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1. 发明申请

US20100099124A1 Method for Diagnosing Diseases Based on Levels of Anti-Glycan Antibodies 审中-公开
标题翻译：基于抗糖基化抗体水平诊断疾病的方法
公开(公告)号：US20100099124A1
公开(公告)日：2010-04-22
申请号：US12563493
申请日：2009-09-21
申请人： Nir Dotan , Avinoam Dukler
发明人： Nir Dotan , Avinoam Dukler
IPC分类号： G01N33/53 , G01N33/00 , G01N33/564 , C40B40/12
CPC分类号： G01N33/543 , G01N33/6854 , G01N33/6893 , G01N2800/065 , Y10S435/942 , Y10S436/811
摘要： Disclosed are methods for diagnosing Crohn's disease (CD) or anti-phospholipid syndrome by measuring levels of antibodies to glycans in a biological sample.
摘要翻译：公开了通过测量生物样品中聚糖的抗体水平来诊断克罗恩病（CD）或抗磷脂综合征的方法。

2. 发明授权

US07135308B1 Process for the production of ethanol from algae 有权
标题翻译：从藻类生产乙醇的方法
公开(公告)号：US07135308B1
公开(公告)日：2006-11-14
申请号：US11363675
申请日：2006-02-28
申请人： Ronnie A. Bush , Kevin M. Hall
发明人： Ronnie A. Bush , Kevin M. Hall
IPC分类号： C12P39/00 , C12P7/14 , C12N1/16 , C12N1/12
CPC分类号： C12P7/06 , Y02E50/17 , Y10S435/942 , Y10S435/946
摘要： The present invention describes a process for the production of ethanol by harvesting starch-accumulating filament-forming or colony-forming algae to form a biomass, initiating cellular decay of the biomass in a dark and anaerobic environment, fermenting the biomass in the presence of a yeast, and the isolating the ethanol produced. The present invention further relates to processing of the biomass remaining after ethanol production to recovering biodiesel starting materials and/or generation of heat and carbon dioxide via combustion.
摘要翻译：本发明描述了一种生产乙醇的方法，该方法是通过收集淀粉积累的成丝细菌或集落形成藻类形成生物质，在黑暗和厌氧环境中引发生物量的细胞衰变，在生物量存在下发酵生物质酵母，并分离生成的乙醇。本发明还涉及在乙醇生产后剩余的生物质回收生物柴油起始材料和/或通过燃烧产生热和二氧化碳的处理。

3. 发明申请

US20020106784A1 METHOD AND APPARATUS FOR THE BIOLOGICAL CONVERSION OF ORGANIC WASTE INTO HUMIC PRODUCTS 失效
标题翻译：有机废物生物转化为人造产品的方法与装置
公开(公告)号：US20020106784A1
公开(公告)日：2002-08-08
申请号：US09257011
申请日：1999-02-25
发明人： RICCARDO REVERSO
IPC分类号： C07F001/00 , C05F011/08 , C12M001/00
CPC分类号： C05F17/0027 , C05F17/0036 , Y02P20/145 , Y02W30/43 , Y10S435/822 , Y10S435/831 , Y10S435/832 , Y10S435/834 , Y10S435/838 , Y10S435/839 , Y10S435/853 , Y10S435/854 , Y10S435/855 , Y10S435/856 , Y10S435/857 , Y10S435/878 , Y10S435/886 , Y10S435/898 , Y10S435/904 , Y10S435/911 , Y10S435/921 , Y10S435/942
摘要： A method for converting organic solid waste into humic products and the corresponding apparatus, in which a preliminary aerobic fermentation of the organic solid waste is performed, followed by a second aerobic fermentation of the organic waste in the presence of specific microorganisms in order to provide a basic precursor on which the selective metabolization occurs of specific bacterial strains to provide the humic product.
摘要翻译：一种将有机固体废物转化成腐殖质的方法，以及相应的装置，其中进行有机固体废物的初步好氧发酵，然后在特定微生物存在下对有机废物进行第二次好氧发酵，以提供选择性代谢发生特定细菌菌株以提供腐殖质的基本前体。

