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1. 发明申请

US20190315768A1 NITRATED HYDROCARBONS, DERIVATIVES, AND PROCESSES FOR THEIR MANUFACTURE 审中-公开
公开(公告)号：US20190315768A1
公开(公告)日：2019-10-17
申请号：US16451509
申请日：2019-06-25
申请人： Angus Chemical Company
发明人： Daniel M. Trauth , George D. Green , Raymond J. Swedo , Richard L. James , Ian A. Tomlinson
IPC分类号： C07D498/10 , C07D498/04 , A01N43/90 , C07C201/08 , C07C201/12 , C07C205/02 , C07C215/28 , C07C205/04 , C07C205/05 , C07C205/15 , C07C205/16 , C07C215/20 , C08G18/32 , A01N43/76 , C07D263/52 , C07D263/04 , C07C239/10 , C07C215/42 , C07C215/08 , C07C205/18 , C07C205/06
摘要： Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications.

2. 发明申请

US20190039999A1 CELL SEEDING PLATE, METHOD FOR MANUFACTURING THE SAME, AND CELL SHEET SEPARATING METHOD 审中-公开
公开(公告)号：US20190039999A1
公开(公告)日：2019-02-07
申请号：US15689002
申请日：2017-08-29
申请人： HON HAI PRECISION INDUSTRY CO., LTD.
发明人： HSIU-WEN CHIEN
IPC分类号： C07C233/11 , C07C205/04 , C07C69/145 , C07C43/164
摘要： A cell seeding plate comprises a substrate and a photolysis layer formed on a surface of the substrate. The photolysis layer comprises a plurality of photolysis groups, and each of the plurality of photolysis groups has a chemical structural formula of R1 and R3 each represents alkane group, R2 comprises alkane group or olefin group, R5, R6 and R7 each represents hydrogen group or alkane group. Each of the plurality of photolysis groups is bonded to the surface by the amide group.

3. 发明授权

US07514475B2 Benzylamine analogues 失效
标题翻译：苄胺类似物
公开(公告)号：US07514475B2
公开(公告)日：2009-04-07
申请号：US11583499
申请日：2006-10-19
申请人： Kazuo Koyama , Shinji Marumoto , Narihiro Toda , Hiroshi Kogen , Keiko Suzuki
发明人： Kazuo Koyama , Shinji Marumoto , Narihiro Toda , Hiroshi Kogen , Keiko Suzuki
IPC分类号： A61K31/137 , C07C205/04
CPC分类号： C07C219/30 , C07C271/44 , C07C323/20 , C07C323/25 , C07C333/04 , C07D213/64 , C07D213/68 , C07D215/20 , C07D317/58 , C07D333/38
摘要： A compound of the formula (I): wherein R1 is a C1-C6 alkyl, an amino, a (C1-C6 alkyl)amino, a di(C1-C6 alkyl)amino or a nitrogen-containing saturated heterocyclic; R2 and R3 are the same or different and are a hydrogen or a C1-C6 alkyl; Arom is an unsubstituted or substituted aryl or an unsubstituted or substituted heteroaryl; wherein the substituted aryl is substituted at 1 to 5 positions and the substituted heteroaryl is substituted at 1 to 3 positions; wherein the heteroaryl is furyl, thiolyl, pyrrolyl, azepinyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1,2,3 oxadiazolyl, pyranyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl or quinolyl; and wherein the substituents of the substituted aryl and of the substituted heteroaryl are independently halogen, C1-C6 alkyl, halogeno C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, C1-C3 alkylenedioxy, C1-C7 alkanoyl, C2-C7 alkyloxycarbonyl, amino, C1-C7 alkanoylamino, hydroxyl, mercapto, cyano, nitro or carboxyl; A is an ethylene or propylene; Ra is a hydrogen, a C1-C6 alkyl or a C2-C6 alkenyl; E is a single bond, an oxygen, a sulfur or —NR4—, wherein R4 is a hydrogen or a C1-C7 alkanoyl; X1 and X2 are the same or different and are an oxygen or a sulfur, or a pharmacologically acceptable salt or ester thereof.
摘要翻译：式（I）的化合物：其中R1是C1-C6烷基，氨基，（C1-C6烷基）氨基，二（C1-C6烷基）氨基或含氮饱和杂环; R2和R3相同或不同，为氢或C1-C6烷基; Arom是未取代或取代的芳基或未取代或取代的杂芳基; 其中取代的芳基在1至5个位置被取代，并且取代的杂芳基在1至3个位置被取代; 吡唑基，咪唑基，恶唑基，异恶唑基，噻唑基，异噻唑基，1,2,3-恶二唑基，吡喃基，吡啶基，哒嗪基，嘧啶基，吡嗪基或喹啉基;其中杂芳基为呋喃基，噻吩基，吡咯基，并且其中取代的芳基和取代的杂芳基的取代基独立地为卤素，C 1 -C 6烷基，卤代C 1 -C 6烷基，C 1 -C 6烷氧基，C 1 -C 6烷硫基，C 1 -C 3亚烷基二氧基，C 1 -C 7烷酰基， C7烷氧基羰基，氨基，C1-C7烷酰基氨基，羟基，巯基，氰基，硝基或羧基; A是乙烯或丙烯; R a是氢，C 1 -C 6烷基或C 2 -C 6烯基; E是单键，氧，硫或-NR4-，其中R4是氢或C1-C7烷酰基; X1和X2相同或不同，为氧或硫，或其药理学上可接受的盐或酯。

