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1. 发明授权

US09927417B2 High reflectivity integrating cavity and optical amplification device 有权
公开(公告)号：US09927417B2
公开(公告)日：2018-03-27
申请号：US15001238
申请日：2016-01-20
申请人： The Texas A&M University System
发明人： Vladislav Victorovich Yakovlev , Edward S. Fry , John David Mason , Joel Nathan Bixler , Michael Thomas Cone , Brett Harrison Hokr
IPC分类号： G01N21/25 , G01N33/18 , G01N21/64 , G01N21/39
CPC分类号： G01N33/1826 , G01N21/39 , G01N21/645 , G01N2021/6469 , G01N2201/065 , G01N2201/0697
摘要： Disclosed is a high reflectivity integrating cavity and device to amplify and detect luminescent emissions produced by small concentrations of materials to be analyzed. Femto or nano molar concentrations of a material can be placed within the high reflectivity integrating cavity. At least the interior surface of the high reflectivity integrating cavity can comprise a coating that, at a designated wavelength of electromagnetic radiation, is transparent and non-absorbing to such designated wavelengths of electromagnetic radiation. In addition to the isotropic field induced by the interior surface of the high reflectivity integrating cavity, the high reflectivity of the interior surface of the high reflectivity integrating cavity leads to very large effective optical path lengths within the interior of the high reflectivity integrating cavity, thereby amplifying the luminescent emissions produced by the sample.

2. 发明授权

US09835543B2 Particle detector 有权
公开(公告)号：US09835543B2
公开(公告)日：2017-12-05
申请号：US15047389
申请日：2016-02-18
申请人： Azbil Corporation
发明人： Masashi Furuya , Daisuke Obara
IPC分类号： G21K7/00 , G01N15/14 , G01N15/10 , G01N21/53 , G01N21/64
CPC分类号： G01N15/1436 , G01N15/1459 , G01N21/53 , G01N2015/1006 , G01N2021/6469
摘要： A particle detector that includes an inspection light source that irradiates a flow cell with inspection light, the flow cell that allows a fluid containing a particle to flow therethrough, the flow cell including a semispherical reflective film that reflects reaction light generated by the particle irradiated with the inspection light, and a semispherical lens portion through which the reaction light reflected by the semispherical reflective film passes, an elliptical mirror that has a first focus at a position of the flow cell, and that reflects the reaction light having passed through the semispherical lens portion of the flow cell, and an optical detector that is disposed at a second focus of the elliptical mirror and that detects the reaction light reflected by the elliptical mirror.

3. 发明授权

US09423339B2 Spectrum measuring device and spectrum measuring method 有权
标题翻译：光谱测量装置和光谱测量方法
公开(公告)号：US09423339B2
公开(公告)日：2016-08-23
申请号：US14764805
申请日：2013-09-17
申请人： HAMAMATSU PHOTONICS K.K.
发明人： Shigeru Eura , Kengo Suzuki , Kenichiro Ikemura , Kazuya Iguchi
IPC分类号： G01J1/04 , G01N21/31 , G01J3/44 , G01N21/64 , G01J3/02 , G01J3/42
CPC分类号： G01N21/31 , G01J3/0254 , G01J3/0291 , G01J3/42 , G01J3/4406 , G01N21/645 , G01N21/6489 , G01N2021/6469 , G01N2021/6482 , G01N2021/6491 , G01N2201/062 , G01N2201/065 , G01N2201/12
摘要： A spectral measurement apparatus includes a light source for generating a excitation light; an integrator having an input opening portion and an output opening portion; a housing portion arranged in the integrator and for housing a sample; an incidence optical system for making the excitation light incident to the sample; a photodetector for detecting a light to be measured output from the output opening portion; and an analysis means for calculating a light absorptance of the sample, based on a detection value detected by the photodetector, and an irradiation area with the excitation light at a position of incidence to the sample is set larger than an irradiated area of the sample, and the analysis means performs an area ratio correction regarding the irradiation area with the excitation light and the irradiated area of the sample, with respect to the light absorptance calculated.
摘要翻译：光谱测量装置包括用于产生激发光的光源; 积分器，具有输入开口部分和输出开口部分; 布置在所述积分器中并用于容纳样品的壳体部分; 用于使激发光入射到样品的入射光学系统; 用于检测从所述输出开口部分输出的待测光的光电检测器; 以及分析装置，用于基于由所述光电检测器检测的检测值来计算样品的光吸收率，并且将入射到所述样品的位置处的激发光的照射面积设定为大于所述样品的照射面积，并且分析装置相对于计算的光吸收率执行关于具有激发光的照射区域和样品的照射面积的面积比率校正。

