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1. 发明授权

US11946933B2 Biomarkers for early diagnosis and differentiation of mycobacterial infection 有权
公开(公告)号：US11946933B2
公开(公告)日：2024-04-02
申请号：US17170856
申请日：2021-02-08
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人： Adel M. Talaat
IPC分类号： G01N33/569 , C12Q1/689
CPC分类号： G01N33/5695 , C12Q1/689 , G01N33/56933 , C12Q2600/158 , G01N2333/30 , G01N2469/10 , G01N2469/20
摘要： Mycobacterial-specific biomarkers and methods of using such biomarkers for diagnosis of mycobacterial infection in a mammal are disclosed.

2. 发明公开

US20230176052A1 MYCOPLASMA PNEUMONIAE IMMUNOASSAY METHOD AND IMMUNOASSAY INSTRUMENT 审中-公开
公开(公告)号：US20230176052A1
公开(公告)日：2023-06-08
申请号：US17917622
申请日：2021-04-06
申请人： Denka Company Limited
发明人： Risa KOHIYAMA , Tomomi TAKANO , Takashi MIYAZAWA
IPC分类号： G01N33/569 , G01N33/543 , C07K16/12
CPC分类号： G01N33/56933 , C07K16/1253 , G01N33/54387 , G01N2333/30
摘要： An immunoassay utilizing a monoclonal antibody which specifically reacts with both of P1 protein and P30 protein of Mycoplasma pneumoniae, which monoclonal antibody has a higher affinity with P1 protein and P30 protein of Mycoplasma pneumoniae than the known monoclonal antibodies, is disclosed. The immunoassay utilizes an antigen-antibody reaction between a monoclonal antibody which specifically reacts with P1 protein and P30 protein of Mycoplasma pneumoniae and which specifically reacts with a peptide containing an amino acid sequence composed of PPQPG or antigen-binding fragment thereof, and P1 protein and P30 protein derived from Mycoplasma pneumoniae.

3. 发明授权

US09856505B2 Identification of mycoplasm contamination using Raman spectroscopy 有权
公开(公告)号：US09856505B2
公开(公告)日：2018-01-02
申请号：US15082330
申请日：2016-03-28
申请人： Battelle Memorial Institute
发明人： Andrew P. Bartko
IPC分类号： G01J3/44 , C12Q1/04 , G01N33/48 , A61B5/00 , G01N21/65 , G01N33/569 , G01N21/85
CPC分类号： C12Q1/04 , G01N21/65 , G01N21/85 , G01N33/56933 , G01N2333/30
摘要： A manufacturing method comprises collecting a sample from a cell culture used by a manufacturing application, and controlling a Raman spectrometer to collect a Raman spectrum of a targeted volume within the sample. The method further comprises obtaining reference spectra uniquely associated with a known cell line, which comprise at least two of: spectral measurements of mycoplasma by itself, a contaminated cell line, and a pure cell line. Moreover, the method comprises comparing the reference spectra to the collected spectrum, and identifying whether there is at least one unnatural molecular composition within the collected spectrum based upon the comparison of the reference spectra to the collected spectrum. An indication is provided as to whether mycoplasma is detected in the collected Raman spectrum where at least one unnatural molecular composition is identified within the collected spectrum, and the manufacturing application is stopped where mycoplasma is detected in the collected Raman spectrum.

4. 发明授权

US09834681B2 2,7-disubstituted cephalosporin derivatives as beta-lactamase substrates and methods for their use for the diagnosis of tuberculosis 有权
公开(公告)号：US09834681B2
公开(公告)日：2017-12-05
申请号：US14613214
申请日：2015-02-03
申请人： The Texas A&M University System , The Board of Trustees of the Leland Stanford Junior University
发明人： Jianghong Rao , Hexin Xie , Yunfeng Cheng , Jeffrey D. Cirillo
IPC分类号： C07D501/52 , C07D501/62 , C09B11/24 , C09B57/02 , C12Q1/04 , C12Q1/18 , C12Q1/34
CPC分类号： C09B11/24 , C07D501/52 , C07D501/62 , C09B57/02 , C12Q1/04 , C12Q1/18 , C12Q1/34 , G01N2333/30 , G01N2333/986 , G01N2800/12 , G01N2800/52
摘要： β-Lactamase substrates and methods for using the substrates to detect β-lactamase and to diagnose tuberculosis.

