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1. 发明授权

US10689579B2 Flame-retardant vanillin-derived small molecules 有权
公开(公告)号：US10689579B2
公开(公告)日：2020-06-23
申请号：US16276878
申请日：2019-02-15
申请人： International Business Machines Corporation
发明人： Brandon M. Kobilka , Joseph Kuczynski , Jacob T. Porter , Jason T. Wertz
IPC分类号： C09K21/12 , C08K5/5313 , C08K5/5317 , C08K5/5337 , C08K5/372 , C07F9/12 , C07F9/14 , C07F9/145 , C07F9/24 , C07F9/40 , C07F9/42 , C07F9/44 , C09K21/14 , C08K5/52 , C08K5/5399 , C07C15/04 , C07F9/08
摘要： A flame-retardant vanillin-derived small molecule, a process for forming a flame-retardant polymer, and an article of manufacture comprising a material that contains the flame-retardant vanillin-derived small molecule are disclosed. The flame-retardant vanillin-derived small molecule can be synthesized from vanillin obtained from a bio-based source, and can have at least one phosphoryl or phosphonyl moiety with phenyl, allyl, or thioether substituents. The process for forming the flame-retardant polymer can include reacting a diol vanillin derivative and a flame-retardant phosphorus-based molecule to form the flame-retardant vanillin-derived small molecule, and binding the flame-retardant vanillin-derived small molecule to a polymer. The material in the article of manufacture can be flame-retardant, and contain the flame-retardant vanillin-derived small molecules. Examples of materials that can be in the article of manufacture can include resins, plastics, adhesives, polymers, etc.

2. 发明授权

US10251982B2 Biocompatible, biomimetic ampholyte materials 有权
公开(公告)号：US10251982B2
公开(公告)日：2019-04-09
申请号：US15429835
申请日：2017-02-10
申请人： BioInteractions Ltd.
发明人： Fanny Burrows , John E. Mckendrick , Alan Rhodes , Simon J. Onis , Shivpal S. Sandhu
IPC分类号： C08F18/22 , A61L33/00 , C08F222/02 , A61L27/34 , A61L31/10 , C07F9/10 , C07F9/6574 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/14 , A61L31/16 , A61L33/06 , C08F230/02 , C07F9/09 , C08F220/18 , C08F220/28 , C09D133/14 , G02B1/04 , C07F9/40 , C07F9/06 , C07F9/08 , C07F9/32 , C07F9/36 , C08F130/02 , C08F122/02 , C08F30/02 , C08F8/40 , C08F8/30 , C08F16/14 , C08F216/14 , C08F116/14
摘要： New ampholyte biomaterial compounds containing ampholyte moieties are synthesized and integrated into polymeric assemblies to provide hydrophilic polymers exhibiting improved biocompatibility, haemocompatibility, hydrophilicity non-thrombogenicity, anti-bacterial ability, and mechanical strength, as well as suitability as a drug delivery platform.

3. 发明申请

US20150353471A1 XANTHINE OXIDASE INHIBITORS AND METHODS OF USE 有权
标题翻译： XANTHINE氧化酶抑制剂及其使用方法
公开(公告)号：US20150353471A1
公开(公告)日：2015-12-10
申请号：US14508960
申请日：2014-10-07
申请人： Baylor College of Medicine
发明人： Changyi Chen , Qizhi YAO , Jian-Ming LU
IPC分类号： C07C205/37 , C07F9/08 , C07C217/58 , C07F7/18 , C07C69/017 , C07D317/62 , C07D317/64 , C07C323/16 , C07C69/02
CPC分类号： C07C205/37 , A61K31/09 , A61K31/11 , A61K31/137 , A61K31/222 , A61K31/275 , A61K31/357 , A61K31/385 , A61K31/4166 , A61K31/426 , A61K31/661 , C07C205/43 , C07C205/44 , C07C207/04 , C07C217/58 , C07C239/12 , C07C251/48 , C07C305/24 , C07C323/16 , C07D317/62 , C07D317/64 , C07F7/1804 , C07F9/12
摘要： Small molecule xanthine oxidase inhibitors are provided, as well as compositions, methods for their use for treating disorders, mediated at least in part, by xanthine oxidase.
摘要翻译：提供了小分子黄嘌呤氧化酶抑制剂，以及组合物，其用于治疗至少部分由黄嘌呤氧化酶介导的病症的方法。