4. 发明授权

US6066756A Phenylacetic acid derivatives, preparation thereof and intermediates therefor, and compositions containing them 失效
标题翻译：苯乙酸衍生物，其制备方法及其中间体，以及含有它们的组合物
公开(公告)号：US6066756A
公开(公告)日：2000-05-23
申请号：US97863
申请日：1998-06-16
申请人： Herbert Bayer , Hubert Sauter , Ruth Muller , Wassilios Grammenos , Albrecht Harreus , Reinhard Kirstgen , Franz Rohl , Eberhard Ammermann , Gisela Lorenz
发明人： Herbert Bayer , Hubert Sauter , Ruth Muller , Wassilios Grammenos , Albrecht Harreus , Reinhard Kirstgen , Franz Rohl , Eberhard Ammermann , Gisela Lorenz
IPC分类号： C07D249/08 , A01N20060101 , A01N37/00 , A01N37/36 , A01N37/44 , A01N37/50 , A01N41/10 , A01N43/00 , A01N43/08 , A01N43/10 , A01N43/12 , A01N43/36 , A01N43/40 , A01N43/42 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/58 , A01N43/60 , A01N43/66 , A01N43/707 , A01N43/72 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/824 , A01N43/836 , A01N43/88 , A01N47/02 , A01P3/00 , A01P7/04 , C07C20060101 , C07C205/04 , C07C249/08 , C07C251/34 , C07C251/36 , C07C251/38 , C07C251/48 , C07C251/50 , C07C251/52 , C07C251/54 , C07C251/56 , C07C251/60 , C07C255/07 , C07C255/12 , C07C255/62 , C07C255/64 , C07C259/06 , C07C259/14 , C07C309/04 , C07C309/28 , C07C317/18 , C07C317/22 , C07C317/26 , C07C317/44 , C07C323/12 , C07C323/19 , C07C323/23 , C07C325/00 , C07C327/38 , C07C327/42 , C07C327/48 , C07C327/58 , C07D207/32 , C07D207/323 , C07D207/333 , C07D207/36 , C07D211/72 , C07D211/88 , C07D213/30 , C07D213/50 , C07D213/53 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/71 , C07D213/79 , C07D213/80 , C07D215/20 , C07D215/22 , C07D231/12 , C07D231/20 , C07D231/22 , C07D233/61 , C07D233/64 , C07D237/08 , C07D237/12 , C07D237/14 , C07D239/26 , C07D239/28 , C07D239/30 , C07D239/34 , C07D239/36 , C07D239/38 , C07D239/74 , C07D241/12 , C07D241/16 , C07D241/18 , C07D241/44 , C07D251/16 , C07D251/26 , C07D251/30 , C07D261/06 , C07D261/08 , C07D261/10 , C07D261/12 , C07D263/32 , C07D263/34 , C07D263/46 , C07D271/06 , C07D271/10 , C07D275/02 , C07D277/20 , C07D277/24 , C07D277/28 , C07D277/32 , C07D277/34 , C07D277/36 , C07D285/08 , C07D285/12 , C07D307/12 , C07D307/36 , C07D307/42 , C07D307/52 , C07D307/56 , C07D307/58 , C07D333/16 , C07D333/22 , C07D333/28 , C07D333/32
CPC分类号： C07D207/333 , A01N37/36 , A01N37/50 , A01N43/08 , A01N43/36 , A01N43/40 , A01N43/54 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/88 , C07C249/08 , C07C251/38 , C07C251/48 , C07C251/60 , C07C327/58 , C07D213/53 , C07D213/64 , C07D239/34 , C07D239/36 , C07D261/08 , C07D261/10 , C07D263/32 , C07D271/06 , C07D277/24 , C07D307/12 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要： Phenylacetic acid derivatives of the formula I ##STR1## where the sqtstituents and the index have the following meanings; X it NOCH.sub.3, CHOC.sub.3, CHCH.sub.3 and [sic] CHCH.sub.2 CH.sub.3 ;R.sup.1 is hydrogen and [sic] alkyl;R.sup.2 is cyano, nitro, triflaormethyl, halogen, alkyl and [sic] alkoxy;m is 0, 1 or 2, it being possible for the R.sup.2 radicals to be different if m is 2;R.sup.3 hydrogen, cyano, nitro, hydroxyl, amino, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, alkylamino or dialkylamine;R.sub.4 is hydrogen, cyano, nitro, hydroxyl, amino, halogen,R.sup.5 is hydrogen,substituted or substituted alkyl, cycloalkyl, alkenyl, alkynyl, alkylcarbonyl, alkenylcarbonyl, alkynylcarbonyl or alkylsulfonyl;unsubstituted or substituted aryl, arylcarbonyl, arylsulfonyl, hetaryl, hetarylcarbonyl or hetarylsulfonyl,and their salts, processes and intermediates for their preparation, and their use.
摘要翻译：式I的苯乙酸衍生物，其中平均取代基和指数具有以下含义; X，NOCH 3，CHOC 3，CHCH 3和[CH 2] CHCH 2 CH 3; R1是氢和[sic]烷基; R2是氰基，硝基，三氟甲基，卤素，烷基和[sic]烷氧基; m为0,1或2，如果m为2，则R2基团可能不同; R3，氰基，硝基，羟基，氨基，卤素，烷基，卤代烷基，烷氧基，卤代烷氧基，烷硫基，烷基氨基或二烷基胺; R4是氢，氰基，硝基，羟基，氨基，卤素，R5是氢，取代或取代的烷基，环烷基，烯基，炔基，烷基羰基，烯基羰基，炔基羰基或烷基磺酰基; 未取代或取代的芳基，芳基羰基，芳基磺酰基，杂芳基，杂芳基羰基或杂芳基磺酰基，及其盐，其制备方法和中间体及其用途。

