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1. 发明授权

US06686498B2 Process for the preparation of Michael-adducts 有权
标题翻译：迈克尔加合物的制备方法
公开(公告)号：US06686498B2
公开(公告)日：2004-02-03
申请号：US10077551
申请日：2002-02-14
申请人： Denis Jacoby
发明人： Denis Jacoby
IPC分类号： C07C6966
CPC分类号： C07C49/12 , C07C45/73 , C07C67/347 , C07C69/716
摘要： The present invention relates to the field of organic synthesis and more specifically to a process for the preparation of Michael-adducts, as defined below, by reacting a &bgr;,&bgr;- or a &agr;,&bgr;-disubstituted, or a &agr;,&bgr;,&bgr;-trisubstituted, &agr;,&bgr;-unsaturated ketone (I) with a &bgr;-ketoester or a &bgr;-diketone (II) in presence of a suitable catalyst of formula M(X)n, according to scheme 1:
摘要翻译：本发明涉及有机合成领域，更具体地涉及如下定义的通过使β，β或α，β-二取代或α，β，β反应制备迈克尔加成物的方法根据方案1，在合适的式M（X）n催化剂的存在下，使用β-酮酯或β-二酮（II）将三 - 取代的α，β-不饱和酮（I）

2. 发明授权

US06489505B2 Process for producing 3,3-dimethyl-2-formylcyclopropane-carboxylic acid ester 失效
标题翻译： 3,3-二甲基-2-甲酰基环丙烷 - 羧酸酯的制备方法
公开(公告)号：US06489505B2
公开(公告)日：2002-12-03
申请号：US09769290
申请日：2001-01-26
申请人： Koji Hagiya , Ichiro Komoto , Akio Kurihara
发明人： Koji Hagiya , Ichiro Komoto , Akio Kurihara
IPC分类号： C07C6966
CPC分类号： C07C67/333 , C07C69/757
摘要： There is provided a process for producing 3,3-dimethyl-2-formylcyclopropanecarboxylic ester of formula (1): wherein R represents an alkyl group, a cycloalkyl group or an optionally substituted aralkyl group, which comprises reacting chrysanthemic acid ester of formula (2): wherein R represents the same meaning as that described above, with hydrogen peroxide in the presence of at least one catalyst selected from tungstic oxide, tungstic acid, tugstate, alkylrhenium trioxide, molybdic oxide, molybdate, a heteropoly acid comprising a hetero atom selected from a phosphorus, boron or silicone atom and a poly atom selected from tungsten or molybdenum and a salt of said heteropoly acid.
摘要翻译：提供了一种制备式（1）的3,3-二甲基-2-甲酰基环丙烷羧酸酯的方法：其中R代表烷基，环烷基或任意取代的芳烷基，其包括使式（2）的菊酸酯与）：其中R表示与上述相同的含义，过氧化氢在至少一种选自氧化钨，钨酸，钨酸盐，三氧化锑，氧化钼，钼酸盐，包含选择的杂原子的杂多酸的催化剂存在下存在从磷，硼或硅酮原子和选自钨或钼的聚原子和所述杂多酸的盐。

3. 发明授权

US06476254B1 Alkoxylated fatty alcohol dicarboxylic acid esters 有权
标题翻译：烷氧基化脂肪醇二羧酸酯
公开(公告)号：US06476254B1
公开(公告)日：2002-11-05
申请号：US09410585
申请日：1999-10-01
申请人： Abel G. Pereira , Patrick Obukowho
发明人： Abel G. Pereira , Patrick Obukowho
IPC分类号： C07C6966
CPC分类号： A61Q19/00 , A61K8/39 , A61Q5/12 , A61Q15/00 , A61Q17/04
摘要： Fatty alkoxylated esters consisting of diesters of aliphatic or aromatic dicarboxylic acids, formed by reacting the acid with a stoichiometric excess of one or more polyalkoxylated fatty alcohols. Non-aqueous compositions for topical application are also disclosed including one or more active ingredients, and an emollient agent of the fatty alkoxylated esters of the present invention.
摘要翻译：由酸与化学计量过量的一种或多种聚烷氧基化脂肪醇反应形成的由脂族或芳族二羧酸的二酯组成的脂肪烷氧基化酯。还公开了用于局部施用的非水性组合物，其包括一种或多种活性成分，以及本发明的脂肪烷氧基化酯的软化剂。