4. 发明授权

US06387683B1 Recombinant yeast PDI and process for production thereof 失效
标题翻译：重组酵母PDI及其制备方法
公开(公告)号：US06387683B1
公开(公告)日：2002-05-14
申请号：US09368588
申请日：1999-08-05
申请人： Nobuyoshi Ishii , Yasuo Suzuki , Kohji Uchida , Yushi Matuo , Hideo Tanaka
发明人： Nobuyoshi Ishii , Yasuo Suzuki , Kohji Uchida , Yushi Matuo , Hideo Tanaka
IPC分类号： C12N990
CPC分类号： C12N9/90 , Y10S435/942
摘要： The present invention provides a process for producing biologically active recombinant yeast protein disulfide isomerase, which includes the steps of: a) deleting, substituting, or adding one or more bases in a region encoding an endoplasmic reticulum retention signal in a gene encoding protein disulfide isomerase of yeast to modify the gene so as not to encode part or all of the endoplasmic reticulum retention signal; b) incorporating the modified gene into an expression vector; c) transforming host cells with the expression vector; and d) culturing the host cells transformed with the expression vector in a culture medium kept at a nearly neutral pH, thereby causing protein disulfide isomerase to be secreted in an active state outside the host cells. According to the process of the invention, recombinant yeast protein disulfide isomerase can be secreted in a large amount in a biologically active state into a culture medium, and can be collected by a simple purification method.
摘要翻译：本发明提供生产生物活性重组酵母蛋白二硫键异构酶的方法，其包括以下步骤：a）在编码蛋白质二硫键异构酶的基因的编码内质网保持信号的区域中缺失，取代或添加一个或多个碱基的酵母修饰基因，以免编码部分或全部内质网保持信号; b）将修饰的基因并入表达载体中; c）用表达载体转化宿主细胞; 和d）在保持接近中性pH的培养基中培养用表达载体转化的宿主细胞，从而使蛋白质二硫键异构酶以宿主细胞外的活性状态分泌。根据本发明的方法，可以将重组酵母蛋白二硫键异构酶以大量的生物活性状态分泌到培养基中，并且可以通过简单的纯化方法收集。

5. 发明授权

US6140107A Organometallic-metabolizing yeast 失效
标题翻译：有机金属代谢酵母
公开(公告)号：US6140107A
公开(公告)日：2000-10-31
申请号：US719572
申请日：1996-09-25
申请人： Ping Yang , Houn Simon Hsia
发明人： Ping Yang , Houn Simon Hsia
IPC分类号： A23L1/28 , A23L1/30 , A23L1/304 , C07G99/00 , C12P3/00 , C12N1/14 , C12N1/16
CPC分类号： C12R1/85 , A23L31/00 , A23L33/14 , A23L33/16 , C07G17/00 , C12P3/00 , Y10S435/90 , Y10S435/94 , Y10S435/942
摘要： The present invention includes a novel yeast strain of the genus Saccharomyces boulardii sequela PY31 ATCC 74366 that is able to process certain metallic compounds into biologically active forms suitable for supplementing the human diet. The present invention also includes methods for isolating such yeast, nutritional supplement compositions containing such yeast, and methods of administering the nutritional supplement compositions to humans.
摘要翻译：本发明包括能够将某些金属化合物加工成适于补充人类饮食的生物活性形式的新型酵母属酵母菌株PY31 ATCC 74366的酵母菌株。本发明还包括分离这种酵母的方法，含有这种酵母的营养补充剂组合物，以及向人类施用营养补充剂组合物的方法。

6. 发明授权

US6013485A Low-molecular weight active ingredient extract from yeasts and method for producing it 失效
标题翻译：来自酵母的低分子量活性成分提取物及其生产方法
公开(公告)号：US6013485A
公开(公告)日：2000-01-11
申请号：US956458
申请日：1997-10-23
申请人： Christa Jaeger
发明人： Christa Jaeger
IPC分类号： A61K36/064 , C07K14/395 , C12P1/02 , C12P21/04
CPC分类号： C07K14/395 , A61K36/064 , Y10S435/94 , Y10S435/942
摘要： The invention relates to low-molecular, metabolism-activating mixtures of active ingredients from yeast fungi of the order Saccharomycetes and is characterized in that they are obtained from yeasts of the said order of Saccharomycetes, which are cultivated for some hours at temperatures starting at 37.degree. C., are heated to a maximum of 45.degree. C. and, following cooling, are subsequently processed in a manner known per se.
摘要翻译：本发明涉及来自酵母菌酵母真菌的活性成分的低分子，代谢活化混合物，其特征在于它们是从酵母菌的所述顺序的酵母获得的，其在37℃开始培养几小时加热至最高45℃，然后冷却后，以本身已知的方式进行加工。

7. 发明授权

US5919651A Expression of polypeptides in yeast 失效
标题翻译：多肽在酵母中的表达
公开(公告)号：US5919651A
公开(公告)日：1999-07-06
申请号：US465927
申请日：1995-06-06
申请人： Ronald A. Hitzeman , Franklin E. Hagie, IV , Benjamin D. Hall , Gustav Ammerer
发明人： Ronald A. Hitzeman , Franklin E. Hagie, IV , Benjamin D. Hall , Gustav Ammerer
IPC分类号： C12N15/09 , C07H21/04 , C07K14/555 , C07K14/56 , C07K14/575 , C07K14/61 , C07K14/62 , C07K14/655 , C12N1/16 , C12N1/19 , C12N1/21 , C12N15/00 , C12N15/81 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/865
CPC分类号： C12N15/81 , C07K14/555 , C07K14/56 , C07K14/57581 , C07K14/61 , C07K14/62 , C07K14/655 , C12P21/02 , Y10S435/942
摘要： DNA expression vectors capable, in a transformant strain of yeast, of expressing a polypeptide under the control of a genetically distinct yeast promoter, processes of forming transformant strains of yeast and transformed yeast strains are disclosed.
摘要翻译：公开了在转基因酵母菌株中能够在遗传上不同的酵母启动子控制下表达多肽的DNA表达载体，形成酵母和转化酵母菌株的转化菌株的方法。