5. 发明授权

US06018020A Amino acid derivatives 失效
标题翻译：氨基酸衍生物
公开(公告)号：US06018020A
公开(公告)日：2000-01-25
申请号：US96570
申请日：1998-06-12
申请人： Michael Richard Attwood , David Nigel Hurst , Philip Stephen Jones , Paul Brittain Kay , Tony Michael Raynham , Francis Xavier Wilson
发明人： Michael Richard Attwood , David Nigel Hurst , Philip Stephen Jones , Paul Brittain Kay , Tony Michael Raynham , Francis Xavier Wilson
IPC分类号： C12N15/09 , A01N43/34 , A01N43/36 , A61K38/00 , A61P31/12 , A61P31/14 , C07C205/04 , C07C205/45 , C07C271/18 , C07D207/12 , C07D207/20 , C07D211/70 , C07D223/04 , C07D227/04 , C07D405/10 , C07D407/10 , C07D409/10 , C07K7/06 , A61K38/08
CPC分类号： C07K7/06 , A61K38/00
摘要： The invention provides amino acid derivatives of the formula ##STR1## wherein E represents CHO or B(OH).sub.2 ;R.sup.1 represents lower alkyl (optionally substituted by halo, cyano, lower alkylthio, aryl-lower alkylthio, aryl or heteroaryl), lower alkenyl or lower alkynyl;R.sup.2 represents lower alkyl optionally substituted by hydroxy, carboxy, aryl, aminocarbonyl or lower cycloalkyl; andR.sup.3 represents hydrogen or lower alkyl; orR.sup.2 and R.sup.3 together represent di- or trimethylene optionally substituted by hydroxy;R.sup.4 represents lower alkyl (optionally substituted by hydroxy, lower cycloalkyl, carboxy, aryl, lower alkylthio, cyano-lower alkylthio or aryl-lower alkylthio), lower alkenyl, aryl or lower cycloalkyl;R.sup.5 represents lower alkyl (optionally substituted by hydroxy, lower alkylthio, aryl, aryl-lower alkylthio or cyano-lower alkylthio) or lower cycloalkyl;R.sup.6 represents hydrogen or lower alkyl;R.sup.7 represent lower alkyl (optionally substituted by hydroxy, carboxy, aryl or lower cycloalkyl) or lower cycloalkyl;R.sup.8 represents lower alkyl optionally substituted by hydroxy, carboxy or aryl; andR.sup.9 represents lower alkylcarbonyl, carboxy-lower alkylcarbonyl, arylcarbonyl, lower alkylsulphonyl, arylsulphonyl, lower alkoxycarbonyl or aryl-lower alkoxycarbonyl,and salts of acidic compounds of formula I with bases, which are viral proteinase inhibitors useful as antiviral agents, especially for the treatment or prophylaxis of infections caused by Hepatitis C, Hepatitis G and human GB viruses.
摘要翻译：本发明提供下式的氨基酸衍生物，其中E代表CHO或B（OH）2; R 1表示低级烷基（任选被卤素，氰基，低级烷硫基，芳基 - 低级烷硫基，芳基或杂芳基取代），低级烯基或低级炔基; R 2表示任选被羟基，羧基，芳基，氨基羰基或低级环烷基取代的低级烷基; 并且R 3表示氢或低级烷基; 或R 2和R 3一起表示任选被羟基取代的二 - 或三亚甲基; R4代表低级烷基（任选被羟基，低级环烷基，羧基，芳基，低级烷硫基，氰基 - 低级烷硫基或芳基 - 低级烷硫基取代），低级烯基，芳基或低级环烷基; R5代表低级烷基（任选被羟基，低级烷硫基，芳基，芳基 - 低级烷硫基或氰基 - 低级烷硫基取代）或低级环烷基; R6代表氢或低级烷基; R7代表低级烷基（任选被羟基，羧基，芳基或低级环烷基取代）或低级环烷基; R8代表任选被羟基，羧基或芳基取代的低级烷基; 并且R 9表示低级烷基羰基，羧基 - 低级烷基羰基，芳基羰基，低级烷基磺酰基，芳基磺酰基，低级烷氧基羰基或芳基 - 低级烷氧基羰基，以及式I酸性化合物与碱的碱，其为用作抗病毒剂的病毒蛋白酶抑制剂，治疗或预防丙型肝炎，丙型肝炎和人类GB病毒引起的感染。

