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1. 发明申请

US20180328822A1 PREPARATION OF BIOLOGICAL CELLS ON MASS SPECTROMETRIC SAMPLE SUPPORTS FOR DESORBING IONIZATION 审中-公开
公开(公告)号：US20180328822A1
公开(公告)日：2018-11-15
申请号：US15968428
申请日：2018-05-01
申请人： Bruker Daltonik GmbH
发明人： Katrin SPARBIER , Beatrix WEGEMANN
IPC分类号： G01N1/40 , C12Q1/18 , G01N33/68
CPC分类号： G01N1/4044 , C12Q1/045 , C12Q1/18 , G01N1/28 , G01N1/4055 , G01N33/6851
摘要： The invention relates to the preparation of biological cells for the mass spectrometric analysis of cellular properties such as taxonomic classification, antibiotic resistances, response to drugs or other active substances, and others. The cells can be prokaryotic or eukaryotic microorganisms which have particularly been cultivated directly on a mass spectrometric sample support, or eukaryotic cells from tissues or cell cultures. The invention proposes that the cells are not disrupted by adding matrix solution for a subsequent ionization by matrix-assisted laser desorption (MALDI), but that they are disrupted in a separate treatment step using acids and/or solvents on the sample support itself. Surprisingly, the cell proteins released then adhere to the sample support so that they can be carefully washed with buffer solution to remove salts and other soluble impurities which can stem from earlier treatment steps, for example from nutrient solution.

2. 发明申请

US20180275029A1 METHOD FOR CONCENTRATING EXTRACELLULAR VESICLES 审中-公开
公开(公告)号：US20180275029A1
公开(公告)日：2018-09-27
申请号：US15935445
申请日：2018-03-26
申请人： SYSMEX CORPORATION
发明人： Koya YAMAWAKI , Yuki AIHARA
IPC分类号： G01N1/40 , G01N33/543
CPC分类号： G01N1/4055 , G01N1/4077 , G01N33/5432
摘要： Disclosed is a method for concentrating extracellular vesicles, comprising preparing a mixture comprising a first fraction and a second fraction by mixing a liquid sample comprising extracellular vesicles, a polysaccharide, and a polyether having an average molecular weight of 20,000 or less, wherein the first fraction comprises a higher concentration of extracellular vesicles than the second fraction, and the first fraction comprises a higher concentration of extracellular vesicles than the liquid sample.

3. 发明申请

US20180120335A1 DIGITAL MICROFLUIDIC LIQUID-LIQUID EXTRACTION DEVICE AND METHOD OF USE THEREOF 审中-公开
公开(公告)号：US20180120335A1
公开(公告)日：2018-05-03
申请号：US15853515
申请日：2017-12-22
申请人： Noha Ahmed MOUSA , Mais J. JEBRAIL , Mohamed Omar ABDELGAWAD , Aaron R. WHEELER , Robert Fredric Joseph CASPER
发明人： Noha Ahmed MOUSA , Mais J. JEBRAIL , Mohamed Omar ABDELGAWAD , Aaron R. WHEELER , Robert Fredric Joseph CASPER
IPC分类号： G01N33/74 , G01N1/40 , B01L3/00
CPC分类号： G01N33/74 , B01L3/502761 , B01L3/502784 , B01L2300/087 , B01L2300/089 , B01L2400/0415 , G01N1/4055 , G01N2001/4061
摘要： Methods and devices for liquid-liquid extraction using digital microfluidic arrays are provided. A polar droplet is transported to a separation region containing a substantially non-polar solvent, where non-polar impurities may be extracted from the polar droplet while maintaining a distinct phase separation. In a preferred embodiment, biological samples containing hormones are dried on a digital microfluidic array, lysed by a lysing solvent, dried, subsequently dissolved in a polar solvent, and further purified in a separation step in which droplets are transported through a volume of non-polar solvent. The method disclosed herein provides the distinct advantage of an automated sample preparation method that is capable of extracting hormones from low sample volumes with high precision and recovery.

4. 发明申请

US20180033600A1 DEVICE AND METHOD FOR ANALYSIS OF BIOFLUIDS BY ION GENERATION USING WETTED POROUS MATERIAL 审中-公开
公开(公告)号：US20180033600A1
公开(公告)日：2018-02-01
申请号：US15549948
申请日：2016-02-10
申请人： Indiana University Research and Technology Corporation
发明人： Nicholas MANICKE , Chengsen ZHANG
IPC分类号： H01J49/04 , G01N27/62 , G01N1/40 , H01J49/00 , G01N30/95
CPC分类号： H01J49/0413 , G01N1/405 , G01N1/4055 , G01N27/622 , G01N30/72 , G01N30/95 , G01N2001/4061 , G01N2030/009 , H01J49/0031 , H01J49/0431 , H01J49/168
摘要： The present disclosure provides a mass spectrometry cartridge and methods of use thereof.

