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1. 发明授权

US11298326B2 Nucleic acid-containing lipid nanoparticles 有权
公开(公告)号：US11298326B2
公开(公告)日：2022-04-12
申请号：US15560854
申请日：2016-03-24
申请人： Kyowa Kirin Co., Ltd.
发明人： Kentaro Hatanaka , Nobuhiro Yagi , Takeshi Kuboyama , Kaori Yagi , Shintaro Hosoe
IPC分类号： A61K9/51 , C07C217/28 , A61K9/127 , C07D223/04 , C07C229/12 , A61K31/713 , A61P29/00 , C07C237/22 , C07D401/04 , A61K9/00 , C07D295/088 , C07D207/12 , A61P35/00 , C07D317/28 , C07D211/22 , C07D207/08 , C12N15/11 , A61K31/7088 , C07C211/63 , C07C215/08 , C07C219/08 , C07C229/06 , C07C233/20 , C07C237/08 , C07C271/16 , C07D451/14 , C12N15/113
摘要： The present invention provides nucleic acid-containing lipid nanoparticles containing a lipid (lipid A) which has a hydrophilic unit having a single quaternary ammonium group, and three independent, optionally substituted hydrocarbon groups, a lipid derivative or fatty acid derivative of a water-soluble polymer, and a nucleic acid.

2. 发明授权

US10974168B2 Materials and methods for the selective recovery of monovalent products from aqueous solutions using continuous ion exchange 有权
公开(公告)号：US10974168B2
公开(公告)日：2021-04-13
申请号：US15491018
申请日：2017-04-19
申请人： INV NYLON CHEMICALS AMERICAS, LLC
发明人： Alex Conradie , Gary J. Smith , Paul S. Pearlman , Gregory S. Kirby , Mariusz Kamionka
IPC分类号： C07C51/47 , B01D15/36 , C07C227/40 , C07C67/58 , B01D15/20 , B01D15/18 , C07C53/126 , C07C229/06
摘要： This document describes a process for the high purity and high concentration recovery of monovalent products via continuous ion exchange from aqueous solution for further down-stream purification.

3. 发明授权

US10208210B2 Hydrophilic oil repellent and production method of same, surface coating material, coating film, resin composition, oil-water separation filter material, and porous body 有权
公开(公告)号：US10208210B2
公开(公告)日：2019-02-19
申请号：US15329408
申请日：2015-07-29
申请人： MITSUBISHI MATERIALS CORPORATION , Mitsubishi Materials Electronic Chemicals Co., Ltd.
发明人： Masato Fujita , Masakazu Uotani , Takeshi Kamiya , Tsunetoshi Honda , Daisuke Takano
IPC分类号： C09D5/16 , B01D17/02 , C09D7/00 , C07C229/12 , C07C227/16 , C07C233/05 , C07C231/02 , C07C311/05 , C07C303/38 , C07C309/13 , C07C303/02 , C07D211/38 , C07D265/30 , C07D207/10 , C07D241/04 , C02F1/40 , C09D7/40 , C07C303/22 , C07C303/40 , C07C309/04 , C07C309/29 , C07C311/03 , C07C227/06 , C07C227/08 , C07C227/18 , C07C229/06 , C07C231/12 , C07C233/08 , C08K5/17 , C09D201/00 , C09K3/00 , C08L101/00 , C09D7/20
摘要： The hydrophilic oil repellent includes one or more types of nitrogen-containing fluorine-based compounds. The nitrogen-containing fluorine-based compound includes any one hydrophilicity imparting group selected from the group consisting of anion type hydrophilicity imparting groups, cation type hydrophilicity imparting groups, and amphoteric type hydrophilicity imparting groups in the molecule.

4. 发明申请

US20180093202A1 MATERIALS AND METHODS FOR THE SELECTIVE RECOVERY OF MONOVALENT PRODUCTS FROM AQUEOUS SOLUTIONS USING CONTINUOUS ION EXCHANGE 审中-公开
公开(公告)号：US20180093202A1
公开(公告)日：2018-04-05
申请号：US15564888
申请日：2016-04-08
申请人： INVISTA NORTH AMERICA S.A.R.L.
发明人： Alex Conradie
IPC分类号： B01D15/36 , B01D15/20 , B01D15/18 , C07C227/40 , C07C229/06 , C07C51/47 , C07C53/126
CPC分类号： B01D15/362 , B01D15/1892 , B01D15/20 , B01D15/361 , C07C51/47 , C07C53/126 , C07C67/58 , C07C227/40 , C07C229/06
摘要： This document describes a process for the high purity and high concentration recovery of monovalent products via continuous ion exchange from aqueous solution for further downstream purification.

