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1. 发明申请

US20170159189A1 METHOD FOR PRODUCING 1,5-DIAMINONAPHTHALENE AND 1-AMINO-5-NITRONAPHTHALENE BY DIRECT ELECTROCHEMICAL AMINATION OF NON-ACTIVATED OR DEACTIVATED AROMATIC SYSTEMS ON BORON-DOPED DIAMOND ANODES 审中-公开
公开(公告)号：US20170159189A1
公开(公告)日：2017-06-08
申请号：US15309875
申请日：2015-05-12
申请人： Covestro Deutschland AG
发明人： Frank Richter , Heike Heckroth , Reinhard Halpaap , Siegfried R. Waldvogel , Sebastian Herold , Hartmut Nefzger
IPC分类号： C25B3/02 , C25B11/12 , C07C211/58 , C07C209/62 , C07D213/16 , C07C211/59
CPC分类号： C25B3/02 , C07C209/36 , C07C209/62 , C07C211/58 , C07C211/59 , C07D213/127 , C07D213/16 , C25B11/12
摘要： The invention relates to a method for oxidative electrochemical amination of non-activated or deactivated aromatic systems by means of boron-doped diamond anodes, and in particular to the production of 1,5-diaminonaphthalene and 1-amino-5-nitronaphthalene according to said method.

2. 发明申请

US20110301356A1 Method for Producing 2-aminobiphenylene 有权
标题翻译： 2-氨基联苯的制备方法
公开(公告)号：US20110301356A1
公开(公告)日：2011-12-08
申请号：US13201562
申请日：2010-02-18
申请人： Thomas Zierke , Volker Maywald , Sebastian Peer Smidt
发明人： Thomas Zierke , Volker Maywald , Sebastian Peer Smidt
IPC分类号： C07D231/14 , C07C211/59
CPC分类号： C07C209/68 , C07B37/04 , C07C211/52 , C07C251/24 , C07C257/12
摘要： The present invention relates to a process for preparing 2-aminobiphenyls of the formula I in which n is 0, 1, 2 or 3, R1 is hydrogen, cyano or fluorine, and each R2 is independently selected from cyano, fluorine, C1-C4-alkyl, C1-C4-fluoroalkyl, C1-C4-alkoxy, C1-C4-fluoroalkoxy, C1-C4-alkylthio and C1-C4-fluoroalkylthio. The invention also relates to a process for preparing pyrazolecarboxamides of such 2-aminobiphenyls.
摘要翻译：本发明涉及一种制备式I的2-氨基联苯的方法，其中n为0,1,2或3，R 1为氢，氰基或氟，每个R 2独立地选自氰基，氟，C 1 -C 4 - 烷基，C 1 -C 4 - 氟烷基，C 1 -C 4 - 烷氧基，C 1 -C 4 - 氟烷氧基，C 1 -C 4 - 烷硫基和C 1 -C 4 - 氟代烷硫基。本发明还涉及制备这种2-氨基联苯的吡唑酰胺的方法。

3. 发明申请

US20080309229A1 Arylamine Polymer 有权
标题翻译：芳胺聚合物
公开(公告)号：US20080309229A1
公开(公告)日：2008-12-18
申请号：US12158912
申请日：2006-12-18
申请人： Annette Steudel , Nalinkumar Lallubhai Patel , Jonathan Pillow , Mary McKiernan , Sophie Heidenhain , Natasha Conway
发明人： Annette Steudel , Nalinkumar Lallubhai Patel , Jonathan Pillow , Mary McKiernan , Sophie Heidenhain , Natasha Conway
IPC分类号： H01J1/63 , C08G73/02 , C07C211/56 , B05D5/12 , C07C211/59 , C07D403/10
CPC分类号： C08G73/02 , C08G61/12 , C08G61/124 , H01L51/0035 , H01L51/0036 , H01L51/0039 , H01L51/0043 , H01L51/5016 , H01L51/5048
摘要： A semiconductive polymer comprising a first repeat unit in the polymer backbone comprising general formula 1: where a=1 or 2; b=0 or 1; and c=0, 1 or 2, provided that when c=0 then b=0; Ar1, Ar2, Ar3, Ar4, Ar5, and Ar6 each independently represent an aryl or heteroaryl ring or a fused derivative thereof; characterised in that at least one of Ar1, Ar2, Ar4, and Ar5 is non-conjugating; and provided that (a) when a=1, Ar1 is not linked to Ar2 by a direct bond, (b) when b=1 and c=1, Ar4 is not linked to Ar5 by a direct bond, (c) when b=0 and c=1, Ar2 is not linked to Ar5 by a direct bond, (d) when a=2, the Ar1 groups are not linked by a single bond, and (e) when c=2, the Ar5 groups are not linked by a single bond.
摘要翻译：在聚合物骨架中包含通式1的第一重复单元的半导体聚合物：其中a = 1或2; b = 0或1; 并且c = 0,1或2，条件是当c = 0时，b = 0; Ar1，Ar2，Ar3，Ar4，Ar5和Ar6各自独立地表示芳基或杂芳基环或其稠合衍生物; 其特征在于Ar1，Ar2，Ar4和Ar5中的至少一个是非共轭的; （a）当a = 1时，Ar1通过直接键不与Ar2连接，（b）当b = 1且c = 1时，Ar4不与Ar5直接键合，（c）当b = 0，c = 1，Ar2不与Ar5连接，（d）当a = 2时，Ar 1基团不通过单键连接，（e）当c = 2时，Ar 5基团为没有通过单一的联系链接。