4. 发明授权

US08889760B2 Photoactivatable crosslinker 有权
标题翻译：可光活化交联剂
公开(公告)号：US08889760B2
公开(公告)日：2014-11-18
申请号：US13074537
申请日：2011-03-29
申请人： Aleksey V. Kurdyumov , Dale G. Swan
发明人： Aleksey V. Kurdyumov , Dale G. Swan
IPC分类号： C07F9/08 , C07F9/12 , C07C49/786 , C07F9/145 , C07F9/40 , A61L17/14 , A61L27/34 , A61L29/08 , A61L31/10 , C07F7/10 , C07F7/18 , C08F2/48
CPC分类号： C09D7/63 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2400/18 , A61L2420/02 , C07F7/10 , C07F7/1804 , C07F7/184 , C07F9/06 , C07F9/12 , C07F9/145 , C07F9/4025 , C07F9/4084 , C08F2/48 , C08K5/51 , C08K5/5419 , C08K5/544 , C09D7/1233
摘要： Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
摘要翻译：本文描述了分子式为Photo1-LG-Photo2的可降解连接剂，其中Photo1和Photo2独立地表示至少一个光反应性基团，LG代表包含一个或多个硅原子或一个或多个磷原子的连接基团。可降解交联剂包括至少一个光反应基团和连接基团之间的共价键，其中至少一个光反应基团和连接基团之间的共价键被至少一个杂原子中断。还描述了用可降解的连接剂，涂覆的支撑表面和医疗装置涂覆支撑表面的方法。

5. 发明申请

US20120010407A1 COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY 有权
公开(公告)号：US20120010407A1
公开(公告)日：2012-01-12
申请号：US13241037
申请日：2011-09-22
申请人： Hui Li , Thilo J. Heckrodt , Yan Chen , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Rose Yen
发明人： Hui Li , Thilo J. Heckrodt , Yan Chen , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Rose Yen
IPC分类号： C07F9/08
CPC分类号： C07D413/12 , A61K31/155 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/635 , A61K31/675 , A61K45/06 , C07D401/14 , C07D403/12 , C07D413/04 , C07D413/14 , C07D419/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/08 , C07D498/04 , C07F9/65583
摘要： Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.

6. 发明申请

US20120010173A1 Fosfluconazole Derivatives, Synthesis, and Use in Long Acting Formulations 审中-公开
标题翻译：氟康唑衍生物，合成和用于长效配方
公开(公告)号：US20120010173A1
公开(公告)日：2012-01-12
申请号：US13256875
申请日：2010-03-03
申请人： Yves Rene Johanna Paul Gonnissen , Jody Firmin Marceline Voorspoels
发明人： Yves Rene Johanna Paul Gonnissen , Jody Firmin Marceline Voorspoels
IPC分类号： A61K31/675 , A61K31/683 , C07J43/00 , A61P31/10 , C07F9/146 , C07F9/24 , C07F9/08 , C07F9/6518 , A61K31/685
CPC分类号： C07F9/65583 , A61K31/675 , C07F9/6518
摘要： The invention relates to a compound of formula (I) and the salts, N-oxides, quaternary amines, and stereoisomers thereof, wherein R1 to R8 are as defined in the claims. The invention further relates to intermediates and methods for the preparation of the compounds of formula (I). The invention also relates to the compounds of formula (I) for use as a medicament, particularly for the prevention or treatment of fungal infections.
摘要翻译：本发明涉及式（I）化合物及其盐，N-氧化物，季胺及其立体异构体，其中R 1至R 8如权利要求中所定义。本发明还涉及制备式（I）化合物的中间体和方法。本发明还涉及用作药物，特别是用于预防或治疗真菌感染的式（I）化合物。

7. 发明申请

US20110313182A1 PHOSPHAPLATINS AND THEIR USE IN THE TREATMENT OF CANCERS RESISTANT TO CISPLATIN AND CARBOPLATIN 有权
标题翻译：磷酸钙及其在治疗抗癌药和卡波品的癌症中的应用
公开(公告)号：US20110313182A1
公开(公告)日：2011-12-22
申请号：US13221458
申请日：2011-08-30
申请人： Rathindra N. Bose
发明人： Rathindra N. Bose
IPC分类号： C07F9/08
CPC分类号： C07F15/0086 , A61K31/6615 , A61K31/663 , A61K31/665 , A61K33/24
摘要： The present invention provides phosphaplatins, stable isolated monomeric phosphato complexes of platinum (II) and (IV), and methods of use thereof for treating cancers, including cisplatin- and carboplatin-resistant cancers. Unlike cisplatin, these complexes do not readily undergo hydrolysis and are quite soluble and stable in aqueous solutions. Moreover, these complexes—unlike cisplatin, carboplatin, and related platinum-based anti-cancer agents—do not bind DNA. Rather, data suggests that phosphaplatins trigger overexpression of fas and fas-related transcription factors and some proapoptotic genes such as Bak and Bax. Nevertheless, the complexes exhibit tremendous cytotoxicity towards cancer cells. Thus, the present invention provides novel platinum anticancer agents that have a different molecular target than those in the art.
摘要翻译：本发明提供了磷酸铂蛋白，铂（II）和（IV）的稳定的分离的单体磷酸复合物及其用于治疗癌症的方法，包括顺铂和卡铂耐药性癌症。与顺铂不同，这些复合物不容易经历水解，并且在水溶液中是非常可溶的和稳定的。此外，这些复合物 - 不像顺铂，卡铂和相关的铂类抗癌剂 - 不结合DNA。相反，数据表明磷酸蛋白酶引发fas和fas相关转录因子的过度表达以及一些促细胞凋亡基因如Bak和Bax。然而，复合物对癌细胞表现出巨大的细胞毒性。因此，本发明提供了与本领域相比具有不同分子靶标的新型铂抗癌剂。