6. 发明授权

US6013840A Process for the acylation of aromatic ethers 失效
标题翻译：芳香醚酰化的方法
公开(公告)号：US6013840A
公开(公告)日：2000-01-11
申请号：US765533
申请日：1997-01-09
申请人： Michel Spagnol , Laurent Gilbert , Eric Benazzi , Christian Marcilly
发明人： Michel Spagnol , Laurent Gilbert , Eric Benazzi , Christian Marcilly
IPC分类号： B01J29/08 , C07C45/46 , C07C49/84 , C07C205/04 , C07C211/09 , C07C231/12 , C07C235/32 , C07C253/30 , C07C255/40 , C07C45/00
CPC分类号： B01J29/084 , C07C45/46
摘要： The present invention concerns a process for the acylation of an aromatic ether.Preferably the invention relates to a process for the acylation of a substituted aromatic ether, in particular veratrol.The acylation process of the invention consists of reacting the ether with an acylation agent in the presence of a zeolitic catalyst, and is characterized in that the acylation reaction is carried out in the presence of an effective quantity of a catalyst comprising a faujasite type zeolite or a Y zeolite with the following physico-chemical characteristics:an atomic ratio denoted "global Si/Me.sup.1 " between the number of atoms of the element silicon and the number of atoms of every trivalent element Me.sup.1 contained in the zeolite in the range 2.4 to 90, preferably in the range 2.4 to 75, and more preferably in the range 2.4 to 60;an Me.sup.2 alkali metal content such that the atomic ratio Me.sup.2 /Me.sup.1(IV) between the number of atoms of alkali metal Me.sup.2 and the number of atoms of every trivalent element Me.sup.1(IV) included in the zeolitic network is less than 0.2, preferably less than 0.1, and more preferably less than 0.05.
摘要翻译： PCT No.PCT / FR96 / 00716 Sec。 371日期1997年1月9日 102（e）日期1997年1月9日PCT提交1996年5月10日PCT公布。出版物WO96 / 35655 日期：1996年11月14日本发明涉及一种酰化芳族醚的方法。优选地，本发明涉及酰化取代的芳族醚，特别是藜芦醇的方法。本发明的酰化方法包括在沸石催化剂存在下使醚与酰化剂反应，其特征在于酰化反应在有效量的含有八面沸石型沸石的催化剂或具有以下物理化学特性的Y沸石：在元素硅的原子数与沸石中所含的每个三价元素Me1的原子数在2.4至90之间的原子比表示为“全局Si / Me1” ，优选在2.4至75范围内，更优选在2.4至60范围内; Me2碱金属含量使得碱金属Me2的原子数与沸石网络中包含的每个三价元素Me1（IV）的原子数之间的原子比Me2 / Me1（IV）小于0.2，优选较少小于0.1，更优选小于0.05。

