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1. 发明申请

US20170014794A1 LIGHT-CONTROLLED ELECTROKINETIC ASSEMBLY OF PARTICLES NEAR SURFACES 审中-公开
标题翻译：颗粒附近的光控电动总成近似表面
公开(公告)号：US20170014794A1
公开(公告)日：2017-01-19
申请号：US15216775
申请日：2016-07-22
申请人： BioArray Solutions, Ltd.
发明人： Michael SEUL
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00713 , B01L3/502707 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2200/0663 , B01L2200/0668 , B01L2300/0636 , B01L2300/0816 , B01L2300/0864 , B01L2300/0877 , B01L2300/089 , B01L2400/0415 , B01L2400/0427 , B01L2400/0454 , C12Q1/6825 , C12Q1/6837 , C40B40/00 , C40B40/04 , G01N15/1468 , G01N27/447 , G01N33/54313 , G01N33/54386 , G01N33/6845 , G01N2015/149 , G01N2015/1497 , G02B3/0012 , G02B3/0056 , G02B3/0075 , H05H3/04 , Y10S435/808 , Y10S435/81 , Y10S435/814 , Y10S436/806 , Y10S436/808 , Y10S436/809 , Y10T436/25125 , C12Q2565/501 , C12Q2563/155 , C12Q2565/607
摘要： A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components.
摘要翻译：一种用于在诸如氧化硅的绝缘电极和电解质溶液之间的界面处操作胶体颗粒和生物分子的方法和装置。表面附近颗粒的光控电动组装取决于三个功能元件的组合：交流电场引起的平面聚集体的组装; 电解质/氧化硅/硅界面的图案化以在组装过程上施加空间控制; 并通过外部照明实现对装配过程的实时控制。本发明提供一组基本操作，使得能够对几种类型的颗粒和生物分子的平面阵列的创建和放置以及阵列形状和尺寸的操纵进行交互式控制。本发明使得能够以阵列格式进行诊断测定和生化分析的样品制备和处理以及这些操作的功能整合。此外，本发明提供了用于产生具有所需性质的材料表面和用于制造表面安装光学部件的步骤。

2. 发明申请

US20160327574A1 Method and Device for Monitoring Medication Usage 审中-公开
公开(公告)号：US20160327574A1
公开(公告)日：2016-11-10
申请号：US15217688
申请日：2016-07-22
申请人： Marshfield Clinic, Inc.
发明人： Michael E.M. Larson , Thomas M. Richards
IPC分类号： G01N33/70 , G01N33/94
CPC分类号： G01N33/70 , G01N33/94 , G01N33/946 , G01N33/9486 , Y10S436/808 , Y10S436/901 , Y10T436/141111 , Y10T436/145555 , Y10T436/147777 , Y10T436/173845
摘要： The present invention provides methods for detecting and quantifying metabolites in a biological sample by measuring the concentration of a test metabolite in the sample and comparing that concentration against the concentration of the reference metabolite; enabling accurate metabolite concentration measurements to determine aberrant drug usage patterns. Also disclosed is an analytical testing device and related computer-assisted products for detecting and quantifying metabolites in a biological sample efficiently and accurately.

3. 发明申请

US20150323534A1 METHODS AND COMPOSITIONS FOR ANALYTE DETECTION 审中-公开
标题翻译：用于分析物检测的方法和组合物
公开(公告)号：US20150323534A1
公开(公告)日：2015-11-12
申请号：US14688946
申请日：2015-04-16
申请人： Nexus Dx, Inc.
发明人： Richard Laswell Egan , Graham Peter Lidgard , David Dickson Booker , Christopher Johann Johnson
IPC分类号： G01N33/569
CPC分类号： G01N33/56983 , B01L3/5023 , B01L3/5029 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2300/0832 , B01L2300/087 , B01L2400/0478 , B01L2400/0683 , C12Q1/701 , G01N33/558 , G01N2333/11 , G01N2469/10 , Y10S435/81 , Y10S436/808 , Y10S436/81
摘要： The present invention is directed to methods and apparatus for detection of one or more analytes. Analytes include agents or components of infectious agents such as pathogenic virus, as well as enzymes, proteins and biomarkers.
摘要翻译：本发明涉及用于检测一种或多种分析物的方法和装置。分析物包括感染因子如致病性病毒以及酶，蛋白质和生物标志物的试剂或成分。