8. 发明申请

US20100254931A1 USE OF LONG CARBON CHAIN QUATERNARY AMMONIUM SALT PHOSPHORIC ACID ESTER AS CONDITIONER FOR HAIR 有权
标题翻译：长碳链季铵盐磷酸酯作为发胶的调理剂的应用
公开(公告)号：US20100254931A1
公开(公告)日：2010-10-07
申请号：US12734405
申请日：2007-10-30
申请人： Changguo Wang , Evelyn Su
发明人： Changguo Wang , Evelyn Su
IPC分类号： A61K8/55 , C07F9/08 , A61Q5/12
CPC分类号： A61Q5/12 , A61K8/55 , A61Q5/02
摘要： Use of long carbon chain quaternary ammonium salt phosphoric acid ester of formula (I) as conditioner for hair.
摘要翻译：使用式（I）的长碳链季铵盐磷酸酯作为头发的调理剂。

9. 发明授权

US07745655B1 Method for the preparation of biphosphites 失效
标题翻译：亚磷酸酯的制备方法
公开(公告)号：US07745655B1
公开(公告)日：2010-06-29
申请号：US10505879
申请日：2002-11-28
申请人： Cornelia Borgmann
发明人： Cornelia Borgmann
IPC分类号： C07F9/08
CPC分类号： C07F9/65746 , C07F9/65744
摘要： The present invention relates to a process for preparing bisphosphites which contain dioxaphosphorinone units.
摘要翻译：本发明涉及一种制备含有二氧磷基荧光酮单元的二亚磷酸酯的方法。

10. 发明申请

US20100093239A1 Ethylene Diphosphinic Acids 有权
标题翻译：乙二膦酸
公开(公告)号：US20100093239A1
公开(公告)日：2010-04-15
申请号：US12444794
申请日：2007-10-06
申请人： Harald Bauer , Werner Krause , Peter Staniek
发明人： Harald Bauer , Werner Krause , Peter Staniek
IPC分类号： C08K5/53 , C07F9/08 , B32B27/04
CPC分类号： C07F9/305 , B27K3/34 , B27K2240/30 , C02F5/14 , C02F2103/10 , C02F2103/16 , C02F2303/08 , C07F9/485 , C08G18/388 , C08G18/40 , C08G2101/00 , C08K5/5313 , C09K21/12 , Y10T442/2672 , Y10T442/3976
摘要： The invention relates to ethylene diphosphinic acids and salts thereof of general formula A-P(O)(OX)—CR1R2—CR3R4—P(O)(OX)-A, in which A, H and/or CR5R6—OH,R1,R2,R3,R4,R5,R6 are the same or different, and denote independently from each other H, C1-C20 alkyl, C6-C20 aryl and or C6-C20 aralkyl, and X denotes H, an alkali metal, an element of the second main and secondary group, an element of the third main and secondary group, an element of the fourth main and secondary group, an element of the fifth main and secondary group, an element of the sixth secondary group, an element of the seventh secondary group, an element of the eight secondary group and/or a nitrogen base. Also disclosed are a method for producing same and the use thereof.
摘要翻译：本发明涉及通式AP（O）（OX）-CR1R2-CR3R4-P（O）（OX）-A）的乙烯二磷酸及其盐，其中A，H和/或CR5R6-OH，R1，R2 ，R 3，R 4，R 5，R 6相同或不同，彼此独立地表示H，C 1 -C 20烷基，C 6 -C 20芳基和/或C 6 -C 20芳烷基，X表示H，碱金属，第二主要和次要组，第三主要和第二组的一个元素，第四主要和第二组的元素，第五主要和第二组的元素，第六中等组的元素，第七主要和次要的元素二次基团，八个仲
子基团和/或氮基团的元素。还公开了其制造方法及其用途。

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