专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20170037184A1 VITAMIN E-BASED NANOCARRIERS FOR DRUG DELIVERY AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：用于药物输送的维生素E基纳米颗粒及其制备和使用方法
公开(公告)号：US20170037184A1
公开(公告)日：2017-02-09
申请号：US15304626
申请日：2015-04-17
申请人： THE CORPORATION OF MERCER UNIVERSITY
发明人： Chalet Tan , Wei Fan
IPC分类号： C08G65/331 , A61K31/337 , A61K9/00 , A61K31/727 , A61K9/107 , C08G65/333 , C12N15/113 , A61K31/713 , C08G65/334 , A61K47/34
CPC分类号： C08G65/3318 , A61K9/0019 , A61K9/10 , A61K9/1075 , A61K31/337 , A61K31/713 , A61K31/727 , A61K47/10 , A61K47/22 , A61K47/34 , C08G65/3322 , C08G65/33306 , C08G65/334 , C08G2650/04 , C08G2650/20 , C08G2650/38 , C12N15/113 , C12N2310/141 , C12N2320/31 , C12N2320/32
摘要： Vitamin E-based amphiphilic copolymers are disclosed. Compositions containing vitamin E-based amphiphilic copolymers and/or nanocarriers are also disclosed. Methods of making vitamin E-based amphiphilic copolymers and/or nanocarriers and methods of using vitamin E-based amphiphilic copolymers and/or nanocarriers are also disclosed.
摘要翻译：公开了维生素E型两亲性共聚物。还公开了含有维生素E基两亲共聚物和/或纳米载体的组合物。还公开了制备维生素E基两亲共聚物和/或纳米载体的方法和使用维生素E基两亲共聚物和/或纳米载体的方法。

2. 发明授权

US07625898B2 Posaconazole polymer conjugates and methods of treatment using posaconazole and polymer conjugates thereof 失效
标题翻译：泊沙康唑聚合物缀合物和使用泊沙康唑及其聚合物共轭物的治疗方法
公开(公告)号：US07625898B2
公开(公告)日：2009-12-01
申请号：US12014391
申请日：2008-01-15
申请人： Hong Zhao
发明人： Hong Zhao
IPC分类号： A01N43/58
CPC分类号： A61K31/496 , A61K31/74 , A61K47/60 , C08G65/331 , C08G65/3318 , C08G65/3326 , C08G65/33317 , C08G65/33396 , C08L2203/02
摘要： Improved posaconazole-based compositions and methods of treating and preventing fungal infections, cancer or metastatic diseases are disclosed. In preferred aspects, the conjugates are PEG-posaconazole conjugates in which the PEG has a molecular weight of about 20,000 daltons.
摘要翻译：公开了基于泊沙康唑的组合物的改进和治疗和预防真菌感染，癌症或转移性疾病的方法。在优选的方面，缀合物是PEG-泊沙康唑缀合物，其中PEG具有约20,000道尔顿的分子量。

3. 发明申请

US20170152456A1 FLUOROPOLYETHER COMPOUND, LUBRICANT, AND MAGNETIC DISK 审中-公开
公开(公告)号：US20170152456A1
公开(公告)日：2017-06-01
申请号：US15318511
申请日：2015-06-22
申请人： MORESCO CORPORATION
发明人： Ryosuke SAGATA , Haruo KASAI
IPC分类号： C10M105/54 , C08G65/331 , G11B5/725 , C10M107/38
CPC分类号： C10M105/54 , C07C43/137 , C07C43/315 , C08G65/007 , C08G65/3318 , C08G65/337 , C10M107/38 , C10M147/04 , C10M2213/04 , C10M2213/043 , C10M2213/06 , C10M2213/0606 , C10N2230/10 , C10N2230/56 , C10N2240/204 , G11B5/725 , G11B5/82
摘要： The disclosure provides a fluoropolyether compound represented by formula (1): R1—CH2—R2—CH2—R3 wherein R1 is C1-C10 alkoxy; R2 is —(CF2)pO(CF2O)x(CF2CF2O)y(CF2CF2CF2O)z(CF2CF2CF2CF2O)w(CF2)p—; x and y are each a real number of 0 to 30; z is a real number of 0 to 30; w is a real number of 0 to 20; p is an integer of 1 to 3; R3 is —OCH2CH(OH)CH2OH, —OCH2CH(OH)CH2OCH2CH(OH)CH2OH, —O(CH2)mOH, or —OCH2(OH)CHCH2—OC6H4—R4; m is an integer of 2 to 8; and R4 is hydrogen, C1-C4 alkoxy, amino, or an amide residue; and also provides a lubricant having the compound and a magnetic disk.

