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1. 发明授权

US09610367B2 Particle and contrast agent having the particle 有权
公开(公告)号：US09610367B2
公开(公告)日：2017-04-04
申请号：US13817711
申请日：2011-08-23
申请人： Shinzaburo Ito , Masato Minami , Tatsuki Fukui , Kouichi Kato , Fumio Yamauchi , Yoshinori Tomida , Satoshi Yuasa , Tetsuya Yano , Satoshi Ogawa , Kengo Kanazaki , Atsushi Takahashi , Daisuke Sasaguri , Hiroyuki Aoki
发明人： Shinzaburo Ito , Masato Minami , Tatsuki Fukui , Kouichi Kato , Fumio Yamauchi , Yoshinori Tomida , Satoshi Yuasa , Tetsuya Yano , Satoshi Ogawa , Kengo Kanazaki , Atsushi Takahashi , Daisuke Sasaguri , Hiroyuki Aoki
IPC分类号： A61K9/00 , A61K49/00 , A61K9/51 , A61K49/22 , B82Y15/00 , B82Y30/00
CPC分类号： A61K49/0093 , A61K9/5153 , A61K49/0034 , A61K49/0052 , A61K49/225 , B82Y15/00 , B82Y30/00
摘要： There is provided an ICG-loaded polymer nanoparticle that is dynamically stable, prevents the leakage of contained ICG and the resulting discoloration, and has a high molar absorbance coefficient. The particle contains a hydrophilic dye having a sulfonate group and a hydrophobic polymer, and the particle further contains at least one of a lipid having a positively charged region, a nicotinic acid derivative and a thiamine derivative.

2. 发明授权

US08773126B2 Nuclear magnetic resonance measuring method using an isotope-labeled compound 有权
标题翻译：使用同位素标记化合物的核磁共振测量方法
公开(公告)号：US08773126B2
公开(公告)日：2014-07-08
申请号：US12676239
申请日：2008-09-08
申请人： Katsuaki Kuge , Kimihiro Yoshimura , Fumio Yamauchi , Tetsuya Yano , Masahiro Shirakawa , Yasuhiro Aoyama
发明人： Katsuaki Kuge , Kimihiro Yoshimura , Fumio Yamauchi , Tetsuya Yano , Masahiro Shirakawa , Yasuhiro Aoyama
IPC分类号： G01V3/00 , G01R33/485 , G01R33/46 , G01R33/483 , G01R33/56
CPC分类号： G01R33/485 , G01R33/4608 , G01R33/4633 , G01R33/4833 , G01R33/5605 , G01R33/5607
摘要： The present invention provides a method for measuring nuclear magnetic resonance that employs a compound in which a plurality of nuclei is labeled with isotopes as a probe agent, highly selectively and highly sensitively obtains a nuclear magnetic resonance signal of the above described probe agent, and can attach a spatial positional information to the above described nuclear magnetic resonance signal, and an apparatus therefore.
摘要翻译：本发明提供一种测定核磁共振的方法，其使用多个核被同位素标记的化合物作为探针剂，高度选择性且高度灵敏地获得上述探针剂的核磁共振信号，并且可以将空间位置信息附加到上述核磁共振信号，因此装置。

3. 发明申请

US20120165646A1 COMPOSITE PARTICLE, CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING, AND PHOTOACOUSTIC IMAGING METHOD 审中-公开
标题翻译：复合颗粒，摄影成像对比剂和光电成像方法
公开(公告)号：US20120165646A1
公开(公告)日：2012-06-28
申请号：US13328802
申请日：2011-12-16
申请人： Fumio Yamauchi , Satoshi Ogawa , Kengo Kanazaki , Tatsuki Fukui , Sachiko Inoue
发明人： Fumio Yamauchi , Satoshi Ogawa , Kengo Kanazaki , Tatsuki Fukui , Sachiko Inoue
IPC分类号： A61B5/05 , A61K49/00 , G01N33/53 , C07K16/00
CPC分类号： A61K49/225 , A61B5/0095 , A61B8/481
摘要： Regarding a composite particle in the related art, an antibody and a dye are bound to the surface of the particle. Therefore, it is not possible to bind both the antibody and the dye high in number. Accordingly, the present invention provides a composite particle, wherein a large acoustic wave can be emitted and both the antibody and the dye can be bound high in number. A composite particle including a core particle, a dye bound to the above described core particle, and an antibody, wherein the above described antibody is bound to the above described dye, is suitable for use.
摘要翻译：关于现有技术的复合粒子，抗体和染料与粒子的表面结合。因此，不能将抗体和数量高的染料结合。因此，本发明提供一种复合颗粒，其中可以发射大的声波，并且抗体和染料都可以结合数量高。包含核心颗粒，与上述核心颗粒结合的染料和其中上述抗体与上述染料结合的抗体的复合颗粒适合使用。

