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1. 发明授权

US5747068A Flouxetine pharmaceutical formulations 失效
标题翻译：氟西汀药物制剂
公开(公告)号：US5747068A
公开(公告)日：1998-05-05
申请号：US503570
申请日：1995-07-18
申请人： Flavia Arce Mendizabal
发明人： Flavia Arce Mendizabal
IPC分类号： A61J3/10 , A61K9/00 , A61K9/20 , A61K31/135 , A61K31/137 , A61K31/138 , A61K47/30 , A61K47/36 , A61K47/38 , A61P25/24 , A61P25/26 , A61K9/46 , C07C91/22 , C07C93/06
CPC分类号： A61K9/2054 , A61K31/138 , A61K9/0056 , A61K9/0095 , A61K9/2059 , A61K9/2095 , A61K9/2018 , A61K9/2027
摘要： Pharmaceutical formulations of fluoxetine or an acid addition salt thereof, suitable for manufacturing dispersible tablets by direct compression and comprising, in addition to the active ingredient, the appropriate excipients and coadjuvants, selected from among disintegrants, diluents, lubricants, anti-adherents, sweeteners, flavorings and, optionally, colorants. Said formulations are suitable for manufacturing dispersible tablets which disintegrate in less than three minutes in water at 19.degree. C.-21.degree. C., and are appropriate for treatment of depression.
摘要翻译：氟西汀或其酸加成盐的药物制剂，适用于通过直接压制制造可分散片剂，并且除了活性成分之外还包含选自崩解剂，稀释剂，润滑剂，抗粘附剂，甜味剂的合适的赋形剂和辅佐剂，调味剂和任选的着色剂。所述制剂适用于制造在19℃-21℃下在不到三分钟的时间内分解的可分散片剂，并且适于治疗抑郁症。

2. 发明授权

US4609758A Phenoxyethylamine derivatives 失效
标题翻译：苯氧乙胺衍生物
公开(公告)号：US4609758A
公开(公告)日：1986-09-02
申请号：US732478
申请日：1985-05-09
申请人： George E. M. Husbands
发明人： George E. M. Husbands
IPC分类号： A61K31/135 , A61K31/165 , A61K31/22 , A61P25/24 , A61P25/26 , C07C67/00 , C07C205/18 , C07C213/00 , C07C217/14 , C07C217/44 , C07C217/52 , C07C217/60 , C07C219/24 , C07C231/00 , C07C233/10 , C07C233/11 , C07C233/12 , C07C235/06 , C07C235/40 , C07C251/00 , C07C255/31 , C07C255/32 , C07C93/06 , C07C103/26
CPC分类号： C07C233/12
摘要： This invention provides a group of hydroxycycloalkanephenoxyethylamine antidepressant derivatives of the following structural formula: ##STR1## in which R.sub.1 is hydrogen or alkyl of 1 to 6 carbon atoms;R.sub.2 is alkyl of 1 to 6 carbon atoms;R.sub.3 and R.sub.4 are independently hydrogen, hydroxyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 7 carbon atoms, halo or trifluoromethyl;R.sub.5 is hydrogen, alkyl of 1 to 6 carbon atoms or alkanoyl of 2 to 7 carbon atoms;and n is one of the integers 0, 1, 2 or 3;or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供以下结构式的羟基环烷基苯氧基乙胺抗抑郁药衍生物：其中R 1为氢或1至6个碳原子的烷基的 R2是1-6个碳原子的烷基; R 3和R 4独立地为氢，羟基，1至6个碳原子的烷基，1至6个碳原子的烷氧基，2至7个碳原子的烷酰氧基，卤素或三氟甲基; R5是氢，1-6个碳原子的烷基或2-7个碳原子的烷酰基; 并且n是整数0,1,2或3之一; 或其药学上可接受的盐。

3. 发明授权

US4584404A Substituted phenoxyphenylproply dimethylamines 失效
标题翻译：取代苯氧基苯基丙二胺
公开(公告)号：US4584404A
公开(公告)日：1986-04-22
申请号：US544654
申请日：1983-10-24
申请人： Bryan B. Molloy , Klaus K. Schmiegel
发明人： Bryan B. Molloy , Klaus K. Schmiegel
IPC分类号： A61K31/135 , A61K31/205 , C07C93/06
CPC分类号： A61K31/135
摘要： Selective biogenic amine uptake inhibitors, 3-substituted phenyloxy-3-phenylpropyldimethylamines.
摘要翻译：选择性生物胺吸收抑制剂，3-取代苯氧基-3-苯基丙基二甲基胺。

