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1. 发明授权

US09123518B2 Curved ion guide with non mass to charge ratio dependent confinement 有权
标题翻译：具有非质荷比依赖性限制的弯曲离子导向器
公开(公告)号：US09123518B2
公开(公告)日：2015-09-01
申请号：US14001078
申请日：2012-02-24
申请人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , Jason Lee Wildgoose , David. J. Langridge
发明人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , Jason Lee Wildgoose , David. J. Langridge
IPC分类号： H01J49/26 , H01J49/06 , H01J49/42
CPC分类号： H01J49/063 , H01J49/065 , H01J49/26 , H01J49/42
摘要： A non-linear ion guide is disclosed comprising a plurality of electrodes. An ion guiding region is arranged between the electrodes, and the ion guiding region curves at least in a first direction. A DC voltage is applied to at least some of the electrodes in order to form a DC potential well which acts to confine ions within the ion guiding region in the first direction.
摘要翻译：公开了一种包括多个电极的非线性离子导向器。离子引导区域布置在电极之间，并且离子引导区域至少沿第一方向弯曲。 DC电压被施加到至少一些电极，以便形成用于将离子限制在第一方向上的离子引导区域内的DC势阱。

2. 发明授权

US08481921B2 Tandem ion trapping arrangement 有权
标题翻译：串联离子捕集装置
公开(公告)号：US08481921B2
公开(公告)日：2013-07-09
申请号：US12676154
申请日：2008-09-03
申请人： Martin Raymond Green , Jason Lee Wildgoose
发明人： Martin Raymond Green , Jason Lee Wildgoose
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/06 , H01J49/0031 , H01J49/004 , H01J49/025 , H01J49/26 , H01J49/4265 , H01J49/427
摘要： A mass spectrometer is disclosed comprising a first storage ion trap arranged upstream of a high performance analytical ion trap. According to an embodiment ions are simultaneously scanned from both the first and second ion trap. At any instant in time the quantity of charge present within the second ion trap is limited or restricted so that the second ion trap does not suffer from space charge saturation effects and hence the performance of the second ion trap is not degraded.
摘要翻译：公开了一种质谱仪，其包括布置在高性能分析离子阱的上游的第一存储离子阱。根据一个实施例，离子同时从第一和第二离子阱两者扫描。在任何时刻，存在于第二离子阱内的电荷量被限制或限制，使得第二离子阱不会受到空间电荷饱和效应的影响，因此第二离子阱的性能不会降低。

3. 发明授权

US08362424B2 Mass spectrometer 有权
公开(公告)号：US08362424B2
公开(公告)日：2013-01-29
申请号：US12744384
申请日：2008-11-24
申请人： Jeffery Mark Brown , Martin Raymond Green
发明人： Jeffery Mark Brown , Martin Raymond Green
IPC分类号： H01J49/40
CPC分类号： H01J49/065 , H01J49/0072
摘要： An ion-ion reaction cell is provided comprising a plurality of electrodes forming an ion guide. A transient DC voltage wave is applied to the electrodes in order to load reagent anions into the ion guide. Analyte cations are then subsequently transmitted through the ion-ion reaction cell by a subsequent transient DC voltage wave. Ion are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of a transient DC voltage wave.

4. 发明授权

US08063358B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08063358B2
公开(公告)日：2011-11-22
申请号：US11916430
申请日：2006-06-01
申请人： Robert Harold Bateman , Jeffery Mark Brown , Martin Raymond Green , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Jeffery Mark Brown , Martin Raymond Green , Jason Lee Wildgoose
IPC分类号： H01J49/26
CPC分类号： H01J49/0036
摘要： A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analyzed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output.
摘要翻译：公开了一种质谱法，其中分析了来自离子检测器的电压信号。获得每个电压信号的第二差分，并且确定观察到的电压峰值的开始和结束时间。然后确定每个电压峰值的强度和平均时间，并存储强度和时间值。然后通过组合与多个实验运行中观察到的每个电压峰值相关的强度和时间值来形成中间复合质谱。然后将各种时间和强度数据对被整合以产生平滑的连续质谱。然后可以通过确定连续质谱的第二差分来进一步处理连续质谱。可以确定在连续质谱中观察到的质量峰的开始和结束时间。然后可以确定在连续质谱中观察到的每个质量峰的强度和质荷比。然后可以显示或输出包括仅每个离子种类的强度值和质荷比的最终离散质谱。

5. 发明申请

US20110062323A1 Electron Transfer Dissociation Device 有权
标题翻译：电子转移离解装置
公开(公告)号：US20110062323A1
公开(公告)日：2011-03-17
申请号：US12937806
申请日：2009-04-03
申请人： Jeffery Mark Brown , Martin Raymond Green
发明人： Jeffery Mark Brown , Martin Raymond Green
IPC分类号： H01J49/00 , H01J49/06
CPC分类号： H01J49/28 , H01J49/0072 , H01J49/065
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.
摘要翻译：公开了一种质谱仪，其包括电子转移离解装置，其包括离子导向器。控制系统确定离子导向器内的前体离子的碎裂和电荷减少的程度，并且改变离子通过离子导向器传输的速度，以便优化碎裂和电荷还原过程。

