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1. 发明授权

US3920660A Tetrahydropyrrolo{8 1,2-a{9 pyrazine-1(2H),4(3H)-diones 失效
标题翻译：四氢吡咯并[b 1,2-a {9吡嗪-1（2H），4（3H） - 二酮
公开(公告)号：US3920660A
公开(公告)日：1975-11-18
申请号：US40824373
申请日：1973-10-19
申请人： LEPETIT SPA
发明人： FONTANELLA LUIGI , MARIANI LUIGI
IPC分类号： C07D471/04 , C07D207/16 , C07D487/04 , C07D241/00
CPC分类号： C07D487/04 , C07D207/16
摘要： 6,7,8,8A-Tetrahydropyrrolo(1,2-a)pyrazine-1(2H)-4(3H)-diones of the formula

where R is hydrogen, lower alkyl, a phenyl or a benzyl radical, R1 is hydrogen or a lower alkyl radical, R2 is (a) a COR3 radical where R3 is selected from the group hydroxy, lower alkoxy, monoand di-lower alkylamino-lower alkoxy, amino, mono- and di-lower alkylamino, mono- and di-lower alkylamino-lower alkylamino, a phenylamino, hydroxyamino, a morpholine, pyrrolidine, piperidine, and piperazine ring which ring may also have 1 or 2 lower alkyl substituents; (b) a CH2R4 radical where R4 is selected from the group hydroxy, carboxy, carbo(lower alkoxy), lower acyloxy and carbamyloxy. The compounds of the invention are useful as C.N.S. depressants and in particular as tranquilizing agents.
摘要翻译： 6,7,8,8-四氢吡咯并[1,2-a]吡嗪-1（2H）-4（3H） - 二氢ion LE LE LE LE LE LE LE LE LE（（（（（（（（其中R是氢，低级烷基，苯基或苄基，R 1是氢或低级烷基，R 2是（a）COR 3基团，其中R 3选自羟基，低级烷氧基，和二低级烷基氨基 - 低级烷氧基，氨基，一 - 和二 - 低级烷基氨基，一 - 和二 - 低级烷基氨基 - 低级烷基氨基，苯基氨基，羟基氨基，吗啉，吡咯烷，哌啶和哌嗪环， 1或2个低级烷基取代基; （b）CH2R4基团，其中R4选自羟基，羧基，碳（低级烷氧基），低级酰氧基和氨基甲酰氧基。本发明的化合物可用作C.N.S. 抑郁剂，特别是镇定剂。

2. 发明授权

US3900465A 3-formylrifamycin azines 失效
标题翻译： 3-FORMYLRIFAMYCIN AZINES
公开(公告)号：US3900465A
公开(公告)日：1975-08-19
申请号：US34836473
申请日：1973-04-05
申请人： LEPETIT SPA
发明人： CRICCHIO RENATO , LANCINI GIANCARLO
IPC分类号： A61K38/45 , C07D519/00 , C07D41/00 , C07D41/06 , C07D87/54
CPC分类号： C07D519/00 , A61K38/45
摘要： Azine and bis-azine derivatives of 3-formylrifamycin SV of formula (I)

and the corresponding 25-desacetyl and 16, 17; 18, 19; 28, 29hexahydro derivatives wherein Me is methyl; A is (1) a direct bond connecting the 2 nitrogen atoms, or (2) an

wherein y is a -CO-, -CNH-, -CS-, -SO2a divalent aliphatic, cycloaliphatic, aromatic, araliphatic or heterocyclic group, and R2 and R3 independently are hydrogen, lower alkyl or taken together form an aliphatic divalent chain of 1 to 4 carbon atoms connecting the two terminal nitrogen atoms or (3) a divalent

wherein X is a direct bond between the 2 carbon atoms, a divalent aliphatic, cycloaliphatic, aromatic or a heterocyclic group; and R and R1 may independently be hydrogen, alkyl, cycloalkyl, aryl, heterocyclic or, taken together, form an aliphatic chain of 1 to 8 carbon atoms connecting the 2 terminal carbon atoms.