5. 发明授权

US09816973B2 Industrial process stream compositional headspace analysis 有权
公开(公告)号：US09816973B2
公开(公告)日：2017-11-14
申请号：US14592656
申请日：2015-01-08
申请人： Nathaniel J. Peterson , Yoav Barshad
发明人： Nathaniel J. Peterson , Yoav Barshad
IPC分类号： G01N30/74 , G01N33/00 , G01N1/40 , G01N21/85 , G01N30/12 , G01N21/64
CPC分类号： G01N33/0004 , G01N1/405 , G01N1/4055 , G01N21/85 , G01N30/12 , G01N2001/4066 , G01N2021/6417 , G01N2021/8578
摘要： A system and method for compositional analysis of a process stream in an industrial process transports a liquid process stream through an absorption/desorption packed column (A/D column), along with a carrier gas. A gas phase combination of the carrier gas and one or more solutes from the liquid process stream is passed out of the A/D column to a flow cell for analysis by an analyzer to determine presence and concentration of the one or more solutes within the gas phase. A processor uses the concentration of the solutes within the gas phase to perform a headspace analysis to determine the concentration of the solutes in the process stream.

6. 发明申请

US20170248500A1 DETERMINATION OF ANALYTES IN A SAMPLE MATRIX BY SOLVENT EXTRACTION 审中-公开
公开(公告)号：US20170248500A1
公开(公告)日：2017-08-31
申请号：US15515794
申请日：2014-10-20
申请人： FOSS ANALYTICAL A/S
发明人： Claus HOLM , Malin DAHL , Christer Zoffman BISGAARD
IPC分类号： G01N1/40 , G01N1/34 , G01N30/60 , B01D11/02
CPC分类号： G01N1/40 , A23L5/23 , B01D11/02 , B01D11/0203 , G01N1/34 , G01N1/4055 , G01N15/1012 , G01N15/1459 , G01N30/60 , G01N33/543 , G01N33/569 , G01N2001/2893 , G01N2001/4061 , G01N2015/1006 , G01N2015/1018 , G01N2030/009 , G01N2030/062
摘要： Determination of Analytes in a Sample Matrix by Solvent Extraction A method for the assay of one or more analytes in a sample matrix comprising the steps of: performing analyte extraction on the sample matrix, said analyte extraction comprising combining the sample matrix with a solvent for an extraction period which is less than that required for reaching equilibrium; and separating the analyte containing solvent from the sample matrix; next measuring a level of analyte present in the separated solvent; and then applying in a computer a calibration by which is established a mathematical relationship between levels of analyte extracted from each of a plurality of reference samples by means of the process employed above in the extraction for the sample matrix and a reference value of the levels of analyte for each reference sample to thereby derive a measure of the level of analyte in the sample matrix. Specifically a method to determine the amount of mycotoxins in cereal grain, especially OTA (ochratoxin A) and DON (deoxynivalenol) by mixing with a solvent comprising water alcohol mixture, with 20-40% ethanol by volume.

7. 发明申请

US20160069854A1 Method for Recovering Metal and Kit for Recovery of Metal for Use in the Same 审中-公开
标题翻译：用于回收金属和试剂盒以回收金属的方法
公开(公告)号：US20160069854A1
公开(公告)日：2016-03-10
申请号：US14943432
申请日：2015-11-17
申请人： ARKRAY, Inc.
发明人： Yuka Shimomura
IPC分类号： G01N33/20 , G01N1/40
CPC分类号： G01N33/20 , G01N1/4044 , G01N1/4055 , G01N33/84 , G01N2001/4061
摘要： A method for recovering a metal, capable of recovering a metal easily without requiring the use of an organic medium, is provided. A first complex between a first chelating agent and a metal present in a sample is formed in a first mixture prepared by mixing the first chelating agent and the sample. Then, the first complex is recovered from the first mixture, and a second complex between the metal derived from the first complex and a second chelating agent is formed in a second mixture prepared by mixing the first complex and an aqueous solution of the second chelating agent. The aqueous solution is under the pH conditions where the first chelating agent can be insoluble in the aqueous solution. Then, a liquid fraction containing the second complex is recovered from the second mixture. Thus, the metal can be recovered.
摘要翻译：提供一种能够容易地回收金属而不需要使用有机介质的金属的回收方法。通过混合第一螯合剂和样品制备的第一混合物中形成第一螯合剂和样品中存在的金属之间的第一复合物。然后，从第一混合物回收第一配合物，并且通过将第一配合物和第二螯合剂的水溶液混合制备的第二混合物中形成来自第一配合物的金属和第二螯合剂之间的第二配合物。水溶液处于第一螯合剂可溶于水溶液的pH条件下。然后，从第二混合物中回收含有第二配合物的液体馏分。因此，可以回收金属。