4. 发明授权

US09637592B2 Vitamin functionalized gel-forming block copolymers for biomedical applications 有权
公开(公告)号：US09637592B2
公开(公告)日：2017-05-02
申请号：US15343537
申请日：2016-11-04
申请人： International Business Machines Corporation , Agency For Science, Technology and Research
发明人： James L. Hedrick , Ashlynn L. Z. Lee , Victor W. L. Ng , Yi Yan Yang
IPC分类号： A61K47/34 , C08G64/18 , A61K47/48
CPC分类号： C08G64/183 , A61K9/0024 , A61K9/06 , A61K31/355 , A61K31/592 , A61K31/593 , A61K47/34 , A61K47/551 , A61K47/60 , A61K2039/505 , A61K2039/54 , A61P35/00 , C07K16/32 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C08G65/3318 , C08G2210/00 , Y02A50/473
摘要： Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound.

5. 发明授权

US08492503B2 Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method 有权
标题翻译：聚合α-羟基醛和酮试剂及共轭法
公开(公告)号：US08492503B2
公开(公告)日：2013-07-23
申请号：US13063720
申请日：2009-09-11
申请人： Sean M. Culbertson , Xiaoming Shen , Antoni Kozlowski , Samuel P. McManus
发明人： Sean M. Culbertson , Xiaoming Shen , Antoni Kozlowski , Samuel P. McManus
IPC分类号： C08G12/04
CPC分类号： C08G65/2606 , A61K38/00 , A61K47/60 , C07K1/003 , C07K17/08 , C08G65/26 , C08G65/2609 , C08G65/331 , C08G65/3315 , C08G65/3318 , C08G65/3326 , C08G65/33306 , C08G65/33313 , C08G65/33317 , C08G65/33327 , C08L71/02
摘要： Provided herein are polymeric α-hydroxy aldehyde or α-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the α-carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol.
摘要翻译：本文提供的是聚合的α-羟基醛或α-羟基酮试剂，其可以与含胺化合物缀合以在单步反应中形成稳定的共轭物。在选择的实施方案中，聚合物试剂本身包含内部质子抽提（碱性）官能团，以促进更有效的反应。如果需要，取代基通过接头适当地定位，以使基团定位用于质子抽取，优选在抽提原子和α-碳上的氢原子之间提供4或5键间距。还提供了使用试剂和试剂的稳定的，溶解的缀合物与生物活性化合物的方法。在优选的实施方案中，试剂或缀合物的聚合物组分是聚乙二醇。

