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1. 发明授权

US11913861B2 Electrostatic loading of powder samples for ionization 有权
公开(公告)号：US11913861B2
公开(公告)日：2024-02-27
申请号：US17330121
申请日：2021-05-25
申请人： IonSense Inc.
发明人： Brian D Musselman , Frederick Li
IPC分类号： G01N1/38 , G01N1/44 , H01J49/16 , H01J49/12 , H01J49/04
CPC分类号： G01N1/38 , G01N1/44 , H01J49/0459 , H01J49/12 , H01J49/165 , G01N2001/386
摘要： Methods and devices for pretreatment of a conducting sampling substrate which enable an electrostatic charge to be used to transfer analyte molecules onto a sampling substrate, where the analyte molecules are in powder or particulate form. In an embodiment of the present invention, the electrostatic charge can be used to transfer powder samples containing nitrogenous bases, nucleosides, food additives, and prescription drugs such as acetaminophen, oxycodone, and dextromethorphan. In an embodiment of the present invention, a powder sample is transferred to a pre-treated sampling substrate using an electrostatic charge. The spatial distribution of the powder on the original surface is retained on the pre-treated sampling substrate using the electrostatic charge transfer. The electrostatic charge transfer can be used to transfer powder samples present on a surface or in the chambers of 96, 384 and 1536 well plate formats to either pins or mesh and analyzed with ambient desorption ionization.

2. 发明授权

US09080936B2 Glow discharge ion source 有权
标题翻译：辉光放电离子源
公开(公告)号：US09080936B2
公开(公告)日：2015-07-14
申请号：US13055612
申请日：2009-07-27
申请人： Jeffery Mark Brown , Martin Raymond Green , Steven Derek Pringle
发明人： Jeffery Mark Brown , Martin Raymond Green , Steven Derek Pringle
IPC分类号： G01N24/00 , H01J49/00 , H01J49/10 , H01J49/12 , H01J49/16 , H01J49/04
CPC分类号： H01J49/12 , G01N24/00 , H01J49/0009 , H01J49/0072 , H01J49/0495 , H01J49/107 , H01J49/165 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode (14) located within an isolation valve (15) which is provided in the vacuum chamber. Reagent vapor may be provided through the tubular electrode (14) which is then subsequently ionized by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.
摘要翻译：公开了质谱仪，其包括在质谱仪的初始真空室内的辉光放电装置。辉光放电装置可以包括设置在真空室中的隔离阀（15）内的管状电极（14）。可以通过管状电极（14）提供试剂蒸汽，然后其随后通过辉光放电电离。所得的试剂离子可用于由大气压离子源产生的分析物离子的电子转移离解。考虑其他实施例，其中由辉光放电装置产生的离子可用于通过质子转移反应来减少分析物离子的电荷状态，或者可以作为锁定质量或参考离子。

3. 发明授权

US08901489B2 Looped ionization source 有权
标题翻译：环状电离源
公开(公告)号：US08901489B2
公开(公告)日：2014-12-02
申请号：US14126259
申请日：2012-06-15
申请人： Daniel Levin , Vlad Sergeyev , Volodimir Bondarenko , Bohdan Atamanchuk , Qunzhou Bian , Henryk Zaleski , Mark Piniarski , Simon Feldberg , Ronald Jackson
发明人： Daniel Levin , Vlad Sergeyev , Volodimir Bondarenko , Bohdan Atamanchuk , Qunzhou Bian , Henryk Zaleski , Mark Piniarski , Simon Feldberg , Ronald Jackson
IPC分类号： H01J49/00 , G01N27/62 , H01J49/12
CPC分类号： G01N27/622 , H01J49/12 , H01J49/168
摘要： Looped ionization sources for ion mobility spectrometers are described. The ionization sources can be used to ionize molecules from a sample of interest in order to identify the molecules based on the ions. In an implementation, an electrical ionization source includes a wire that is looped between electrical contacts. The wire is used to form a corona responsive to application of voltage between the wire and the walls of an ionization chamber. The corona can form when a sufficient voltage is applied between the wire and the walls. A difference in electrical potential between the wire and a wall forming an ionization chamber, in which wire is contained, can be used to draw the ions away from the wire. In embodiments, the wire can be heated to reduce the voltage used to strike the corona. The ions, subsequently, may ionize the molecules from the sample of interest. The looped corona source can also be used in mass spectrometers (MS).
摘要翻译：描述了用于离子迁移率光谱仪的环形电离源。电离源可以用于从感兴趣的样品中离子化分子，以便基于离子鉴定分子。在一个实施方案中，电离电离源包括在电触头之间环绕的导线。导线用于响应于在电线和电离室的壁之间施加电压而形成电晕。当电线和墙壁之间施加足够的电压时，可以形成电晕。电线和形成电离室的壁之间的电位差可以用于将离子从电线中吸出。在实施例中，可以加热导线以降低用于击打电晕的电压。离子，随后可能离开目标样品的分子。环形电晕源也可用于质谱仪（MS）。