4. 发明申请

US20200216448A1 INHIBITORS OF KIDNEY-TYPE GLUTAMINASE, GLS-1 审中-公开
公开(公告)号：US20200216448A1
公开(公告)日：2020-07-09
申请号：US16735479
申请日：2020-01-06
申请人： CORNELL UNIVERSITY , ITHACA COLLEGE
发明人： Richard CERIONE , Kristin CERIONE , Clint STALNECKER , Scott ULRICH
IPC分类号： C07D471/04 , C07D221/18 , C07D207/16 , C07D277/82 , C07D295/135 , C07C211/58 , C07C217/90 , C07C237/40 , C07D221/06 , C07D401/10 , C07C311/37 , C07C211/49 , C07C211/52 , C07D233/61 , C07C211/59 , C07C311/21 , C07D221/04 , C07D221/12 , C12N9/80 , C12N9/96 , C12Q1/34
摘要： The present invention relates generally to glutaminase inhibitors of Formula I, Formula II, or Formula III, as well as pharmaceutical compounds containing them and methods of their use.

5. 发明授权

US10526322B2 Inhibitors of kidney-type glutaminase, GLS-1 有权
公开(公告)号：US10526322B2
公开(公告)日：2020-01-07
申请号：US15533198
申请日：2015-12-05
申请人： CORNELL UNIVERSITY , ITHACA COLLEGE
发明人： Richard Cerione , Kristin Cerione , Clint Stalnecker , Scott Ulrich
IPC分类号： C07D471/04 , C07D207/16 , C07D221/04 , C07D221/06 , C07D221/12 , C07D221/18 , C07D233/61 , C07D277/82 , C07D295/135 , C07D401/10 , C07C211/49 , C07C211/42 , C07C211/58 , C07C211/59 , C07C237/40 , C07C311/21 , C07C311/37 , C12N9/80 , C12N9/96 , C12Q1/34 , C07C211/52 , C07C217/90
摘要： The present invention relates generally to glutaminase inhibitors of Formula I, Formula II, or Formula III, as well as pharmaceutical compounds containing them and methods of their use.

6. 发明申请

US20120187383A1 ELECTROACTIVE COMPOUND AND COMPOSITION AND ELECTRONIC DEVICE MADE WITH THE COMPOSITION 审中-公开
标题翻译：电致化合物及其组合物和电子器件
公开(公告)号：US20120187383A1
公开(公告)日：2012-07-26
申请号：US13195044
申请日：2011-08-01
申请人： WEIYING GAO , Weishi Wu , Kalindi Dogra , Vsevolod Rostovtsev , Kerwin D. Dobbs
发明人： WEIYING GAO , Weishi Wu , Kalindi Dogra , Vsevolod Rostovtsev , Kerwin D. Dobbs
IPC分类号： H01L51/54 , C09K11/06 , C07C211/59 , C07C15/24 , C07C255/51
CPC分类号： C07C15/24 , C07B59/001 , C07B2200/05 , C07C255/50 , C07C255/51 , C07C2601/14 , C07C2603/18 , C09B57/00 , C09B57/001 , C09B57/008 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , H01L51/0054 , H01L51/0058 , H01L51/006 , H01L51/5012
摘要： There is provided an a host material and a dopant material, wherein the host material is a compound having one of Formulae I-VI: In the formulae, R1 is the same or different at each occurrence and represents an optional substituent which may be present at any or all of the available sites and may be D, alkyl, aryl, alkoxy, aryloxy, oxyalkyl, alkenyl, silyl, or siloxane; Ar1, Ar2, and Ar3 are the same or different at each occurrence and are aryl groups; a is an integer from 2-6; and b is an integer from 1-3.
摘要翻译：提供了主体材料和掺杂剂材料，其中主体材料是具有式I-VI之一的化合物：在该式中，R 1在每次出现时相同或不同，并且表示任选的取代基，其可以存在于任何或所有可用的位点，并且可以是D，烷基，芳基，烷氧基，芳氧基，烷氧基，烯基，甲硅烷基或硅氧烷; Ar1，Ar2和Ar3在每次出现时相同或不同，为芳基; a是2-6的整数; b为1-3的整数。

