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1. 发明授权

US3880876A Process for the preparation of 6-aryl-4H-s-triazolo-{8 4,3-a{9 {8 1,4{9 benzodiazepines 失效
标题翻译：制备6-芳基-4H-s-三唑并 - {8,4-a {9 {8 1,4 {9 benzodiazepines
公开(公告)号：US3880876A
公开(公告)日：1975-04-29
申请号：US30358972
申请日：1972-11-03
申请人： AMERICAN HOME PROD
发明人： SELLSTEDT JOHN H
IPC分类号： C07D243/20 , C07D487/04 , C07D99/02
CPC分类号： C07D487/04 , C07D243/20
摘要： A process for the preparation of 6-aryl-4H-s-triazolo(4,3a)(1,4)benzodiazepines from 2-halo-5-aryl-3H-1,4-benzodiazepines, and carboxylic acid hydrazides. The products are known CNS depressants with low toxicity.
摘要翻译：一种从2-卤代-5-芳基-3H-1,4-苯并二氮杂制得6-芳基-4H-哒嗪并[4,3-a] [1,4]苯并二吖庚因的方法和羧酸酰肼。该产品是具有低毒性的已知的CNS抑制剂。

2. 发明授权

US3869450A S-triazolo (4,3-d) (1,4) benzodiazepin-6(7H)-ones 失效
标题翻译：（4,3-d）（1,4）苯并二氮杂-6（7H） - 酮
公开(公告)号：US3869450A
公开(公告)日：1975-03-04
申请号：US37091773
申请日：1973-06-18
申请人： SANDOZ AG
发明人： KATHAWALA FAIZULLA G
IPC分类号： C07D487/04 , C07D53/06 , C07D55/00 , C07D99/02
CPC分类号： C07D487/04
摘要： S-triazolo(4,3-d)(1,4)benzodiazepin-6(7H)-ones, e.g., 10-chloro7-methyl-3-(o-chlorophenyl)-5H-s-triazolo(4,3d)(1,4)benzodiazepin -6(7H)-one are prepared from a corresponding 1,4-benzodiazepin-2-one, and are useful as anti-convulsants and minor tranquilizers.
摘要翻译： 3-三唑并[4,3-d] [1,4]苯并二氮杂-6（7H） - 酮，例如10-氯-7-甲基-3-（邻氯苯基）-5H- 3-d] [1,4]苯并氮杂-6（7H） - 酮由相应的1,4-苯并二氮杂-2-酮制备，可用作抗惊厥药和小镇静剂。

3. 发明授权

US3853904A DIBENZA-{8 b,f{9 -S-TRIAZOLO-{8 4,3-d{9 {8 1,4{9 OXAZEPIN-3-(2H)-ONES 失效
标题翻译： DIBENZA- {8 b，f {9 -S-三唑 - {8,3,3-d {9 {8 1,4 {9-氧杂-3-（2H） - 酮
公开(公告)号：US3853904A
公开(公告)日：1974-12-10
申请号：US38627873
申请日：1973-08-07
申请人： UPJOHN CO
发明人： SZMUSZKOVICZ J
IPC分类号： C07D267/20 , C07D487/04 , C07D498/04 , C07D99/02
CPC分类号： C07D487/04 , C07D267/20
摘要： Compounds of the formula III:

wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms, inclusive and

IN WHICH R7 and R8 are hydrogen and alkyl, as defined above and n is 2 or 3, or together

IS PYRROLIDINO, PIPERIDINO OR N-methylpiperazino; wherein R3 and R4 are hydrogen, fluoro, chloro, bromo, nitro, alkyl defined as above, trifluoromethyl, or alkoxy, of 1 to 3 carbon atoms, inclusive, are prepared by reacting a thio compound of formula I:

wherein R3 and R4 are defined as above, in sequence; 1. WITH AN ALKYLCARBAZATE; AND THE RESULTING INTERMEDIATE PRODUCT II 2. with an alkylating agent of the formula R1''X in which R1'' is alkyl,

AS DEFINED ABOVE AND X is chlorine, bromine, or iodine, to obtain a compound III as defined above. Compounds of formula III and the pharmacologically acceptable acid addition salts thereof have anti-depressant activity and tranquilizing activity and can be used in mammals.
摘要翻译：式III化合物：

4. 发明授权

US3847901A 3-alkenyl substituted rifamycin sv compounds 失效
标题翻译： 3-ALKENYL取代的RIFAMYCIN SV化合物
公开(公告)号：US3847901A
公开(公告)日：1974-11-12
申请号：US31773272
申请日：1972-12-22
申请人： LEPETIT SPA
发明人： CRICCHIO R
IPC分类号： C07D498/08 , C07D99/02 , C07D99/04
CPC分类号： C07D498/08
摘要： 1. A 3-ALKENYL RIFAMYCIN SV COMPOUND OF THE FORMULA

