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1. 发明申请

US20090041847A1 METHOD OF QUENCHING ELECTRONIC EXCITATION OF CHROMOPHORE-CONTAINING ORGANIC MOLECULES IN PHOTOACTIVE COMPOSITIONS 失效
标题翻译：光电组合物中包含有机分子的电子激发的方法
公开(公告)号：US20090041847A1
公开(公告)日：2009-02-12
申请号：US12022758
申请日：2008-01-30
申请人： Craig A. Bonda , Anna Pavlovic
发明人： Craig A. Bonda , Anna Pavlovic
IPC分类号： A61K9/14 , A61K8/40 , A61Q17/04 , C07C63/64 , C07C15/12
CPC分类号： A61K8/40 , A61K2800/52 , A61Q17/04
摘要： The photostabilizing electronic excited state energy—particularly singlet state energy from a UV-absorbing molecule has been found to be readily transferred to (accepted by) α-cyanodiphenylacrylate compounds of formulas (I) and (V) having an alkoxy radical preferably in the four (para) position (hereinafter methoxycrylenes) on one or both of the phenyl rings: wherein at least one of R1 and R2 is a straight or branched chain C1-C12 alkoxy radical, preferably C1-C8, more preferably C1-C4, and most preferably methoxy, and any non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C24 alkyl radical, preferably C12-C24, more preferably C20; wherein A and B are the same or different and are selected from the group consisting of oxygen, amino and sulfur; R1 and R3 are the same or different and are selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2-C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne, aryl, substituted aryl, heteroaryl, heterocycloalkyl, substituted heteroaryl and substituted heterocycloalkyl; R2 is selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2-C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkyl, C3-C8 substituted cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne; R4, R5, R6 and R7 are the same or different and are selected from the group consisting of C1-C30 alkoxy straight chain on branched and a, b, c and d are each either 0 or 1, and a, b, c and d add up to 1, 2, 3, or 4.
摘要翻译：已经发现光稳定化电子激发态能量 - 特别是来自紫外线吸收分子的单态能量已经被发现容易地转移到具有烷氧基的式（I）和（V）的α-氰基二苯基丙烯酸酯化合物（接受）（对位）位置（以下为甲氧基）;其中R 1和R 2中的至少一个为直链或支链C 1 -C 12烷氧基，优选C 1 -C 8，更优选C 1 -C 4，最优选优选甲氧基，任何非烷氧基R 1或R 2为氢; 并且R 3是直链或支链C 1 -C 24烷基，优选C 12 -C 24，更优选C 20; 其中A和B相同或不同，并且选自氧，氨基和硫; R 1和R 3相同或不同，选自C 1 -C 30烷基，C 2 -C 30亚烷基，C 2 -C 30炔基，C 3 -C 8环烷基，C 1 -C 30取代的亚烷基，C 2 -C 30取代的炔基，芳基，取代的芳基，杂芳基，杂环烷基，取代的杂芳基和取代的杂环烷基; R 2选自C 1 -C 30烷基，C 2 -C 30亚烷基，C 2 -C 30炔基，C 3 -C 8环烷基，C 1 -C 30取代的烷基，C 3 -C 8取代的环烷基，C 1 -C 30取代的亚烷基，C 2 -C 30取代的炔烃 R4，R5，R6和R7相同或不同，选自支链上的C1-C30烷氧基直链，a，b，c和d各自为0或1，a，b，c和 d加起来1，2，3或4。

2. 发明申请

US20080227638A1 Use of abscisic acid to enhance growth control 审中-公开
标题翻译：使用脱落酸来增强生长控制
公开(公告)号：US20080227638A1
公开(公告)日：2008-09-18
申请号：US12011810
申请日：2008-01-30
申请人： Xiaozhong Liu , Peter D. Petracek , Daniel F. Heiman , Mark Beach , Prem Warrior
发明人： Xiaozhong Liu , Peter D. Petracek , Daniel F. Heiman , Mark Beach , Prem Warrior
IPC分类号： A01N37/06 , C07C63/64 , A01P21/00
CPC分类号： A01N37/42 , A01N43/653 , A01N2300/00
摘要： This invention describes the use of S-(+)-abscisic acid (ABA) or its salts in combination with gibberellin biosynthesis inhibitors to improve the performance of gibberellin synthesis inhibitors, and to increase water conservation in plants such as turfgrass.
摘要翻译：本发明描述了S - （+） - 脱落酸（ABA）或其盐与赤霉素生物合成抑制剂的组合用于改善赤霉素合成抑制剂的性能，并增加植物如草坪草中的水分保持。

