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1. 发明授权

US09523091B2 Nucleic-acid extraction method and nucleic-acid extraction cartridge 有权
标题翻译：核酸提取方法和核酸提取盒
公开(公告)号：US09523091B2
公开(公告)日：2016-12-20
申请号：US13533348
申请日：2012-06-26
申请人： Tasuku Yotoriyama , Tomohiko Nakamura , Naohisa Sakamoto , Kazumine Ito , Tomoteru Abe , Michihiro Ohnishi
发明人： Tasuku Yotoriyama , Tomohiko Nakamura , Naohisa Sakamoto , Kazumine Ito , Tomoteru Abe , Michihiro Ohnishi
IPC分类号： C07H21/00 , B01D59/42 , C12N15/10
CPC分类号： C12N15/1006 , C12N15/101
摘要： The present disclosure provides a nucleic-acid extraction method for carrying out the following procedures in the same cell, the procedures including: performing an ultrasonic process on a sample containing a nucleic acid; adsorbing substances contained in the sample by making use of an adsorption carrier; and condensing the nucleic acid by damming the nucleic acid moving in an electrophoresis phenomenon. In accordance with the nucleic-acid extraction method, it is possible to carry out an ultrasonic process, an adsorption process and an electrophoresis process in the same cell. Thus, it is possible to eliminate an operation to transfer the sample from one cell to another one for each of the processes.
摘要翻译：本公开内容提供了用于在相同细胞中进行以下程序的核酸提取方法，其方法包括：对含有核酸的样品进行超声波处理; 通过使用吸附载体吸附样品中所含的物质; 并通过阻止以电泳现象移动的核酸来冷凝核酸。根据核酸提取方法，可以在同一电池中进行超声波处理，吸附处理和电泳处理。因此，可以消除用于每个处理将样品从一个单元传送到另一个单元的操作。

2. 发明授权

US09056272B2 Isotopes separation and purification in an electrolytic medium 有权
标题翻译：电解质中同位素分离和纯化
公开(公告)号：US09056272B2
公开(公告)日：2015-06-16
申请号：US11307947
申请日：2006-02-28
申请人： Tarek A. Z. Farag
发明人： Tarek A. Z. Farag
IPC分类号： B01D59/38 , B01D59/42 , B01D53/22 , B01D53/24 , B01D53/32 , B01D61/44
CPC分类号： B01D59/42 , B01D53/226 , B01D53/229 , B01D53/24 , B01D53/326 , B01D61/44 , B01D2259/814 , B01D2311/2603 , B01D2311/2676
摘要： A system and method for continuously separating different isotopes of a particular element, such as Uranium, Zirconium, or Hydrogen, in an electrolytic medium. The ions of the isotopes to be separated are moved in the electrolytic medium using electric field. As the lighter ions will move faster than the heavier ions, the separation will happen and the lighter ions will be ahead of the heavier ions by a separation distance. To improve the separation, other forces (either proportional to the mass or not) are generated on the ions in directions that add additional separation factors. These forces could be centrifugal, electromagnetic, resistive dragging, mechanical (flow), etc. The invented separation process and device is simple and less expensive than other comparable devices, providing outstanding separation at low cost, and could be built using the already available materials and technologies that exist in any country in the world.
摘要翻译：用于在电解介质中连续分离特定元素如铀，锆或氢的不同同位素的系统和方法。待分离的同位素的离子使用电场在电解介质中移动。由于较轻的离子将比较重的离子移动得更快，所以分离将发生，较轻的离子将在较重的离子之前通过间隔距离。为了改善分离，在离子上产生另外的力（与质量成比例的）与添加附加分离因子的方向相反。这些力可以是离心式，电磁式，电阻式拖动，机械（流动）等。本发明的分离方法和装置比其他可比较的装置简单且便宜，以低成本提供优异的分离，并且可以使用已经提供的材料和世界任何国家都存在的技术。

3. 发明授权

US08476063B2 Microfluidic devices 有权
公开(公告)号：US08476063B2
公开(公告)日：2013-07-02
申请号：US12815685
申请日：2010-06-15
申请人： Stevan Bogdan Jovanovich , Iuliu Ioan Blaga
发明人： Stevan Bogdan Jovanovich , Iuliu Ioan Blaga
IPC分类号： C12M1/34 , C12M3/00 , C12M1/00 , C12Q1/68 , C12P19/34 , C12N13/00 , C07H21/04 , B01D59/42
CPC分类号： C12Q1/6869 , B01F11/0071 , B01F13/0059 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/502738 , B01L3/502753 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/0668 , B01L2200/10 , B01L2300/0627 , B01L2300/0636 , B01L2300/0654 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844 , B01L2400/0415 , B01L2400/0421 , B01L2400/0481 , B01L2400/0655 , C12N15/1003 , C12N15/1013 , C12Q1/24 , C12Q1/6806 , C12Q1/6844 , C12Q1/686 , C12Q1/70 , G01N2035/00514 , Y10T436/163333 , Y10T436/25875
摘要： Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.

