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1. 发明申请

US20220249436A1 Small Molecule Agonists and Antagonists of NR2F6 Activity in Humans 有权
公开(公告)号：US20220249436A1
公开(公告)日：2022-08-11
申请号：US17698924
申请日：2022-03-18
申请人： KCL THERAPEUTICS, INC
发明人： Harry M. Lander , David R. Koos
IPC分类号： A61K31/366 , A61K31/4706 , A61K31/506 , A61P35/00 , A61K31/4245 , A61K31/496 , A61K45/06 , A61K31/5377 , A61P37/06 , A61K35/17 , C07D311/08 , C07D311/12
摘要： The present technology is directed to modulators of nuclear receptor activity, specifically to the modulation of NR2F6 activity and NR2F6 utilizing compounds, and the immune modulation and modulation of cancer stem cell activity through administration of compounds described herein to humans.

2. 发明授权

US11040990B2 Compounds containing Si atoms for optically active devices 有权
公开(公告)号：US11040990B2
公开(公告)日：2021-06-22
申请号：US16485886
申请日：2018-02-14
申请人： Merck Patent GmbH
发明人： Lars Dobelmann-Mara , Stefan Riedmueller , Martin Schraub
IPC分类号： C07D311/12 , C07D405/04 , C07D407/04 , C07D409/04 , C07F7/18 , C08G77/24 , C08G77/00 , G02B1/04
摘要： The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for compositions and ophthalmic devices as well as to compositions and ophthalmic devices comprising such compounds.

3. 发明授权

US10227323B2 Glucosylceramide synthase inhibitors for the treatment of diseases 有权
公开(公告)号：US10227323B2
公开(公告)日：2019-03-12
申请号：US15023337
申请日：2014-09-19
申请人： BIOMARIN PHARMACEUTICAL INC.
发明人： Bing Wang , Daniel Chu , Alexander James Bridges
IPC分类号： C07D471/12 , C07D471/04 , C07D491/056 , C07D211/46 , C07D205/02 , C07D231/56 , C07D215/06 , C07D319/18 , C07D405/14 , C07D309/10 , C07D311/12 , C07D333/16 , C07D333/62 , C07D235/06 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D205/04 , C07D265/30 , C07D277/22 , C07D209/04 , C07D277/62 , C07D295/12 , C07D213/46 , C07D213/64 , C07D307/79 , C07B59/00 , C07D213/56 , C07D213/61 , C07D235/08 , C07D277/30 , C07D295/13 , C07D305/08 , C07D307/81 , C07D309/12 , C07D311/58 , C07D333/24 , C07D333/60 , C07D405/06 , C07D471/08 , C07D487/08
摘要： Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

4. 发明申请

US20160207878A1 MAO-B Selective Inhibitor Compounds, Pharmaceutical Compositions Thereof and Uses Thereof 审中-公开
标题翻译： MAO-B选择性抑制剂化合物，药物组合物及其用途
公开(公告)号：US20160207878A1
公开(公告)日：2016-07-21
申请号：US14915474
申请日：2014-08-29
申请人： THE UNIVERSITY OF BRTISH COLUMBIA , CENTRE FOR DRUG RESEARCH AND DEVELOPMENT
发明人： Edward Ewald Putnins , David Scott Grierson , Ronan F.B. Gealageas , Alice Andree Valentine Devineau , Edith Mary Dullaghan
IPC分类号： C07C229/36 , C07D213/74 , C07F9/38 , C07D233/64 , C07D231/12 , C07D231/14 , C07D233/90 , C07C235/74 , C07D311/12
CPC分类号： C07C229/36 , C07C217/60 , C07C229/14 , C07C235/74 , C07C255/42 , C07C255/43 , C07C255/54 , C07D213/30 , C07D213/74 , C07D231/12 , C07D231/14 , C07D233/64 , C07D233/90 , C07D311/12 , C07D311/16 , C07F9/3886
摘要： Described herein are a series of compounds having the structure of Formula I: for use in the inhibition of MAO and uses thereof for the treatment of a barrier disease, obesity, solid epithelial cell tumor metastasis, diabetes, an auto-immune and inflammatory disease or a cardiometabolic disorder.
摘要翻译：本文描述了一系列具有式I结构的化合物：用于抑制MAO及其用途，用于治疗屏障疾病，肥胖症，固体上皮细胞肿瘤转移，糖尿病，自身免疫和炎性疾病或心脏代谢障碍。

5. 发明授权

US09296728B2 Therapeutic compounds 有权
标题翻译：治疗化合物
公开(公告)号：US09296728B2
公开(公告)日：2016-03-29
申请号：US14373615
申请日：2013-01-18
申请人： Regents of the University of Minnesota
发明人： Venkatram R. Mereddy , Lester R. Drewes , Mohammed Abrar Alam , Sravan K. Jonnalagadda , Shirisha Gurrapu
IPC分类号： C07D311/02 , C07D405/04 , C07D407/14 , C07C255/41 , C07D295/155 , C07C255/63 , C07D207/09 , C07D311/12
CPC分类号： C07C255/41 , C07C255/63 , C07D207/09 , C07D295/155 , C07D311/12 , C07D311/16 , C07D405/04 , C07D407/14
摘要： The invention provides compounds of formula (I) or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula (I) and therapeutic methods for treating cancer or treating autoimmune diseases or preventing transplant rejection using compounds of formula (I).
摘要翻译：本发明提供了本文所述的式（I）化合物或其盐。本发明还提供包含式（I）化合物，制备式（I）化合物的方法，用于制备式（I）化合物的中间体和治疗癌症或治疗自身免疫性疾病或预防移植排斥的治疗方法的药物组合物，其使用式（I）化合物。