4. 发明申请

US20160209388A1 HIGH REFLECTIVITY INTEGRATING CAVITY AND OPTICAL AMPLIFICATION DEVICE 有权
标题翻译：高反射性集成腔和光放大器件
公开(公告)号：US20160209388A1
公开(公告)日：2016-07-21
申请号：US15001238
申请日：2016-01-20
申请人： The Texas A&M University System
发明人： Vladislav Victorovich Yakovlev , Edward S. Fry , John David Mason , Joel Nathan Bixler , Michael Thomas Cone , Brett Harrison Hokr
IPC分类号： G01N33/18 , G01N21/64 , G01N21/65 , G01N21/47
CPC分类号： G01N33/1826 , G01N21/39 , G01N21/645 , G01N2021/6469 , G01N2201/065 , G01N2201/0697
摘要： Disclosed is a high reflectivity integrating cavity and device to amplify and detect luminescent emissions produced by small concentrations of materials to be analyzed. Femto or nano molar concentrations of a material can be placed within the high reflectivity integrating cavity. At least the interior surface of the high reflectivity integrating cavity can comprise a coating that, at a designated wavelength of electromagnetic radiation, is transparent and non-absorbing to such designated wavelengths of electromagnetic radiation. In addition to the isotropic field induced by the interior surface of the high reflectivity integrating cavity, the high reflectivity of the interior surface of the high reflectivity integrating cavity leads to very large effective optical path lengths within the interior of the high reflectivity integrating cavity, thereby amplifying the luminescent emissions produced by the sample.
摘要翻译：公开了集成腔和器件的高反射率，以放大和检测由待分析的小量材料产生的发光发射。毫微米或毫摩尔浓度的材料可以放置在高反射率积分腔内。至少高反射率积分腔的内表面可以包括在电磁辐射的指定波长处是透明的并且不吸收到这种指定波长的电磁辐射的涂层。除了由高反射率积分腔的内表面引起的各向同性场外，高反射率积分腔的内表面的高反射率导致在高反射率积分腔的内部内的非常大的有效光程长度，从而放大样品产生的发光发射。

5. 发明授权

US09063007B2 Bioanalytical instrumentation using a light source subsystem 有权
标题翻译：使用光源子系统的生物分析仪器
公开(公告)号：US09063007B2
公开(公告)日：2015-06-23
申请号：US12938224
申请日：2010-11-02
申请人： Claudia B. Jaffe , Steven M. Jaffe , Michieal L. Jones
发明人： Claudia B. Jaffe , Steven M. Jaffe , Michieal L. Jones
IPC分类号： G01J3/10 , G01N21/25 , G01N21/64 , G01N21/47 , G01N21/51 , G01N21/53
CPC分类号： G01J3/10 , G01N21/253 , G01N21/255 , G01N21/4788 , G01N21/51 , G01N21/53 , G01N21/6452 , G01N2021/6419 , G01N2021/6469 , G01N2021/6484 , G01N2201/06193
摘要： The invention relates to a light source for irradiating molecules present in a detection volume with one or more selected wavelengths of light and directing the fluorescence, absorbance, transmittance, scattering onto one or more detectors. Molecular interactions with the light allow for the identification and quantitation of participating chemical moieties in reactions utilizing physical or chemical tags, most typically fluorescent and chromophore labels. The invention can also use the light source to separately and simultaneously irradiate a plurality of capillaries or other flow confining structures with one or more selected wavelengths of light and separately and simultaneously detect fluorescence produced within the capillaries or other flow confining structures. In various embodiments, the flow confining structures can allow separation or transportation of molecules and include capillary, micro bore and milli bore flow systems. The capillaries are used to separate molecules that are chemically tagged with appropriate fluorescent or chromophore groups.
摘要翻译：本发明涉及用于用存在于检测体积中的分子照射一种或多种所选波长的光并将荧光，吸光度，透射率，散射引导到一个或多个检测器上的光源。与光的分子相互作用允许使用物理或化学标签（最常见的荧光和发色团标记）在反应中鉴定和定量参与的化学部分。本发明还可以使用光源单独地并且同时用一个或多个选择的波长的光照射多个毛细管或其它流动约束结构，并且分别并且同时检测在毛细管或其它流动限制结构内产生的荧光。在各种实施方案中，流动限制结构可以允许分子的分离或运输，并且包括毛细管，微孔和毫里流系统。毛细血管用于分离用适当荧光或发色团组化学标记的分子。

6. 发明授权

US08427641B2 Compact detector for simultaneous particle size and fluorescence detection 有权
标题翻译：紧凑型检测器可同时进行粒径和荧光检测
公开(公告)号：US08427641B2
公开(公告)日：2013-04-23
申请号：US12642705
申请日：2009-12-18
申请人： John Y. Babico , Chen Liang
发明人： John Y. Babico , Chen Liang
IPC分类号： G01N15/02
CPC分类号： G01J3/4406 , G01J3/02 , G01J3/0216 , G01J3/0229 , G01N15/1436 , G01N15/1459 , G01N21/53 , G01N21/645 , G01N21/6486 , G01N2015/0088 , G01N2015/1493 , G01N2021/6469
摘要： A particle detection and classification system is disclosed. The system determines the size of measured particles by measuring light scattered by the particles. The system simultaneously determines whether measured particles are biological or non-biological by measuring fluorescent light from the particles. The system uses a parabolic reflector, and optionally, a spherical reflector to collect fluorescence light.
摘要翻译：公开了一种粒子检测和分类系统。该系统通过测量由颗粒散射的光来确定测量的颗粒的尺寸。该系统通过测量来自颗粒的荧光来同时确定测量的颗粒是生物的还是非生物的。该系统使用抛物面反射器，并且可选地使用球形反射器来收集荧光。