3. 发明授权

US3871965A Production of rifamycin B 失效
标题翻译：生产利福霉素B
公开(公告)号：US3871965A
公开(公告)日：1975-03-18
申请号：US35481173
申请日：1973-04-26
申请人： LEPETIT SPA
发明人： WHITE RICHARD J , LANCINI GIANCARLO
IPC分类号： C12P17/18 , A01K20060101 , A61K20060101 , C07D498/08 , C12P1/06 , C12R1/465 , C12D9/00
CPC分类号： C07D498/18
摘要： Rifamycin B is produced by fermentation by a mutant strain of Streptomyces mediterranei of an aqueous nutrient medium under aerobic conditions.
摘要翻译：利福霉素B通过在需氧条件下通过水性营养培养基的水稻链霉菌（Streptomyces mediterranei）的突变株发酵而产生。

4. 发明授权

US3865847A Ethyl fluoro-(2-dibenzofuranyl)-acetate 失效
标题翻译：（2-二苯并呋喃基）乙酸乙酯
公开(公告)号：US3865847A
公开(公告)日：1975-02-11
申请号：US28409072
申请日：1972-08-28
申请人： LEPETIT SPA
发明人： CAVALLERI BRUNO , BELLASIO ELVIO , TESTA EMILIO , MAFFII GIULIO
IPC分类号： C07D307/91 , C07D5/44
CPC分类号： C07D307/91
摘要： A new class of derivatives of the ethyl ester of fluoroacetic acid is described and some methods for their preparation are reported. The compounds have a pharmacological interest, because of their marked antiinflammatory activity.
摘要翻译：描述了一类新的氟乙酸乙酯的衍生物，并报道了其制备方法。这些化合物具有药理学意义，因为它们具有显着的抗炎活性。

5. 发明授权

US3829417A Imidazole substituted rifamycins 失效
标题翻译：咪唑取代的RIFAMYCINS
公开(公告)号：US3829417A
公开(公告)日：1974-08-13
申请号：US31965772
申请日：1972-12-29
申请人： LEPETIT SPA
发明人： MAGGI N , CRICCHIO R
IPC分类号： C07D498/08 , C07D99/02 , C07D99/04
CPC分类号： C07D498/08
摘要： DISCLOSED ARE 3-SUBSTITUTED RIFAMYCINS OF FORMULA I AND THEIR 25-DESACETYL AND 16,17; 18,19; AND 28,29 HEXAHYDRO DERIVATIVES

1,3-DI(R4-),2-(R-N(-R6)-N=C(-R5)-),5-R3,6-R2,7-R1-BENZIMI

8-(1-R,4-R1,5-R2-IMIDAZOL-2-YL)-RIFAMYCIN SV (I)

DAZOLIUM X(-)

WHEREIN R REPRESENTS HYDROGEN, LOWER ALKYL, PHENYL AND PHENYL-LOWER ALKYL, R1 AND R2 TOGETHER REPRESENT A CARBOCYCLIC CHAIN FORMING WITH THE DOUBLE BOND OF THE ADJACENT IMIDAZOLE MOIETY A BENZENE RING, A MONO OR POLY-SUBSITUTED BENZENE RING WHEREIN THE SUBSTITUENTS ARE INDEPENDENTLY SELECTED FROM LOWER ALKYL, ALKOXY, HALO, CARBOXY, CARBALKOXY, SULFO, SULFAMOYL, NITRO, TRIFLUOROMETHYL, CARBAMYL, MONO AND DI-LOWER ALKYL-CARBAMYL AND METHYLENEDIOXY, OR A SUBSTITUTED OR UNSUBSTITUTED FUSED POLYNUCLEAR AROMATIC GROUP INCLUDING 2-3 CONDENSED RINGS EACH OF 5-6 CARBON ATOMS. THE COMPOUNDS OF THE INVENTION ARE USEFUL AS ANTIBACTERIAL AGENTS.

6. 发明授权

US3719599A Solid lubricant composition and method of preparation 失效
标题翻译：固体润滑剂组合物及其制备方法
公开(公告)号：US3719599A
公开(公告)日：1973-03-06
申请号：US3719599D
申请日：1970-11-04
申请人： LEPETIT SPA
发明人： CRIVELLARO G , OLDANI F
IPC分类号： A61K9/20 , A61K9/46 , A61K9/50 , C10M111/04 , C10M7/48 , C10M7/02
CPC分类号： A61K9/2095 , A61K9/0007 , A61K9/2036 , A61K9/50 , C10M111/04 , C10M2201/08 , C10M2201/081 , C10M2201/082 , C10M2201/084 , C10M2229/041 , C10N2240/00 , C10N2240/22 , C10N2240/30 , C10N2240/50 , C10N2240/52 , C10N2240/54 , C10N2240/56 , C10N2240/58 , C10N2240/60 , C10N2240/66
摘要： A lubricating agent suitable for use in the preparation of water soluble tablets and a method of its preparation are disclosed. The agent comprises in combination a composition of substantially anhydrous sodium sulfate and a dimethylpolysiloxane.