5. 发明申请

US20170146506A1 POTENCY TEST FOR VACCINE FORMULATIONS 审中-公开
公开(公告)号：US20170146506A1
公开(公告)日：2017-05-25
申请号：US15426206
申请日：2017-02-07
申请人： Intervet Inc.
发明人： Michelle Allen , Mark Garrett , Urs Peter Bruderer , Martinus Antonius Johannes Thijssen
IPC分类号： G01N33/15 , G01N33/569
CPC分类号： G01N33/15 , A61K39/12 , G01N33/5306 , G01N33/54306 , G01N33/56933 , G01N33/56983 , G01N2333/01 , G01N2333/30 , G01N2469/10 , G01N2500/04
摘要： The invention relates to certain methods for the determination of an antigen content of a first antigen in a mixture comprising two or more antigens. The invention also relates to a potency test for an antigen in a combination vaccine. The method allows the determination of the antigen content in a mixture additionally comprising antibodies that are capable of binding with the antigen.

6. 发明申请

US20160202257A1 MYCOPLASMA PNEUMONIAE IMMUNOLOGICAL DETECTION METHOD AND KIT 审中-公开
公开(公告)号：US20160202257A1
公开(公告)日：2016-07-14
申请号：US14913612
申请日：2014-08-22
申请人： BL CO., LTD.
发明人： Kenji SAITO
IPC分类号： G01N33/569 , C07K16/12
CPC分类号： C07K16/1253 , G01N33/558 , G01N33/56933 , G01N2333/30 , G01N2800/26
摘要： [Problem]An object of the present invention is to provide a detection marker that can simply and rapidly detect Mycoplasma pneumoniae, which is a pathogen of mycoplasma pneumonia, at a high sensitivity, a specific antibody against the marker, and also an immunological detection method and a kit containing the antibody.[Solution]Infection with Mycoplasma pneumoniae can be rapidly and specifically diagnosed by producing an antibody specifically reactive to P30 protein of Mycoplasma pneumoniae and performing an immunological assay using the P30 protein as a detection marker. The present invention enables easy and rapid detection of Mycoplasma pneumoniae and diagnosis of infection with the bacteria at a hospital or the like without need of specialized instruments or skilled techniques.
摘要翻译：发明内容本发明的目的在于提供一种检测标记，其能够以高灵敏度，针对标记物的特异性抗体简单快速地检测肺炎支原体（肺炎支原体），其为支原体肺炎病原体，以及免疫检测方法和含有抗体的试剂盒。 [解决方案]通过产生对肺炎支原体的P30蛋白特异性反应的抗体，并使用P30蛋白作为检测标记进行免疫测定，可以快速，特异性地诊断肺炎支原体感染。本发明能够容易且快速地检测肺炎支原体和在医院等处诊断细菌的感染，而无需专门的仪器或熟练的技术。

7. 发明申请

US20140363882A1 RAPID DETECTION OF ANALYTES IN LIQUID SAMPLES 有权
标题翻译：快速检测液体样品中的分析物
公开(公告)号：US20140363882A1
公开(公告)日：2014-12-11
申请号：US14274086
申请日：2014-05-09
申请人： Advanced Animal Diagnostics, Inc.
发明人： Reha O. Azizoglu , Stefano Bresolin , David A. Calderwood , Robert L. Cheek , Joy Parr Drach , John Groelke , Tobias M. Heineck , Mitchell Hockett , David Newcomb , Duane Olsen , Chris Paul , Jasper N. Pollard , Rodolfo R. Rodriguez , Demetris Young
IPC分类号： G01N33/543 , G02B21/26 , G01N33/569
CPC分类号： G01N33/54366 , G01N33/56911 , G01N33/56938 , G01N2333/30
摘要： A device for detecting at least one analyte in a liquid sample generally comprises (i) a support having a chamber for receiving a biological fluid (e.g., milk) therein, wherein said chamber is an elongate chamber having a length axis; (ii) a (stationary or movable) carrier (in some embodiments in the form of an end cap, or connected to an end cap; in other embodiments in the form of an agitator in said elongate chamber).
摘要翻译：用于检测液体样品中的至少一种分析物的装置通常包括（i）具有用于在其中接收生物流体（例如牛奶）的室的支撑件，其中所述室是具有长度轴的细长室; （ii）（静止或可移动）载体（在一些实施例中为端盖的形式，或连接到端盖;在其它实施例中为所述细长室中的搅拌器的形式）。

