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1. 发明授权

US3829417A Imidazole substituted rifamycins 失效
标题翻译：咪唑取代的RIFAMYCINS
公开(公告)号：US3829417A
公开(公告)日：1974-08-13
申请号：US31965772
申请日：1972-12-29
申请人： LEPETIT SPA
发明人： MAGGI N , CRICCHIO R
IPC分类号： C07D498/08 , C07D99/02 , C07D99/04
CPC分类号： C07D498/08
摘要： DISCLOSED ARE 3-SUBSTITUTED RIFAMYCINS OF FORMULA I AND THEIR 25-DESACETYL AND 16,17; 18,19; AND 28,29 HEXAHYDRO DERIVATIVES

1,3-DI(R4-),2-(R-N(-R6)-N=C(-R5)-),5-R3,6-R2,7-R1-BENZIMI

8-(1-R,4-R1,5-R2-IMIDAZOL-2-YL)-RIFAMYCIN SV (I)

DAZOLIUM X(-)

WHEREIN R REPRESENTS HYDROGEN, LOWER ALKYL, PHENYL AND PHENYL-LOWER ALKYL, R1 AND R2 TOGETHER REPRESENT A CARBOCYCLIC CHAIN FORMING WITH THE DOUBLE BOND OF THE ADJACENT IMIDAZOLE MOIETY A BENZENE RING, A MONO OR POLY-SUBSITUTED BENZENE RING WHEREIN THE SUBSTITUENTS ARE INDEPENDENTLY SELECTED FROM LOWER ALKYL, ALKOXY, HALO, CARBOXY, CARBALKOXY, SULFO, SULFAMOYL, NITRO, TRIFLUOROMETHYL, CARBAMYL, MONO AND DI-LOWER ALKYL-CARBAMYL AND METHYLENEDIOXY, OR A SUBSTITUTED OR UNSUBSTITUTED FUSED POLYNUCLEAR AROMATIC GROUP INCLUDING 2-3 CONDENSED RINGS EACH OF 5-6 CARBON ATOMS. THE COMPOUNDS OF THE INVENTION ARE USEFUL AS ANTIBACTERIAL AGENTS.

2. 发明授权

US3808221A Antiandrogenic n-(3,5-dilower alkyl-4-heterocyclic)methyl)phthalimides 失效
标题翻译：反式N-（3,5-二硝基-4-羟基-4-甲基）甲基）对苯二胺
公开(公告)号：US3808221A
公开(公告)日：1974-04-30
申请号：US20576071
申请日：1971-12-07
申请人： HOFFMANN LA ROCHE
发明人： BORIS A , SCOTT J
IPC分类号： C07D209/48 , C07D261/08 , C07D261/18 , C07D275/02 , C07D295/145 , C07D57/00 , C07D99/04 , C07D99/10
CPC分类号： C07D209/48 , C07D261/08 , C07D261/18 , C07D275/02 , C07D295/145
摘要： A NOVEL CLASS OF NON-STERODIAL ANTIANDROGENIC COMPOUNDS ARE DESCRIBED. THE COMPOUNDS CAN BE GENERICALLY DESIGNATED AS N-((3,5-DILOWER ALKYL-4-HETEROCYCLIC)METHYL)PHTHALIMIDES AND DERIVATIVES OF THE AROMATIC RING THEREOF.

3. 发明授权

US3804849A 2-amino-4,5,7,8-tetrahydro-6h-thiazolo or oxazolo(5,4-d)azepines and salts 失效
标题翻译： 2-氨基-4,5,7,8-四氢-6H-噻唑或奥昔洛尔（5,4-D）盐酸盐和盐
公开(公告)号：US3804849A
公开(公告)日：1974-04-16
申请号：US16906571
申请日：1971-08-04
申请人： BOEHRINGER SOHN INGELHEIM
发明人： GRISS G , KLEEMANN M , GRELL W , BALLHAUSE H
IPC分类号： C07D498/04 , C07D513/04 , C07D99/04 , C07D99/10
CPC分类号： C07D513/04 , Y10S514/916 , Y10S514/937 , Y10S514/96 , Y10S514/962 , Y10S514/966
摘要： COMPOUNDS OF THE FORMULA