7. 发明申请

US20080300274A1 Novel Pyrrolidino-1,4-Naphthoquinone Deriviatives and their Use for Treating Malignancies and Cardiovascular Diseases 失效
标题翻译：新型吡咯烷基-1,4-萘醌衍生物及其用于治疗恶性肿瘤和心血管疾病的用途
公开(公告)号：US20080300274A1
公开(公告)日：2008-12-04
申请号：US11658304
申请日：2005-07-21
申请人： Yossi Granot , Shmuel Bittner
发明人： Yossi Granot , Shmuel Bittner
IPC分类号： A61K31/445 , C07C211/59 , C07D211/30 , C12N9/12 , A61P35/00 , A61K31/136
CPC分类号： C07C225/30 , C07C233/80 , C07D295/116
摘要： The invention provides pyrrolidino-substituted 1,4-naphthoquinone derivatives that modulate the activity of protein kinases, and it relates to the use of the derivatives in pharmaceutical compositions for treating cardiovascular disorders and malignancies. The invention particularly provides medicaments for treating disorders associated with MAPKs signaling, ERKs signaling, p38 signaling, and JNKs signaling.
摘要翻译：本发明提供调节蛋白激酶活性的吡咯烷子基取代的1,4-萘醌衍生物，它涉及药物组合物中衍生物在治疗心血管疾病和恶性肿瘤中的用途。本发明特别提供用于治疗与MAPKs信号传导，ERKs信号传导，p38信号传导和JNK信号传导相关的疾病的药物。

