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1. 发明申请

US20190187060A1 CONTINUOUS INTERLEAVED PROCESS FOR CONDUCTING AN ASSAY IN A MULTI-WELL PLATE 审中-公开
公开(公告)号：US20190187060A1
公开(公告)日：2019-06-20
申请号：US16270062
申请日：2019-02-07
申请人： MESO SCALE TECHNOLOGIES, LLC
发明人： Charles M. CLINTON , Eli N. GLEZER , Sharon WEST , George SIGAL , Carl STEVENS , Michael L. VOCK
IPC分类号： G01N21/76 , G01N35/02 , G01N21/69 , G01N35/00
CPC分类号： G01N21/76 , G01N21/69 , G01N35/0092 , G01N35/028 , G01N35/1079 , G01N2035/0425 , Y10T436/114165
摘要： We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

2. 发明申请

US20180348102A1 IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD 审中-公开
公开(公告)号：US20180348102A1
公开(公告)日：2018-12-06
申请号：US16102166
申请日：2018-08-13
申请人： Lee H. Angros
发明人： Lee H. Angros
IPC分类号： G01N1/31 , B01L3/02 , G01N1/44 , G01N35/00 , B01L7/00
CPC分类号： G01N1/312 , B01J2219/0036 , B01J2219/00477 , B01J2219/00495 , B01J2219/00533 , B01J2219/00659 , B01L3/0293 , B01L7/54 , B01L2200/04 , B01L2200/16 , B01L2300/0822 , B01L2300/14 , B01L2400/0478 , G01N1/44 , G01N35/00029 , G01N2035/00039 , G01N2035/00138 , G01N2035/00168 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165
摘要： A microscope slide staining system has a chamber, a plurality of slide support elements, a plurality of spreading devices positionable in association with microscope slides supported on the slide support elements so the spreading devices define a gap between the spreading device and the microscope slide and so the spreading device and the microscope slide are movable relative to one another to spread at least one reagent on the microscope slide independent of the other spreading devices and microscope slides.

3. 发明申请

US20180238919A1 IN-VITRO DIAGNOSTIC ANALYSIS METHOD AND SYSTEM 审中-公开
公开(公告)号：US20180238919A1
公开(公告)日：2018-08-23
申请号：US15961182
申请日：2018-04-24
申请人： Roche Diagnostics Operations, Inc.
发明人： Thomas Meyer , Gottlieb Schacher , Rolf Sigrist , Christian Guzek
IPC分类号： G01N35/00 , G01N35/10 , G01N35/02 , G01N33/86
CPC分类号： G01N35/0092 , G01N33/86 , G01N35/026 , G01N35/1002 , G01N35/1065 , G01N2035/00356 , G01N2035/00524 , G01N2035/0094 , Y10T436/113332 , Y10T436/114165 , Y10T436/115831 , Y10T436/2575
摘要： A method and system for automatic in-vitro diagnostic analysis are described. The method includes adding a first reagent type and a second reagent type to a first test liquid during a first and second cycle times respectively. The addition of the first reagent type to the first test liquid includes parallel addition of a second reagent type to a second test liquid during the first cycle time. The addition of the second reagent type to the first test liquid includes parallel addition of a first reagent type to a third test liquid during the second cycle time, respectively.

4. 发明授权

US09952238B2 Automatic method of preparing samples of total blood for analysis, and an automatic device for implementing the method 有权
公开(公告)号：US09952238B2
公开(公告)日：2018-04-24
申请号：US11994959
申请日：2006-07-04
申请人： Roger Le Comte
发明人： Roger Le Comte
IPC分类号： G01N35/00 , G01N35/04 , G01N35/10
CPC分类号： G01N35/00594 , G01N35/00584 , G01N35/00712 , G01N35/0092 , G01N35/0099 , G01N35/04 , G01N35/1097 , G01N2035/00524 , G01N2035/0406 , Y10T436/10 , Y10T436/114165
摘要： The present invention relates to a method of preparing analyses of total blood samples and to a device that is useful for implementing the method, said samples being conserved in tubes including at least one identification means for identifying the sample, the device comprising: at least one compartment constituting a said storage zone for storing said tubes before and after analysis; and at least one said read means for reading said identification means of said tubes; and at least one preparation zone for preparing said blood samples prior to analysis and including means for verifying and/or treating said tubes containing said samples, and in particular at least one agitator means for agitating said tubes; and at least one access zone giving access to at least one automatic analyzer of total blood, said access zone enabling a said tube to be placed in said analyzer; and robotic gripper and displacement means controlled by an automatic controller and suitable for taking hold of and replacing said tubes individually in said storage zone and for conveying them in at least three directions XYZ between said storage zone, said preparation zone and said access zone giving access to said analyzer, said analyzer preferably being connected to and/or controlled by said automatic controller.