4. 发明授权

US08287708B2 Microfluidic system and method for creating an encapsulated droplet with a removable shell 有权
标题翻译：微流体系统和用可移除壳体创建封装液滴的方法
公开(公告)号：US08287708B2
公开(公告)日：2012-10-16
申请号：US12815580
申请日：2010-06-15
申请人： Shih-Kang Fan , Yao-Wen Hsu , Chiun-Hsun Chen
发明人： Shih-Kang Fan , Yao-Wen Hsu , Chiun-Hsun Chen
IPC分类号： B01D57/02 , B01D59/42 , B01D59/50 , C02F1/469 , C07K1/26 , C08F2/58 , C25B7/00 , C25B15/00 , G01F1/64 , G01L1/20 , G01L9/18
CPC分类号： B01J13/04 , Y10T436/2575
摘要： A microfluidic system for creating encapsulated droplets whose shells can be further removed comprises: two electrode plates and a spacing structure disposed between the two electrode plates. One of the electrode plates has three reservoir electrodes and a plurality of channel electrodes. The three electrodes are respectively used for accommodating a shell liquid, a core liquid, and a removing liquid which is able to remove the shell liquid. The channel electrodes are used for communicating droplets among the three reservoir electrodes. Via these arrangements, the microfluidic system can create a quantitative shell droplet and a quantitative core droplet, and then merge the shell and core droplets to form an encapsulated droplet. Moreover, the shell of the encapsulated droplet can be removed by mixing it with the removing liquid. This invention is further provided with a method for creating an encapsulated droplet with a removable shell.
摘要翻译：用于产生可以进一步去除其外壳的封装液滴的微流体系统包括：两个电极板和设置在两个电极板之间的间隔结构。一个电极板具有三个储存电极和多个通道电极。三个电极分别用于容纳壳体液体，核心液体和能够去除壳液体的去除液体。通道电极用于在三个储存器电极之间连通液滴。通过这些布置，微流体系统可以产生定量的壳滴和定量核心液滴，然后合并壳核和液滴以形成包封的液滴。此外，可以通过将其与除去液体混合来除去包封液滴的壳。本发明进一步提供了一种用可移除的外壳形成包封的液滴的方法。

5. 发明申请

US20120156093A1 METHOD AND APPARATUS FOR SUPPLYING LIQUID WITH IONS, STERILIZATION METHOD AND APPARATUS 失效
标题翻译：用于提供液体的离子的方法和装置，灭菌方法和装置
公开(公告)号：US20120156093A1
公开(公告)日：2012-06-21
申请号：US13404691
申请日：2012-02-24
申请人： Katsuhisa KITANO
发明人： Katsuhisa KITANO
IPC分类号： A61L2/20 , B01D59/42
CPC分类号： C02F1/4608 , A23L3/26 , A61L2/14 , A61L2/18 , C02F2303/04 , H05H1/2406 , H05H2001/2462 , H05H2245/1225
摘要： A method and apparatus is provided for efficiently supplying a liquid with ions or radicals generated by plasma and so on, or for effectively sterilizing microorganisms present in a liquid or on the surface thereof. The method includes generating plasma in a gas phase by a plasma generation device, producing ions or radicals in the gas phase by the plasma; electrophoresing the ions or radicals toward the liquid by an electric field applied to the produced ions or radicals; and diffusing the ions or radicals into the liquid. The liquid is adjusted to have a pH value of 4.8 or lower for effective sterilization.
摘要翻译：提供了一种方法和装置，用于有效地向液体供应由等离子体等产生的离子或自由基，或用于有效地灭菌存在于液体中或其表面上的微生物。该方法包括通过等离子体产生装置在气相中产生等离子体，通过等离子体在气相中产生离子或自由基; 通过施加到产生的离子或自由基的电场将离子或自由基电荷流向液体; 并将离子或自由基扩散到液体中。将液体调节至pH值为4.8以下，进行有效的灭菌。