8. 发明授权

US06867310B1 Arylation and vinylation of activated carbons 有权
标题翻译：活性炭的酰化和乙烯化
公开(公告)号：US06867310B1
公开(公告)日：2005-03-15
申请号：US09239024
申请日：1999-01-27
申请人： Stephen L. Buchwald , John P. Wolfe , Jens Ahman , Malisa Troutman , Michael Palucki , Ken Kamikawa , Andre Chieffi
发明人： Stephen L. Buchwald , John P. Wolfe , Jens Ahman , Malisa Troutman , Michael Palucki , Ken Kamikawa , Andre Chieffi
IPC分类号： C07C1/26 , C07C17/26 , C07C41/16 , C07C45/68 , C07C45/71 , C07C67/31 , C07C205/04 , C07C205/06 , C07C209/10 , C07C209/18 , C07C211/48 , C07C211/55 , C07C211/59 , C07C213/02 , C07C213/08 , C07C217/40 , C07C217/84 , C07C217/92 , C07C221/00 , C07C225/12 , C07C225/22 , C07C227/08 , C07C227/18 , C07C229/36 , C07C229/60 , C07C231/12 , C07C233/07 , C07C235/46 , C07C249/02 , C07C249/16 , C07C251/24 , C07C251/86 , C07C253/30 , C07C255/33 , C07C255/50 , C07C255/54 , C07C255/56 , C07C255/58 , C07D209/08 , C07D213/50 , C07D213/72 , C07D213/74 , C07D295/02 , C07D295/023 , C07D295/033 , C07D295/096 , C07D295/112 , C07D295/13 , C07D295/155 , C07D307/33 , C07D317/22 , C07D317/26 , C07D317/66 , C07D333/08 , C07D333/66 , C07D401/04 , C07F7/18 , C07F9/48 , C07F9/50 , C07F9/572 , C07F9/653 , C07F9/6547 , C07F9/6571 , C07F15/00 , C07D317/44
CPC分类号： C07D213/74 , C07C1/26 , C07C17/263 , C07C45/68 , C07C45/71 , C07C67/31 , C07C201/12 , C07C209/10 , C07C209/18 , C07C211/59 , C07C213/02 , C07C213/08 , C07C221/00 , C07C225/12 , C07C227/08 , C07C227/18 , C07C231/12 , C07C249/02 , C07C249/16 , C07C251/24 , C07C253/30 , C07C2601/02 , C07C2601/08 , C07C2601/16 , C07C2602/08 , C07C2602/10 , C07D209/08 , C07D213/50 , C07D213/72 , C07D295/023 , C07D295/033 , C07D295/096 , C07D295/112 , C07D295/13 , C07D295/155 , C07D307/33 , C07D317/22 , C07D317/26 , C07D317/66 , C07D333/08 , C07D333/66 , C07D401/04 , C07F7/1892 , C07F9/4875 , C07F9/5022 , C07F9/5027 , C07F9/5728 , C07F9/653 , C07F9/6547 , C07F9/65719 , C07F15/0066 , C07C25/18 , C07C49/657 , C07C49/755 , C07C49/215 , C07C49/245 , C07C49/782 , C07C49/683 , C07C49/213 , C07C49/84 , C07C49/255 , C07C47/575 , C07C49/67 , C07C69/92 , C07C211/48 , C07C211/55 , C07C217/40 , C07C217/84 , C07C217/92 , C07C225/22 , C07C229/36 , C07C229/60 , C07C233/07 , C07C235/46 , C07C251/86 , C07C255/33 , C07C255/50 , C07C255/54 , C07C255/56 , C07C255/58 , C07C205/04 , C07C205/06
摘要： The present invention provides transition-metal-catalyst-based methods for the arylation and vinylation of activated methyl, methylene, and methine carbons with aryl halides, vinyl halides, and the like. The methods of the invention provide several improvements over existing methods, including the ability to synthesize efficiently and under mild conditions α-aryl and α-vinyl products from a wide range of starting materials, including ketones, esters, hydrazones, and imines. Furthermore, the methods of the invention may be used in an asymmetric sense, i.e. to produce enantiomerically-enriched chiral α-aryl and α-vinyl products.
摘要翻译：本发明提供了基于过渡金属催化剂的方法，用于芳基卤化物，卤代乙烯等的活化的甲基，亚甲基和次甲基碳的芳基化和乙烯基化的方法。本发明的方法相对于现有方法提供了若干改进，包括在温和条件下有效合成α-芳基和α-乙烯基产物的能力，所述α-芳基和α-乙烯基产物包括酮，酯，腙和亚胺。此外，本发明的方法可以以不对称方式使用，即产生对映异构体富集的手性α-芳基和α-乙烯基产物。

9. 发明授权

US5831128A Synthesis of aromatic amines from chloroamatics 失效
标题翻译：从氯化物合成芳香胺
公开(公告)号：US5831128A
公开(公告)日：1998-11-03
申请号：US984554
申请日：1997-12-03
申请人： Matthias Beller , Thomas Riermeier , Claus Peter Reisinger , Wolfgang Anton Herrmann , Holger Geissler
发明人： Matthias Beller , Thomas Riermeier , Claus Peter Reisinger , Wolfgang Anton Herrmann , Holger Geissler
IPC分类号： B01J27/13 , C07B61/00 , C07C209/10 , C07C211/48 , C07C211/52 , C07C211/54 , C07C211/56 , C07C211/57 , C07C211/59 , C07C215/76 , C07C215/86 , C07C309/46 , C07C309/47 , C07C317/32
CPC分类号： C07C209/10
摘要： The present invention relates to a process for the preparation of aromatic amines of the formula (I) Ar--NR.sup.1 R.sup.2 (I) in which Ar is ##STR1## and R.sup.3 to R.sup.9 independently of one another are hydrogen, C.sub.1 -C.sub.8 -alkyl, alkoxy-(C.sub.1 -C.sub.8), acyloxy-(C.sub.1 -C.sub.8), OAr, Ar, fluorine, chlorine, bromine, iodine, OH, NO.sub.2, CN, CO.sub.2 H, CHO, SO.sub.3 H, SO.sub.2 R, SOR, NH.sub.2, NH-alkyl-(C.sub.1 -C.sub.12), N-alkyl.sub.2 -(C.sub.1 -C.sub.12), NHCO-alkyl-(C.sub.1 -C.sub.12), CO-alkyl-(C.sub.1 -C.sub.12), NHCHO, COAr, CO.sub.2 Ar, CF.sub.3, CONH.sub.2, CHCHCO.sub.2 R, POAr.sub.2, PO-alkyl.sub.2 -(C.sub.1 -C.sub.12), 5-ring heteroaryl, 6-ring heteroaryl, Si-alkyl.sub.3 -(C.sub.1 -C.sub.12), where R=alkyl(C.sub.1 -C.sub.8), aryl(C.sub.5 -C.sub.10) and R.sup.1 and R.sup.2 independently of one another are hydrogen, C.sub.1 -C.sub.12 -alkyl, Ar as defined above, 5-ring heteroaryl, 6-ring heteroaryl, by reacting chloroaromatics of the formula II Ar--Cl (II) with ammonia or primary or secondary amines of the formula III R.sup.1 R.sup.2 NH (III) in which Ar and R.sup.1 and R.sup.2 are as defined above, which comprises reacting the starting materials in the presence of a palladium catalyst, a strong base and a halide cocatalyst in an inert solvent at temperatures of 80.degree.-200.degree. C.
摘要翻译：本发明涉及制备式（Ⅰ）Ar-NR1R2（Ⅰ）的芳香族胺的方法，其中Ar为囟素，C 1 -C 8烷基，烷氧基 - （C 1 -C 8 ），酰氧基 - （C1-C8），OAr，Ar，氟，氯，溴，碘，OH，NO2，CN，CO2H，CHO，SO3H，SO2R，SOR，NH2，NH-烷基 - （C1-C12） N-烷基-2-（C1-C12），NHCO-烷基 - （C1-C12），CO-烷基 - （C1-C12），NHCHO，COAr，CO2Ar，CF3，CONH2，CHCHCO2R，POAr2，PO-烷基 -C 12），5-环杂芳基，6-环杂芳基，3-烷基3-（C 1 -C 12），其中R =烷基（C 1 -C 8），芳基（C 5 -C 10）和R 1和R 2彼此独立地是氢，C 1 -C 12 - 烷基，如上所定义的Ar，5-环杂芳基，6-环杂芳基，通过使式IIAr-Cl（II）的氯芳族化合物与式IIIR1R2NH（III）的氨或伯或仲胺反应，其中 Ar和R 1和R 2如上所定义，其包括在惰性溶剂中在钯催化剂，强碱和卤助助催化剂存在下，在温度 80°-200℃