3. 发明申请

US20080075692A1 METHODS FOR TREATING BLOOD DISORDERS 审中-公开
标题翻译：治疗血液病的方法
公开(公告)号：US20080075692A1
公开(公告)日：2008-03-27
申请号：US11746543
申请日：2007-05-09
申请人： Susan Perrine
发明人： Susan Perrine
IPC分类号： A61K38/20 , A61K31/10 , A61K31/19 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/41 , C07C63/64 , C07D317/44 , C07D277/04 , C07D215/12 , A61P7/00 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/517 , A61K31/54
CPC分类号： C07D311/12 , A61K31/192 , A61K31/194 , A61K31/353 , A61K31/36 , A61K31/39 , A61K31/415 , A61K31/433 , A61K31/517 , C07D285/125
摘要： Methods of treating blood disorders are described.
摘要翻译：描述治疗血液病症的方法。

4. 发明授权

US5766610A Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof 失效
标题翻译：多环芳族化合物及其组合的药物/化妆品组合物
公开(公告)号：US5766610A
公开(公告)日：1998-06-16
申请号：US429096
申请日：1995-04-26
申请人： Jean-Michel Bernardon
发明人： Jean-Michel Bernardon
IPC分类号： C07D333/38 , A61K8/00 , A61K8/06 , A61K8/14 , A61K8/18 , A61K8/19 , A61K8/25 , A61K8/30 , A61K8/33 , A61K8/36 , A61K8/362 , A61K8/368 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/67 , A61K8/72 , A61K31/06 , A61K31/085 , A61K31/12 , A61K31/135 , A61K31/19 , A61K31/22 , A61K31/255 , A61K31/38 , A61K31/381 , A61K31/44 , A61K45/06 , A61P9/00 , A61P11/00 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/08 , A61P17/10 , A61P27/02 , A61P29/00 , A61P35/00 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q19/00 , A61Q19/08 , C07C43/257 , C07C47/575 , C07C49/255 , C07C49/84 , C07C63/64 , C07C65/26 , C07C69/157 , C07C69/16 , C07C69/24 , C07C69/28 , C07C69/92 , C07C205/36 , C07C211/54 , C07C317/14 , C07C317/18 , C07C317/22 , C07C317/24 , C07C323/62 , C07D213/70 , C07D213/78 , C07D327/06 , C07D333/40 , A61K7/48 , C07C321/00
CPC分类号： A61Q5/12 , A61K45/06 , A61K8/33 , A61K8/368 , A61K8/445 , A61K8/46 , A61K8/466 , A61K8/4913 , A61K8/4926 , A61K8/4973 , A61K8/4986 , A61Q19/00 , A61Q5/00 , A61Q5/02 , Y10S514/844 , Y10S514/846 , Y10S514/855 , Y10S514/937 , Y10S514/944
摘要： Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
摘要翻译：新颖的药物/化妆活性多环芳族化合物具有结构式（I）：其中Ar是具有式（a） - （e）之一的基团：并且是有用的用于治疗各种各样的疾病状态，无论是人类还是兽医，例如皮肤病学，风湿性，呼吸道，心血管和眼科疾病，以及用于治疗哺乳动物皮肤和毛发病症/病症。