4. 发明申请

US20110117023A1 CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING AND PHOTOACOUSTIC IMAGING METHOD USING THE SAME 审中-公开
标题翻译：用于摄影成像的对比剂和使用其的光电成像方法
公开(公告)号：US20110117023A1
公开(公告)日：2011-05-19
申请号：US13014345
申请日：2011-01-26
申请人： Fumio Yamauchi , Satoshi Ogawa , Kengo Kanazaki , Sachiko Inoue , Tatsuki Fukui , Masato Minami , Mayuko Kishi
发明人： Fumio Yamauchi , Satoshi Ogawa , Kengo Kanazaki , Sachiko Inoue , Tatsuki Fukui , Masato Minami , Mayuko Kishi
IPC分类号： A61K49/00 , C07K16/00 , C07K2/00 , G01N33/53 , C12Q1/02
CPC分类号： A61K41/00 , A61K47/6855 , A61K49/225 , A61K49/226 , Y10T428/2982
摘要： It is intended to provide a novel contrast agent for photoacoustic imaging that is highly capable of binding to a target molecule and generates high photoacoustic signals. The present invention provides a contrast agent for photoacoustic imaging represented by Formula 1: MNP-((L)l-(P)m)n (Formula 1) (wherein MNP represents a particle containing an iron oxide particle; L represents a linker molecule; P represents a ligand molecule; l represents 0 or 1; and m and n represent an integer of 1 or larger), the contrast agent for photoacoustic imaging including: a particle containing an iron oxide particle that absorbs light in a near-infrared region; and at least one or more ligand molecule(s) immobilized on the particle containing an iron oxide particle, wherein the immobilization density of the ligand molecule is equal to or higher than the cell surface density of a target molecule.
摘要翻译：旨在提供一种新颖的光声成像造影剂，其具有高度能够结合靶分子并产生高光声信号。本发明提供了由式1表示的光声成像造影剂：MNP - （（L）1-（P）m）n（式1）（其中MNP表示含有氧化铁颗粒的颗粒; L表示连接分子 ; P表示配体分子; l表示0或1; m和n表示1或更大的整数），光声成像用造影剂包括：含有吸收近红外区域的光的氧化铁粒子的粒子 ; 和固定在含有氧化铁颗粒的颗粒上的至少一种或多种配体分子，其中配体分子的固定密度等于或高于靶分子的细胞表面密度。

5. 发明申请

US20110081294A1 CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING AND PHOTOACOUSTIC IMAGING METHOD 有权
标题翻译：对比成像和光电成像方法
公开(公告)号：US20110081294A1
公开(公告)日：2011-04-07
申请号：US12893074
申请日：2010-09-29
申请人： Tatsuki Fukui , Fumio Yamauchi , Satoshi Yuasa , Sachiko Inoue
发明人： Tatsuki Fukui , Fumio Yamauchi , Satoshi Yuasa , Sachiko Inoue
IPC分类号： A61K49/00 , C07D209/04 , C09B5/00 , C07D209/58 , A61P43/00
CPC分类号： C07D209/58 , A61K41/00 , A61K49/0032 , A61K49/0036 , A61K49/0093 , C07D209/60 , C07D209/62 , C07D487/22 , C09B23/0033 , C09B23/0066 , C09B23/086 , C09B47/0673
摘要： A method of detecting a contrast agent for photoacoustic imaging provides a high signal intensity. In a contrast agent for photoacoustic imaging, each particle containing an inorganic material supports at least an organic dye having an absorption coefficient in the near infrared region by means of chemical bonding.
摘要翻译：检测光声成像造影剂的方法提供高信号强度。在用于光声成像的造影剂中，含有无机材料的每个颗粒通过化学键合至少支持在近红外区域具有吸收系数的有机染料。

