专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20180065985A1 PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS 审中-公开
公开(公告)号：US20180065985A1
公开(公告)日：2018-03-08
申请号：US15807992
申请日：2017-11-09
申请人： Merck Sharp & Dohme. Corp. , MSD R&D (China) Co., Ltd. , Merck Sharp & Dohme Limited
发明人： Hongming Li , Jingjun Yin , Kevin M. Belyk , Kevin R. Campos , Qinghao Chen , Alan M. Hyde , Tetsuji Itoh , Artis Klapars , Matthew Thomas Tudge , Edward Cleator , Aaron M. Dumas , Louis-Charles Campeau , Yonggang Chen , Ji Qi , Wensong Xiao
IPC分类号： C07D498/04 , C07F9/6509 , C07D413/04 , C07D417/04 , C07C251/24 , C07D265/14
CPC分类号： C07D498/04 , C07C251/24 , C07D239/74 , C07D265/14 , C07D265/36 , C07D413/04 , C07D413/14 , C07D417/04 , C07F9/650994 , C07F17/02
摘要： The present invention is directed to a process for making Tetracyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein X1, X2, R1, R2 and R3 are defined above herein. The present invention is also directed to compounds that may be useful as synthetic intermediates in the process of the invention.

2. 发明申请

US20170166586A1 PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS 审中-公开
公开(公告)号：US20170166586A1
公开(公告)日：2017-06-15
申请号：US15325392
申请日：2015-07-10
申请人： Hongming LI , Jingjun YIN , Kevin M. BELYK , Kevin R. CAMPOS , Qinghao CHEN , Alan M. HYDE , Tetsuji ITOH , Artis KLAPARS , Mathew Thomas TUDGE , Edward CLEATOR , Aaron M. DUMAS , Louis-Charles CAMPEAU , Yonggang CHEN , Ji QI , Wensong XIAO , MERCK SHARP & DOHME CORP. , MERCK SHARP & DOHME LIMITED , MSD R&D (CHINA) CO., LTD
发明人： Hongming Li , Jingjun Yin , Kevin M. Belyk , Kevin R. Campos , Qinghao Chen , Alan M. Hyde , Tetsuji Itoh , Artis Klapars , Matthew Thomas Tudge , Edward Cleator , Aaron M. Dumas , Louis-Charles Campeau , Yonggang Chen , Ji Qi , Wensong Xiao
IPC分类号： C07D498/04 , C07F9/6509 , C07D265/14 , C07D413/04 , C07C251/24 , C07D417/04
CPC分类号： C07D498/04 , C07C251/24 , C07D239/74 , C07D265/14 , C07D265/36 , C07D413/04 , C07D413/14 , C07D417/04 , C07F9/650994 , C07F17/02
摘要： The present invention is directed to a process for making Tetracyclic Heterocycle Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein X1, X2, R1, R2 and R3 are defined above herein. The present invention is also directed to compounds that are useful as synthetic intermediates in the process of the invention.

3. 发明申请

US20170121276A1 HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF 有权
公开(公告)号：US20170121276A1
公开(公告)日：2017-05-04
申请号：US13996483
申请日：2011-12-22
申请人： Yitshak FRANCIS , Mauro FA , Ottavio ARANCIO , Jole FIORITO , Shixian DENG , Donald W. LANDRY , Michal LUZAC , Yan FENG
发明人： Yitshak FRANCIS , Mauro FA , Ottavio ARANCIO , Jole FIORITO , Shixian DENG , Donald W. LANDRY , Michal LUZAC , Yan FENG
IPC分类号： C07C217/22 , C07D295/088 , C07D265/14 , C07D209/48
CPC分类号： C07C217/22 , C07C217/58 , C07C235/60 , C07C235/64 , C07C251/24 , C07D209/48 , C07D265/14 , C07D265/36 , C07D295/088
摘要： The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.