(1,2-DIHYDRO-5,6,9,17,19-PENTA(HO-),23-(H3C-O-),

2,4,12,16,18,20,22-HEPT(H3C-),1,11-DI(O=),8-(R-C(=X)-

C(-R)=CH-),21-(R1-O-)-2,7-(EPOXYPENTADECA(1,11,13)

TRIENIMINO)NAPHTHO(2,1-B)-FURAN

WHEREIN R REPRESENTS HYDROGEN, ALKYL OF FROM 1 TO 8 CARBON ATOMS OR PHENYL-LOWER ALKYL, R1 REPRESENTS HYDROGEN OR ACETYL, R2 REPRESENTS HYDROGEN OR LOWER ALKYL, X REPRESENTS OXYGEN, IMINO, SUBSTITUTED IMINO, OXIMINO, SUBSTITUTED OXIMINO, HYDRAZONO OR SUBSTITUTED HYDRAZONO, SAID LOWER ALKYL GROUPS CONTAINING FROM 1 TO 4 CARBON ATOMS AND SAID SUBSTITUTED IMINO, (A), OXIMINO, (B), AND HYDRAZONO GROUPS, (C), HAVING THE HYDROGEN MEMBER SUBSTITUTED RESPECTIVELY, BY (A) DIMETHYLAMINOPROPYL OR ALPHA-METHYL-BENZYL, (B) ETHYL, PROPYL, BUTYL, OCTYL, PROPENYL, PROPYNYL, DIPROPYLMETHYL, DIPHENYLMETHYL, BENZYL, PHENETHYL, PHENYLPROPYL, PHENOXYETHYL, CARBOXYETHYL, PYRIDYLETHYL, PHENOXYETHYL OR GERANYL, OR (C) METHYL, ETHYL, DIMETHYL, DIETHYL, DIPROPYL, PHENYLPROPYL, HYDROXYETHYL, DI-(2-HYDROXYETHYL), (DIETHYLAMINO)ETHYL, BENZYL, PHENYLPROPYL, PROPENYL, CINNAMYL, (N-METHYL, -N-PHENYL), (N-METHYL, N-BENZYL) OR PHENYL GROUP AND FURTHER CHARACTERIZED IN THAT IN THE SUBSTITUTED HYDRAZONO GROUP, THE SUBSTITUENTS ON THE NITROGEN ATOM ALSO MAY FORM A HETEROCYCLIC RING OF THE GROUP CONSISTING OF PIPERAZINE, 4-METHYL-1-PIPERAZINE, MORPHOLINE, PIPERIDINE, HEPTAMETHYLENEIMINE, OCTAMETHYLENEIMINE OR 3,8-DIAZABICYCLO(3,2,1)OCTANE; AND THE 16,17; 18,19; AND 28,29-HEXAHYDRO DERIVATIVES OF SAID ALKENYL COMPOUNDS.

5. 发明授权

US3759943A Amido and amino triazolo benzodiazepines 失效
标题翻译： AMIDO和AMINO TRIAZOLO BENZODIAZEPINES
公开(公告)号：US3759943A
公开(公告)日：1973-09-18
申请号：US3759943D
申请日：1971-04-28
申请人： UPJOHN CO
发明人： HESTER J
IPC分类号： C07D487/04 , C07D57/02 , C07D99/02
CPC分类号： C07D487/04
摘要： WHEREIN R1, R2, R3, R4, and R5 are defined as above and R is alkyl of one to three carbon atoms, inclusive.

WHEREIN R'' and R'''' are hydrogen, alkyl of one to three carbon atoms, inclusive, or together

Compounds of the formula:
摘要翻译：下式的化合物：

6. 发明授权

US3682907A 4,4{40 -bis(2-{62 -sulfoethylamino-4-amino-1,3,5-triazine-6-ylamino)stilbene-2,2{40 -disulfonic 失效
标题翻译： 4,4 {40 -BIS（2- {62-巯基乙酰氨基-4-氨基-1,3,5-三嗪-6-基]氨基]苯乙烯-2,2 {40-二
公开(公告)号：US3682907A
公开(公告)日：1972-08-08
申请号：US3682907D
申请日：1969-09-02
申请人： SUMITOMO CHEMICAL CO
发明人： OHKAWA MASAAKI , MATSUO MASATOSHI , SAKAGUCHI TADAO , SATO SYOZI
IPC分类号： B03D1/02 , D06L3/12 , C07D99/02
CPC分类号： B03D1/02 , D06L4/657
摘要： Novel compounds of the formula WHEREIN X is morpholino or alkanolamino and M is a hydrogen atom or an alkali metal, useful as optical brightening agents, and process for the production thereof, whitened textile materials and process for production thereof, and whitened and resinfinished textile materials and process for production thereof.
摘要翻译：式WHEREIN X的新型化合物是吗啉代或链烷醇氨基，M是可用作荧光增白剂的氢原子或碱金属，及其生产方法，增白纺织材料及其制备方法，以及增白和树脂精制纺织材料及其生产方法。