5. 发明授权

US5698755A Process for preparing aromatic olefins using palladacycle catalysis 失效
标题翻译：使用聚酰胺催化制备芳族烯烃的方法
公开(公告)号：US5698755A
公开(公告)日：1997-12-16
申请号：US493359
申请日：1995-06-21
申请人： Matthias Beller , Hartmut Fischer , Wolfgang Anton Herrmann , Christoph Brossmer
发明人： Matthias Beller , Hartmut Fischer , Wolfgang Anton Herrmann , Christoph Brossmer
IPC分类号： B01J31/12 , B01J31/24 , C07B37/04 , C07B61/00 , C07C2/86 , C07C15/44 , C07C15/50 , C07C22/08 , C07C25/24 , C07C25/28 , C07C37/11 , C07C39/20 , C07C39/24 , C07C43/20 , C07C45/68 , C07C47/52 , C07C49/20 , C07C49/76 , C07C63/64 , C07C67/343 , C07C69/618 , C07C69/73 , C07C69/732 , C07C69/734 , C07C69/738 , C07C201/12 , C07C205/06 , C07C205/34 , C07C209/68 , C07C211/44 , C07C255/50 , C07C303/22 , C07C303/30 , C07C309/29 , C07C309/65 , C07C315/04 , C07C317/14 , C07C2/68
CPC分类号： B01J31/2404 , B01J31/2447 , C07B37/04 , C07C45/68 , C07C67/343 , B01J2231/4261 , B01J2531/0205 , B01J2531/824 , B01J31/0235 , B01J31/04
摘要： The invention relates to a process for preparing monofunctional, bifunctional or polyfunctional aromatic olefins of the formula (I) ##STR1## by reaction of haloaromatics of the formula (II) ##STR2## with olefins of the formula (III) ##STR3## , wherein a palladium compound of the formula (IV) ##STR4## is used as the catalyst.
摘要翻译：本发明涉及通过式（Ⅳ）的式（II）的卤代芳族化合物的反应制备式（I）的单官能，双官能或多官能的芳族烯烃的方法。用作催化剂。

6. 发明授权

US5356919A Leukotriene B.sub.4 synthesis inhibitors 失效
标题翻译：白三烯B4合成抑制剂
公开(公告)号：US5356919A
公开(公告)日：1994-10-18
申请号：US707522
申请日：1991-05-30
申请人： Stevan W. Djuric , Richard A. Haack , Julie M. Miyashiro
发明人： Stevan W. Djuric , Richard A. Haack , Julie M. Miyashiro
IPC分类号： C07C43/215 , C07C63/64 , C07C63/66 , C07C65/32 , C07C65/34 , C07C65/38 , C07C65/40 , C07D213/79 , C07D257/04 , C07D307/68 , C07D333/38 , C07F7/08 , A61K31/41
CPC分类号： C07F7/0818 , C07C43/215 , C07C63/64 , C07C63/66 , C07C65/32 , C07C65/34 , C07C65/38 , C07C65/40 , C07D213/79 , C07D257/04 , C07D307/68 , C07D333/38
摘要： This invention relates to a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein X is oxygen, sulfur, --CH.dbd.CH--, or --CH.dbd.N--; wherein R.sup.1 is --CO.sub.2 R.sup.2 or tetrazole; wherein R.sup.2 is hydrogen, alkyl of 1 to 6 carbons or a pharmaceutically acceptable cation; wherein R is an alkyl of from 1 to 20 carbons, --(CH.sub.2).sub.p CF.sub.3 or --(CH.sub.2).sub.q R.sup.3 wherein R.sup.3 is alkoxy, phenoxy or alkoxy substituted phenoxy wherein the alkoxy group has from 1 to 8 carbons; wherein p and q are integers from 0 to 20; wherein n is 0 or 1; and wherein m is 0, 1, 2, or 3.
摘要翻译：本发明涉及下式的化合物或其药学上可接受的盐，其中X是氧，硫，-CH = CH-或-CH = N-; 其中R 1是-CO 2 R 2或四唑; 其中R2是氢，1至6个碳的烷基或药学上可接受的阳离子; 其中R是1至20个碳的烷基， - （CH 2）p CF 3或 - （CH 2）q R 3，其中R 3是烷氧基，苯氧基或烷氧基取代的苯氧基，其中烷氧基具有1至8个碳; 其中p和q为0至20的整数; 其中n为0或1; 并且其中m为0,1,2或3。