8. 发明授权

US09250221B2 Standard sample and method of preparing same 有权
标题翻译：标准样品及其制备方法
公开(公告)号：US09250221B2
公开(公告)日：2016-02-02
申请号：US14172662
申请日：2014-02-04
申请人： KABUSHIKI KAISHA TOSHIBA
发明人： Shoko Ito
IPC分类号： G01N1/40 , G01N33/00
CPC分类号： G01N33/00 , G01N1/4055 , G01N1/4077 , G01N2001/4027
摘要： In one embodiment, a method of preparing a standard sample includes forming a second layer containing an analysis target element on a substrate via a first layer. The method further includes dissolving the first and second layers to form a plurality of droplets containing the analysis target element on the substrate. The method further includes drying the droplets to form a plurality of particles containing the analysis target element on the substrate.
摘要翻译：在一个实施方案中，制备标准样品的方法包括通过第一层在衬底上形成含有分析目标元素的第二层。该方法还包括溶解第一和第二层以在基底上形成含有分析目标元素的多个液滴。该方法还包括干燥液滴以在基底上形成含有分析目标元素的多个颗粒。

9. 发明授权

US09207152B2 Pretreatment apparatus and mass analyzing apparatus equipped with the same 有权
标题翻译：预处理装置和配备有其的质量分析装置
公开(公告)号：US09207152B2
公开(公告)日：2015-12-08
申请号：US13377154
申请日：2010-06-24
申请人： Makoto Nogami , Katsuhiro Kanda , Izumi Waki
发明人： Makoto Nogami , Katsuhiro Kanda , Izumi Waki
IPC分类号： G01N33/48 , G01N1/40 , G01N35/02 , G01N30/00 , H01J49/00
CPC分类号： G01N1/4055 , G01N35/025 , G01N2001/4061 , G01N2030/009 , H01J49/00
摘要： A biological sample preprocessing apparatus includes solid-phase extraction cartridges which purify/concentrate specific constituents of a biological sample, cartridge holders which hold one of the solid-phase extraction cartridges, a cartridge transport that carries the cartridge holders along a continuous track surface, a sample probe that discharges the biological sample into the solid-phase extraction cartridge held in the cartridge holders, a water-based solvent probe that discharges a water-based solvent into the solid-phase extraction cartridge held in the cartridge holder, an organic solvent probe that discharges an organic solvent into the solid-phase extraction cartridge held in the cartridge holder, a pressure loader that applies an air pressure load to the solid-phase extraction cartridge held in the cartridge holder, and a control unit that controls operation of the cartridge transport, the sample probe, the solvent probes, and the pressure loader, wherein sample addition and solvent addition alternate with pressure loading.
摘要翻译：生物样品预处理装置包括净化/浓缩生物样品的特定组分的固相萃取盒，固定一个固相萃取筒的盒保持器，沿连续轨迹表面承载盒保持器的盒输送器将生物样品排出到保持在盒保持器中的固相提取盒中的样品探针，将水性溶剂排放到保持在盒保持器中的固相萃取盒中的水性溶剂探针，有机溶剂探针将有机溶剂排放到保持在盒保持器中的固相提取盒中，对保持在盒保持器中的固相提取盒施加空气压力负荷的压力装载器和控制盒的操作的控制单元运输，样品探针，溶剂探针和压力装载机，其中样品添加溶剂添加与压力负荷交替。

10. 发明申请

US20150338323A1 PORTABLE SYSTEM FOR AUTOMATED PREPARATION OF LIQUID AND/OR SOLID SAMPLES 审中-公开
标题翻译：用于自动制备液体和/或固体样品的便携式系统
公开(公告)号：US20150338323A1
公开(公告)日：2015-11-26
申请号：US14720857
申请日：2015-05-25
申请人： CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Développement
发明人： Sarah Heub
IPC分类号： G01N1/40
CPC分类号： G01N1/405 , G01N1/4055 , G01N2001/4061
摘要： Portable automated sample preparation device comprising a housing, said housing containing: a collecting chamber for receiving a sample; at least one extraction device comprising an input in operative connection with an output of said collecting chamber, and comprising an output for outputting a concentrated sample; a solvent reservoir adapted to contain solvent, said solvent reservoir being in operative connection with the input of said extraction device; a source of pressurised gas or liquid in operative connection with the collecting chamber and with the solvent reservoir, and arranged to cause said sample and said solvent to pass through said extraction device; a controller adapted to control operation of the extraction device.
摘要翻译：便携式自动样品制备装置，包括壳体，所述壳体包含：用于接收样品的收集室; 至少一个提取装置，包括与所述收集室的输出端可操作连接的输入，并且包括用于输出浓缩样品的输出; 溶剂储存器，其适于容纳溶剂，所述溶剂储存器与所述提取装置的输入端可操作地连接; 与收集室和溶剂储存器可操作地连接的加压气体或液体源，并且布置成使所述样品和所述溶剂通过所述提取装置; 适于控制提取装置的操作的控制器。

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