4. 发明申请

US20140246581A1 LOOPED IONIZATION SOURCE 有权
标题翻译：循环离子源
公开(公告)号：US20140246581A1
公开(公告)日：2014-09-04
申请号：US14126259
申请日：2012-06-15
申请人： Daniel Levin , Vlad Sergeyev , Volodimir Bondarenko , Bohdan Atamanchuk , Qunzhou Bian , Henryk Zaleski , Mark Piniarski , Simon Feldberg , Ronald Jackson
发明人： Daniel Levin , Vlad Sergeyev , Volodimir Bondarenko , Bohdan Atamanchuk , Qunzhou Bian , Henryk Zaleski , Mark Piniarski , Simon Feldberg , Ronald Jackson
IPC分类号： G01N27/62 , H01J49/12
CPC分类号： G01N27/622 , H01J49/12 , H01J49/168
摘要： Looped ionization sources for ion mobility spectrometers are described. The ionization sources can be used to ionize molecules from a sample of interest in order to identify the molecules based on the ions. In an implementation, an electrical ionization source includes a wire that is looped between electrical contacts. The wire is used to form a corona responsive to application of voltage between the wire and the walls of an ionization chamber. The corona can form when a sufficient voltage is applied between the wire and the walls. A difference in electrical potential between the wire and a wall forming an ionization chamber, in which wire is contained, can be used to draw the ions away from the wire. In embodiments, the wire can be heated to reduce the voltage used to strike the corona. The ions, subsequently, may ionize the molecules from the sample of interest. The looped corona source can also be used in mass spectrometers (MS).
摘要翻译：描述了用于离子迁移率光谱仪的环形电离源。电离源可以用于从感兴趣的样品中离子化分子，以便基于离子鉴定分子。在一个实施方案中，电离电离源包括在电触头之间环绕的导线。导线用于响应于在电线和电离室的壁之间施加电压而形成电晕。当电线和墙壁之间施加足够的电压时，可以形成电晕。电线和形成电离室的壁之间的电位差可以用于将离子从电线中吸出。在实施例中，可以加热导线以降低用于击打电晕的电压。离子，随后可能离开目标样品的分子。环形电晕源也可用于质谱仪（MS）。

5. 发明申请

US20090294649A1 Method and Apparatus for Generation of Reagent Ions in a Mass Spectrometer 有权
标题翻译：用于在质谱仪中产生试剂离子的方法和装置
公开(公告)号：US20090294649A1
公开(公告)日：2009-12-03
申请号：US12473570
申请日：2009-05-28
申请人： Jeffrey Shabanowitz , Philip D. Compton , Lee Earley , George C. Stafford, JR. , Donald F. Hunt , Christopher Mullen
发明人： Jeffrey Shabanowitz , Philip D. Compton , Lee Earley , George C. Stafford, JR. , Donald F. Hunt , Christopher Mullen
IPC分类号： B01D59/44 , H01J49/00 , H01J27/00
CPC分类号： H01J49/12 , H01J49/0072
摘要： A front-end reagent ion source for a mass spectrometer is disclosed. Reagent vapor is supplied to a reagent ionization volume located within a chamber of the mass spectrometer and maintained at a low vacuum pressure. Reagent ions are formed by interaction of the reagent vapor molecules with an electrical discharge (e.g., a glow discharge) within the ionization volume, and pass into the chamber of the mass spectrometer. At least one ion optical element located along the analyte ion path transports the reagent ions to successive chambers of the mass spectrometer. The reagent ions may be combined with the analyte ions to perform ion-ion studies such as electron transfer dissociation (ETD).
摘要翻译：公开了用于质谱仪的前端试剂离子源。将试剂蒸气供给到位于质谱仪室内的试剂电离体并保持在低真空压力下。试剂离子通过试剂蒸气分子与离子化体积内的放电（例如，辉光放电）的相互作用而形成，并进入质谱仪的室。沿着分析物离子路径定位的至少一个离子光学元件将试剂离子输送到质谱仪的连续室。试剂离子可与分析物离子组合以进行离子离子研究，例如电子转移离解（ETD）。

6. 发明申请

US20070040112A1 Glow discharge source 有权
标题翻译：辉光放电源
公开(公告)号：US20070040112A1
公开(公告)日：2007-02-22
申请号：US11336491
申请日：2006-01-20
申请人： Lothar Rottmann , Wolfgang Schottker , Nicole Frerichs
发明人： Lothar Rottmann , Wolfgang Schottker , Nicole Frerichs
IPC分类号： H01J49/00
CPC分类号： H01J49/12
摘要： The invention relates to a glow discharge source, in particular for the analysis of solid specimens by means of glow discharge, with an anode and a cathode and with means for the direct or indirect cooling of a specimen. The glow discharge source according to the invention is characterized in that at least one Peltier element is provided as the cooling means.
摘要翻译：本发明涉及辉光放电源，特别是用于通过辉光放电对阳极和阴极分析固体样品以及用于直接或间接冷却试样的装置。根据本发明的辉光放电源的特征在于，提供至少一个珀耳帖元件作为冷却装置。