4. 发明授权

US09114170B2 Highly loaded amorphous efavirenz composition and process for preparing the same 有权
标题翻译：高度无定形的依法韦仑组合物及其制备方法
公开(公告)号：US09114170B2
公开(公告)日：2015-08-25
申请号：US13843224
申请日：2013-03-15
申请人： ISP Investments Inc.
发明人： Yunxia Bi , Mohammed Abdul Rahman , James David Lester , Thomas Durig , Randy Bull
IPC分类号： A61K31/536 , C07D265/14 , A61K47/38 , A61K47/32 , B29C43/00 , A61K9/14 , A61K9/16
CPC分类号： A61K47/38 , A61K9/146 , A61K9/1635 , A61K31/536 , A61K47/32 , B29C43/003
摘要： A stable and high loading ternary solid dispersion composition comprising (a) about 50% wt. to about 90% wt. of amorphous Efavirenz; (b) about 10% wt. to about 50% wt. of polyvinyl pyrrolidone (PVP), a first polymer; (c) about 1% wt. to about 30% wt. of a water-soluble second polymer; and (d) optionally about 0.1% wt. to about 50% wt. of at least one pharmaceutically acceptable excipient. Also discloses a high loading ternary composition comprising (a) a solid dispersion composition comprising (i) about 50% wt. to about 90% wt. of amorphous Efavirenz; (ii) about 10% wt. to about 50% wt. of polyvinyl pyrrolidone, a first polymer; (b) about 1% wt. to about 30% wt. of a water-soluble second polymer blended with solid dispersion of composition of (a); and (c) optionally about 0.1% wt. to about 50% wt. of at least one pharmaceutically acceptable excipient. Additionally discloses a method for preparing solid dosage forms comprising (i) amorphous Efavirenz and (ii) polyvinyl pyrrolidone (PVP), a first polymer; (iii) a water-soluble second polymer; and (iv) optionally, at least one pharmaceutical excipients.
摘要翻译：一种稳定且高负载的三元固体分散体组合物，其包含（a）约50重量％至约90重量％的无定形依非韦伦; （b）约10重量％至约50重量％聚乙烯吡咯烷酮（PVP），第一聚合物; （c）约1重量％至约30重量％的水溶性第二聚合物; 和（d）任选地约0.1重量％至约50重量％的至少一种药学上可接受的赋形剂。还公开了一种高负载三元组合物，其包含（a）固体分散体组合物，其包含（i）约50重量％至约90重量％的无定形依非韦伦; （ii）约10重量％至约50重量％聚乙烯吡咯烷酮，第一聚合物; （b）约1重量％至约30重量％与（a）的组合物的固体分散体共混的水溶性第二聚合物; 和（c）任选地约0.1重量％至约50重量％的至少一种药学上可接受的赋形剂。另外公开了一种制备固体剂型的方法，其包含（i）非依依夫韦恩和（ii）聚乙烯吡咯烷酮（PVP），第一聚合物; （iii）水溶性第二聚合物; 和（iv）任选的至少一种药物赋形剂。

5. 发明申请

US20120149617A1 POLYTETRAHYDROBENZOXAZINES AND BISTETRAHYDROBENZOXAZINES AND USE THEREOF AS A FUEL ADDITIVE OR LUBRICANT ADDITIVE 有权
标题翻译：聚四氢呋喃并苯并噻唑并二苯并噻唑并作为燃料添加剂或润滑剂添加剂使用
公开(公告)号：US20120149617A1
公开(公告)日：2012-06-14
申请号：US13313400
申请日：2011-12-07
申请人： Arno LANGE , Harald Böhnke , Wolfgang Grabarse , Hannah Maria König , Markus Hansch , Ludwig Völkel , Ivette Garcia Castro
发明人： Arno LANGE , Harald Böhnke , Wolfgang Grabarse , Hannah Maria König , Markus Hansch , Ludwig Völkel , Ivette Garcia Castro
IPC分类号： C10L1/233 , C10M169/04 , C07D265/14
CPC分类号： C10L10/04 , C07D265/16 , C10L1/233 , C10L1/238 , C10L2200/0259 , C10L2230/22 , C10L2270/026 , C10M133/48 , C10M149/14 , C10M2215/225 , C10M2217/041 , C10N2220/021
摘要： Polytetrahydrobenzoxazines and bistetrahydrobenzoxazines, obtainable by (A) reacting at least one diamine of the formula H2N-A-NH2 with a C1- to C12-aldehyde and a C1- to C8-alkanol at 20 to 80° C. with elimination and removal of water, (B) reacting the condensation product from (A) with a phenol which bears a long-chain substituent at 30 to 120° C., and optionally (C) heating the reaction product from (B) to 125 to 280° C. The resulting polytetrahydrobenzoxazines and bistetrahydrobenzoxazines are suitable as fuel or lubricant additives, especially as detergent additives for diesel fuels.
摘要翻译：可通过（A）使式H2N-A-NH2的至少一种二胺与C 1 -C 12 - 醛和C 1 -C 8烷醇在20至80℃下反应得到的聚四氢苯并恶嗪和双四氢苯并恶嗪，同时除去和除去水，（B）使来自（A）的缩合物与长链取代基的苯酚在30〜120℃下反应，任选（C）将反应产物从（B）加热至125〜280℃ 所得聚四氢苯并恶嗪和双四氢苯并恶嗪适用作燃料或润滑剂添加剂，特别是作为柴油燃料的洗涤剂添加剂。