6. 发明申请

US20110064666A1 COMPOUND 失效
标题翻译：复合
公开(公告)号：US20110064666A1
公开(公告)日：2011-03-17
申请号：US12821711
申请日：2010-06-23
申请人： Satoshi Ogawa , Fumio Yamauchi , Kengo Kanazaki , Mayuko Kishi
发明人： Satoshi Ogawa , Fumio Yamauchi , Kengo Kanazaki , Mayuko Kishi
IPC分类号： A61K49/00 , C07K16/00 , G01N33/53 , C12P21/00 , A61P43/00
CPC分类号： A61K49/221 , A61K49/0058 , A61K49/16 , C07K16/32 , C07K2317/622 , C07K2319/33 , C07K2319/50
摘要： When an antigen present at lesion sites is detected using a compound containing a single-chain antibody moiety, the single-chain antibody moiety binds to the antigen present at sites other than lesion sites. As a result, the detection of the lesion sites with high sensitivity and high contrast is difficult, and a compound solving this problem is demanded.The present invention provides a compound including a polymer represented by general formula (1): L-Y-A (1) wherein, A is a single-chain antibody moiety, which is a polypeptide including an antigen-binding site; L is a linker moiety, which is a polypeptide including a protease cleavage site; Y is a peptide moiety, which including 0 or more amino acids connecting the linker moiety L with the single-chain antibody moiety A; and the linker moiety L binds to an N terminus of the peptide moiety Y or an N terminus of the single-chain antibody moeity A.
摘要翻译：当使用含有单链抗体部分的化合物检测存在于病变部位的抗原时，单链抗体部分与存在于除病变部位之外的位点处的抗原结合。结果，难以检测具有高灵敏度和高对比度的病变部位，需要解决这个问题的化合物。本发明提供包含通式（1）表示的聚合物的化合物：L-Y-A（1）其中A是单链抗体部分，其是包含抗原结合位点的多肽; L是连接体部分，其是包含蛋白酶切割位点的多肽; Y是肽部分，其包括连接部分L与单链抗体部分A的0个或更多个氨基酸; 并且连接体部分L结合于肽部分Y的N末端或单链抗体动力学A的N末端。

7. 发明申请

US20100248279A1 SUBSTRATE PROBE, ENZYME-ACTIVITY DETECTION METHOD BY A MULTI-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE METHOD AND ENZYME-ACTIVITY IMAGING METHOD 有权
标题翻译：基质探针，酶活性检测方法多维核磁共振法和酶活性成像方法
公开(公告)号：US20100248279A1
公开(公告)日：2010-09-30
申请号：US12675511
申请日：2008-09-08
申请人： Fumio Yamauchi , Kimihiro Yoshimura , Katsuaki Kuge , Tetsuya Yano , Masahiro Shirakawa , Yasuhiro Aoyama , Shinsuke Sando
发明人： Fumio Yamauchi , Kimihiro Yoshimura , Katsuaki Kuge , Tetsuya Yano , Masahiro Shirakawa , Yasuhiro Aoyama , Shinsuke Sando
IPC分类号： C12Q1/54 , C12Q1/32 , C12Q1/37
CPC分类号： C12Q1/54 , C12Q1/32 , C12Q1/34 , G01N24/088 , G01R33/281 , G01R33/4633 , G01R33/465 , G01R33/483 , G01R33/5601 , Y02P20/582
摘要： Substrate probe capable of detecting enzyme activity with high accuracy and a method for detecting the enzyme activity by a multi nuclear magnetic resonance method using the substrate probe. Multi-dimensional nuclear magnetic resonance is performed by using a substrate probe, which is used for measuring enzyme activity by a multi-dimensional nuclear magnetic resonance method and characterized by containing a enzyme recognition site that is selectively recognized by an active-state enzyme, as at least one constitutional unit, and a group to which at least three nuclear magnetic resonance active nuclei each having a nuclear spin and a different resonance frequency are connected, being present specifically to the enzyme recognition, thereby detecting presence of the substrate probe and the enzyme activity. Alternatively, imaging of the enzyme activity is performed by a multi-dimensional nuclear resonance imaging method.
摘要翻译：能够高精度地检测酶活性的底物探针和使用底物探针的多核磁共振法检测酶活性的方法。通过使用用于通过多维核磁共振法测定酶活性的底物探针进行多维核磁共振，其特征在于含有被活性酶选择性识别的酶识别位点作为至少一个结构单元和至少三个具有核自旋和不同共振频率的核磁共振活性核连接的基团，其特异性地存在于酶识别中，从而检测底物探针和酶的存在活动。或者，通过多维核共振成像方法进行酶活性的成像。