6. 发明授权

US07534750B2 Composition, magnetic recording medium, head slider, and magnetic recording device 有权
标题翻译：组合物，磁记录介质，磁头滑块和磁记录装置
公开(公告)号：US07534750B2
公开(公告)日：2009-05-19
申请号：US11063737
申请日：2005-02-24
申请人： Hiroshi Chiba , Yukiko Oshikubo , Keiji Watanabe , Eishin Yamakawa , Takeshi Toukairin
发明人： Hiroshi Chiba , Yukiko Oshikubo , Keiji Watanabe , Eishin Yamakawa , Takeshi Toukairin
IPC分类号： C10M169/04
CPC分类号： C08G65/007 , C08G65/2639 , C08G65/3318 , C09J171/02 , G11B5/725
摘要： There are provided a composition that exhibits sufficient flowability and also displays high substrate adhesion, and a magnetic recording medium, a head slider and a magnetic recording device that use this composition as a lubricant and are thus not prone to faults. The composition comprises a fluorine-containing polyether represented by formula (1), (in formula (1), p and q represent, independently of the symbols in other formulae, any chosen integers). The composition can be produced by reacting a polymer represented by formula (2) with glycidol, HOCH2CF2O(CF2CF2O)p(CF2O)qCF2CH2OH (2) (in formula (2), p and q represent, independently of the symbols in other formulae, any chosen integers).
摘要翻译：提供了表现出足够的流动性并且还显示出高的基材粘附性的组合物，以及使用该组合物作为润滑剂并因此不易发生故障的磁记录介质，磁头滑块和磁记录装置。该组合物包含由式（1）表示的含氟聚醚，（式（1）中，p和q独立于其它式中的符号表示任意选定的整数）。该组合物可以通过使由式（2）表示的聚合物与缩水甘油反应来制备，<？in-line-formula description =“In-line Formulas”end =“lead”？> HOCH2CF2O（CF2CF2O）p（CF2O）qCF2CH2OH （在公式（2）中，p和q独立于其他公式中的符号，表示任何所选择的整数）。

7. 发明申请

US20080171013A1 POSACONAZOLE POLYMER CONJUGATES AND METHODS OF TREATMENT USING POSACONAZOLE AND POLYMER CONJUGATES THEREOF 失效
标题翻译：噻唑并噻唑聚合物联合方法及其用途及其聚合物联合治疗方法
公开(公告)号：US20080171013A1
公开(公告)日：2008-07-17
申请号：US12014391
申请日：2008-01-15
申请人： Hong Zhao
发明人： Hong Zhao
IPC分类号： A61K31/74 , A61K31/496 , C08G65/333
CPC分类号： A61K31/496 , A61K31/74 , A61K47/60 , C08G65/331 , C08G65/3318 , C08G65/3326 , C08G65/33317 , C08G65/33396 , C08L2203/02
摘要： Improved posaconazole-based compositions and methods of treating and preventing fungal infections, cancer or metastatic diseases are disclosed. In preferred aspects, the conjugates are PEG-posaconazole conjugates in which the PEG has a molecular weight of about 20,000 daltons.
摘要翻译：公开了基于泊沙康唑的组合物的改进和治疗和预防真菌感染，癌症或转移性疾病的方法。在优选的方面，缀合物是PEG-泊沙康唑缀合物，其中PEG具有约20,000道尔顿的分子量。

8. 发明授权

US07097789B2 Thermoplastic containers exhibiting excellent protection to various ultraviolet susceptible compounds 有权
公开(公告)号：US07097789B2
公开(公告)日：2006-08-29
申请号：US10278664
申请日：2002-10-23
申请人： Daniel M. Connor , Sean M. Bernhardt
发明人： Daniel M. Connor , Sean M. Bernhardt
IPC分类号： F21V9/04 , C08K5/06
CPC分类号： G02B5/208 , C08G65/2612 , C08G65/3318 , C08G65/33368 , C08K5/005
摘要： Novel thermoplastic articles that contain novel ultraviolet absorbing compounds that are liquid in nature, are extremely low in color (and thus permit use without the concomitant necessity of adding large amounts of other coloring agents to combat any discoloring within clear, colorless applications), are substantially non-migratory from target resins, and are highly effective in providing protection in wavelength ranges for which previous attempts at low-color ultraviolet absorbers have failed are provided. In effect, the inventive thermoplastic articles, provide excellent protection for certain vitamins, flavorings, and colorants, for example, from ultraviolet degradation, particularly above the 370 nm wavelength that is typically the high end of protection for clear thermoplastics having low migratory, colorless UV absorbers therein.