4. 发明授权

US4322437A Spiro substituted indanones and tetralones 失效
标题翻译：螺环取代的茚满酮和四氢萘酮
公开(公告)号：US4322437A
公开(公告)日：1982-03-30
申请号：US795439
申请日：1977-05-10
申请人： Richard Berthold , Trevor G. Payne
发明人： Richard Berthold , Trevor G. Payne
IPC分类号： A61K31/12 , A61K31/40 , A61K31/445 , A61K31/495 , A61P3/08 , A61P7/10 , A61P9/10 , A61P9/12 , C07C213/02 , C07C213/08 , C07C217/38 , C07D207/06 , C07D211/14 , C07D241/12 , C07D295/092 , A01N37/30 , A01N33/02 , C07C93/06
CPC分类号： C07D295/088 , C07C217/38 , C07C2103/94 , Y10S514/821 , Y10S514/866
摘要： The present invention relates to a compound of formula I, ##STR1## wherein A is straight chain alkylene of 2 to 4 carbon atoms, or straight chain alkenylene of 2 to 4 carbon atoms,n is 1, 2 or 3,R is hydrogen or halogen of atomic number from 9 to 35, andeither (i) R.sub.1 is a group of formula II, ##STR2## wherein R.sub.2 and R.sub.3, independently, are hydrogen or alkyl of 1 to 4 carbon atoms, andR.sub.4 is alkyl of 1 to 4 carbon atoms, alkoxyalkyl of 2 to 5 carbon atoms, alkylthioalkyl of 2 to 5 carbon atoms, phenylalkyl or phenoxyalkyl or phenylthioalkyl, wherein the alkyl moiety has from 1 to 3 carbon atoms, or phenyl, the phenyl ring of each of the last four radicals being unsubstituted or mono-substituted by, or disubstituted independently by, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, hydroxy or halogen of atomic number from 9 to 35, andR.sub.5 is hydrogen,or (ii) R.sub.1 and R.sub.5 together with the nitrogen atom to which they are bound are (a) 2,2,6,6-tetramethylpiperidinyl, (b) 2,2,5,5-tetramethylpyrrolidinyl,or (c) piperazinyl substituted in the 4 position by alkyl of 1 to 4 carbon atoms or phenyl which is unsubstituted, or mono-substituted by, or di-or tri-substituted independently by, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, or halogen of atomic number from 9 to 35,useful as anti-hypertensives.
摘要翻译：本发明涉及式Ⅰ化合物，其中A为2至4个碳原子的直链亚烷基或2至4个碳原子的直链亚烯基，n为1,2或3，R为氢或原子序数为9至35的卤素，和（i）R 1是式II，其中R 2和R 3独立地是氢或1-4个碳原子的烷基，R 4是 1至4个碳原子，2至5个碳原子的烷氧基烷基，2至5个碳原子的烷硫基烷基，苯基烷基或苯氧基烷基或苯硫基烷基，其中烷基部分有1至3个碳原子，或苯基，最后四个基团是未取代的或被1至4个碳原子的烷基，1至4个碳原子的烷氧基单独取代或原子数为9至35的羟基或卤素单取代，R5为氢或（ ii）R 1和R 5与它们所连接的氮原子一起是（a）2,2,6,6-四甲基哌啶基，（b）2,2，或（c）在4位上被1至4个碳原子的烷基取代的哌嗪基或未被取代的或被1或2的烷基独立地被二取代或二取代或三取代的苯基取代的哌嗪基 4个碳原子，1至4个碳原子的烷氧基或9至35个原子序数的卤素，可用作抗高血压药。

5. 发明授权

US4322220A Multipurpose hydrocarbon fuel and lubricating oil additive 失效
标题翻译：多用途碳氢燃料和润滑油添加剂
公开(公告)号：US4322220A
公开(公告)日：1982-03-30
申请号：US813027
申请日：1977-07-05
申请人： Warren H. Machleder , Joseph M. Bollinger
发明人： Warren H. Machleder , Joseph M. Bollinger
IPC分类号： C08F8/32 , C10L1/22 , C10L1/2387 , F02B75/02 , C10M1/22 , C07C93/06 , C10L1/18 , C10M1/34
CPC分类号： C10M1/08 , C08F8/32 , C10L1/221 , C10L1/2387 , C10M2207/023 , C10M2209/00 , C10M2209/02 , C10M2209/10 , C10M2215/042 , C10N2270/02 , F02B2075/027
摘要： Substituted phenol/epichlorohydrin/amine adducts as multipurpose, low concentration additives for hydrocarbon fuels, lubricating oils and mixtures thereof.
摘要翻译：作为碳氢燃料，润滑油及其混合物的多用途，低浓度添加剂的取代苯酚/表氯醇/胺加合物。