7. 发明申请

US20120282639A1 LIGHT COLLECTION SYSTEM 审中-公开
标题翻译：光收藏系统
公开(公告)号：US20120282639A1
公开(公告)日：2012-11-08
申请号：US13491337
申请日：2012-06-07
申请人： Dar BAHATT , Konrad Faulstich
发明人： Dar BAHATT , Konrad Faulstich
IPC分类号： C12M1/34 , G01N21/76
CPC分类号： C12Q1/66 , G01N21/6428 , G01N21/645 , G01N21/66 , G01N21/763 , G01N33/581 , G01N2021/6439 , G01N2021/6469
摘要： The present teachings provide a detection cell for a biological material and methods for detecting biological material including a photosensitive material optically coupled to an interior volume containing the biological material so to avoid optical components or an external light source.
摘要翻译：本教导提供了用于生物材料的检测单元和用于检测生物材料的方法，所述生物材料包括与包含生物材料的内部空间光学耦合的感光材料，以避免光学部件或外部光源。

8. 发明申请

US20110195492A1 Optical Apparatus 有权
标题翻译：光学仪器
公开(公告)号：US20110195492A1
公开(公告)日：2011-08-11
申请号：US13086223
申请日：2011-04-13
申请人： Johnathan Sharpe , Peter Niven Schaare
发明人： Johnathan Sharpe , Peter Niven Schaare
IPC分类号： G01N21/49 , G01N33/48 , C12M1/34
CPC分类号： G01N15/1436 , G01N15/1434 , G01N15/1459 , G01N21/49 , G01N2015/1452 , G01N2015/149 , G01N2021/6469 , G02B5/04
摘要： An optical apparatus for illuminating particles and for detecting emissions from illuminated particles in a flow cytometer having an optical configuration aligned with a flow or particles.
摘要翻译：一种用于照射颗粒并用于检测具有与流体或颗粒对准的光学构型的流式细胞仪中的照射颗粒的排放物的光学装置。

9. 发明申请

US20100165341A1 Compact Detector For Simultaneous Particle Size And Fluorescence Detection 有权
标题翻译：用于同时粒径和荧光检测的紧凑型检测器
公开(公告)号：US20100165341A1
公开(公告)日：2010-07-01
申请号：US12642705
申请日：2009-12-18
申请人： John Y. Babico , Chen Liang
发明人： John Y. Babico , Chen Liang
IPC分类号： G01N15/02 , G01J1/58
CPC分类号： G01J3/4406 , G01J3/02 , G01J3/0216 , G01J3/0229 , G01N15/1436 , G01N15/1459 , G01N21/53 , G01N21/645 , G01N21/6486 , G01N2015/0088 , G01N2015/1493 , G01N2021/6469
摘要： A particle detection and classification system is disclosed. The system determines the size of measured particles by measuring light scattered by the particles. The system simultaneously determines whether measured particles are biological or non-biological by measuring fluorescent light from the particles. The system uses a parabolic reflector, and optionally, a spherical reflector to collect fluorescence light.
摘要翻译：公开了一种粒子检测和分类系统。该系统通过测量由颗粒散射的光来确定测量的颗粒的尺寸。该系统通过测量来自颗粒的荧光来同时确定测量的颗粒是生物的还是非生物的。该系统使用抛物面反射器，并且可选地使用球形反射器来收集荧光。

10. 发明申请

US20060160209A1 Systems and methods for measurement optimization 有权
标题翻译：用于测量优化的系统和方法
公开(公告)号：US20060160209A1
公开(公告)日：2006-07-20
申请号：US11250179
申请日：2005-10-13
申请人： Jonathan Larson , Gregory Yantz , George Seward , David Johnson , Jeffrey Krogmeier
发明人： Jonathan Larson , Gregory Yantz , George Seward , David Johnson , Jeffrey Krogmeier
IPC分类号： C12M1/34 , G01J3/00
CPC分类号： G01N21/6452 , B01L3/5025 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/087 , B01L2300/168 , B01L2400/0415 , B01L2400/0487 , G01N21/05 , G01N2021/0346 , G01N2021/058 , G01N2021/6463 , G01N2021/6469 , G01N2021/6478
摘要： The invention relates to methods and systems for detecting and or analyzing an agent in a sample with a chip having optical components incorporated therein.
摘要翻译：本发明涉及用于检测和/或分析具有并入其中的光学元件的芯片的样品中的试剂的方法和系统。

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