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1. 发明申请

US20210246108A1 Method for Producing Alpha-Azidoaniline Derivative or Alpha,AlphaPrime-Diazide Derivative 有权
公开(公告)号：US20210246108A1
公开(公告)日：2021-08-12
申请号：US16973286
申请日：2019-06-12
申请人： Tokuyama Corporation
发明人： Masahiko Seki
IPC分类号： C07D235/26 , C07C247/18 , C07C227/16 , C07C247/16
摘要： Provided is a method for producing an α-azidoaniline derivative or an α,α′-diazide derivative using an aniline derivative as a starting material that includes a method for producing an α-azidoaniline derivative or an α,α′-diazide derivative represented by Formula (2), including the step of: contacting an aniline derivative represented by Formula (1) with an azidating agent in presence of water, a persulfate, and a copper compound.

2. 发明授权

US11084002B2 Universal scalable and cost-effective surface modifications 有权
公开(公告)号：US11084002B2
公开(公告)日：2021-08-10
申请号：US16404372
申请日：2019-05-06
申请人： The Regents of the University of California
发明人： Eric M. Hoek , Richard B. Kaner , Brian T. McVerry
IPC分类号： B01D71/78 , B01D65/08 , B01D67/00 , B01D71/76 , B01D61/08 , C02F1/44 , C07C247/18 , B01D69/08 , B01D61/02 , B01D69/02 , B01D71/56 , C02F103/08
摘要： Disclosed are fouling resistant filtration membranes comprising a polymeric thin-film membrane comprising a surface. Also disclosed are methods of modifying thin-film filtration membranes, thereby improving, for example, the anti-fouling properties of the membranes. Also disclosed are methods of purifying water using the disclosed membranes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

3. 发明申请

US20180346460A1 INHIBITORS OF LYSINE GINGIPAIN 审中-公开
公开(公告)号：US20180346460A1
公开(公告)日：2018-12-06
申请号：US15996660
申请日：2018-06-04
申请人： Cortexyme, Inc.
发明人： Andrei Konradi , Stephen S. Dominy , Casey Crawford Lynch , Craig Coburn , Joseph Vacca
IPC分类号： C07D417/12 , C07D213/50 , C07D409/12 , C07D277/64 , C07D277/24 , C07C247/16 , C07D277/28 , C07D213/53 , C07C233/62 , C07C233/78 , C07C247/18
CPC分类号： C07D417/12 , C07B2200/07 , C07C233/62 , C07C233/78 , C07C247/16 , C07C247/18 , C07C2601/08 , C07D213/50 , C07D213/53 , C07D277/24 , C07D277/28 , C07D277/64 , C07D409/12
摘要： The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.

4. 发明申请

US20170296986A1 UNIVERSAL SCALABLE AND COST-EFFECTIVE SURFACE MODIFICATIONS 审中-公开
公开(公告)号：US20170296986A1
公开(公告)日：2017-10-19
申请号：US15581783
申请日：2017-04-28
申请人： The Regents of the University of California
发明人： ERIC M.V. HOEK , Richard B. Kaner , Brian T. McVerry
IPC分类号： B01D71/78 , B01D65/08 , B01D67/00 , B01D71/76 , C02F1/44 , B01D61/08 , C07C247/18 , C02F103/08 , B01D69/02 , B01D69/08 , B01D71/56 , B01D61/02
CPC分类号： B01D71/78 , B01D61/025 , B01D61/08 , B01D65/08 , B01D67/0088 , B01D67/0093 , B01D69/02 , B01D69/08 , B01D71/56 , B01D71/76 , B01D2323/345 , B01D2323/36 , B01D2325/48 , C02F1/441 , C02F2103/08 , C07C247/18
摘要： Disclosed are fouling resistant filtration membranes comprising a polymeric thin-film membrane comprising a surface. Also disclosed are methods of modifying thin-film filtration membranes, thereby improving, for example, the anti-fouling properties of the membranes. Also disclosed are methods of purifying water using the disclosed membranes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