7. 发明授权

US4798911A Catalyst composition and method for selective dehydrogenation 失效
标题翻译：催化剂组合物和选择性脱氢方法
公开(公告)号：US4798911A
公开(公告)日：1989-01-17
申请号：US75375
申请日：1987-07-20
申请人： Carl M. Lentz , Bruce L. Gustafson , Paul S. Wehner
发明人： Carl M. Lentz , Bruce L. Gustafson , Paul S. Wehner
IPC分类号： B01J23/89 , C07B35/04 , C07B61/00 , C07C5/00 , C07C5/32 , C07C5/333 , C07C11/02 , C07C37/06 , C07C39/15 , C07C41/18 , C07C43/215 , C07C45/65 , C07C47/548 , C07C49/794 , C07C51/347 , C07C63/64 , C07C69/76 , C07C69/94 , C07C317/14 , C07C5/367 , C07C39/12
CPC分类号： C07C41/18 , B01J23/8926 , C07C37/001 , C07C37/06 , C07C5/325 , C07C5/3337 , C07C67/297 , C07C67/317 , C07C2101/14 , C07C2521/18 , C07C2523/44 , C07C2523/72 , C07C2523/89
摘要： A method for selective dehydrogenation of a compound, comprising contacting a compound of the formula ##STR1## wherein each R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is independently selected from the group consisting of H, (C.sub.1 -C.sub.20) alkyl, (C.sub.3 -C.sub.20) cycloalkyl, (C.sub.6 -C.sub.20) aryl, (C.sub.7 -C.sub.20) alkylaryl, (C.sub.7 -C.sub.20) aralkyl groups, as well as substituted (C.sub.1 -C.sub.20) alkyl, (C.sub.3 -C.sub.20) cycloalkyl, (C.sub.6 -C.sub.20) aryl, (C.sub.7 -C.sub.20) aralkyl and (C.sub.7 -C.sub.20) arylalkyl moieties, optionally further substituted with --OR, wherein R is R.sup.1, R.sup.2, R.sup.3 or R.sup.4 ; and wherein R.sup.1 and R.sup.2 or R.sup.3 and R.sup.4 may be joined as part of a ring structure, at a dehydrogenation temperature in the presence of a catalyst comprising about 0.01 wt %-19.9 wt % Pd and about 0.01 wt %-19.9 wt % Cu on a carbon support, wherein the total amount of (Pd+Cu) on the support is about 0.02 wt % to 20 wt %, the weight ratio of Pd:Cu is about 1:1 to 10:1, and the carbon support has a surface area of at least about 100 m.sup.2 /g and is essentially free of reactive sulfur.A selective dehydrogenation catalyst having the composition described supra is disclosed as is a method of preparing the same. This catalyst is highly selective for dehydrogenating a variety of substrates while minimizing the formation of unwanted hydrogenolysis by-products.
摘要翻译：一种化合物的选择性脱氢的方法，包括使下式化合物与其中每个R 1，R 2，R 3和R 4独立地选自H，（C 1 -C 20）烷基，（C 3 -C 20）环烷基，（C 6 -C 20）芳基，（C 7 -C 20）烷基芳基，（C 7 -C 20）芳烷基以及取代的（C 1 -C 20）烷基，（C 3 -C 20）环烷基，（C 6 -C 20） C7-C20）芳烷基和（C7-C20）芳烷基部分，任选进一步被-OR取代，其中R是R 1，R 2，R 3或R 4; 并且其中R 1和R 2或R 3和R 4可以作为环结构的一部分在脱氢温度下在催化剂存在下接合，所述催化剂包含约0.01重量％-19.9重量％的Pd和约0.01重量％-19.9重量％的Cu 碳载体，其中载体上的（Pd + Cu）的总量为约0.02重量％至20重量％，Pd：Cu的重量比为约1:1至10:1，并且碳载体具有表面积至少约100m 2 / g，基本上不含活性硫。作为其制备方法，公开了具有上述组成的选择性脱氢催化剂。该催化剂对于使各种底物脱氢而具有高选择性，同时最小化不想要的氢解副产物的形成。

