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1. 发明授权

US06861565B2 Process for producing a fluoroalkanol 失效
标题翻译：氟烷醇的制备方法
公开(公告)号：US06861565B2
公开(公告)日：2005-03-01
申请号：US10383688
申请日：2003-03-10
申请人： Toshihiko Tohma , Akihiro Wada
发明人： Toshihiko Tohma , Akihiro Wada
IPC分类号： C07C29/44 , C07C29/64 , C07C31/38 , C07C31/34 , C07C31/42 , C07C31/44
CPC分类号： C07C29/44 , C07C31/38
摘要： A process for producing a fluoroalkanol which can easily be industrially practiced with high selectivity, is provided.CHR1R2OH, a radical initiator and CF2═CFRf are continuously supplied and reacted at from 105 to 135° C., and H—(RfCFCF2)n—CR1R2—OH formed, is continuously discharged. Here, each of R1 and R2 is a hydrogen atom or a C1-3 alkyl group, Rf is a fluorine atom or a C1-4 polyfluoroalkyl group, and n is an integer of from 1 to 4.
摘要翻译：提供了可以容易地以高选择性工业实践的氟烷醇的制备方法。连续供给CHR 1 R 2 OH，自由基引发剂和CF 2 = CFR f，并在105〜135℃下反应形成的C，和H-（R f CFCF 2）n-CR 1 R 2 -OH被连续地排出。这里，R 1和R 2各自为氢原子或C 1-3烷基，R f为氟原子或C 1-4多氟烷基，n为1〜 4。

2. 发明授权

US6166156A Method for making photocurable halofluorinated acrylates 有权
标题翻译：制备可光固化的氟氟化丙烯酸酯的方法
公开(公告)号：US6166156A
公开(公告)日：2000-12-26
申请号：US190194
申请日：1998-11-12
申请人： Chengjiu Wu , Baopei Xu , James T. Yardley
发明人： Chengjiu Wu , Baopei Xu , James T. Yardley
IPC分类号： G02B6/12 , C07C29/147 , C07C29/149 , C07C31/42 , C07C51/093 , C07C51/285 , C07C55/32 , C07C67/08 , C07C67/14 , C07C69/63 , C07C69/653 , C08F8/00 , C08F8/04 , C08F8/06 , C08F8/26 , C08F14/18 , C08G63/682 , C08G64/10 , C08G69/42 , C08F20/22 , C08F6/00 , C08F120/22 , C08F220/22
CPC分类号： C07C51/285 , C07C29/149 , C07C31/42 , C07C67/08 , C07C69/653 , C08F8/00 , C08F8/04 , C08F8/06 , C08F8/10 , C08F8/14 , C08F2800/10 , C08F2810/30 , Y10S526/914 , C07C55/32 , C07C69/63 , C08F20/00 , C08F214/24
摘要： Halofluorinated alkylene monomers are made by a method comprising the steps of: (a) subjecting a first polymer which is the reaction product of a fluorinated vinyl monomer and a vinyl comonomer to dehydrohalogenation to form a second polymer; (b) treating the second polymer with an oxidizing agent to form an oxidation product consisting of a .alpha., .omega.-dicarboxylic acid or an ester derivative thereof; and (c) treating said oxidation product with a reducing agent to form a reduction product consisting of a a .alpha., .omega.-diol. Preferably, the first polymer has a structure of --[CH.sub.2 CYZ(CF.sub.2 CFX).sub.n ].sub.m -- wherein X and Y=F, Cl or Br; X and Y may be the same or different; Z=H, F, Cl, Br, alkyl or perfluoroalkyl containing from about 1 to about 10 carbon atoms; n=an integer larger than about 1; and m is an integer between about 2 and about 10.sup.5. The .alpha., .omega.-dicarboxylic acids and .alpha., .omega.-diols produced herein can be directly used as polycondensation monomers. Alternatively, the .alpha., .omega.-dicarboxylic acids and .alpha., .omega.-diols can be further derivitized to tri-, tetra- or other multifunctional alcohols which may be directly used as condensation monomers or they may be converted to acrylates which may be photocured in the presence of a radical photoinitiator into transparent polymers which are useful as optical waveguiding materials.
摘要翻译：通过包括以下步骤的方法制备卤代亚烷基单体：（a）使作为氟化乙烯基单体和乙烯基共聚单体的反应产物的第一聚合物进行脱卤化氢以形成第二聚合物; （b）用氧化剂处理第二聚合物以形成由α，ω-二羧酸或其酯衍生物组成的氧化产物; 和（c）用还原剂处理所述氧化产物以形成由α，ω-二醇组成的还原产物。优选地，第一聚合物具有 - [CH 2 CYZ（CF 2 CFX）n] m - 的结构，其中X和Y = F，Cl或Br; X和Y可以相同或不同; Z = H，F，Cl，Br，含有约1至约10个碳原子的烷基或全氟烷基; n =大于1的整数; m为约2至约105的整数。本文生产的α，ω-二羧酸和α，ω-二醇可直接用作缩聚单体。或者，可以将α，ω-二羧酸和α，ω-二醇进一步衍生为可以直接用作缩合单体的三元，四元或其它多官能醇，或者它们可以转化成丙烯酸酯，其可以在将自由基光引发剂存在于用作光波导材料的透明聚合物中。