7. 发明授权

US5817878A Process for the acylation of aromatic ethers 失效
标题翻译：芳香醚酰化的方法
公开(公告)号：US5817878A
公开(公告)日：1998-10-06
申请号：US765537
申请日：1997-01-09
申请人： Michel Spagnol , Laurent Gilbert , Eric Benazzi , Christian Marcilly
发明人： Michel Spagnol , Laurent Gilbert , Eric Benazzi , Christian Marcilly
IPC分类号： B01J29/70 , B01J29/04 , C07C45/46 , C07C49/84 , C07C205/04 , C07C211/09 , C07C231/12 , C07C235/32 , C07C253/30 , C07C255/40 , C07C45/45
CPC分类号： B01J29/04 , C07C45/46
摘要： The present invention concerns a process for the acylation of an aromatic ether. Preferably, the invention relates to a process for the acylation of an unsubstituted aromatic ether, in particular anisole. The acylation process of the invention consists of reacting the ether with an acylation agent in the presence of a zeolitic catalyst, and is characterized in that the acylation reaction is carried out in the presence of an effective quantity of a catalyst comprising a beta zeolite with an atomic ratio denoted "global Si/Me.sup.1 " between the number of atoms of the element silicon and the number of atoms of every trivalent element Me.sup.1 contained in the zeolite of no less than 15, preferably in the range 15 to 55, and more preferably in the range 18 to 35.
摘要翻译： PCT No.PCT / FR96 / 00717 Sec。 371日期1997年1月9日 102（e）日期1997年1月9日PCT提交1996年5月10日PCT公布。 WO96 / 35656PC PCT出版物日期：1996年11月14日本发明涉及一种酰化芳族醚的方法。优选地，本发明涉及酰化未取代芳族醚，特别是苯甲醚的方法。本发明的酰化方法包括在沸石催化剂存在下使醚与酰化剂反应，其特征在于酰化反应在有效量的包含β沸石的催化剂存在下进行，原子比在元素硅的原子数与沸石中所含的每个三价元素Me1的原子数之间的“全局Si / Me1”表示为不小于15，优选在15至55的范围内，更优选在范围18到35。

8. 发明授权

US5478728A Process for antibody combining site-catalyzed SYN elimination in the formation of a CIS olefin 失效
标题翻译：用于在形成CIS烯烃中的位点催化的SYN消除的抗体结合方法
公开(公告)号：US5478728A
公开(公告)日：1995-12-26
申请号：US296323
申请日：1994-08-25
申请人： Benjamin F. Cravatt , Jon A. Ashley , Kim D. Janda , Dale L. Boger , Richard A. Lerner
发明人： Benjamin F. Cravatt , Jon A. Ashley , Kim D. Janda , Dale L. Boger , Richard A. Lerner
IPC分类号： C07C45/65 , C07C205/04 , C07C205/45 , C07C219/24 , C12P5/00 , C12P7/26 , C12P13/00 , C12P21/08 , C12P1/00 , C12N9/00
CPC分类号： C12P13/001 , C07C201/12 , C07C219/24 , C07C221/00 , C07C45/65 , C12P5/026 , C12P7/26 , C07C2102/42
摘要： A process is disclosed by which a substrate is catalytically converted to a cis olefin via a syn elimination reaction. The catalyst is a monoclonal antibody or paratope-containing molecule that binds to the substrate as well as to a bicyclo[2.2.1]heptane or bicylo[2.2.2]octane compound that is an analogue to the substrate having its bulky substituents in eclipsed positions. The chemical reaction is carried out in an aqueous medium. The catalyst molecules and hybridoma cells that secrete those molecules are also contemplated, as is a process for using cyclopentadiene or cyclohexadiene to prepare a hapten used to induce production of the catalyst molecules.
摘要翻译：公开了一种通过其顺序消除反应将底物催化转化为顺式烯烃的方法。催化剂是与底物结合的单克隆抗体或辅助聚合物分子，以及与底物相似的双环[2.2.1]庚烷或双环[2.2.2]辛烷化合物，其具有笨重的取代基职位化学反应在水性介质中进行。还考虑分泌这些分子的催化剂分子和杂交瘤细胞，使用环戊二烯或环己二烯制备用于诱导催化剂分子生产的半抗原的方法也是如此。