8. 发明授权

US5798256A Catabolite non-repressed substrate-limited yeast strains 失效
标题翻译： Catabolite非抑制底物限制酵母菌株
公开(公告)号：US5798256A
公开(公告)日：1998-08-25
申请号：US631529
申请日：1996-04-12
申请人： David J. Domingues
发明人： David J. Domingues
IPC分类号： A21D6/00 , A21D8/04 , A21D10/00 , A21D10/02 , C12N1/18 , C12P7/06
CPC分类号： C12P7/06 , A21D10/02 , A21D10/025 , A21D6/001 , A21D8/047 , C12N1/18 , Y02E50/17 , Y10S435/942
摘要： The present invention includes a yeast cell utilizing solely galactose as a carbohydrate source in the presence of glucose.
摘要翻译：本发明包括在葡萄糖存在下仅使用半乳糖作为碳水化合物源的酵母细胞。

9. 发明授权

US5700684A Process for preparing a biomass, use of the biomass so prepared, and panification ferment 失效
标题翻译：制备生物质的方法，使用如此制备的生物质，以及整理发酵
公开(公告)号：US5700684A
公开(公告)日：1997-12-23
申请号：US440768
申请日：1995-05-15
申请人： Aloyse Ehret
发明人： Aloyse Ehret
IPC分类号： A21D8/04 , C12N1/18 , C12N1/20 , A23L1/28 , A23L1/221
CPC分类号： C12N1/20 , A21D8/045 , A21D8/047 , C12N1/18 , Y02E50/17 , Y10S435/819 , Y10S435/853 , Y10S435/855 , Y10S435/857 , Y10S435/942
摘要： A biomass constituted of yeast and of lactic acid bacteria, which can be used directly as panification ferment without previous separation of the culture medium and the biomass, is prepared by cocultivating at least one strain of yeast and at least one strain of lactic acid bacteria in a mixed and/or sequential culture, in a culture medium specified in the description. Preferably, the said ferment comprises as yeast the strain Saccharomyces cerevisiae steineri DSM 9211 and as lactic acid bacteria one or several strains of Lactobacillus brevis DSM 9209, Lactobacillus plantarum DSM 9208, Leuconostoc mesenteroides DSM 9207 and/or Pediococcus pentosaceus DSM 9210.
摘要翻译：通过共培养至少一种酵母菌株和至少一种乳酸菌菌株来制备由酵母和乳酸菌组成的生物质，其可以直接用作均化发酵而不经过培养基和生物质的分离，在本说明书中指定的培养基中的混合和/或顺序培养物。优选地，所述发酵物包含酿酒酵母酿酒酵母DSM 9211和乳酸菌一种或几种短乳杆菌DSM 9209，植物乳杆菌DSM 9208，肠膜明串管芽孢杆菌DSM 9207和/或戊糖片球菌DSM 9210。

10. 发明授权

US5693497A Process for expressing the hepatitis B virus antigen using a Saccharomyces cerevisiae transformant 失效
标题翻译：使用酿酒酵母转化体表达乙型肝炎病毒抗原的方法
公开(公告)号：US5693497A
公开(公告)日：1997-12-02
申请号：US378011
申请日：1995-01-25
申请人： Akihisa Takamizawa , Hiroyuki Fujita , Sadao Manabe , Masahiko Kato , Juichiro Osame , Iwao Yoshida , Takeo Konobe , Keisuke Takaku
发明人： Akihisa Takamizawa , Hiroyuki Fujita , Sadao Manabe , Masahiko Kato , Juichiro Osame , Iwao Yoshida , Takeo Konobe , Keisuke Takaku
IPC分类号： A61K39/29 , A61K39/00 , C07K14/00 , C07K14/02 , C07K14/10 , C07K14/18 , C12N15/00 , C12N15/09 , C12P21/02 , C12R1/865 , C12N1/19 , C12N15/51
CPC分类号： C07K14/005 , A61K39/00 , C12N2730/10122 , Y10S435/942
摘要： There is disclosed an antigen comprising an amino acid sequence of the suce antigen of a hepatitis B virus. The present antigen can be produced easily and safely at low cost by means of recombinant DNA technique. The present antigen can be used as an effective vaccine and diagnostic for hepatitis B.
摘要翻译：公开了包含乙型肝炎病毒的表面抗原的氨基酸序列的抗原。本发明的抗原可以通过重组DNA技术以低成本容易且安全地生产。本抗原可用作乙型肝炎的有效疫苗和诊断。

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