5. 发明申请

US20160001236A1 Universal Scalable and Cost-Effective Surface Modifications 有权
标题翻译：通用可扩展且具有成本效益的表面修改
公开(公告)号：US20160001236A1
公开(公告)日：2016-01-07
申请号：US14768887
申请日：2014-02-21
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Eric M.V. Hoek , Richard B. Kaner , Brian T. McVerry
IPC分类号： B01D71/78 , B01D67/00 , C07C247/18 , B01D61/08 , B01D65/08 , B01D71/56 , C02F1/44
CPC分类号： B01D71/78 , B01D61/025 , B01D61/08 , B01D65/08 , B01D67/0088 , B01D67/0093 , B01D69/02 , B01D69/08 , B01D71/56 , B01D71/76 , B01D2323/345 , B01D2323/36 , B01D2325/48 , C02F1/441 , C02F2103/08 , C07C247/18
摘要： Disclosed are fouling resistant filtration membranes comprising a polymeric thin-film membrane comprising a surface. Also disclosed are methods of modifying thin-film filtration membranes, thereby improving, for example, the anti-fouling properties of the membranes. Also disclosed are methods of purifying water using the disclosed membranes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译：披露的是具有防污性的过滤膜，其包括包含表面的聚合物薄膜膜。还公开了改性薄膜过滤膜的方法，从而改善了例如膜的防污性能。还公开了使用所公开的膜来净化水的方法。该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

6. 发明申请

US20100228041A1 CYCLOOCTENE MONOMERS 有权
标题翻译：环保单体
公开(公告)号：US20100228041A1
公开(公告)日：2010-09-09
申请号：US12761664
申请日：2010-04-16
申请人： Todd Shannon Emrick , Kurt Breitenkamp
发明人： Todd Shannon Emrick , Kurt Breitenkamp
IPC分类号： C07C247/18
CPC分类号： C07C247/18 , C07C2601/18 , C08F290/00 , C08F290/06 , C08G61/08 , C08K5/315 , C08K5/5205
摘要： Azidoaryl-substituted cyclooctene monomers and synthesized and used in the preparation of various copolymers. Among these copolymers are those prepared from ring-opening metathesis polymerization of cyclooctene, polyethylene glycol-substituted cyclooctene, and azidoaryl-substituted cyclooctene. These copolymers are useful in the formation of crosslinked films that reduce fouling of water purification membranes.
摘要翻译：叠氮芳基取代的环辛烯单体，合成并用于制备各种共聚物。这些共聚物是由环辛烯，聚乙二醇取代的环辛烯和叠氮基芳基取代的环辛烯的开环易位聚合制备的共聚物。这些共聚物可用于形成减少水净化膜结垢的交联膜。