3. 发明授权

US5426240A Process for the co-production of dichloroacetaldehyde hydrate and chloral 失效
标题翻译：共同生产二氯乙醛水合物和氯醛的方法
公开(公告)号：US5426240A
公开(公告)日：1995-06-20
申请号：US271779
申请日：1994-07-07
申请人： Takashi Wakasugi , Tadashi Miyakawa , Fukuichi Suzuki
发明人： Takashi Wakasugi , Tadashi Miyakawa , Fukuichi Suzuki
IPC分类号： C07C29/09 , C07C31/42 , C07C45/63 , C07C45/81 , C07C45/82 , C07C47/14 , C07C47/16 , C07C45/00
CPC分类号： C07C31/42 , C07C45/63
摘要： A process for producing dichloroacetaldehyde hydrate together with chloral from acetaldehyde or para-aldehyde. The process comprises a step of chlorinating acetaldehyde or para-aldehyde to obtain a chlorinated solution containing dichloroacetaldehyde as a major component, a step of distilling this chlorinated solution to obtain a distillate having a boiling point of 90.degree.-100.degree. C. and containing 50% or more of dichloroacetaldehyde, a step of adding water to this distillate, crystallizing dichloroacetaldehyde hydrate, and separating the crystals, and a step of chlorinating the remaining aldehyde components into chloral. The process enables dichloroacetaldehyde hydrate to be separated at a high purity and the raw materials to be utilized efficiently.
摘要翻译：一种从乙醛或对醛生产二氯乙醛水合物和氯醛的方法。该方法包括将乙醛或对醛进行氯化以获得含有二氯乙醛为主要成分的氯化溶液的步骤，蒸馏该氯化溶液以获得沸点为90-100℃的馏出物并含有50 ％以上的二氯乙醛，向该馏出物中加入水，结晶二氯乙醛水合物和分离晶体的步骤，以及将剩余的醛组分氯化为氯醛的步骤。该方法能够使二氯乙醛水合物以高纯度分离，并且有效地利用原料。