7. 发明申请

US20060284103A1 Glow discharge and photoionization source 有权
标题翻译：辉光放电和光电离源
公开(公告)号：US20060284103A1
公开(公告)日：2006-12-21
申请号：US11138594
申请日：2005-05-25
申请人： Jack Syage
发明人： Jack Syage
IPC分类号： H01J27/24
CPC分类号： G01N27/622 , H01J49/105 , H01J49/107 , H01J49/12 , H01J49/162
摘要： A detector that may contain a glow discharge ionizer and a photo-ionizer. The existence of both ionizers may increase the accuracy and number of chemical compounds that can be simultaneously monitored for chemical screening applications. The detector is particularly useful for screening explosives, chemical agents, and other illicit chemicals.
摘要翻译：可以包含辉光放电电离器和光电离器的检测器。两种电离器的存在可能会增加可以同时监测化学筛选应用的化合物的准确性和数量。检测器特别适用于筛选爆炸物，化学试剂和其他非法化学品。

8. 发明申请

US20020017605A1 Ion mobility spectrometer 有权
标题翻译：离子迁移谱仪
公开(公告)号：US20020017605A1
公开(公告)日：2002-02-14
申请号：US09910197
申请日：2001-07-20
发明人： Anthony Jenkins , William J. McGann
IPC分类号： H01J049/40
CPC分类号： H01J49/12 , G01N27/622
摘要： An ion trap mobility spectrometer is provided with a reaction chamber and a drift chamber. Ions are produced in the reaction chamber by high voltage electronic pulses. More particularly, the ions are formed periodically and are allowed to thermalize in a field-free environment of the reaction chamber. The ions then react with molecular species in the gas phase in the reaction chamber. After a short period, the ions are pulsed into the drift section and are collected on a collector electrode disposed at the end of the drift chamber remote from the reaction chamber. The reaction period may be varied to sample the ion population at different intervals. This enables the ion-molecule reactions to be monitored as the ion population approaches equilibrium. The monitoring results can be used to determine differences between reacting species because the molecular ion population varies at different time points approaching equilibrium. This in turn provides improved identification of target materials.
摘要翻译：离子阱迁移谱仪设有反应室和漂移室。离子在高压电子脉冲在反应室中产生。更具体地，周期性地形成离子，并且允许在无反应室的无场环境中热离子化。离子然后与反应室中的气相中的分子物质反应。短时间后，将离子脉冲进入漂移部分，并收集在设置在远离反应室的漂移室末端的集电极上。可以改变反应时间以以不同的间隔对离子群进行取样。这使得离子分子反应可以随着离子群体接近平衡而被监测。监测结果可用于确定反应物质之间的差异，因为分子离子群体在接近平衡的不同时间点变化。这反过来又提供了目标材料的改进识别。

9. 发明授权

US5184016A Glow discharge spectrometry 失效
标题翻译：玻璃放电光谱
公开(公告)号：US5184016A
公开(公告)日：1993-02-02
申请号：US639802
申请日：1991-01-10
申请人： Gerard A. Ronan , Alistair Cole
发明人： Gerard A. Ronan , Alistair Cole
IPC分类号： G01N21/67 , G01N27/62 , H01J49/04 , H01J49/10 , H01J49/12
CPC分类号： H01J49/0459 , G01N21/67 , H01J49/12
摘要： The invention provides glow discharge optical or mass spectrometers wherein a solid sample may be mounted in a unitary source assembly adjacent to a first electrode means. A second electrode means, spaced from sample by an insulating washer, is also part of the source assembly and engages with a discharge chamber into which a discharge gas is introduced. A glow discharge is maintained in the discharge by a potential differential difference applied between the first and second electrode means. In a mass spectrometer, ions formed in the discharge pass to a mass analyzer, while in an optical spectrometer, optical radiation form the discharge is spectroscopically analyzed. Particularly in the case of a mass spectrometer, the source assembly may be mounted on an insertion probe allowing it to be easily withdrawn from the vacuum envelope to facilitate sample changing and maintenance.

10. 发明授权

US4918307A Sample holder for glow discharge mass spectrometer 失效
标题翻译：用于辉光放电质谱仪的样品架
公开(公告)号：US4918307A
公开(公告)日：1990-04-17
申请号：US213199
申请日：1988-06-29
申请人： Masahiro Shibata
发明人： Masahiro Shibata
IPC分类号： H01J49/04
CPC分类号： H01J49/0409 , H01J49/12
摘要： A sample holder for a glow discharge mass spectrometer which is made of quartz or a sample holder comprising a sample holder body and a coating film of an insulating material covering the surface of the sample holder body for precisely analyzing the content of a trace element in a material.

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