6. 发明授权

US08137512B2 Process for analyzing sample by capillary electrophoresis method 有权
标题翻译：毛细管电泳法分析样品的方法
公开(公告)号：US08137512B2
公开(公告)日：2012-03-20
申请号：US12376744
申请日：2007-08-29
申请人： Yoshihide Tanaka , Shinichi Wakida , Yusuke Nakayama , Satoshi Yonehara
发明人： Yoshihide Tanaka , Shinichi Wakida , Yusuke Nakayama , Satoshi Yonehara
IPC分类号： B01D57/02 , B01D59/42 , C02F1/469 , C07K1/26
CPC分类号： G01N27/447 , G01N27/44756
摘要： A process for analyzing a sample by a capillary electrophoresis method is provided that allows the apparatus to be reduced in size, allows a high analytical precision to be obtained, and can be carried out easily. The analytical process of the present invention is a process for analyzing a sample by a capillary electrophoresis method. The analytical process includes preparing a capillary tube to be used for the capillary electrophoresis method, and performing electrophoretic separation of a complex of a sample and an anionic group-containing compound that are bonded together, in the capillary tube, wherein the capillary tube includes an anionic layer that is formed of the anionic group-containing compound and that is coated on the inner wall of the capillary tube, and the anionic layer is fixed to the inner wall of the capillary tube by a covalent bond.
摘要翻译：提供了一种通过毛细管电泳方法分析样品的方法，其允许减小装置的尺寸，允许获得高分析精度，并且可以容易地进行。本发明的分析方法是通过毛细管电泳法分析样品的方法。分析方法包括制备用于毛细管电泳方法的毛细管，并且在毛细管中进行电泳分离粘合在一起的样品和含阴离子基团的化合物的络合物，其中毛细管包括阴离子层，其由含阴离子基团的化合物形成并被涂布在毛细管的内壁上，阴离子层通过共价键固定在毛细管的内壁上。

7. 发明申请

US20100126866A1 METHODS OF DETERMINING POLYDISPERSITY AND/OR MOLECULAR WEIGHT DISTRIBUTION OF A POLYETHYLENE GLYCOL SAMPLE 审中-公开
标题翻译：确定聚乙二醇样品多聚性和/或分子量分布的方法
公开(公告)号：US20100126866A1
公开(公告)日：2010-05-27
申请号：US12621051
申请日：2009-11-18
申请人： Jasmin Kemptner , Martina Marchetti-Deschmann , Juergen Siekmann , Peter Turecek , Hans-Peter Schwarz , Guenter Allmaier
发明人： Jasmin Kemptner , Martina Marchetti-Deschmann , Juergen Siekmann , Peter Turecek , Hans-Peter Schwarz , Guenter Allmaier
IPC分类号： B01D59/42
CPC分类号： G01N27/624
摘要： Disclosed herein are methods of determining polydispersity (PDI) and molecular mass distribution (MMD) of reactive PEG samples using mass spectrometry. More specifically, a mass spectrometry method called GEMMA is used to determine PDI and MMD of PEG samples which provides more accurate measurements for high molecular weight PEG samples than prior known MALDI-TOF analysis.
摘要翻译：本文公开了使用质谱测定反应性PEG样品的多分散性（PDI）和分子量分布（MMD）的方法。更具体地，使用称为GEMMA的质谱法来测定PEG样品的PDI和MMD，其提供了比现有已知的MALDI-TOF分析更高精度的高分子量PEG样品的测量。

8. 发明申请

US20100038245A1 Electrochemically Driven Pump 有权
标题翻译：电动泵
公开(公告)号：US20100038245A1
公开(公告)日：2010-02-18
申请号：US12192781
申请日：2008-08-15
申请人： Hamish Small , Yan Liu , Christopher A. Pohl
发明人： Hamish Small , Yan Liu , Christopher A. Pohl
IPC分类号： B01D59/42
CPC分类号： G01N30/96 , B01D61/427 , F04B17/00 , G01N30/32 , G01N30/34 , G01N30/6095
摘要： A continuous electrochemical pump comprising a water generator compartment, an anode compartment on one side of said generator compartment, a cation exchange barrier, separating the generator compartment from the anode compartment, a first electrode in electrical communication with the anode compartment, a cathode compartment adjacent the generator chamber, an anion exchange barrier, separating the generation compartment from the cathode compartment, and a second electrode in electrical communication with the cathode compartment. Use of the pump as a sample concentrator. A feedback loop for the pump. A reservoir, with or without an intermediate piston, on the output side of the pump.
摘要翻译：一种连续电化学泵，包括水发生器室，在所述发生器室的一侧上的阳极室，阳离子交换屏障，将发生器室与阳极室分开，与阳极室电连通的第一电极，邻近的阴极室所述发生器室，阴离子交换屏障，将所述发电室与所述阴极室分开，以及与所述阴极室电连通的第二电极。使用泵作为样品浓缩器。泵的反馈回路。在泵的输出侧具有或不具有中间活塞的储存器。