4. 发明申请

US20150017733A1 Method and Device for Monitoring Medication Usage 审中-公开
公开(公告)号：US20150017733A1
公开(公告)日：2015-01-15
申请号：US14457466
申请日：2014-08-12
申请人： Marshfiled Clinic, Inc.
发明人： Michael E.M. Larson , Thomas M. Richards
IPC分类号： G01N33/94 , G01N33/70
CPC分类号： G01N33/70 , G01N33/94 , G01N33/946 , G01N33/9486 , Y10S436/808 , Y10S436/901 , Y10T436/141111 , Y10T436/145555 , Y10T436/147777 , Y10T436/173845
摘要： The present invention provides methods for detecting and quantifying metabolites in a biological sample by measuring the concentration of a test metabolite in the sample and comparing that concentration against the concentration of the reference metabolite; enabling accurate metabolite concentration measurements to determine aberrant drug usage patterns. Also disclosed is an analytical testing device and related computer-assisted products for detecting and quantifying metabolites in a biological sample efficiently and accurately.

5. 发明申请

US20140213597A1 Methods of Predicting and Treating Adverse Cardiac Events 审中-公开
标题翻译：预防和治疗不良心脏事件的方法
公开(公告)号：US20140213597A1
公开(公告)日：2014-07-31
申请号：US14227281
申请日：2014-03-27
申请人： Mohan Rajapurkar , Suhas Lele , Sudhir Shah
发明人： Mohan Rajapurkar , Suhas Lele , Sudhir Shah
IPC分类号： G01N33/20
CPC分类号： G01N33/20 , A61K31/4439 , G01N33/6893 , G01N33/84 , G01N2800/324 , G01N2800/325 , G01N2800/56 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/807 , Y10S436/808 , Y10S436/81 , Y10S436/811
摘要： The invention provides methods for treatment of acute coronary syndrome and prediction of adverse cardiac events on the basis of elevations of catalytic iron in biological fluid of a human subject. An embodiment of the invention provides a method for early detection of acute coronary syndrome (ACS) in a human subject at the time of presentation of the chest pain. The method includes analyzing a test sample of the biological fluid for amount of catalytic iron and detecting acute coronary syndrome in the human subject.
摘要翻译：本发明提供了治疗急性冠状动脉综合征的方法，并且基于人类受试者的生物流体中催化铁的升高来预测不良心脏事件。本发明的一个实施方案提供了在呈现胸痛时在人类受试者中早期检测急性冠状动脉综合征（ACS）的方法。该方法包括分析生物流体的测试样品中的催化铁量并检测人类受试者的急性冠脉综合征。

6. 发明授权

US08691953B2 Binding compounds for IL-27 有权
标题翻译： IL-27的结合化合物
公开(公告)号：US08691953B2
公开(公告)日：2014-04-08
申请号：US13330902
申请日：2011-12-20
申请人： Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
发明人： Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
IPC分类号： C07K16/00
CPC分类号： C07K14/54 , C07K14/5434 , C07K16/244 , C12Q1/6881 , Y10S436/808
摘要： Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译：提供了编码来自哺乳动物的细胞因子或复合细胞因子的纯化基因，与其相关的试剂，包括纯化蛋白质，特异性抗体和编码这些分子的核酸。还提供了使用所述试剂和诊断试剂盒的方法。

7. 发明授权

US08163560B2 Coated test elements 有权
标题翻译：涂层测试元素
公开(公告)号：US08163560B2
公开(公告)日：2012-04-24
申请号：US10581409
申请日：2004-12-03
申请人： Rudolf Pachl , Jürgen Hoferer , Branislav Babic , Martin Frank , Wilfried Schmid
发明人： Rudolf Pachl , Jürgen Hoferer , Branislav Babic , Martin Frank , Wilfried Schmid
IPC分类号： G01N33/48
CPC分类号： B01L3/502715 , A61B2562/0295 , B01L3/502707 , B01L2200/027 , B01L2300/0825 , B01L2300/0887 , B01L2300/166 , B01L2400/0406 , Y10S436/808
摘要： The invention concerns coated test elements and in particular test elements comprising a capillary gap which have a hydrophobic structured coating at least in the area surrounding the capillary gap.
摘要翻译：本发明涉及涂覆的测试元件，特别是包括至少在围绕毛细管间隙的区域中具有疏水性结构化涂层的毛细管间隙的测试元件。