6. 发明申请

US20110105481A1 FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC 有权
标题翻译：菲林蛋白结合抗炎和毒理学
公开(公告)号：US20110105481A1
公开(公告)日：2011-05-05
申请号：US12719624
申请日：2010-03-08
申请人： Lindsay Burns Barbier , Hoau-Yan Wang , Nan-Horng Lin , Andrei Blasko
发明人： Lindsay Burns Barbier , Hoau-Yan Wang , Nan-Horng Lin , Andrei Blasko
IPC分类号： A61K31/54 , C07D497/10 , A61K31/438 , C07D471/10 , C07D265/14 , A61K31/537 , C07D279/04 , A61P29/00
CPC分类号： A61K31/438 , A61K31/537 , A61K31/54 , C07D471/10 , C07D498/10
摘要： A compound or its pharmaceutically acceptable salt, optionally including both individual enantiomeric forms, a racemate, diastereomers and mixtures thereof, composition and method are disclosed that can provide analgesia and reduce inflammation. A contemplated compound has a structure that corresponds to Formula A, wherein the R group substituents, d, e, f, k, n, m, D, E, F, K, G, P, Q, W, and Z are defined within.
摘要翻译：公开了可以提供止痛和减轻炎症的化合物或其药学上可接受的盐，任选地包括单独的对映体形式，外消旋物，非对映异构体及其混合物。考虑的化合物具有对应于式A的结构，其中R基团取代基d，e，f，k，n，m，D，E，F，K，G，P，Q，W和Z被定义中。

7. 发明授权

US07867949B2 Hydrazide compound and pesticidal use of the same 有权
标题翻译：酰肼化合物和杀虫剂使用相同
公开(公告)号：US07867949B2
公开(公告)日：2011-01-11
申请号：US11992490
申请日：2006-10-10
申请人： Hiroshi Ikegami , Markus Jachmann , Yoshihiko Nokura , Chiemi Iwata
发明人： Hiroshi Ikegami , Markus Jachmann , Yoshihiko Nokura , Chiemi Iwata
IPC分类号： A01N43/40 , A01N43/56 , A61K31/5355 , C07D265/14 , C07D401/00 , C07D231/10
CPC分类号： C07D231/14 , C07D207/34 , C07D401/04 , C07D403/04
摘要： A hydrazide compound represented by the formula (1): has excellent pesticidal activity.
摘要翻译：由式（1）表示的酰肼化合物：具有优良的杀虫活性。

8. 发明授权

US07740693B2 Organic fluorescent sulfonyl ureido benzoxazinone pigments 有权
标题翻译：有机荧光磺酰脲基苯并嗪酮颜料
公开(公告)号：US07740693B2
公开(公告)日：2010-06-22
申请号：US11906289
申请日：2007-10-01
申请人： Thomas Potrawa , Joachim Schulz
发明人： Thomas Potrawa , Joachim Schulz
IPC分类号： C09D11/00 , C09K11/06 , C07D265/14 , C08K5/1545 , B05D1/00 , B42D15/10 , D21H21/40
CPC分类号： C07D265/22 , B42D25/387 , B42D2033/20 , C08K5/43 , C09D5/22 , C09D11/322 , C09D11/50 , C09K11/06 , C09K2211/1007 , C09K2211/1033 , D21H17/07 , Y02P20/582
摘要： The present disclosure provides Benzoxazinone compounds represented by the formula: wherein each R1, R2, R3, and R4 is independently selected from hydrogen, alkyl of 1-12 carbon atoms, substituted alkyl, aryl of 6-12 carbon atoms, substituted aryl, halo, and alkoxy; and R5 is selected from alkyl of 1-12 carbon atoms, substituted alkyl, aryl of 6-12 carbon atoms, substituted aryl, halo, and alkoxy; wherein each of the substituted alkyl and the substituted aryl groups have a substituent selected from alkyl, aryl, halo, and alkoxy. The present disclosure provides a mark having a benzoxazinone compound, and a method for applying the mark onto an article. Also provided is a process for preparing benzoxazinone compounds.
摘要翻译：本公开提供由下式表示的苯并恶嗪酮化合物：其中每个R 1，R 2，R 3和R 4独立地选自氢，1-12个碳原子的烷基，取代的烷基，6-12个碳原子的芳基，取代的芳基，卤素和烷氧基; R 5选自1-12个碳原子的烷基，取代的烷基，6-12个碳原子的芳基，取代的芳基，卤素和烷氧基; 其中取代的烷基和取代的芳基各自具有选自烷基，芳基，卤素和烷氧基的取代基。本公开提供了具有苯并恶嗪酮化合物的标记，以及将标记施加到制品上的方法。还提供了制备苯并恶嗪酮化合物的方法。