2-(R2-NH-),6-R1-5,6,7,8-TETRAHYDRO-4H-THIAZOLO(4,5-D)-

AZEPINE OR

2-NH2,6-R1-5,6,7,8-TETRAHYDRO-4H-OXAZOLO(4,5-D)AZEPINE

WHEREIN R1 IS HYDROGEN, STRAIGHT OR BRANCHED ALKYL OF 1 TO 4 CARBON ATOMS, HYDROXY-ALKYL OF 1 TO 4 CARBON ATOMS, ALKYL, CHLOALKYL, HEXAHYDROBENZYL, PHENYL, PHENETHYL, BENZYL, MONO-OR DI-HAOBENZYL OR (ALKYL OR 1 TO 3 THOXYBENZYL, TRIFULOROMETHYL-BENZYL OR (ALKYL OF 1 TO 3 CARBON ATOMS)-BENZYL, AND R2 IS HYDROGEN, STRAIGHT OR BRANCHED ALKYL OF 1 TO 5 CARBON ATOMS, ALLYL, CYCLOALKYL, PHENYL, BENZYL OR PHENETHYL, AND NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, THE COMPOUNDS AS WEL AS THEIR SALTS ARE USEFUL AS HYPOTENSIVES, SEDATIVES, ANTITUSSIVES AND ANTIPHLOGISTICS.

4. 发明授权

US3755319A Xanthone derivatives 失效
标题翻译： XANTHONE衍生物
公开(公告)号：US3755319A
公开(公告)日：1973-08-28
申请号：US3755319D
申请日：1972-03-08
申请人： ALLEN & HANBURYS LTD
发明人： BAYS D
IPC分类号： C07D311/86 , C07D99/04
CPC分类号： C07D311/86 , Y10S514/826 , Y10S514/861
摘要： Xanthone derivatives of the formula:

IN WHICH X represents a carboxyl or 5-(1H)-tetrazolyl group; and R1 and R2 which may be the same or different each represent a hydrogen atom, an alkyl group containing from 1 to 4 carbon atoms, a nitro group, a halogen atom or a group of the formula NR3R4 or OR3 or NR5SO2R6, (in which the groups R3 and R4 which may be the same or different each represent a hydrogen atom, a phenyl group, a benzyl group or an alkyl group which may optionally be substituted by an alkoxy group containing from 1 to 6 carbon atoms, a phenoxy group, phenyl group, an amino, alkylamino or dialkylamino group or by one or more hydroxy groups; and in which R5 is a hydrogen atom or an alkyl group containing from 1 to 6 carbon atoms and R6 is an alkyl group containing from 1 to 6 carbon atoms); with the proviso that when X represents a carboxyl group R1 and R2 do not both represent hydrogen atoms; and pharmaceutically acceptable non-toxic salts and esters of such compounds. These derivatives have pharmacological activity and in particular inhibit the release of spasmogen mediators from antigen-antibody reactions.

5. 发明授权

US3686186A Substituted isochroman or phthalan piperidenes 失效
标题翻译：取代的ISOCHROMAN或PHTHALAN PIPERIDENES
公开(公告)号：US3686186A
公开(公告)日：1972-08-22
申请号：US3686186D
申请日：1970-10-05
申请人： HOULIHAN WILLIAM J , JEFFREY NADELSON
发明人： HOULIHAN WILLIAM J , NADELSON JEFFREY
IPC分类号： C07D211/48 , C07D211/52 , C07D491/10 , C07D99/04
CPC分类号： C07D491/10 , C07D211/48 , C07D211/52
摘要： SUBSTITUTED ISOCHROMAN OR PHTHALAN PIPERIDENES, E.G., 1''BENZYLSPIRO(ISOCHROMAN-3,4''-PIPERIDEN) - 1 - ONE, PREPARED BY REFLUXING THE CORRESPONDING 2-(SUBSTITUTED-4-HYDROXY-4PIPERIDYL)-SUBSTITUTED BENZYLAMIDE. THE COMPOUNDS ARE USEFUL AS HYPROTRIGLYCERIDEMIC, ANTI-HYPERTENSIVE AND ANTIDEPRESSANT AGENTS.