8. 发明授权

US4362891A Alkanoic acid derivatives 失效
标题翻译：烷酸衍生物
公开(公告)号：US4362891A
公开(公告)日：1982-12-07
申请号：US160426
申请日：1980-06-17
申请人： Alfredo Guerrato , Michele Perchinunno
发明人： Alfredo Guerrato , Michele Perchinunno
IPC分类号： A61K31/19 , A61K31/215 , A61P7/08 , A61P25/04 , A61P29/00 , C07C45/46 , C07C49/807 , C07C51/00 , C07C57/42 , C07C57/58 , C07C57/60 , C07C59/48 , C07C67/00 , C07C63/64 , C07C69/76
CPC分类号： C07C59/48 , C07C45/46 , C07C49/807 , C07C57/58 , C07C57/60 , Y10S514/916
摘要： An alkanoic acid compound is disclosed of formula: ##STR1## and certain of its physiologically acceptable salts and esters. The alkanoic acid compound and its salts and esters have an unexpectedly greater anti-inflammatory activity than representative members of a broad class of compounds, phenyl alkane derivatives, known to have therapeutic properties. The alkanoic acid compound also has unexpectedly high antipyretic and analgesic activity. The compounds may be formulated in conventional manner as pharmaceutical compositions.The compound may be prepared from 2-[4-(1-hydroxy-2-dimethylethyl)phenyl] propionic acid directly by dehydration or via an ester by dehydration in the presence of an alkanol followed by hydrolysis.
摘要翻译：公开了一种链烷酸化合物，其分子式如下：＆lt; IMAGE＆gt;和其某些生理上可接受的盐和酯。链烷酸化合物及其盐和酯具有比已知具有治疗性质的广泛类别化合物苯基烷衍生物的代表性成员具有出乎意料的更大的抗炎活性。链烷酸化合物也具有意想不到的高解热和止痛活性。化合物可以以常规方式配制成药物组合物。该化合物可以直接通过脱水或通过在烷醇存在下脱水然后通过酯水解从2- [4-（1-羟基-2-二甲基乙基）苯基]丙酸制备。

9. 发明申请

US20210009498A1 COMPOUND FOR MODULATING DDAH AND ADMA LEVELS, AS WELL AS METHODS OF USING THEREOF TO TREAT DISEASE 有权
公开(公告)号：US20210009498A1
公开(公告)日：2021-01-14
申请号：US17040832
申请日：2019-04-30
申请人： THE TRUSTEES OF INDIANA UNIVERITY
发明人： Jaipal SINGH , Kerry FOWLER
IPC分类号： C07C65/19 , C07C65/24 , C07C65/17 , C07C233/81 , C07C233/65 , C07D257/04 , C07C317/32 , C07C211/55 , C07C323/62 , C07C215/74 , C07C65/40 , C07C49/513 , C07C63/64 , C07D209/18 , C07D263/32 , C07D213/55 , C07C65/10 , C07D295/16 , C07D277/30 , C07D333/24
摘要： Disclosed are compounds that can modulate DDAH and the amount of asymmetric dimethylarginine (ADMA) in a subject. Also provided are pharmaceutical compositions comprising these compounds, as well as methods of using these compositions to treat and/or prevent diseases associated with elevated or low levels of DDAH and ADMA.

10. 发明授权

US10253131B2 Polymers prepared from functionalized dimethoxyphenol monomers 有权
公开(公告)号：US10253131B2
公开(公告)日：2019-04-09
申请号：US15208135
申请日：2016-07-12
申请人： Angela L. Holmberg , Kaleigh H. Reno , Thomas H. Epps, III
发明人： Angela L. Holmberg , Kaleigh H. Reno , Thomas H. Epps, III
IPC分类号： C08F12/22 , C08F12/24 , C07C39/19 , C07C39/20 , C07C63/04 , C07C63/64 , C07C49/794 , C08F293/00 , C07C69/54
摘要： Dimethoxyphenol-based monomers containing polymerizable functional groups such as [meth]acrylate groups are useful for the preparation of polymers, wherein one or more dimethoxyphenyl moieties are part of side chains pendant to the backbones of the polymers. The polymers thereby obtained may have different, improved properties, such as higher glass transition temperatures, thermal stability and solvent resistance, as compared to polymers based on other types of lignin-derived monomers.

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