7. 发明授权

US3676490A New antibiotic 失效
标题翻译：新抗生素
公开(公告)号：US3676490A
公开(公告)日：1972-07-11
申请号：US3676490D
申请日：1965-07-09
申请人： LEPETIT SPA
发明人： THIEMANN JOSEF , MURTHY YELAHANKA K S , CORONELLI CAROLINA
IPC分类号： C07G11/00 , C12P13/04 , C07C101/30 , A61K21/00
CPC分类号： C12P13/04 , C07G11/00 , Y10S435/886
摘要： The invention is concerned with a new antibiotic, named alanosine, whose chemical structure corresponds to L-(-)-2-amino3-nitrosohydroxylamino-propionic acid. It is obtained by cultivating a new species of Actinomyces of the genus Streptomyces, designated Streptomyces alanosinicus n.sp. ATCC 15710.
摘要翻译：本发明涉及一种新的抗生素，命名为alanosine，其化学结构对应于L - （ - ） - 2-氨基-3-亚硝基羟基氨基 - 丙酸。通过培养链霉菌属的放线菌属（Streptomyces）的一种新种，命名为链霉菌（Streptomyces alanosinicus n.sp.） ATCC 15710。

8. 发明授权

US3642792A Pyridazine derivatives 失效
标题翻译：吡啶衍生物
公开(公告)号：US3642792A
公开(公告)日：1972-02-15
申请号：US3642792D
申请日：1968-02-26
申请人： LEPETIT SPA
发明人： BELLASIO ELVIO , MAFFII GIULIO
IPC分类号： C07D237/20 , C07D401/04 , C07D403/04 , C07D413/04 , C07D51/04
CPC分类号： C07D401/04 , C07D237/20 , C07D403/04 , C07D413/04
摘要： PYRIDAZINES, HAVING IN POSITIONS 3 AND 6 RESPECTIVELY A HYDRAZINO AND AN AMINO GROUP VARIOUSLY SUBSTITUTED, ARE DESCRIBED. THE COMPOUNDS HAVE PHARMACOLOGICAL INTEREST BECAUSE OF THEIR HYPOTENSIVE ACTIVITY.

9. 发明授权

US3634403A Antibiotic substance defined as rifamycin l 失效
标题翻译：抗生素物质定义为RIFAMYCIN L
公开(公告)号：US3634403A
公开(公告)日：1972-01-11
申请号：US3634403D
申请日：1969-06-09
申请人： LEPETIT SPA
发明人： LANCINI GIANCARLO
IPC分类号： A61K31/395 , A61P31/04 , C07D498/08 , C12P17/18 , C07D99/04 , C07D99/02
CPC分类号： C07D498/08 , Y10S435/886
摘要： A NEW RIFAMYCIN, NAMELY RIFAMYCIN L, IS DESCRIBED, WHICH IS OBTAINED BY SUBJECTING RIFAMYCIN S OR SV TO THE ENZYMATIC ACTIVITY OF THE MYCELIUM OF STREPTOMYCES MEDITERRAMEI ATTC 13685 IN A WATER-LOWER ALKANOL MEDIUM. THE PRODUCT HAS GOOD ANTIBOTIC ACTIVITY AND IS PRACTICALLY DEVOID OF TOXICITY.

10. 发明授权

US3542762A Process for rifamycins 失效
标题翻译：辛伐他汀的方法
公开(公告)号：US3542762A
公开(公告)日：1970-11-24
申请号：US3542762D
申请日：1968-05-21
申请人： LEPETIT SPA
发明人： GIANANTONIO ANACLETO , FABRUCCI ALDO , SACERDOTI SERGIO , SOUTZO ALEXANDRA
IPC分类号： C07D498/08 , C07C47/18
CPC分类号： C07D498/08

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