7. 发明授权

US07301006B2 Methods and materials for the synthesis of modified peptides 有权
标题翻译：用于合成修饰肽的方法和材料
公开(公告)号：US07301006B2
公开(公告)日：2007-11-27
申请号：US10622078
申请日：2003-07-16
申请人： Travis G. Young , Laura L. Kiessling
发明人： Travis G. Young , Laura L. Kiessling
IPC分类号： C07C247/04 , C07C247/06 , C07C247/18 , C07K1/06
CPC分类号： C07K1/1072 , C07C271/22 , Y02P20/55
摘要： Methods and protected amino acids useful as building blocks (protected monomers) for the synthesis of peptides and proteins that are selectively modified at one or more side-chain hydroxyl groups. Azide-bearing protecting groups allow the selective deprotection of side-chain hydroxyl groups of amino acids after synthesis of a peptide. Reaction conditions for removal of the azide-bearing protecting group can be selected which are substantially orthogonal to those that will remove α-amino protecting groups typically employed in peptide synthesis, such that hydroxyl groups protected with the azide-bearing protecting group remain protected during synthesis of the peptide chain. Various protecting groups which are readily available can be used for protecting potentially reactive side chain groups of amino acids in the peptide or protein to be modified. Preferred side-chain protecting groups are chemically distinguishable from the azide-bearing protecting group and substantially orthogonal reaction conditions can be selected such that side-chain protection of other amino acids is maintained when the azide-bearing protecting group is removed. The use of the azide-bearing protecting group of this invention for one or more hydroxy amino acids during peptide synthesis allows the selective unmasking of those azide-protected side-chain hydroxyl groups and selective modification of the hydroxyl groups that are selectively unmasked. The methods and materials herein are particularly used in synthesis of sulfated, phosphorylated and glycosylated peptides and proteins. Kits and methods of synthesizing a modified peptide or protein using the kits are also provided.
摘要翻译：用作合成在一个或多个侧链羟基上选择性修饰的肽和蛋白质的结构单元（保护单体）的方法和保护的氨基酸。含有叠氮基的保护基允许在合成肽后氨基酸的侧链羟基的选择性去保护。可以选择用于除去含叠氮基保护基团的反应条件，其基本上与将除去通常用于肽合成中的α-氨基保护基团正交的那些，使得在含有叠氮基保护基团的情况下保护的羟基在合成期间保持保护的肽链。易于获得的各种保护基团可用于保护待修饰的肽或蛋白质中氨基酸的潜在的活性侧链基团。优选的侧链保护基团与含叠氮基保护基团在化学上是可区分的，并且可以选择基本上正交的反应条件，使得当除去含叠氮保护基团时，维持其它氨基酸的侧链保护。在肽合成期间使用本发明的含叠氮保护基的一个或多个羟基氨基酸允许选择性地掩蔽那些叠氮化物保护的侧链羟基并选择性地修饰选择性地未掩蔽的羟基。本文的方法和材料特别用于硫酸化，磷酸化和糖基化肽和蛋白质的合成。还提供了使用试剂盒合成修饰的肽或蛋白质的试剂盒和方法。

8. 发明授权

US5057302A Bifunctional chelating agents 失效
标题翻译：双功能螯合剂
公开(公告)号：US5057302A
公开(公告)日：1991-10-15
申请号：US136180
申请日：1988-01-04
申请人： David K. Johnson , Steven J. Kline
发明人： David K. Johnson , Steven J. Kline
IPC分类号： G01N33/536 , A61K47/48 , C07C67/00 , C07C229/36 , C07C229/42 , C07C239/00 , C07C241/00 , C07C245/20 , C07C247/18 , C07C275/42 , C07C291/04 , C07C325/00 , C07C331/28 , C07C335/20 , C07C335/22 , C07C337/06 , C07K1/22 , C07K14/00 , C07K16/00 , C09K3/00 , G01N33/58
CPC分类号： C07C275/42 , A61K47/48 , C07C335/22
摘要： The present invention provides bifunctional chelating agents comprising a unique substrate reactive moiety incorporated into a carboxymethyl arm of a polyaminopolycarboxylate chelating framework capable of forming stable complexes with metal ions.

9. 发明申请

US20190322659A1 INHIBITORS OF LYSINE GINGIPAIN 审中-公开
公开(公告)号：US20190322659A1
公开(公告)日：2019-10-24
申请号：US16399821
申请日：2019-04-30
申请人： Cortexyme, Inc.
发明人： Andrei W. Konradi , Stephen S. Dominy , Casey Crawford Lynch , Craig Coburn , Joseph Vacca
IPC分类号： C07D417/12 , C07D213/53 , C07D409/12 , C07D277/24 , C07C247/18 , C07D277/28 , C07D277/64 , C07C233/62 , C07C233/78 , C07C247/16 , C07D213/50
摘要： The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.

10. 发明授权

US10301301B2 Inhibitors of lysine gingipain 有权
公开(公告)号：US10301301B2
公开(公告)日：2019-05-28
申请号：US15996660
申请日：2018-06-04
申请人： Cortexyme, Inc.
发明人： Andrei Konradi , Stephen S. Dominy , Casey Crawford Lynch , Craig Coburn , Joseph Vacca
IPC分类号： C07D417/12 , C07D213/53 , C07D277/28 , C07D277/64 , C07C233/62 , C07C233/78 , C07C247/16 , C07D409/12 , C07D213/50 , C07C247/18 , C07D277/24
摘要： The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.

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