10. 发明授权

US4293566A Pesticidally active 1-arylamino-2,4-dinitronaphthalenes 失效
标题翻译：杀虫活性1-芳基氨基-2,4-二硝基萘
公开(公告)号：US4293566A
公开(公告)日：1981-10-06
申请号：US57056
申请日：1979-07-12
申请人： Rainer Hamprecht , Alfons Hartmann , Erich Klauke , Ingeborg Hammann , Peter Roessler , Wilhelm Brandes
发明人： Rainer Hamprecht , Alfons Hartmann , Erich Klauke , Ingeborg Hammann , Peter Roessler , Wilhelm Brandes
IPC分类号： A01N33/18 , A01N33/22 , A01N33/26 , A01N37/20 , A01N37/22 , A01N37/34 , A01N41/04 , A01N41/10 , A01N43/30 , A01P7/04 , C07C67/00 , C07C209/00 , C07C209/08 , C07C209/10 , C07C211/58 , C07C211/59 , C07D319/08 , C07C87/00 , C07C121/78
CPC分类号： C07D319/08 , A01N33/18 , A01N33/22 , A01N33/26 , A01N37/20 , A01N37/22 , A01N37/34 , A01N43/30
摘要： 1, Arylamino-2,4-dinitronaphthalenes of the formula ##STR1## in which R each independently is hydrogen, alkyl, halogenoalkyl, alkenyl, alkynyl, alkoxy, alkylmercapto, alkylsulphonyl, sulphonate, halogenoalkoxy, halogenoalkylmercapto, acylamino, alkoxycarbonyl, phenylazo, halogen, CN or nitro, or two radicals R in orthoposition to one another can, conjointly with the two adjoining carbon atoms of the phenyl ring, form an optionally halogen-substituted 1,3-dioxane ring, andn is 1,2,3,4 or 5 which possess arthropodicidal, fungicidal and bactericidal properties.
摘要翻译： 1，其中R各自独立地为氢，烷基，卤代烷基，烯基，炔基，烷氧基，烷基巯基，烷基磺酰基，磺酸酯，卤代烷氧基，卤代烷基巯基，酰基氨基，烷氧基羰基，苯偶氮，卤素的芳基氨基-2,4-二硝基萘，CN或硝基，或两个彼此定位的基团R可以与苯环的两个邻接的碳原子一起形成任选的卤素取代的1,3-二恶烷环，n为1,2,3， 4或5具有杀虫，杀菌，杀菌等特点。

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