5. 发明申请

US20170274086A1 CATIONIC LIPID FOR NUCLEIC ACID DELIVERY 审中-公开
公开(公告)号：US20170274086A1
公开(公告)日：2017-09-28
申请号：US15504239
申请日：2015-08-07
申请人： NOF CORPORATION , NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
发明人： Shota SASAKI , Masaki OTA , Kazuhiro KUBO , Hideyoshi HARASHIMA , Hidetaka AKITA , Hiroto HATAKEYAMA , Yuki NOGUCHI , Kota TANGE , Yuta NAKAI , Nayuta SHIMIZU
IPC分类号： A61K48/00 , A61K9/127 , C12N15/63 , C12P7/64 , A61K9/107 , C07C229/06
CPC分类号： A61K9/107 , A61K9/127 , A61K31/7088 , A61K47/18 , A61K47/48046 , A61K48/00 , C07C229/12 , C12P7/6445 , Y02P20/55
摘要： The invention provides a cationic lipid capable of achieving higher intracellular delivery efficiency than conventional cationic lipids, when used as a lipid membrane structure which is a carrier for delivering functional nucleic acid. The cationic lipid is represented by the formula (1): wherein each symbol is as defined herein.

6. 发明申请

US20150225439A1 Dendrimer Scaffolds for Pharmaceutical Use 有权
标题翻译：树枝状支架用于制药用途
公开(公告)号：US20150225439A1
公开(公告)日：2015-08-13
申请号：US14425602
申请日：2013-09-05
申请人： Victoria Link Limited
发明人： Phillip Martin Rendle , Steven Toms
IPC分类号： C07H15/04 , C07C229/06 , C07C229/38
CPC分类号： C07H15/04 , A61K47/32 , A61K47/48192 , A61K47/59 , A61K49/0021 , A61K49/0054 , A61K49/124 , C07C229/06 , C07C229/10 , C07C229/38 , C07C233/18 , C07C237/08
摘要： This invention relates to certain dendrimer compounds. In particular, this invention relates to novel dendrimer compounds that can be elaborated to give increasingly large and complex compounds. These elaborated compounds can be attached to, or can encapsulate within, active agent(s) so as to beneficially modify the characteristics of that active agent. Alternatively, the elaborated compounds can themselves be beneficially modified into therapeutic agents by the attachment of inactive agents.
摘要翻译：本发明涉及某些树枝状大分子化合物。特别地，本发明涉及新颖的树枝状大分子化合物，其可以被精心制备以产生越来越大的和复杂的化合物。这些精制化合物可以附着于活性剂或可以包封在活性剂中，以有利地改变该活性剂的特性。或者，精制的化合物本身可以通过无活性剂的附着而有益地修饰成治疗剂。

7. 发明授权

US08802644B2 Lipid formulation 有权
标题翻译：脂质配方
公开(公告)号：US08802644B2
公开(公告)日：2014-08-12
申请号：US13357856
申请日：2012-01-25
申请人： Jianxin Chen , Steven Ansell , Akin Akinc , Joseph Robert Dorkin , Xiaojun Qin , William Cantley , Muthiah Manoharan , Kallanthottathil G. Rajeev , Jayaprakash K. Narayanannair , Muthusamy Jayaraman
发明人： Jianxin Chen , Steven Ansell , Akin Akinc , Joseph Robert Dorkin , Xiaojun Qin , William Cantley , Muthiah Manoharan , Kallanthottathil G. Rajeev , Jayaprakash K. Narayanannair , Muthusamy Jayaraman
IPC分类号： C12N15/113 , C07C229/06 , A61K47/12 , A61K47/14
CPC分类号： A61K9/1272 , A61K9/1278 , A61K31/22 , A61K31/7088 , A61K31/712 , A61K31/713 , A61K38/1709 , A61K38/4846 , A61K47/14 , A61K47/549 , A61K47/551 , A61K47/6911 , A61K48/0033 , C07C29/58 , C07C227/18 , C07C227/40 , C07C229/12 , C07D475/04 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2310/3515 , C12N2320/32 , Y02A50/463 , A61K2300/00 , C12N2310/3521 , C12N2310/3533
摘要： The invention features a cationic lipid of formula I, an improved lipid formulation comprising a cationic lipid of formula I and corresponding methods of use. Also disclosed are targeting lipids, and specific lipid formulations comprising such targeting lipids.
摘要翻译：本发明的特征在于式I的阳离子脂质，包含式I的阳离子脂质和相应的使用方法的改进的脂质制剂。还公开了靶向脂质和包含这种靶向脂质的特定脂质制剂。