4. 发明授权

US06420594B1 Polylactate release compounds and methods of using same 有权
标题翻译：聚乳酸脱模化合物及其使用方法
公开(公告)号：US06420594B1
公开(公告)日：2002-07-16
申请号：US09190630
申请日：1998-11-12
申请人： William A. Farone , Stephen S. Koenigsberg , Tracy Palmer
发明人： William A. Farone , Stephen S. Koenigsberg , Tracy Palmer
IPC分类号： C07C6966
CPC分类号： B09C1/10 , C02F1/68 , C08G63/06
摘要： The present invention provides for a family of novel compositions to serve as substrates that release hydroxy acid slowly over time. Preferably the hydroxy acid is an &agr;-hydroxy acid, more preferably it is lactic acid. The compositions are preferably made by reaction of poly(lactic acid) with multifunctional alcohols. Also disclosed are formulations based on the compounds and methods of use for both the compositions and the formulations. The preferred use of the compositions and formulations of the present invention is for bioremediation purposes wherein they provide a time-release source of lactic acid to support the growth and reductive activity of microbes present in a system or medium, such as an aquifer, bioreactor, soil, industrial process, wastestream, body of water, river or well. The microbes destroy or inactivate compounds which are capable of being reduced, such as nitrogen-containing organic compounds, oxygen-containing organic compounds, polyaromatic hydrocarbons, and halogen-containing organic compounds.
摘要翻译：本发明提供了一组新型组合物，其用作缓慢释放羟基酸的底物。优选地，羟基酸是α-羟基酸，更优选地是乳酸。组合物优选通过聚（乳酸）与多官能醇的反应来制备。还公开了基于化合物和用于组合物和制剂的两种方法的制剂。本发明的组合物和制剂的优选用途是用于生物修复目的，其中它们提供乳酸的时间释放源，以支持存在于系统或介质如含水层，生物反应器中的微生物的生长和还原活性，土壤，工业过程，废水，水体，河流或井。微生物破坏或灭活能够还原的化合物，例如含氮有机化合物，含氧有机化合物，多芳族烃和含卤素的有机化合物。

5. 发明授权

US06403825B1 Processes for producing citrate esters 有权
标题翻译：生产柠檬酸酯的方法
公开(公告)号：US06403825B1
公开(公告)日：2002-06-11
申请号：US09437334
申请日：1999-11-30
申请人： Edward P. Frappier , James E. Davis , Martin Grendze , Eric F. V. Scriven , John T. Wyeth , Kuen-Wai Chiu
发明人： Edward P. Frappier , James E. Davis , Martin Grendze , Eric F. V. Scriven , John T. Wyeth , Kuen-Wai Chiu
IPC分类号： C07C6966
CPC分类号： C07C67/08 , C07C69/704
摘要： Described are processes for producing citrate esters in, an economic fashion. Esters are prepared by esterification of a citric acid-containing fermentation broth having been treated to remove cations and optionally other impurities, but containing sugar(s). Esters are also prepared by reacting an impure aqueous citric acid source with an alcohol to provide a heterogeneous aqueous/organic reacted mixture, wherein the organic phase contains the ester and the aqueous phase retains water-soluble impurities. A liquid phase separation is then used to separate the organic and aqueous phases, conveniently separating the impurities from the product and avoiding the energy-intensive distillation of water from the reaction medium.
摘要翻译：描述了以经济方式生产柠檬酸酯的方法。酯通过已经处理以除去阳离子和任选的其它杂质但含有糖的含柠檬酸的发酵液的酯化制备。酯也可以通过使不纯的柠檬酸水溶液与醇反应来制备，以提供非均相的含水/有机反应的混合物，其中有机相含有酯，水相保留水溶性杂质。然后使用液相分离来分离有机相和水相，方便地从产物中分离杂质，并避免水从反应介质中进行能量密集的蒸馏。

6. 发明授权

US06222063B1 Process for transesterifying &agr;-Ketocarboxylic esters 失效
标题翻译：酯交换α-酮羧酸酯的方法
公开(公告)号：US06222063B1
公开(公告)日：2001-04-24
申请号：US09369384
申请日：1999-08-06
申请人： Curt Zimmermann , Johann Friedhuber
发明人： Curt Zimmermann , Johann Friedhuber
IPC分类号： C07C6966
CPC分类号： C07C67/03 , Y02P20/582 , C07C69/716
摘要： Process for transesterifying &agr;-ketocarboxylic esters in an anhydrous alcohol as reaction medium in the presence of tin catalysts, titanium catalysts, zirconium catalysts or lithium catalysts or of acetylacetonates as catalysts.
摘要翻译：在锡催化剂，钛催化剂，锆催化剂或锂催化剂或乙酰丙酮化物作为催化剂的存在下，在无水醇中作为反应介质酯交换α-酮羧酸酯的方法。