6. 发明授权

US4311708A Phenol ethers 失效
标题翻译：苯酚醚
公开(公告)号：US4311708A
公开(公告)日：1982-01-19
申请号：US20463
申请日：1979-03-14
申请人： Philippe M. J. Manoury , Icilio A. G. Cavero , Henry Najer , Don P. R. L. Giudicelli
发明人： Philippe M. J. Manoury , Icilio A. G. Cavero , Henry Najer , Don P. R. L. Giudicelli
IPC分类号： A61K31/13 , A61K31/135 , A61K31/165 , A61P9/06 , A61P9/08 , A61P9/10 , A61P25/02 , C07C67/00 , C07C213/00 , C07C217/32 , C07C233/00 , C07C313/00 , C07C315/04 , C07C317/04 , C07C317/18 , C07C317/22 , C07C323/12 , C07C323/20 , C07D303/24 , A01N33/02 , C07C93/06
CPC分类号： C07D303/24 , A61K31/13 , A61K31/135 , A61K31/16 , A61K31/275 , C07C309/00 , C07C317/00 , C07C323/00
摘要： The invention provides phenol ethers of the formula: ##STR1## whereinR is branched C.sub.3-4 alkyl, C.sub.3-4 cycloalkyl, branched cyano(C.sub.3-4 alkyl), phenyl(C.sub.2-3 alkyl), halophenyl(C.sub.2-3 alkyl), (C.sub.1-4 alkoxy)phenyl(C.sub.2-4 alkyl), or (C.sub.1-4 acyl)amino(C.sub.1-4 alkyl),alk is C.sub.1-4 alkyl substituted by a 3 to 6 membered cycloalkyl group,X is --O--, --S-- or --SO.sub.2 --; andR.sub.1 is --C.sub.1-4 alkyl- or --C.sub.1-4 alkoxy-,in their racemic and optically active forms, and their addition salts with pharmaceutically acceptable acids. These compounds are useful in therapy as .beta.-adrenergic blocking agents. Intermediates are also provided.
摘要翻译：本发明提供下式的苯酚醚：

7. 发明授权

US4252984A Phenol ethers 失效
标题翻译：苯酚醚
公开(公告)号：US4252984A
公开(公告)日：1981-02-24
申请号：US734359
申请日：1976-10-20
申请人： Philippe M. J. Manoury , Icilio A. G. Cavero , Henry Najer , Don Pierre R. L. Giudicelli
发明人： Philippe M. J. Manoury , Icilio A. G. Cavero , Henry Najer , Don Pierre R. L. Giudicelli
IPC分类号： A61K31/13 , A61K31/135 , A61K31/165 , A61P9/06 , A61P9/08 , A61P9/10 , A61P25/02 , C07C67/00 , C07C213/00 , C07C217/32 , C07C233/00 , C07C313/00 , C07C315/04 , C07C317/04 , C07C317/18 , C07C317/22 , C07C323/12 , C07C323/20 , C07D303/24 , C07C93/06
CPC分类号： C07D303/24 , A61K31/13 , A61K31/135 , A61K31/16 , A61K31/275 , C07C309/00 , C07C317/00 , C07C323/00
摘要： The invention provides phenol ethers of the formula: ##STR1## wherein R is branched C.sub.3-4 alkyl, C.sub.3-4 cycloalkyl, branched cyano(C.sub.3-4 alkyl), phenyl(C.sub.2-3 alkyl), halophenyl(C.sub.2-3 alkyl), (C.sub.1-4 alkoxy)phenyl(C.sub.2-4 alkyl), or (C.sub.1-4 acyl)amino(C.sub.1-4 alkyl),alk is C.sub.1-4 alkyl substituted by a 3 to 6 membered cycloalkyl group,X is --O--, --S-- or --SO.sub.2 --; andR.sub.1 is --C.sub.1-4 alkyl- or --C.sub.1-4 alkoxy-,in their racemic and optically active forms, and their addition salts with pharmaceutically acceptable acids. These compounds are useful in therapy as .beta.-adrenergic blocking agents. Intermediates are also provided.
摘要翻译：本发明提供下式的苯酚醚：其中R为支链C 3-4烷基，C 3-4环烷基，支链氰基（C 3-4烷基），苯基（C 2-3烷基），卤代苯基（C 2-3烷基），（C 1-4烷氧基）苯基（C 2-4烷基）或（C 1-4酰基）氨基（C 1-4烷基），烷基是被3至6元环烷基取代的C 1-4烷基，X是-O - ， - S-或-SO 2 - ; 且R 1为-C 1-4烷基 - 或-C 1-4烷氧基 - ，其外消旋和旋光形式，及其与药学上可接受的酸的加成盐。这些化合物可用于治疗β-肾上腺素能阻断剂。还提供中间体。