6. 发明申请

US20110024618A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20110024618A1
公开(公告)日：2011-02-03
申请号：US12744384
申请日：2008-11-24
申请人： Jeffery Mark Brown , Martin Raymond Green
发明人： Jeffery Mark Brown , Martin Raymond Green
IPC分类号： H01J49/00 , H01J49/28
CPC分类号： H01J49/065 , H01J49/0072
摘要： An ion-ion reaction cell is provided comprising a plurality of electrodes (1) forming an ion guide (2). A transient DC voltage wave is applied to the electrodes (2) in order to load reagent anions into the ion guide (2). Analyte cations are then subsequently transmitted through the ion-ion reaction cell by a subsequent transient DC voltage wave. Ion are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of a transient DC voltage wave.
摘要翻译：提供离子离子反应池，其包括形成离子导向器（2）的多个电极（1）。向电极（2）施加瞬态直流电压波，以便将试剂阴离子负载到离子导向器（2）中。分析物阳离子然后随后通过离子离子反应池通过随后的瞬态DC电压波传输。离子被布置为在反应池内进行离子 - 离子反应，然后在反应池内形成的所得碎片离子随后通过瞬态DC电压波转移出反应池。

7. 发明授权

US09190251B2 Pre-scan for mass to charge ratio range 有权
标题翻译：预扫描质量与充电比例范围
公开(公告)号：US09190251B2
公开(公告)日：2015-11-17
申请号：US14004520
申请日：2012-03-13
申请人： Martin Raymond Green , Jason Lee Wildgoose
发明人： Martin Raymond Green , Jason Lee Wildgoose
IPC分类号： H01J49/00
CPC分类号： H01J49/004 , H01J49/0031
摘要： A method of mass spectrometry is disclosed comprising performing a first analysis of a sample of ions wherein one or more parameters are scanned and/or ions are sorted according to one or more parameters during the first analysis. One or more ranges of interest of the one or more parameters from the first analysis are then automatically determined. A second subsequent analysis of the sample of ions is then automatically performed, wherein the second analysis is restricted to one or more of the ranges of interest of the one or more parameters.
摘要翻译：公开了一种质谱法，其包括在第一次分析期间根据一个或多个参数对离子样品进行第一次分析，其中扫描一个或多个参数和/或离子。然后自动确定来自第一次分析的一个或多个参数的一个或多个感兴趣范围。然后自动执行离子样品的第二次后续分析，其中第二分析限于一个或多个参数的一个或多个感兴趣的范围。

8. 发明授权

US09111654B2 DC ion guide for analytical filtering/separation 有权
标题翻译：用于分析过滤/分离的直流离子导向器
公开(公告)号：US09111654B2
公开(公告)日：2015-08-18
申请号：US14003487
申请日：2012-03-07
申请人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
发明人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/26 , G21K1/00 , H01J49/42 , H01J49/28
CPC分类号： G21K1/00 , H01J49/062 , H01J49/28 , H01J49/427
摘要： An ion guide is disclosed comprising a plurality of electrodes. A first device is arranged and adapted to apply a RF voltage to at least some of the electrodes in order to form, in use, a pseudo-potential well which acts to confine ions in a first direction within the ion guide. A second device is arranged and adapted to apply a DC voltage to at least some of the electrodes in order to form, in use, a DC potential well which acts to confine ions in a second direction within the ion guide. A third device is arranged and adapted to cause ions having desired or undesired mass to charge ratios to be mass to charge ratio selectively ejected from the ion guide in the second direction.
摘要翻译：公开了一种离子导向器，其包括多个电极。第一装置被布置并适于将RF电压施加到至少一些电极，以在使用中形成用于将离子限制在离子导向器内的第一方向上的伪电位阱。第二装置被布置并适于将DC电压施加到至少一些电极，以在使用中形成用于在离子导向器内沿第二方向限制离子的DC势阱。第三装置被布置并适于使具有期望或不需要的质量的充电比例的离子成为从第二方向从离子导向器选择性地喷射的质荷比。

9. 发明授权

US09080936B2 Glow discharge ion source 有权
标题翻译：辉光放电离子源
公开(公告)号：US09080936B2
公开(公告)日：2015-07-14
申请号：US13055612
申请日：2009-07-27
申请人： Jeffery Mark Brown , Martin Raymond Green , Steven Derek Pringle
发明人： Jeffery Mark Brown , Martin Raymond Green , Steven Derek Pringle
IPC分类号： G01N24/00 , H01J49/00 , H01J49/10 , H01J49/12 , H01J49/16 , H01J49/04
CPC分类号： H01J49/12 , G01N24/00 , H01J49/0009 , H01J49/0072 , H01J49/0495 , H01J49/107 , H01J49/165 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode (14) located within an isolation valve (15) which is provided in the vacuum chamber. Reagent vapor may be provided through the tubular electrode (14) which is then subsequently ionized by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.
摘要翻译：公开了质谱仪，其包括在质谱仪的初始真空室内的辉光放电装置。辉光放电装置可以包括设置在真空室中的隔离阀（15）内的管状电极（14）。可以通过管状电极（14）提供试剂蒸汽，然后其随后通过辉光放电电离。所得的试剂离子可用于由大气压离子源产生的分析物离子的电子转移离解。考虑其他实施例，其中由辉光放电装置产生的离子可用于通过质子转移反应来减少分析物离子的电荷状态，或者可以作为锁定质量或参考离子。

10. 发明申请

US20140326867A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20140326867A1
公开(公告)日：2014-11-06
申请号：US14270433
申请日：2014-05-06
申请人： Martin Raymond Green , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Martin Raymond Green , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/00 , H01J49/40
CPC分类号： H01J49/0036 , H01J49/40
摘要： A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised. Arrival time and intensity pairs are calculated for both digitised signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum.
摘要翻译：公开了一种质谱仪，其中离子信号被分成第一和第二信号。第一和第二信号乘以不同的增益并被数字化。对于两个数字化信号计算到达时间和强度对，并且将所得到的时间和强度对组合以形成高动态范围谱。然后将光谱与其他对应的光谱组合以形成相加光谱。

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