9. 发明申请

US20090084680A1 SAMPLE STACKING METHOD USING ON-LINE AUTOMATIC SOLID PHASE EXTRACTION COUPLED TO NONAQUEOUS CAPILLARY ELECTROPHORESIS AND INTERFACE STRUCTURE BETWEEN SOLID-PHASE PRECONCENTRATION CARTRIDGE AND CAPILLARY THEREFOR 有权
标题翻译：采用在线自动固相萃取法与非毛细管电泳耦合的样品堆叠方法和固相预处理盒与其毛细管之间的界面结构
公开(公告)号：US20090084680A1
公开(公告)日：2009-04-02
申请号：US12206221
申请日：2008-09-08
申请人： Doo Soo CHUNG , Lichun LIU , Kihwan CHOI
发明人： Doo Soo CHUNG , Lichun LIU , Kihwan CHOI
IPC分类号： B01D59/42
CPC分类号： G01N27/44743 , G01N1/405
摘要： A sample stacking method using on-line automatic solid phase extraction coupled to nonaqueous capillary electrophoresis, and an interface structure between a solid-phase preconcentration cartridge and a capillary therefor. The sample analysis method using solid phase extraction coupled to nonaqueous capillary electrophoresis by connecting a solid-phase preconcentration cartridge with a capillary includes: extracting a sample on a solid phase; injecting an elution solvent at an outlet terminal of the capillary, the elution solution desorbing analytes adsorbed onto a solid-phase material of a solid-phase preconcentration cartridge; and injecting a nonaqueous buffer solution from the outlet terminal of the capillary to push the elution solvent to the solid-phase material.
摘要翻译：使用在线自动固相萃取耦合到非水性毛细管电泳的样品堆叠方法，以及固相预浓缩筒和其毛细管之间的界面结构。使用固相萃取偶联至非水性毛细管电泳的样品分析方法通过将固相预浓缩滤筒与毛细管连接，包括：在固相上提取样品; 在毛细管的出口端注入洗脱溶剂，洗脱溶液解吸吸附在固相预浓缩筒的固相材料上的分析物; 并从毛细管的出口端注入非水缓冲溶液以将洗脱溶剂推到固相材料中。

10. 发明申请

US20070181428A1 ELECTRODIALYZED COMPOSITIONS AND METHOD OF TREATING AQUEOUS SOLUTIONS USING ELECTRODIALYSIS 审中-公开
标题翻译：电化学组合物和使用电化学处理水溶液的方法
公开(公告)号：US20070181428A1
公开(公告)日：2007-08-09
申请号：US11735160
申请日：2007-04-13
申请人： Colin Crowley , Jimbay Loh
发明人： Colin Crowley , Jimbay Loh
IPC分类号： B01D59/42
CPC分类号： C02F1/4693 , A23L2/74 , B01D61/445 , C02F1/4618 , C02F1/66 , C02F2201/46115 , C02F2209/06
摘要： An electrodialysis system is used to produce electrodialyzed compositions with altered pH but without objectionable odor and taste. An aqueous solution is contacted with a membrane electrodialysis system and an electrical potential is applied in an amount effective for changing the pH of the aqueous solution by at least about 2.0 and for providing an electrodialyzed composition having a total cation or anion concentration of about 1.0N or less, and individual cation or anion concentration of about 0.6N of less, and a free chlorine content of about 2 ppm or less.
摘要翻译：电渗析系统用于生产具有改变的pH但没有令人讨厌的气味和味道的电渗析组合物。将水溶液与膜电渗析系统接触，并且施加的电位以对于将水溶液的pH改变至少约2.0有效的量，并且提供具有约1.0N的总阳离子或阴离子浓度的电渗析组合物或更少，单独的阳离子或阴离子浓度为约0.6N以下，游离氯含量为约2ppm以下。

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