5. 发明授权

US09766165B2 In situ heat induced antigen recovery and staining apparatus and method 有权
公开(公告)号：US09766165B2
公开(公告)日：2017-09-19
申请号：US15050132
申请日：2016-02-22
申请人： Lee H. Angros
发明人： Lee H. Angros
IPC分类号： G01N31/00 , G01N33/53 , G01N1/31 , B01L3/02 , G01N1/44 , G01N35/00 , B01L7/00
CPC分类号： G01N1/312 , B01J2219/0036 , B01J2219/00477 , B01J2219/00495 , B01J2219/00533 , B01J2219/00659 , B01L3/0293 , B01L7/54 , B01L2200/04 , B01L2200/16 , B01L2300/0822 , B01L2300/14 , B01L2400/0478 , G01N1/44 , G01N35/00029 , G01N2035/00039 , G01N2035/00138 , G01N2035/00168 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165
摘要： An automated microscope slide staining system and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments or a pressurizable common chamber for individually and independently processing a plurality of microscope slides. The apparatus preferably features independently movable slide support elements each having an individually operable heating element.

6. 发明授权

US09695467B2 Method for processing nucleic acids-containing fluids 有权
公开(公告)号：US09695467B2
公开(公告)日：2017-07-04
申请号：US14553151
申请日：2014-11-25
申请人： Roche Molecular Systems, Inc.
发明人： Reto Keller , Thomas Meyer
IPC分类号： C12Q1/68 , B01L7/00 , B01L9/00 , B03C1/28 , G01N35/00
CPC分类号： C12Q1/6806 , B01L7/52 , B01L9/523 , B01L2200/0668 , B01L2300/0829 , B01L2300/1805 , B01L2300/1822 , B01L2300/1844 , B03C1/288 , G01N35/0098 , G01N2035/00574 , Y10T436/113332 , Y10T436/114165
摘要： A system and method for the processing of nucleic acids containing fluids involving manipulation of magnetically responsive particles contained therein are disclosed. In the system, a holder holds a plurality of containers containing the fluids, a heating device applies thermal energy to the fluids for incubation, and a separating device magnetically separates the particles. The heating and separating devices move into at least one operative position for processing the fluids and at least one inoperative position with respect to the containers, in which the containers are kept stationary at least during and in-between incubating the fluids and manipulating the magnetically responsive particles.

7. 发明申请

US20170097372A1 LABORATORY SAMPLE DISTRIBUTION SYSTEM, LABORATORY SYSTEM AND METHOD OF OPERATING 审中-公开
公开(公告)号：US20170097372A1
公开(公告)日：2017-04-06
申请号：US15380443
申请日：2016-12-15
申请人： Roche Diagnostics Operations, Inc.
发明人： Michael Heise , Hans Schneider
IPC分类号： G01N35/04 , B65G54/02
CPC分类号： G01N35/04 , B65G37/00 , B65G54/02 , G01N2035/0465 , G01N2035/0477 , Y10T436/114165
摘要： A laboratory sample distribution system is presented. The laboratory sample distribution system comprises a plurality of container carriers. The container carriers each comprise at least one magnetically active device such as, for example, at least one permanent magnet, and carry a sample container containing a sample. The system further comprises a transport plane to carry the multiple container carriers and a plurality of electro-magnetic actuators stationary arranged below the transport plane. The electro-magnetic actuators move a container carrier on top of the transport plane by applying a magnetic force to the container carrier. The system also comprises at least one transfer device to transfer a sample item, wherein the sample item is a container carrier, a sample container, part of the sample and/or the complete sample, between the transport plane and a laboratory station such as, for example, a pre-analytical, an analytical and/or a post-analytical station.