9. 发明申请

US20030155559A1 Thermoplastic containers exhibiting excellent protection to various ultraviolet susceptible compounds 有权
标题翻译：对各种紫外线敏感化合物表现出优异保护的热塑性容器
公开(公告)号：US20030155559A1
公开(公告)日：2003-08-21
申请号：US10278664
申请日：2002-10-23
发明人： Daniel M. Connor , Sean M. Bernhardt
IPC分类号： G02B005/22
CPC分类号： G02B5/208 , C08G65/2612 , C08G65/3318 , C08G65/33368 , C08K5/005
摘要： Novel thermoplastic articles that contain novel ultraviolet absorbing compounds that are liquid in nature, are extremely low in color (and thus permit use without the concomitant necessity of adding large amounts of other coloring agents to combat any discoloring within clear, colorless applications), are substantially non-migratory from target resins, and are highly effective in providing protection in wavelength ranges for which previous attempts at low-color ultraviolet absorbers have failed are provided. In effect, the inventive thermoplastic articles, provide excellent protection for certain vitamins, flavorings, and colorants, for example, from ultraviolet degradation, particularly above the 370 nm wavelength that is typically the high end of protection for clear thermoplastics having low migratory, colorless UV absorbers therein.
摘要翻译：包含本质上是液体的新型紫外线吸收化合物的新型热塑性制品基本上是非常低的颜色（并且因此允许使用而不需要加入大量其它着色剂来抵抗透明，无色应用中的任何褪色）提供了目标树脂非迁移性，并且在提供以前在低色紫外线吸收剂的尝试失败的波长范围内提供保护方面是非常有效的。实际上，本发明的热塑性制品为某些维生素，调味剂和着色剂提供了极好的保护，例如，紫外线降解，特别是在370nm波长以上，通常对具有低迁移性，无色紫外线的透明热塑性塑料的高端保护其中的吸收剂。

10. 发明授权

US5383942A Fuel composition 失效
标题翻译：燃油组成
公开(公告)号：US5383942A
公开(公告)日：1995-01-24
申请号：US79571
申请日：1993-06-22
申请人： Wei-Yang Su , Sheldon Herbstman , Joseph M. Russo , Robert L. Zimmerman , Michael Cuscurida
发明人： Wei-Yang Su , Sheldon Herbstman , Joseph M. Russo , Robert L. Zimmerman , Michael Cuscurida
IPC分类号： C07C231/10 , C07C237/08 , C07D265/32 , C08G65/331 , C08G65/333 , C10L1/22 , C10L1/222 , C10L1/224 , C10L1/233 , C10L1/10
CPC分类号： C10L1/2225 , C07D265/32 , C08G65/3318 , C08G65/33317 , C10L1/221 , C10L1/2335
摘要： An amido alkanolamine composition obtained by reacting, at a temperature of 10.degree. C.-200.degree. C.:(a) a 4-alkyl-2-morpholinone represented by the formula: ##STR1## in which R represents a monovalent aliphatic radical having from 1 to 10 carbon atoms; and(b) a hydrocarbyl oxypolyoxyalkylene amine represented by the formula ##STR2## in which R' represents an alkyl, an alicyclic or an alkyl-alicyclic radical having from 12 to 30 carbon atoms or ##STR3## wherein R" represents a hydrocarbyl radical having from 4 to 30 carbon atoms, x has a value of from about 5 to 50, and R'" is an ethyl radical or a mixture of methyl and ethyl radicals.
摘要翻译：通过在10℃-200℃的温度下反应获得的酰胺链烷醇胺组合物：（a）由下式表示的4-烷基-2-吗啉酮：其中R表示具有 1至10个碳原子; 和（b）由式“IMAGE”表示的烃基氧基聚氧化烯胺，其中R'表示烷基，具有12至30个碳原子的脂环族或烷基脂环族基团或其中R“表示烃基具有4至30个碳原子，x具有约5至50的值，R“'是乙基或甲基和乙基的混合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式