4. 发明授权

US5419817A Electrocatalytic asymmetric dihydroxylation of olefinic compounds 失效
标题翻译：烯烃化合物的电催化不对称二羟基化
公开(公告)号：US5419817A
公开(公告)日：1995-05-30
申请号：US182919
申请日：1994-01-18
申请人： Yun Gao , Charles M. Zepp
发明人： Yun Gao , Charles M. Zepp
IPC分类号： B01J31/16 , B01J31/18 , B01J31/40 , B01J37/34 , C07C29/03 , C07C29/48 , C07C31/20 , C07C31/42 , C07C33/18 , C07C33/20 , C07C33/26 , C07C33/30 , C07C45/51 , C07C49/497 , C07C49/82 , C07C67/31 , C07C69/732 , C25B3/02
CPC分类号： B01J31/183 , B01J31/16 , B01J31/4038 , B01J31/4061 , B01J31/4076 , B01J37/348 , C07C29/48 , B01J2531/825 , C07B2200/07 , C07C2102/10 , Y02P20/584
摘要： A process is disclosed in which optically active glycols are produced through an electrolytic asymmetric dihydroxylation (ADH) reaction involving olefins as substrates. The ADH reaction is mediated by a catalytically active amount of osmium tetroxide or osmium-containing precursor in a protic medium in the presence of chiral ligand. Any lower valent osmium species produced in the course of the ADH reaction is regenerated electrolytically either directly in the absence of a secondary oxidant or indirectly in the presence of a secondary oxidant that itself undergoes electrolytic regeneration.
摘要翻译：公开了一种方法，其中通过涉及烯烃作为底物的电解不对称二羟基化（ADH）反应制备光学活性二醇。在手性配体的存在下，质子介质中的ADH反应由催化活性量的四氧化锇或含锇前体介导。在ADH反应过程中产生的任何较低价锇物质都可以直接在不存在二次氧化剂的情况下电解再生，或间接地在本身进行电解再生的二次氧化剂存在下再生。

5. 发明授权

US4713455A Cyclic derivatives of alkyl dihydroxyalkylxanthenes 失效
标题翻译：烷基二羟基烷基呫吨的环状衍生物
公开(公告)号：US4713455A
公开(公告)日：1987-12-15
申请号：US848139
申请日：1986-04-04
申请人： Harald Furrer , Hiristo Anagnostopulos , Ulrich Gebert
发明人： Harald Furrer , Hiristo Anagnostopulos , Ulrich Gebert
IPC分类号： A61K31/52 , A61K31/522 , A61P11/08 , C07C21/04 , C07C29/10 , C07C31/42 , C07D303/08 , C07D317/16 , C07D317/20 , C07D473/06 , C07D473/08 , C07D473/10 , C07D405/06
CPC分类号： C07D473/08 , C07C29/10 , C07C31/42 , C07D303/08 , C07D317/16 , C07D317/20 , C07D473/06
摘要： Compounds of the formula ##STR1## wherein one of the radicals R.sup.1, R.sup.2 or R.sup.3 denotes a straight-chain alkyl group having 4 to 8 C atoms and two vicinal hydroxyl groups in the .omega.,.omega.-1 or .omega.-1,.omega.-2 positions and the two other radicals represent straight-chain or branched alkyl groups having up to 12 C atoms in the position of R.sup.1 and R.sup.3 and up to 4 C atoms in the position of R.sup.2, the total of C atoms in these two alkyl substituents being a maximum of 14, are prepared by oxidation of the corresponding alkenylxanthines and by alkylation with compounds which introduce the dihydroxyalkyl radical or a precursor thereof. The dihydroxyalkyldialkylxanthines are suitable for the treatment of obstructive respiratory tract diseases.
摘要翻译：式（I）的化合物其中基团R 1，R 2或R 3中的一个表示具有4至8个C原子的直链烷基和ω，ω-1或ω-1中的两个邻位羟基， ω-2位，另外两个基团表示在R 2和R 3的位置具有至多12个C原子的直链或支链烷基，R2的位置中具有至多4个C原子的直链或支链烷基，这两个基团中的C原子总数通过氧化相应的链烯基黄嘌呤并通过引入二羟基烷基或其前体的化合物进行烷基化来制备最多14个的烷基取代基。二羟基烷基二烷基黄嘌呤适用于治疗阻塞性呼吸道疾病。