6. 发明授权

US3658833A Benzofurans 失效
标题翻译： BENZOFURANS
公开(公告)号：US3658833A
公开(公告)日：1972-04-25
申请号：US3658833D
申请日：1970-06-15
申请人： CIBA GEIGY AG
发明人： KABAS GUGLIELMO , SCHLAPFER HANS
IPC分类号： C07C205/35 , C07D307/81 , C07D405/10 , C09B43/06 , C11D1/00 , D06L3/12 , D06M13/10 , D06M13/358 , C07D99/04 , C09K1/02
CPC分类号： C09B43/06 , C07C205/44 , C07D307/81
摘要： 1-(BENZOFUR-2-YL)-4-(4'',5''-DISUBSTITUTED-VTRIAZOLE-2''-YL)-PHENYLENES ARE PREPARED BY DIAZOTISING P(BENZOFUR-2-YL)-ANILINES AND (A) COUPLING THE OBTAINED DIAZONIUM COMPOUND WITH A KETONE, REACTING THE OBTAINED HYDROXYLAMINE TO AN OXIMEHYDRAZONE, CLOSING THE V-TRAZOLE RING BY OXIDISING AND REDUCING THE OBTAINED V-TRIAZOLE-1-OXIDE OR (B) COUPLING WITH AN ANILINE OR NAPHTHYLAMINE AND HEATING THE OBTAINED AZO COMPOUND IN THE PRESENCE OF AN OXIDISING AGNET. THE NEW BENZOFURANS ARE USEFUL AS BRIGHTENERS OR ORGANIC HIGH-MOLECULAR MATERIALS.

7. 发明授权

US3634403A Antibiotic substance defined as rifamycin l 失效
标题翻译：抗生素物质定义为RIFAMYCIN L
公开(公告)号：US3634403A
公开(公告)日：1972-01-11
申请号：US3634403D
申请日：1969-06-09
申请人： LEPETIT SPA
发明人： LANCINI GIANCARLO
IPC分类号： A61K31/395 , A61P31/04 , C07D498/08 , C12P17/18 , C07D99/04 , C07D99/02
CPC分类号： C07D498/08 , Y10S435/886
摘要： A NEW RIFAMYCIN, NAMELY RIFAMYCIN L, IS DESCRIBED, WHICH IS OBTAINED BY SUBJECTING RIFAMYCIN S OR SV TO THE ENZYMATIC ACTIVITY OF THE MYCELIUM OF STREPTOMYCES MEDITERRAMEI ATTC 13685 IN A WATER-LOWER ALKANOL MEDIUM. THE PRODUCT HAS GOOD ANTIBOTIC ACTIVITY AND IS PRACTICALLY DEVOID OF TOXICITY.

8. 发明授权

US3522260A 1,2,3,4 - tetrahydro - 5h - (1)benzopyrano (3,4-d)pyridines and 1,2,3,4,13,14 - hexahydro-5h-(1)benzopyrano(3,4-d)pyridines 失效
标题翻译： 1,2,3,4-四氢-5H-（1）苯并（3,4-D）吡啶和1,2,3,4,13,14-十六氢-5H-（1）苯并噻唑（3,4- D）吡啶
公开(公告)号：US3522260A
公开(公告)日：1970-07-28
申请号：US3522260D
申请日：1968-02-19
申请人： DOW CHEMICAL CO
发明人： SHULGIN ALEXANDER T
IPC分类号： C07D491/04 , C07D491/052 , C07F9/38 , C07F9/6561 , C07D99/04
CPC分类号： C07D491/04 , C07F9/38 , C07F9/6561

9. 发明授权

US3501499A Sulfonylurea derivatives 失效
公开(公告)号：US3501499A
公开(公告)日：1970-03-17
申请号：US3501499D
申请日：1967-02-13
申请人： SANDOZ AG
发明人： SCHENKER ERHARD
IPC分类号： C07D295/28 , C07D295/30 , C07D317/18 , C07D99/04 , C07D41/08
CPC分类号： C07D295/30 , C07D295/32 , C07D317/18

10. 发明授权

US3496180A Heterocyclic binuclear n,n'-diglycidyl compounds 失效
标题翻译：杂环化合物N，N'-二乙基化合物
公开(公告)号：US3496180A
公开(公告)日：1970-02-17
申请号：US3496180D
申请日：1969-01-14
申请人： CIBA LTD
发明人： PORRET DANIEL , HABERMEIER JUERGEN
IPC分类号： C07D239/22 , C07D405/14 , C08G59/26 , C07D99/04 , C08F
CPC分类号： C07D239/22 , C07D405/14 , C08G59/26

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