7. 发明授权

US3649626A Fused ring systems containing (1 3)oxazine 失效
标题翻译：包含（1 3）氧化镁的熔融系统
公开(公告)号：US3649626A
公开(公告)日：1972-03-14
申请号：US3649626D
申请日：1970-04-27
申请人： WARNER LAMBERT CO
发明人： STRANDTMANN MAX VON , COHEN MARVIN P , SHAVEL JOHN JR
IPC分类号： C07D498/04 , C07D498/14 , C07D87/20 , C07D99/02
CPC分类号： C07D498/04 , C07D498/14
摘要： FUSED RING SYSTEMS CONTAINING (1,3) OXAZINE OF FORMULA I AND THE METHOD FOR THEIR PREPARATION HAVE BEEN DISCLOSED.

2,3-(-X-)(-R1),4-R3,5,6-(-Z-)(-R2)-2,3-DIHYDRO-

4H-1,3-OXAZINE

X REPRESENTS 1,2,3,4-TETRAHYDROISOQUINOLINE, 1,2,3,4,-TETRAHYDRO-2-CARBOLINE, TETRAHYDRO-4-PHTHALAZINONE, 1,2DIHYDROQUINAZOLINE, HEXAHYDROPYRIMIDINE; Z IS AN AROMATIC OR HETEROAROMATIC NUCLEUS, R1, R2 AND R3 ARE HYDROGEN OR VARIOUS SUBSTITUENTS. THE COMPOUNDS OF THIS INVENTION ARE HYPOTENSIVE AGENTS.

8. 发明授权

US3506678A Certain 2-substituted thieno(2,3-d) imidazoles 失效
标题翻译：某些2-取代的噻吩（2,3-D）咪唑烷
公开(公告)号：US3506678A
公开(公告)日：1970-04-14
申请号：US3506678D
申请日：1967-02-21
申请人： MERCK & CO INC
发明人： HOFF DALE R , PETERSON LOUIS H
IPC分类号： C07D333/36 , C07D417/12 , C07D495/04 , C07D91/00 , C07D99/02
CPC分类号： C07D417/12 , C07D333/36 , C07D495/04

9. 发明授权

US3455941A 5-((aryldehydropiperidinyl- and aryldehydropyrrolidinyl) - lower - alkyl) - 2-oxazolidinones 失效
标题翻译： 5 - （（三氟乙烯基 - 和二十二烷基吡啶） - 低级 - 烷基） - 2-氧杂环己烷
公开(公告)号：US3455941A
公开(公告)日：1969-07-15
申请号：US3455941D
申请日：1966-06-13
申请人： ROBINS CO INC A H
发明人： LUNSFORD CARL D , WELSTEAD WILLIAM J JR
IPC分类号： A61K31/00 , C07D263/20 , C07D263/24 , C07D99/02 , A61K27/00
CPC分类号： C07D263/20 , A61K31/00 , C07D263/24 , Y10S514/96 , Y10S514/962
摘要： A. Compounds n = 1,2 R = H, alkyl, cycloalkyl, phenylalkyl, subst. phenylalkyl R' = H, Me R2 = H, Me = 2,3-dehydropyrrolidino, 3,4-dehydropyrrolidino, 2,3-dehydropiperidino, 3,4-dehydropiperidino A = opt. subst. phenyl bound to the heterocyclic ring by the C3 or C4 atoms, the other C atoms of the heterocyclic ring carrying H or 1-4 Me groups. B. Acid addition salts and cis-trans isomers of I. Tranquillisers for oral or parenteral admin. in conventional formulations. Preferred unit dose contains 5-50 mg.

10. 发明授权

US3446806A Process for the preparation of 1,4-benzodiazepine 4-oxides 失效
标题翻译：制备1,4-二苯并恶嗪-4-氧化物的方法
公开(公告)号：US3446806A
公开(公告)日：1969-05-27
申请号：US3446806D
申请日：1966-01-19
申请人： HOFFMANN LA ROCHE
发明人： ARCHER GILES A , STERNBACH LEO HENRYK
IPC分类号： A61K31/505 , A61K31/517 , C07D239/74 , C07D239/76 , C07D243/20 , C07D243/24 , C07D401/06 , C07D403/06 , C07D413/06 , C07D99/02 , C07D51/48 , C07D53/06
CPC分类号： C07D239/74 , C07C249/04 , C07D239/76 , C07D243/20 , C07D243/24 , C07D401/06 , C07D403/06 , C07D413/06 , C07C251/48

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