6. 发明授权

US4456613A 6-Keto- and 6-hydroxy-8-azaprostanoids and anti-ulcer use thereof 失效
标题翻译： 6-酮基和6-羟基-8-氮芥类药物及其抗溃疡用途
公开(公告)号：US4456613A
公开(公告)日：1984-06-26
申请号：US452883
申请日：1982-12-27
申请人： Chia-Lin J. Wang
发明人： Chia-Lin J. Wang
IPC分类号： C07C29/10 , C07C29/62 , C07C31/42 , C07D207/26 , C07D207/28 , C07D303/14 , C07D309/12 , C07D313/02 , A61K31/40 , C07D207/27
CPC分类号： C07D207/26 , C07C29/10 , C07C29/62 , C07C31/42 , C07D207/28 , C07D303/14 , C07D309/12 , C07D313/02 , Y10S514/925
摘要： Biologically active 6-keto- and 6-hydroxy-8-azaprostanoids having the formula: ##STR1## wherein A is O or ##STR2## R is CO.sub.2 R.sup.4 or CH.sub.2 OH; R.sup.1 is H, CH.sub.3, or C.sub.2 H.sub.5 ;R.sup.2 is H, CH.sub.3, or F;R.sup.3 is CH.sub.3 or CF.sub.3 ;R.sup.4 is H, C.sub.1 to C.sub.12 n-alkyl, branched chain alkyl, or cycloalkyl, or a physiologically acceptable metal or amine salt cation; andn is an integer from 3 to 8.
摘要翻译：具有下式的生物活性6-酮基和6-羟基-8-氮芥类化合物：其中A为O或R为CO 2 R 4或CH 2 OH; R1是H，CH3或C2H5; R2是H，CH3或F; R3是CH3或CF3; R4是H，C1-C12正烷基，支链烷基或环烷基，或生理上可接受的金属或胺盐阳离子; n为3〜8的整数。

7. 发明授权

US4413142A Method for preparing L-carnitine 失效
标题翻译： L-肉毒碱的制备方法
公开(公告)号：US4413142A
公开(公告)日：1983-11-01
申请号：US358326
申请日：1982-03-15
申请人： Mario Fiorini , Claudio Valentini
发明人： Mario Fiorini , Claudio Valentini
IPC分类号： C07C227/26 , C07C29/10 , C07C31/42 , C07C229/22 , C07D317/20 , C07C101/30
CPC分类号： C07C255/00 , C07C29/103 , C07C31/42 , C07D317/20 , C07B2200/07
摘要： L-carnitine is prepared by a synthesizing process starting from D-mannitol. The synthesis is started with the formation of a D-mannitol ketonide (more specifically D-mannitol acetonide from D-mannitol and acetone, whereafter the D-mannitol is split by oxidation to give glyceraldehyde acetonide, which is further reduced to glycerol acetonide. Then the free hydroxyl group is exchanged with a halogen atom (chlorine) with the formation of chlorodihydroxy propane, the primary alcoholic group of which is functionalized with the acid chloride of a sulfonic acid (tosylchloride). The reaction of the tosyl derivative with the salt of hydrogen cyanide leads to the formation of the corresponding nitrile which, when reacted with trimethylamine gives carnitinonitrile. The nitrile group is now hydrolyzed to give L-carnitine chloride. The formation of L-carnitine can then be obtained by exchanging the chloride ion with a hydroxyl ion.
摘要翻译： L-肉碱通过从D-甘露糖醇开始的合成方法制备。从D-甘露糖醇和丙酮形成D-甘露醇酮酮（更具体地说是D-甘露糖醇缩酮化合物）开始合成，然后通过氧化将D-甘露糖醇分裂，得到甘油醛缩酮，进一步还原成甘油丙酮化物游离羟基与卤素原子（氯）交换，形成氯二羟基丙烷，其主要的醇基被磺酸（甲苯磺酰氯）的酰氯官能化，甲苯磺酰基衍生物与盐氰化氢导致相应的腈的形成，当与三甲胺反应产生肉碱腈时，腈基现在被水解以得到L-肉碱氯化物，然后可以通过将氯离子与羟基交换来获得左旋肉碱的形成离子。