8. 发明申请

US20120193574A1 Method Of Controlling Crystallization 审中-公开
标题翻译：控制结晶的方法
公开(公告)号：US20120193574A1
公开(公告)日：2012-08-02
申请号：US13393523
申请日：2010-08-26
申请人： Sharon Jane Cooper , Catherine Emma Nicholson
发明人： Sharon Jane Cooper , Catherine Emma Nicholson
IPC分类号： C07C229/06 , C09K3/00 , C07C229/54
CPC分类号： B01D9/0004 , B01D9/00 , B01D9/0054
摘要： The invention provides a method of crystallising a compound comprising either: (i) providing a first confined solution comprising the compound; and adding more of the compound to and/or increasing the degree of saturation of the first confined solution, whereby to provide a resultant second confined solution that comprises more compound and/or that has a greater degree of supersaturation relative to a confined supersaturated solution of the same compound stabilised solely by being confined; or (ii) providing a first confined melt comprising the compound; and cooling and/or increasing the pressure of the first confined melt, whereby to provide a resultant second confined melt that is cooler and/or is more pressurised relative to a confined super-cooled melt of the same compound stabilised solely by being confined, whereby to effect the crystallising under confinement and under thermodynamic control.
摘要翻译：本发明提供一种结晶化合物的方法，包括：（i）提供包含该化合物的第一限制溶液; 并且将更多的化合物加入到和/或增加第一限制溶液的饱和度，从而提供所得到的第二约束溶液，其包含更多的化合物和/或相对于约束过饱和溶液的过饱和溶液具有更大程度的过饱和度相同的化合物仅通过限制而稳定; 或（ii）提供包含所述化合物的第一限制熔体; 并且冷却和/或增加第一限制熔体的压力，由此提供相对于仅通过限制稳定稳定的相同化合物的约束过冷却熔体而更冷和/或加压的所得第二约束熔体，由此在限制和热力学控制下实现结晶。

9. 发明授权

US08207370B2 Process for producing optically active beta-hydroxy-alpha-aminocarboxylic acid ester 失效
标题翻译：光学活性β-羟基-α-氨基羧酸酯的制备方法
公开(公告)号：US08207370B2
公开(公告)日：2012-06-26
申请号：US12311325
申请日：2007-09-26
申请人： Tatsuya Honda , Tatsuyoshi Tanaka , Masaru Mitsuda
发明人： Tatsuya Honda , Tatsuyoshi Tanaka , Masaru Mitsuda
IPC分类号： C07C209/50 , C07C209/46 , C07C209/00 , C07C229/06
CPC分类号： C07B53/00 , C07C227/16 , C07C231/12 , C07C229/22 , C07C233/18 , C07C233/47
摘要： It is an objective of the present invention to produce an anti-form of an optically active β-hydroxy-α-aminocarboxylic acid ester efficiently, simply and industrially advantageously. The objective can be accomplished by directly and selectively producing the anti-form of the optically active β-hydroxy-α-aminocarboxylic acid ester by asymmetric reduction of a β-keto-α-aminocarboxylic acid ester using an optically active amine complex as a catalyst. Further, the β-keto-α-aminocarboxylic acid ester as a raw material can be produced at a high yield by reacting a glycine derivative with a carboxylic acid derivative.
摘要翻译：本发明的目的是在工业上有效地有效地制备光学活性的α-羟基-α-氨基羧酸酯的抗反型剂。该目的可以通过使用光学活性胺络合物不对称还原反应形式的光学活性的β-羟基-α-氨基羧酸酯来直接和选择性地制备催化剂此外，可以通过使甘氨酸衍生物与羧酸衍生物反应，以高产率制备作为原料的α-酮-α-氨基羧酸酯。

10. 发明申请

US20110008261A1 METHOD TO PRODUCE HYPERPOLARISED AMINO ACIDS AND AMINOSULPHONIC ACIDS 审中-公开
标题翻译：生产高分子氨基酸和氨基酸的方法
公开(公告)号：US20110008261A1
公开(公告)日：2011-01-13
申请号：US12864521
申请日：2009-02-03
申请人： Mathilde H. Lerche , Magnus Karlsson , Pernille R. Jensen
发明人： Mathilde H. Lerche , Magnus Karlsson , Pernille R. Jensen
IPC分类号： A61K49/06 , C12Q1/02 , C07C229/26 , C07C323/58 , C07D207/10 , C07C229/06 , C07C307/02 , C07C303/34 , C07C227/14 , C07C319/12 , G01R33/44
CPC分类号： A61K49/10 , G01N33/58
摘要： The invention relates to a dynamic nuclear polarisation (DNP) method for producing hyperpolarised amino acids and amino sulphonic acids and compositions for use in the method. As a sample, an ammonium salt of an amino acid, an ammonium salt of an aminosulphonic acid, a carboxylate salt of an amino acid, a sulphonate salt of an aminosulphonic acid or mixtures thereof is used.
摘要翻译：本发明涉及用于生产超极化氨基酸和氨基磺酸的动态核极化（DNP）方法和用于该方法的组合物。作为样品，使用氨基酸的铵盐，氨基磺酸的铵盐，氨基酸的羧酸盐，氨基磺酸的磺酸盐或其混合物。

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