9. 发明授权

US5143938A Propanamines, their pharmacological properties and their application for therapeutic in particular antidiarrheal, purposes 失效
标题翻译：丙氨酸，其药理学特性及其在特异性抗病毒治疗中的应用，目的
公开(公告)号：US5143938A
公开(公告)日：1992-09-01
申请号：US660873
申请日：1991-02-26
申请人： Alain Calvet , Agnes Grouhel , Henri Jacobelli , Jean-Louis Junien , Xavier Pascaud
发明人： Alain Calvet , Agnes Grouhel , Henri Jacobelli , Jean-Louis Junien , Xavier Pascaud
IPC分类号： A61K31/135 , A61K31/335 , A61K31/357 , A61K31/385 , C07C205/04 , C07C205/09 , C07C205/32 , C07C205/45 , C07C215/30 , C07C217/72 , C07C225/16 , C07C225/18 , C07C323/29 , C07D317/28 , C07D339/06
CPC分类号： C07C225/16 , C07C205/04 , C07C205/09 , C07C205/32 , C07C205/45 , C07C217/72 , C07D317/28
摘要： A compound which is a propanamine of general formula (I) ##STR1## in which: R1 is a phenyl radical optionally mono-, di- or trisubstituted,or is a 5- or 6-membered monocyclic heteroaryl radical in which the single heteroatom is nitrogen, oxygen or sulfur,R2 is a lower alkyl radical,R3 and R4 are a hydrogen atom or a lower alkyl, lower alkenyl or lower cycloalkylalkyl radical,or, together with the nitrogen atom to which they are attached, form a saturated 5- to 6-membered heterocycle comprising only one heteroatom,R5 is a 5- to 7-membered cycloalkyl radical, a phenyl radical or a 5- or 6-membered monocyclic heteroaryl radical,and W representsa group .dbd.CH--QH,or a heterocycle .dbd.C[Q--(CH2)n--Q],or a group .dbd.C.dbd.Q, in which groupsQ is an oxygen or sulfur atom,n has the value 2 or 3,W being .dbd.C.dbd.Q only when R3 and R4 are not both hydrogen, and their additions salts with pharmaceutically acceptable acids.A pharmaceutical composition comprising a compound of general formula (I) with the above definitions for the treatment of diarrheal states.
摘要翻译：作为通式（I）的丙胺的化合物，其中：R 1是任选被一个，二或三取代的苯基，或是5或6元单环杂芳基，其中单个杂原子是氮，氧或硫，R2是低级烷基，R3和R4是氢原子或低级烷基，低级烯基或低级环烷基烷基，或者与它们相连的氮原子一起形成饱和的5至6元杂环，仅包含一个杂原子，R 5为5-至7-元环烷基，苯基或5-或6-元单环杂芳基，W表示基团= CH-QH，或杂环= C [Q-（CH 2）nQ]或基团= C = Q，其中基团Q是氧或硫原子，n具有值2或3，W仅当R 3为和R4不同时为氢，并且它们与药学上可接受的酸相加。一种药物组合物，其包含具有上述定义用于治疗腹泻状态的通式（I）的化合物。

10. 发明授权

US4410746A Preparation of nitro-olefins 失效
标题翻译：硝基烯烃的制备
公开(公告)号：US4410746A
公开(公告)日：1983-10-18
申请号：US385150
申请日：1982-06-04
申请人： Paul E. Eckler
发明人： Paul E. Eckler
IPC分类号： C07B61/00 , B01J23/00 , B01J27/00 , B01J31/00 , C07C67/00 , C07C201/00 , C07C201/12 , C07C205/03 , C07C205/04 , C07C76/02
CPC分类号： C07C201/12
摘要： A process for the preparation of nitro-olefins comprising reacting a compound of the formula ##STR1## where R and R.sup.1 can be hydrogen, alkyl of 1-20 carbon atoms or phenyl, with an aldehyde acceptor selected from the group consisting of alkylene polyols or aromatic polyols, in the presence of an alkaline catalyst or a Lewis acid catalyst.
摘要翻译：一种制备硝基烯烃的方法，其包括使式（I）的化合物（其中R和R 1可以是氢，1-20个碳原子的烷基或苯基）与选自以下的醛受体反应：亚烷基多元醇或芳族多元醇，在碱性催化剂或路易斯酸催化剂存在下进行。

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