8. 发明授权

US4231964A Nitroamines, processes for their manufacture and their use as diazo components 失效
标题翻译：硝基胺，其制造方法和用作重氮组分
公开(公告)号：US4231964A
公开(公告)日：1980-11-04
申请号：US4608
申请日：1979-01-18
申请人： Rudolf Kuhne , Heinrich Hamal
发明人： Rudolf Kuhne , Heinrich Hamal
IPC分类号： C09B29/02 , C07C67/00 , C07C213/00 , C07C217/84 , C09B35/22 , C09B51/00 , C07C93/06
CPC分类号： C09B51/00 , C09B35/22
摘要： Compounds of the formula ##STR1## wherein one of the pairs of substituents X and X' on the one hand and Y and Y' on the other hand stands for nitro and the other for amino and wherein n is 1 to 4, are diazo components, especially for disazo pigments of high tinctorial strength and purity of shade.
摘要翻译：另一方面，一方面取代基X和X'中的一个和另一方面Y和Y'之一的式“IMAGE”的化合物代表硝基，而另一个代表氨基，其中n是1至4，是重氮组分，特别适用于高着色强度和色纯度的双偶氮染料。

9. 发明授权

US4157400A Terpenophenoxyalkylamines and pharmaceutical compositions and uses thereof 失效
标题翻译：萜类苯氧基烷基胺及其药物组合物及其用途
公开(公告)号：US4157400A
公开(公告)日：1979-06-05
申请号：US822726
申请日：1977-08-08
申请人： Jean Mardiguian
发明人： Jean Mardiguian
IPC分类号： A61K31/13 , A61K31/135 , A61P9/08 , A61P9/12 , A61P25/02 , A61P31/04 , C07C67/00 , C07C213/00 , C07C217/32 , C07D303/22 , C07C93/06
CPC分类号： C07D303/22
摘要： 1-ISOPROPYLAMINO-3-[2-(2-NORBORNYL EXO)PHENOXY]PROPAN-2-OL, ITS 1-ISOPROPYLAMINO-3-[2-NORBORNYL ENDO)PHENOXY]PROPAN-2-OL ISOMER AND THEIR ACID ADDITION SALTS AND THEIR QUATERNARY AMMONIUM SALTS.These compounds can be used as beta-blocking agents against disorders of the cardiac rhythm, anti-anxiety and anti-hypertension medicaments.
摘要翻译： 1-异丙基氨基-3- [2-（2-异丙基苯基）苯基]丙-2-醇，其1-异丙基氨基-3- [2-异丁基内酯]苯氧基]丙-2-醇异构体及其酸添加物和他们的季铵盐

10. 发明授权

US4147805A Alkylthiophenoxyalkylamines and the pharmaceutical use thereof 失效
标题翻译：烷基噻吩氧基烷基胺及其药物用途
公开(公告)号：US4147805A
公开(公告)日：1979-04-03
申请号：US928668
申请日：1978-07-28
申请人： Duane F. Morrow
发明人： Duane F. Morrow
IPC分类号： A61K31/13 , A61K20060101 , A61K31/00 , A61K31/10 , A61K31/135 , A61P9/08 , C07C20060101 , C07C67/00 , C07C313/00 , C07C323/20 , C07C93/06
CPC分类号： C07D409/12
摘要： A new class of alkylthiophenoxyalkylamine derivatives and methods for preparation are described. The compounds have vasodilating and antispasmodic activity, inhibit blood platelet aggregation and are substantially free of beta-adrenergic blocking effects. They are particularly valuable in the treatment of disease states responsive to vasodilation such as obstructive peripheral vascular diseases and cerebral vascular deficiencies. Representative and preferred embodiments of the invention are N-[3-[4-(methylthio)phenoxy]propyl]octylamine and N-[3-[4-(1-methylethyl)thio]phenoxy]-propyl]octylamine.
摘要翻译：描述了一类新的烷基硫代氧烷基胺衍生物及其制备方法。该化合物具有血管扩张和解痉药活性，抑制血小板聚集并且基本上不含β-肾上腺素能阻滞作用。它们在治疗响应于血管舒张的疾病状态（例如阻塞性外周血管疾病和脑血管缺陷）方面特别有价值。本发明的代表性和优选的实施方案是N- [3- [4-（甲硫基）苯氧基]丙基]辛胺和N- [3- [4-（1-甲基乙基）硫代]苯氧基] - 丙基]辛胺。

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