8. 发明授权

US09606034B2 In situ heat induced antigen recovery and staining method 有权
公开(公告)号：US09606034B2
公开(公告)日：2017-03-28
申请号：US14930402
申请日：2015-11-02
申请人： Lee H. Angros
发明人： Lee H. Angros
IPC分类号： G01N21/00 , G01N1/44 , G01N1/31 , G01N33/52 , G01N33/53 , G01N1/30 , B01L9/00
CPC分类号： G01N1/30 , B01L9/52 , G01N1/312 , G01N1/44 , G01N33/52 , G01N33/521 , G01N33/53 , G01N33/5306 , G01N35/00029 , G01N35/00584 , G01N2035/00138 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. The reaction conditions for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide.

9. 发明授权

US09575086B2 Laboratory sample distribution system, laboratory system and method of operating 有权
标题翻译：实验室样品分配系统，实验室系统及操作方法
公开(公告)号：US09575086B2
公开(公告)日：2017-02-21
申请号：US14920097
申请日：2015-10-22
申请人： Roche Diagnostics Operations, Inc.
发明人： Michael Heise , Hans Schneider
IPC分类号： G01N35/04 , B65G47/74 , B65G54/02 , B65G37/00
CPC分类号： G01N35/04 , B65G37/00 , B65G54/02 , G01N2035/0465 , G01N2035/0477 , Y10T436/114165
摘要： A laboratory sample distribution system is presented. The laboratory sample distribution system comprises a plurality of container carriers. The container carriers each comprise at least one magnetically active device such as, for example, at least one permanent magnet, and carry a sample container containing a sample. The system further comprises a transport plane to carry the multiple container carriers and a plurality of electro-magnetic actuators stationary arranged below the transport plane. The electro-magnetic actuators move a container carrier on top of the transport plane by applying a magnetic force to the container carrier. The system also comprises at least one transfer device to transfer a sample item, wherein the sample item is a container carrier, a sample container, part of the sample and/or the complete sample, between the transport plane and a laboratory station such as, for example, a pre-analytical, an analytical and/or a post-analytical station.
摘要翻译：提出了实验室样品分配系统。实验室样品分配系统包括多个容器载体。容器载体各自包括至少一个磁性活动装置，例如至少一个永久磁铁，并携带含有样品的样品容器。该系统还包括一个运送平面，用于承载多个集装箱运送装置和多个固定地布置在运输平面下方的电磁致动器。电磁致动器通过向容器载体施加磁力而将容器载体移动到输送平面的顶部。该系统还包括至少一个转运装置，用于传送样品物品，其中样品物品是运输平面和实验室之间的容器载体，样品容器，样品的一部分和/或完整的样品，例如，预分析，分析和/或分析后站。

10. 发明申请

US20170023449A1 IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD 审中-公开
标题翻译：在原发热诱导的抗原恢复和染色设备和方法
公开(公告)号：US20170023449A1
公开(公告)日：2017-01-26
申请号：US15289675
申请日：2016-10-10
申请人： Lee H. Angros
发明人： Lee H. Angros
IPC分类号： G01N1/30 , G01N1/44 , G01N35/00 , G01N1/31
CPC分类号： G01N1/30 , B01L9/52 , G01N1/312 , G01N1/44 , G01N33/52 , G01N33/521 , G01N33/53 , G01N33/5306 , G01N35/00029 , G01N35/00584 , G01N2035/00138 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. Each treatment step occurs within the same reaction compartment. The reaction conditions of each reaction compartment for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide.
摘要翻译：一种用于处理多个显微镜载片的自动原位热诱导抗原恢复和染色方法和装置。在相同的装置中进行热诱导的抗原恢复过程和在显微镜载玻片上染色生物样品的过程，其中显微镜幻灯片不需要从一个装置物理移除到另一个装置。每个处理步骤发生在相同的反应室内。用于处理载玻片的每个反应室的反应条件可以独立地进行控制，包括各载玻片的各种试剂的应用以及各载玻片的个体化处理。

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