9. 发明申请

US20090258429A1 Colorimetric detection of cyanide with a chromogenic oxazine 有权
标题翻译：用显色恶嗪比色检测氰化物
公开(公告)号：US20090258429A1
公开(公告)日：2009-10-15
申请号：US11991355
申请日：2006-09-01
申请人： Francisco M. Raymo , Massimiliano Tomasulo
发明人： Francisco M. Raymo , Massimiliano Tomasulo
IPC分类号： C07D265/14 , G01N21/78
CPC分类号： G01N33/1826 , C07D498/04 , C09B19/00 , G01N31/22 , Y10T436/172307
摘要： A chromogenic oxazine compound for the colorimetric detection of cyanide was designed. Indeed, the [1,3]oxazine ring of our compound opens to form a phenolate chromophore in response to cyanide. The heterocyclic com-pound may be comprised of fused benzooxazine and indoline rings: wherein R1 is an alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, isobutyl), a substituted alkyl, a cycloalkyl (e.g., cyclopentyl, cyclohexyl), a substituted cycloalkyl, an aryl (e.g., phenyl), or a substituted aryl and R2 is a chromophore (e.g., nitroso, nitro, azo dyes). This quantitative chromogenic transformation permits the detection of micromolar concentrations of cyanide in water. Furthermore, our chromogenic oxazine is insensitive to the presence of large concentrations of fluoride, chloride, bromide or iodide anions, which are generally the principal interferents in the colorimetric detection of cyanide.
摘要翻译：设计了用于氰化物比色检测的显色恶嗪化合物。事实上，我们化合物的[1,3]恶嗪环打开以形成响应于氰化物的酚盐发色团。杂环化合物可以由稠合的苯并恶嗪和二氢吲哚环组成：其中R1是烷基（例如甲基，乙基，丙基，异丙基，丁基，异丁基），取代的烷基，环烷基（例如环戊基，环己基）取代的环烷基，芳基（例如苯基）或取代的芳基，R2是发色团（例如亚硝基，硝基，偶氮染料）。这种定量显色转化允许在水中检测微摩尔浓度的氰化物。此外，我们的显色恶嗪对大量氟化物，氯化物，溴化物或碘化物阴离子的存在不敏感，这些阴离子通常是氰化物比色检测中的主要干扰物。

10. 发明申请

US20090065744A1 USE OF POLYNUCLEAR PHENOLIC COMPOUNDS AS STABILISERS 有权
标题翻译：多元酚类化合物作为稳定剂的使用
公开(公告)号：US20090065744A1
公开(公告)日：2009-03-12
申请号：US12279553
申请日：2007-02-21
申请人： Arno Lange , Helmut Mach , Hans Peter Rath , Dietmar Posselt
发明人： Arno Lange , Helmut Mach , Hans Peter Rath , Dietmar Posselt
IPC分类号： C09K15/08 , C07D265/14
CPC分类号： C10M159/12 , C07C217/58 , C07D265/16 , C08G61/12 , C08G61/122 , C08G61/124 , C08G61/125 , C08G61/126 , C08K5/3437 , C10L1/2225 , C10L1/233 , C10L1/238 , C10L10/18 , C10L2230/081 , C10L2230/086 , C10M133/48 , C10M149/12 , C10M2207/023 , C10M2215/225 , C10M2217/043 , C10N2230/10
摘要： The use of polycyclic phenolic compounds which have up to 20 benzene rings per molecule and are obtainable by reacting a tetrahydrobenzoxazine I where R1 is a hydrocarbyl radical and R2, R3, R4 and R5 are each independently hydrogen atoms, hydroxyl groups or hydrocarbyl radicals with one or more of the same or different phenols II where R7, R8, R9 and R10 are each independently hydrogen atoms, hydroxyl groups or hydrocarbyl radicals, and/or with one or more of the same or different tetrahydrobenzoxazines I, with the proviso that at least one of the substituents has from 13 to 3000 carbon atoms and the remaining substituents, when they are hydrocarbyl radicals, have in each case from 1 to 20 carbon atoms as stabilizers for stabilizing inanimate organic material against the action of light, oxygen and heat.
摘要翻译：每个分子具有多达20个苯环的多环酚类化合物的使用可通过四氢苯并恶嗪I（其中R 1为烃基）和R 2，R 3，R 4和R 5各自独立地为氢原子，羟基或烃基与其一或更多相同或不同的酚II，其中R 7，R 8，R 9和R 10各自独立地为氢原子，羟基或烃基，和/或与一种或多种相同或不同的四氢苯并恶嗪I，条件是至少取代基之一具有13至3000个碳原子，当其为烃基时，其余的取代基在每种情况下具有1至20个碳原子，作为用于稳定无生命有机材料以抵抗光，氧和热的作用的稳定剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式