8. 发明申请

US20090233373A1 MULTISITE PHOSPHORYLATED PEPTIDE (PROTEIN) RECOGNIZING COMPOUND AND DETECTION METHOD, IMAGING METHOD, ALZHEIMER'S DISEASE DIAGNOSING METHOD AND REAGENT KIT USING THE SAME 有权
标题翻译：多肽磷酸化肽（蛋白质）识别化合物和检测方法，成像方法，阿尔茨海默病的诊断方法和使用该试剂的试剂盒
公开(公告)号：US20090233373A1
公开(公告)日：2009-09-17
申请号：US12393011
申请日：2009-02-25
申请人： Itaru Hamachi , Fumio Yamauchi , Tetsuya Yano , Kimihiro Yoshimura , Akio Ojida , Takashi Sakamoto , Masaaki Inoue
发明人： Itaru Hamachi , Fumio Yamauchi , Tetsuya Yano , Kimihiro Yoshimura , Akio Ojida , Takashi Sakamoto , Masaaki Inoue
IPC分类号： G01N33/68 , C07D213/02 , C07F3/06 , C07F5/02
CPC分类号： C07F5/022 , C07D207/335 , C07D401/14 , G01N33/6842 , Y10T436/16 , Y10T436/163333
摘要： There are provided a novel compound which captures a multisite phosphorylated peptide or protein specifically to a phosphorylation site and a method for detecting a multisite phosphorylated peptide or protein using the same. In particular, there are provided a compound which specifically detects an excessively phosphorylated tau protein observed in the brain affected by Alzheimer's disease and a method for diagnosing Alzheimer's disease in vitro or in vivo using the compound. By bringing a metal complex compound having two dipicolylamine (Dpa) moieties and a spacer including a chromogenic or luminescent functional group or atom group into contact with a multisite phosphorylated peptide or protein, the compound recognizes the distance between phosphate groups and specifically binds to the peptide or the protein, and a multisite phosphorylated peptide or protein or a kinase activity is optically detected by measuring the change, or a multisite phosphorylated peptide or protein or kinase activity is imaged by an optical imaging method applying the change in the luminescence.
摘要翻译：提供了一种新颖的化合物，其特异性捕获磷酸化位点的多位点磷酸化肽或蛋白质，以及使用该化合物检测多位点磷酸化肽或蛋白质的方法。特别地，提供了特异性检测在受阿尔茨海默氏病影响的脑中观察到的过度磷酸化的tau蛋白的化合物和使用该化合物在体外或体内诊断阿尔茨海默病的方法。通过使具有两个二聚苯基胺（Dpa）部分的金属配位化合物和包含显色或发光官能团或原子基团的间隔基与多位点磷酸化肽或蛋白质接触，该化合物识别磷酸基团之间的距离并特异性结合肽或蛋白质，以及多位点磷酸化肽或蛋白质或激酶活性通过测量变化进行光学检测，或者通过应用发光变化的光学成像方法对多位点磷酸化肽或蛋白质或激酶活性进行成像。

9. 发明授权

US4690960A Vibration damping material 失效
标题翻译：振动阻尼材料
公开(公告)号：US4690960A
公开(公告)日：1987-09-01
申请号：US691354
申请日：1985-01-14
申请人： Fumio Yamauchi , Tsutomu Tohara , Shigeo Nakano , Shigeo Emoto
发明人： Fumio Yamauchi , Tsutomu Tohara , Shigeo Nakano , Shigeo Emoto
IPC分类号： C08K3/22 , F16F9/30 , B23P11/00 , F16M11/00
CPC分类号： F16F9/306 , C08K3/22 , Y10T29/49844
摘要： A vibration damping material having an improved mechanical strength and excellent vibration damping characteristic is disclosed.The material is made by usage of composition of 40 to 90 weight percent of iron oxide particles 0.1 to 100 .mu.m in size and 60 to 10 weight percent of resin.
摘要翻译：公开了具有改善的机械强度和优异的减振特性的减震材料。该材料通过使用40至90重量％的0.1至100μm的氧化铁颗粒和60至10重量％的树脂的组合物制成。

10. 发明授权

US4076392A Remotely controllable rear view mirror 失效
标题翻译：遥控后视镜
公开(公告)号：US4076392A
公开(公告)日：1978-02-28
申请号：US692086
申请日：1976-06-02
申请人： Toshiyuki Suzuki , Fumio Yamauchi
发明人： Toshiyuki Suzuki , Fumio Yamauchi
IPC分类号： B60R1/072 , G02B7/182 , G02B5/08 , A47G1/24
CPC分类号： G02B7/1827 , B60R1/072 , Y10S248/90
摘要： In an automatically swingable compact rear view mirror carried by a universal pivotal center support within a hood, a drive motor electrically connected to a given remote control equipment for the driver includes an output shaft which extends, on the side opposite to the end opening of said hood which said mirror faces, substantially parallel to the axial direction of a mechanism for moving a universal pivot coupled to the mirror for free swinging of the latter about the center support. Preferably a pair of universal pivots may be provided on the mirror defining a center angle of approximately 90.degree. with respect to the center support.
摘要翻译：在由罩内的通用枢转中心支撑件支撑的可自动摆动的紧凑型后视镜中，与驱动器的给定遥控设备电连接的驱动马达包括输出轴，该输出轴在与所述驱动器的端开口相对的一侧上延伸所述镜面的罩子基本上平行于用于移动联接到镜子的通用枢轴的机构的轴向方向，用于使其绕中心支撑件自由摆动。优选地，可以在反射镜上设置一对通用枢轴，限定相对于中心支撑件大约90°的中心角。

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