6. 发明申请

US20150232440A1 COUMARIN DERIVATIVE 有权
标题翻译： COUMARIN衍生物
公开(公告)号：US20150232440A1
公开(公告)日：2015-08-20
申请号：US14429300
申请日：2013-09-20
申请人： NIPPON ZOKI PHARMACEUTICAL CO., LTD.
发明人： Mitsuru Naiki , Tomoyuki Okada , Kazuyoshi Sawada , Takashi Ogino
IPC分类号： C07D311/12
CPC分类号： C07D311/12 , A61K31/352 , C07D311/18 , C07D405/12 , C07D409/12
摘要： A novel coumarin derivative or a pharmaceutically acceptable salt thereof and also to provide a pharmaceutical agent containing such a compound as an active ingredient is provided. The coumarin derivative or a pharmaceutically acceptable salt thereof exhibits an excellent suppressive action to the destruction of cartilage and suppressive action to the proliferation of synovial cells in a pharmacological test where the release of sulfated glycosaminoglycans (sGAG) and the proliferation of synovial cells are used as indicators whereby it is very useful as an active ingredient of a pharmaceutical composition such as a preventive or therapeutic agent for arthropathy such as osteoarthritis or chronic rheumatoid arthritis.
摘要翻译：提供了一种新型香豆素衍生物或其药学上可接受的盐，并且还提供含有这种化合物作为活性成分的药剂。香豆素衍生物或其药学上可接受的盐在药理学试验中对软骨破坏和对滑膜细胞增殖的抑制作用显示出优异的抑制作用，其中硫酸化糖胺聚糖（sGAG）的释放和滑膜细胞的增殖被用作指标，其作为药物组合物的有效成分非常有用，例如关节病如骨关节炎或慢性类风湿性关节炎的预防或治疗剂。

7. 发明申请

US20140371471A1 CHEMICAL ENHANCEMENT BY NANOMATERIALS UNDER X-RAY IRRADIATION 有权
标题翻译：通过X射线辐射下的纳米材料的化学增强
公开(公告)号：US20140371471A1
公开(公告)日：2014-12-18
申请号：US14370733
申请日：2013-01-11
申请人： The Regents of the University California
发明人： Ting Guo
IPC分类号： C07D311/12
CPC分类号： C07D311/12
摘要： A method for dynamic enhancement of chemical reactions by nanomaterials under hard X-ray irradiation. The nanomaterials were gold and platinum nanoparticles, and the chemical reaction employed was the hydroxylation of coumarin carboxylic acid. The reaction yield was enhanced 2000 times over that predicted on the basis of the absorption of X-rays only by the nanoparticles, and the enhancement was found for the first time to depend on the X-ray dose rate. The maximum turnover frequency was measured at 116×10-4 s-1 Gy-1. We call this process chemical enhancement, which is defined as the increased yield of a chemical reaction due to the chemical properties of the added materials. The chemical enhancement described here is believed to be ubiquitous and may significantly alter the outcome of chemical reactions under X-ray irradiation with the assistance of nanomaterials.
摘要翻译：一种在硬X射线照射下由纳米材料动态增强化学反应的方法。纳米材料是金和铂纳米颗粒，所用的化学反应是香豆素羧酸的羟基化。基于仅通过纳米颗粒吸收X射线而预测的反应产率增加了2000倍，并且首次发现增强取决于X射线剂量率。最大周转频率为116×10-4 s-1 Gy-1。我们称这种过程化学增强，其定义为由于所添加的材料的化学性质引起的化学反应的增加的产率。这里描述的化学增强被认为是普遍存在的，并且可以在纳米材料的帮助下在X射线照射下显着改变化学反应的结果。

8. 发明授权

US08759378B2 Methods for treating blood disorders 有权
标题翻译：治疗血液病症的方法
公开(公告)号：US08759378B2
公开(公告)日：2014-06-24
申请号：US12212000
申请日：2008-09-17
申请人： Susan P Perrine , Regine Bohacek
发明人： Susan P Perrine , Regine Bohacek
IPC分类号： A61K31/353 , A61K31/433 , C07D311/12 , C07D285/125
CPC分类号： C07D311/12 , A61K31/192 , A61K31/194 , A61K31/353 , A61K31/36 , A61K31/39 , A61K31/415 , A61K31/433 , A61K31/517 , C07D285/125
摘要： Methods of treating blood disorders are described.
摘要翻译：描述治疗血液病症的方法。

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