8. 发明申请

US20140065195A1 UREAPLASMA VACCINE AND ANTIBODY FOR PREVENTION AND TREATMENT OF HUMAN, ANIMAL AND CELL CULTURE INFECTION 有权
标题翻译： UREAPLASMA疫苗和预防和治疗人类动物和细胞培养物感染的抗体
公开(公告)号：US20140065195A1
公开(公告)日：2014-03-06
申请号：US14114703
申请日：2012-04-30
申请人： Leonard Weisman , Lingkun Kong
发明人： Leonard Weisman , Lingkun Kong
IPC分类号： A61K39/02
CPC分类号： A61K39/0208 , A61K39/02 , A61K39/0241 , A61K2039/53 , C07K16/1253 , G01N33/56911 , G01N2333/30 , G01N2469/10
摘要： The present invention encompasses methods and compositions for Ureaplasma infection prevention and/or treatment. In specific cases, the invention concerns vaccines for Ureaplasma, including DNA vaccines. In certain embodiments, the invention regards vaccines directed towards the multiple-banded antigen(s) of Ureaplasma.
摘要翻译：本发明包括预防和/或治疗脲原体感染的方法和组合物。在具体情况下，本发明涉及用于解脲支原体的疫苗，包括DNA疫苗。在某些实施方案中，本发明涉及针对多分支抗原（Ureaplasma）的疫苗。

9. 发明申请

US20040265942A1 Assay methods and materials 有权
标题翻译：测定方法和材料
公开(公告)号：US20040265942A1
公开(公告)日：2004-12-30
申请号：US10825607
申请日：2004-04-16
申请人： Cambrex Bio Science Nottingham Limited
发明人： Kevin John Slater , Anthony Pitt , Anne Cox , Sharon Patricia Mary Crouch
IPC分类号： C12Q001/68 , C12Q001/48 , C12Q001/04
CPC分类号： C12Q1/008 , C12Q1/04 , C12Q1/485 , G01N2333/30
摘要： The invention relates to a method of detecting the presence of mycoplasma in a test sample comprising: (i) providing a test sample; and (ii) detecting and/or measuring the activity of acetate kinase and/or carbamate kinase in the test sample, the activity being indicative of contamination by mycoplasma.
摘要翻译：本发明涉及一种检测测试样品中支原体存在的方法，包括：（i）提供测试样品; 和（ii）检测和/或测量测试样品中乙酸激酶和/或氨基甲酸酯激酶的活性，该活性指示由支原体污染。

10. 发明申请

US20030049708A1 Assay of micro-organisms in cell cultures 失效
标题翻译：细胞培养物中微生物的测定
公开(公告)号：US20030049708A1
公开(公告)日：2003-03-13
申请号：US10139740
申请日：2002-05-07
申请人： LUMITECH (UK) LIMITED
发明人： Sharon Patricia Mary Crouch , Dawn Ann Bradbury , Kevin John Slater
IPC分类号： C12Q001/42 , C12Q001/04
CPC分类号： C12Q1/04 , C12Q1/008 , C12Q1/66 , G01N2333/30
摘要： Micro-organisms which over-produce ATPase, especially mycoplasmas in a sample of a cell culture, are detected by making use of the ATPase activity to convert cellular or externally added ATP to ADP. The decrease in ATP externally added or the increase or absolute level of ADP produced from cellular ATP can then be detected or measured. For example, if a reagent such as phosphenol pyruvate/pyruvate kinase is added to convert that ADP back to ATP, the resulting high level of ATP can be detected bioluminescently using the reaction: Luciferinnullluciferase enzymenullATPnullnullnullproducts.
摘要翻译：通过利用ATPase活性将细胞或外部添加的ATP转化成ADP来检测过量产生ATP酶的微生物，特别是细胞培养物样品中的支原体。然后可以检测或测量外部添加的ATP的减少或由细胞ATP产生的ADP的增加或绝对水平。例如，如果加入诸如磷酸酚丙酮酸/丙酮酸激酶的试剂以将该ADP转化回ATP，则可以使用荧光素+荧光素酶+ ATP-> nu +产物的反应来生物发光检测所得到的高水平ATP。

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