8. 发明授权

US4390739A Hydroxylation of olefins 失效
标题翻译：烯烃的羟基化
公开(公告)号：US4390739A
公开(公告)日：1983-06-28
申请号：US310097
申请日：1981-10-09
申请人： Robert C. Michaelson , Richard G. Austin
发明人： Robert C. Michaelson , Richard G. Austin
IPC分类号： B01J23/89 , B01J27/00 , B01J27/08 , B01J31/02 , B01J31/28 , C07C29/03 , C07C29/50 , C07C31/20 , C07C31/22 , C07C31/42 , C07C33/20
CPC分类号： C07C31/20 , B01J27/08 , B01J31/0239 , B01J31/28 , C07C29/03 , C07C29/50 , B01J2231/32 , B01J23/8926 , Y02P20/52
摘要： A process directed to the hydroxylation of olefins by reacting said olefins with an oxygen containing gas and water in the presence of a catalyst composition comprising (i) a catalytically active metal oxide such as OsO.sub.4, (ii) as a co-catalyst I a transition metal salt such as CuBr.sub.2, and (iii) optionally a co-catalyst II salt such as tetra ethyl ammonium bromide is disclosed.
摘要翻译：在催化剂组合物存在下使所述烯烃与含氧气体和水反应的方法，该催化剂组合物包含（i）催化活性金属氧化物如OsO 4，（ii）作为助催化剂I的转变金属盐如CuBr 2，和（iii）任选的助催化剂II盐如四乙基溴化铵。

9. 发明授权

US4313008A Synthesis of S-3-chloro-1,2-propanediol 失效
标题翻译：合成S-3-氯-1,2-丙二醇
公开(公告)号：US4313008A
公开(公告)日：1982-01-26
申请号：US39894
申请日：1979-05-17
申请人： Haydn F. Jones
发明人： Haydn F. Jones
IPC分类号： A61K31/045 , A61K31/047 , B01J25/00 , C07C27/00 , C07C29/09 , C07C29/10 , C07C31/20 , C07C31/42 , C07C67/00 , C07C29/14
CPC分类号： C07C31/20
摘要： The S-enantiomer of 3-chloro-1,2-propanediol is prepared by reaction of a chlorodeoxy-D-saccharide having the partial structure. ##STR1## to cleave the glycol, reduce the aldehyde so formed to an alcohol, and hydrolyse the alcohol under mild acidic conditions.
摘要翻译：通过具有部分结构的氯代脱氧-D-糖的反应来制备3-氯-1,2-丙二醇的S-对映异构体。（I）劈开二醇，将形成的醛还原成醇，并在温和的酸性条件下水解醇。

10. 发明授权

US3826806A Flame retardant polyesters from brominated diols 失效
标题翻译：阻燃聚酯的阻燃聚酯
公开(公告)号：US3826806A
公开(公告)日：1974-07-30
申请号：US26020072
申请日：1972-06-06
申请人： UNION CARBIDE CORP
发明人： COMSTOCK L , SMITH P
IPC分类号： C07C69/753 , C07C27/00 , C07C31/34 , C07C31/42 , C07C41/00 , C07C43/178 , C07C67/00 , C08G63/00 , C08G63/682 , C08F21/02 , C08G17/10 , C08G17/12
CPC分类号： C08G63/6828 , Y10S260/24
摘要： THIS INVENTION RELATES TO BROMINATED, UNSATURATED POLYESTERS, BASED ON A BROMINATED DOL AND AN UNSATURATED POLYCARBOXYLIC ACID OR ANHYDRIDE THEREOF, WHICH ARE SUBSTANTIALLY FREE OF DIBROMINATED DIOL MOIETIES, CONTAIN BROMINE END GROUPS AND POSSESS EXCELLENT FLAME RETARDANT PROPERITIES, EXCELLENT THERMAL STABILITY AND CAN BE USED IN MOLDING APPLICATIONS TO FORM AESTHETICALLY CHEMICAL PHYSICAL A ARTICLES CHARACTERIZED BY EXCELLENT CHEMICAL PHYSICLAL AND ELECTRICAL PROPERTIES.

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