8. 发明授权

US08133718B2 Analytical strip and detecting method using the same 失效
标题翻译：分析带和使用其的检测方法
公开(公告)号：US08133718B2
公开(公告)日：2012-03-13
申请号：US12431915
申请日：2009-04-29
申请人： Yi-Jen Wu , Chih-Wei Hsieh , Wen-Pin Hsieh
发明人： Yi-Jen Wu , Chih-Wei Hsieh , Wen-Pin Hsieh
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , Y10S435/817 , Y10S435/97 , Y10S435/975 , Y10S436/808 , Y10S436/823
摘要： An analytical strip and a detecting method using the analytical strip are provided. The analytical strip includes a substrate having a channel thereon. The channel has a first region, a second region and a third region, which are arranged successively. A first antibody is localized in the first region. A saccharide and a peroxidase are localized in the first or second region. A second antibody for recognizing a different epitope of an identical antigen with the first antibody is immobilized in the second region. A substrate reagent including a saccharide oxidase is localized in the third region.
摘要翻译：提供了使用分析条的分析条和检测方法。分析条包括其上具有通道的基板。通道具有依次布置的第一区域，第二区域和第三区域。第一抗体定位于第一区域。糖和过氧化物酶定位在第一或第二区域。用于识别与第一抗体相同抗原的不同表位的第二抗体固定在第二区域中。含有糖类氧化酶的底物试剂位于第3区域。

9. 发明授权

US08101429B2 Native analyte as a reference in lateral flow assays 有权
标题翻译：天然分析物作为侧流测定中的参考
公开(公告)号：US08101429B2
公开(公告)日：2012-01-24
申请号：US10557300
申请日：2004-06-03
申请人： Gary H. Krauth , David J. Ledden
发明人： Gary H. Krauth , David J. Ledden
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , G01N33/56911 , G01N33/56927 , G01N33/56988 , G01N33/571 , G01N33/6854 , G01N33/6887 , G01N33/689 , Y10S435/805 , Y10S435/81 , Y10S435/969 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/805 , Y10S436/808 , Y10S436/81
摘要： This invention is directed to a lateral flow assay for detecting the presence of an analyte in a liquid test sample. The lateral flow assay represents an improvement in the ability to accurately and with high fidelity to detect the presence or absence of a target analyte in a liquid sample, in part, by encompassing a reference region of immobilized, non-diffusible analyte that allows for detection of any factors that interfere with the interaction and binding of the analyte to the labeled capture reagent. Any influences on the interaction and binding of the analyte that is free in solution in the liquid test sample to its complementary labeled reagent will be encountered in parallel in the binding between the immobilized analyte in reference region to the labeled reagent as it diffuses through the reference region. In one embodiment, the lateral flow assay of the invention is a urine-based human Chorionic Gonadotropin (hCG) assay.
摘要翻译：本发明涉及用于检测液体测试样品中分析物的存在的侧向流动测定。横向流量测定表示准确地并且以高保真度检测液体样品中目标分析物的存在或不存在的能力的改进，部分地通过包含允许检测的固定的不扩散分析物的参考区域干扰分析物与标记的捕获试剂的相互作用和结合的任何因素。在液体测试样品中溶液中游离的分析物与其互补的标记试剂之间的相互作用和结合的任何影响将在参考区域中固定化分析物与标记试剂之间的结合中并行遇到，因为它通过参考文献扩散地区。在一个实施方案中，本发明的侧流测定是基于尿液的人绒毛膜促性腺激素（hCG）测定。

10. 发明申请

US20110269247A1 MEASUREMENT KIT AND AN IMMUNOCHROMATOGRAPHY METHOD 有权
标题翻译：测量套件和免疫组化方法
公开(公告)号：US20110269247A1
公开(公告)日：2011-11-03
申请号：US13177971
申请日：2011-07-07
申请人： Hiroyuki CHIKU , Junichi Katada , Hideyuki Karaki , Hiroki Terada
发明人： Hiroyuki CHIKU , Junichi Katada , Hideyuki Karaki , Hiroki Terada
IPC分类号： G01N33/53 , G01N33/48
CPC分类号： G01N33/558 , Y10S435/805 , Y10S435/81 , Y10S435/96 , Y10S435/97 , Y10S436/808 , Y10S436/81
摘要： It is an object of the present invention to provide a measurement kit for developing a first developing solution and a second developing solution from different directions to suppress background noise, and an immunochromatography kit. The present invention provides a measurement kit, which comprises a first developing member for supplying a first developing solution and a second developing member for supplying a second developing solution, wherein the developing direction of the first developing solution is allowed to intersect with the developing direction of the second developing solution, so that development is carried out by developing the first and second developing solutions in different developing directions, and a water absorbent portion is established on the downstream of each of the developing directions.
摘要翻译：本发明的目的是提供一种用于从不同方向开发第一显影液和第二显影液以抑制背景噪音的测量组件和免疫色谱仪。本发明提供了一种测量套件，其包括用于供应第一显影液的第一显影构件和用于供应第二显影液的第二显影构件，其中使第一显影液的显影方向与显影方向相交，第二显影液，通过在不同的显影方向显影第一和第二显影液进行显影，并且在每个显影方向的下游形成吸水部分。

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