. Also provided are derivatives of the pentapeptide, novel intermediate polypeptides, methods of manufacture of the peptides, therapeutic compositions, and methods for use of the compositions.
摘要翻译：公开了具有以下氨基酸序列作为活性位点的多肽组合物：ARG-LYS-ASP-VAL-TYR这些多肽具有诱导T淋巴细胞分化而不是补体受体（CR +）B淋巴细胞分化的能力，因此在许多治疗领域中是有用的。还提供了五肽的衍生物，新的中间体多肽，肽的制备方法，治疗组合物和使用该组合物的方法。

9. 发明授权

US4002740A Tridecapeptide compositions and methods 失效
标题翻译：十三肽组合物和方法
公开(公告)号：US4002740A
公开(公告)日：1977-01-11
申请号：US606654
申请日：1975-08-21
申请人： Gideon Goldstein , David H. Schlesinger
发明人： Gideon Goldstein , David H. Schlesinger
IPC分类号： A61K38/00 , C07K14/66 , A61K37/00 , C07C103/52
CPC分类号： C07K14/66 , A61K38/00 , Y10S930/18 , Y10S930/28
摘要： There is disclosed a tridecapeptide of the following sequence:H.sub.2 N--Gly--Glu--Gln--Arg--Lys--Asp--Val--Tyr--Val--Gln--Leu--Tyr--Leu--COOHthis tridecapeptide has the capability of including the differentiation of T lymphocytes but not of complement receptor (CR.sup.+) B lymphocytes and thus is useful in a number of therapeutic areas. Also provided are novel intermediate polypeptides and methods of manufacture of the peptides.
摘要翻译：公开了以下序列的十三肽：

10. 发明申请

US20170190793A1 CARRIER IMMUNOGLOBULINS 审中-公开
公开(公告)号：US20170190793A1
公开(公告)日：2017-07-06
申请号：US15405233
申请日：2017-01-12
申请人： AMGEN INC.
发明人： Kenneth W. WALKER , Yue-Sheng LI , Thomas Charles BOONE , George DOELLGAST (DECEASED) , HoSung MIN , Jane TALVENHEIMO , Taruna ARORA , Frederick W. JACOBSEN
IPC分类号： C07K16/44 , C07K14/66 , C07K14/605
CPC分类号： C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
摘要： Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.

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