7. 发明授权

US06790982B2 Process for producing a fluorine atom-containing sulfonyl fluoride compound 失效
标题翻译：含氟原子的磺酰氟化合物的制造方法
公开(公告)号：US06790982B2
公开(公告)日：2004-09-14
申请号：US10442227
申请日：2003-05-21
申请人： Masahiro Ito , Kunio Watanabe , Takashi Okazoe , Isamu Kaneko , Daisuke Shirakawa
发明人： Masahiro Ito , Kunio Watanabe , Takashi Okazoe , Isamu Kaneko , Daisuke Shirakawa
IPC分类号： C07C6966
CPC分类号： C07C309/82 , C07C51/60 , C07C303/22 , C07C59/135
摘要： The present invention provides a process whereby fluorine atom-containing sulfonyl fluoride compound(s) useful as e.g. materials for ion-exchange membranes, can be produced efficiently and at low cost without structural limitations while solving the difficulties in production. The present invention is also directed to a compound of the following formula (I) or a compound of the following formula (II): FSO2CH2CH2OCH2OCOCF(CF3)OCF2CF2CF3 (I) FSO2CF2CF2OCF2CF2OCOCF(CF3)OCF2CF2CF3 (II).
摘要翻译：本发明提供了一种可用于例如氟原子的磺酰氟化合物的方法。用于离子交换膜的材料可以在没有结构限制的情况下有效且低成本地生产，同时解决生产上的困难。本发明还涉及下式（I）的化合物或下式（II）的化合物：

8. 发明授权

US06723871B2 Process for producing optically active alcohol 失效
标题翻译：光学活性醇的制造方法
公开(公告)号：US06723871B2
公开(公告)日：2004-04-20
申请号：US10142983
申请日：2002-05-13
申请人： Kenichi Tada , Takashi Miura
发明人： Kenichi Tada , Takashi Miura
IPC分类号： C07C6966
CPC分类号： C07C67/31 , C07C69/675
摘要： A novel production process capable of obtaining an optically active alcohol in a high optical purity by subjecting a &bgr;-keto ester such as a 3-perfluoroalkyl-3-oxopropionate ester or a 3-trichloroalkyl-3-oxopropionate ester to asymmetric reduction in simple and convenient operations.
摘要翻译：一种能够通过使3-酮基酯如3-全氟烷基-3-氧代丙酸酯或3-三氯烷基-3-氧代丙酸酯通过使简单且不饱和的不对称还原得到高光学纯度的光学活性醇的新型制备方法方便操作。

9. 发明授权

US06465680B2 Process for preparing malonate derivatives or &bgr;-keto esters from epoxide derivatives 失效
标题翻译：由环氧化物衍生物制备丙二酸酯衍生物或β-酮酯的方法
公开(公告)号：US06465680B2
公开(公告)日：2002-10-15
申请号：US09884440
申请日：2001-06-20
申请人： Byeong No Lee , In-Sun Jung , Eun Joo Jang
发明人： Byeong No Lee , In-Sun Jung , Eun Joo Jang
IPC分类号： C07C6966
CPC分类号： C07C67/313 , C07C67/37 , C07C69/38 , C07C69/716 , C07C69/675
摘要： A process for preparing a malonic acid monoester or &bgr;-ketoester from an epoxide includes the steps of reacting an epoxide with carbon monoxide and an alcohol in the presence of a catalytic amount of a cobalt compound and at least one promoter to produce a &bgr;-hydroxyester, separating the &bgr;-hydroxyester from the cobalt compound and the promoter, and oxidizing the &bgr;-hydroxyester to produce a malonic acid monoester or &bgr;-ketoester.
摘要翻译：从环氧化物制备丙二酸单酯或β-酮酯的方法包括以下步骤：在催化量的钴化合物和至少一种助催化剂的存在下使环氧化物与一氧化碳和醇反应，生成β-羟基酯将β-羟基酯与钴化合物和助催化剂分离，并氧化β-羟基酯以产生丙二酸单酯或β-酮酯。

10. 发明授权

US06455728B1 Direct fluorination process for preparing high purity 2-fluoro-1,3-dicarbonyl compounds using oxygen as a radical scavenger 有权
标题翻译：使用氧作为自由基清除剂制备高纯度2-氟-1,3-二羰基化合物的直接氟化方法
公开(公告)号：US06455728B1
公开(公告)日：2002-09-24
申请号：US09432723
申请日：1999-11-01
申请人： William Jack Casteel, Jr. , Wade H. Bailey, III
发明人： William Jack Casteel, Jr. , Wade H. Bailey, III
IPC分类号： C07C6966
CPC分类号： C07C45/63 , C07C67/307 , C07C49/167 , C07C69/716
摘要： A process for fluorinating &bgr;-dicarbonyls to form the corresponding &agr;-fluorinated-&bgr;-dicarbonyl compounds is provided. The process is represented by the following reaction scheme: where R1 is H, alkyl or alkoxy, R2 is H, alkyl or perfluoroalkyl, and R3 is H, Cl, Br, I or alkyl. Use of oxygen in the fluorine stream yields a product which is 90-96% pure and contains radical fluorination impurity levels which are 10-20% lower than when oxygen is not used.
摘要翻译：提供了用于氟化β-二羰基以形成相应的α-氟化-β-二羰基化合物的方法。该方法由以下反应方案表示：其中R 1是H，烷基或烷氧基，R 2是H，烷基或全氟烷基，R 3是H，Cl，Br，I或烷基。在氟流中使用氧气产生纯度为90-96％的产物，其含有比不使用氧气时低10-20％的自由基氟化杂质水平。

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