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1. 发明授权

US10206945B2 Bioactive coatings 有权
公开(公告)号：US10206945B2
公开(公告)日：2019-02-19
申请号：US14263387
申请日：2014-04-28
申请人： BioInteractions Ltd.
发明人： Simon Onis , Fanny Burrows , Krishan Kapoor , Alan Rhodes , Ajay Luthra
IPC分类号： A61K31/728 , A61K47/32 , A61K31/131 , A61K9/00 , A61K31/727 , A61K31/14 , A61L27/16 , A61L27/26 , A61L27/34 , A61L27/54 , A61L29/04 , A61L29/08 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/16 , A61L33/00 , A61L33/06
摘要： Antimicrobial and antithrombogenic polymer or polymeric blend, compounds, coatings, and materials containing the same, as well as articles made with, or coated with the same, and methods of making the same exhibiting improved antimicrobial properties and reduced platelet adhesion. Embodiments include polymers with antimicrobial and antithrombogenic groups bound to a single polymer backbone, an antimicrobial polymer blended with an antithrombogenic polymer, and medical devices coated with the antimicrobial and antithrombogenic polymer or polymeric blend.

2. 发明申请

US20180258363A1 Coating Solutions, Coatings Formed Therefrom, And Coated Medical Devices 审中-公开
公开(公告)号：US20180258363A1
公开(公告)日：2018-09-13
申请号：US15777983
申请日：2016-11-24
申请人： BioInteractions Ltd.
发明人： Alan Rhodes , Bethany Sheila Huddart
IPC分类号： C10M107/42 , C09D139/06 , C09D5/00 , A61L29/08 , A61L29/14 , C10M149/18 , C10M169/04
CPC分类号： C10M107/42 , A61L29/085 , A61L29/14 , A61L2400/10 , A61L2420/02 , A61L2420/06 , B05D1/18 , B05D3/06 , C08F226/10 , C09D5/00 , C09D139/06 , C10M149/18 , C10M169/041 , C10M169/044 , C10M173/00 , C10M2201/02 , C10M2207/0215 , C10M2209/04 , C10M2209/084 , C10M2209/0845 , C10M2209/104 , C10M2209/12 , C10M2215/086 , C10M2215/10 , C10M2215/22 , C10M2217/024 , C10M2217/028 , C10M2217/0285 , C10M2217/044 , C10M2217/045 , C10N2240/66 , C10N2250/08 , C10N2250/121 , C10N2270/00 , C10M2209/062 , C08F220/06 , C08F2220/285
摘要： A method of making a coating solution includes the steps of polymerising an initial monomer feed comprising an N-vinyl pyrrolidone and an acrylate, preferably methacrylate, salt in water to synthesise a copolymer thereof, acidifying the resulting copolymer-water mixture to give free carboxylic acid groups along the copolymer backbone, diluting the aqueous solution down with alcohol, and adding a cross-linking agent which is capable of reacting with the carboxylic acid groups and curing the copolymer at a later stage after the coating solution has been applied to a substrate and the copolymer coated thereon. Also disclosed are a coating solution in storage, a method of coating a substrate which is on, or is part of, a medical device or other article, a substrate, article or medical device having a coating so applied, and a coated medical device packaged in a hydration solution. The aqueous-alcoholic coating solution may be stored for an extended period, suitably for at least one month and desirably for substantially longer, without deteriorating.

3. 发明申请

US20040142016A1 Polysaccharide biomaterials and methods of use thereof 审中-公开
标题翻译：多糖生物材料及其使用方法
公开(公告)号：US20040142016A1
公开(公告)日：2004-07-22
申请号：US10751706
申请日：2004-01-05
申请人： Biointeractions, Ltd., University of Reading
发明人： Ajay K. Luthra , Shivpal S. Sandhu , John O. Hudson
IPC分类号： A61K031/715
CPC分类号： C08B37/0075 , A61L27/20 , A61L27/34 , A61L27/507 , A61L27/52 , A61L33/0011 , A61L33/0064 , C08B37/0063 , C08B37/0069 , Y10S514/822 , Y10S514/944 , Y10S514/953 , C08L39/06
摘要： Materials and methods for reacting polysaccharides are set forth. Examples include reacting polysaccharides with a surface, and reacting polysaccharides with other polysaccharides or polymers to form a polysaccharide polymer. Layers of polysaccharides and/or polysaccharide polymers may be formed on surfaces, for example, medical device surfaces that contact bodily fluids.
摘要翻译：阐述了多糖反应的材料和方法。实例包括使多糖与表面反应，并使多糖与其它多糖或聚合物反应以形成多糖聚合物。可以在表面上形成多糖和/或多糖聚合物层，例如与体液接触的医疗器械表面。

4. 发明授权

US10251982B2 Biocompatible, biomimetic ampholyte materials 有权
公开(公告)号：US10251982B2
公开(公告)日：2019-04-09
申请号：US15429835
申请日：2017-02-10
申请人： BioInteractions Ltd.
发明人： Fanny Burrows , John E. Mckendrick , Alan Rhodes , Simon J. Onis , Shivpal S. Sandhu
IPC分类号： C08F18/22 , A61L33/00 , C08F222/02 , A61L27/34 , A61L31/10 , C07F9/10 , C07F9/6574 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/14 , A61L31/16 , A61L33/06 , C08F230/02 , C07F9/09 , C08F220/18 , C08F220/28 , C09D133/14 , G02B1/04 , C07F9/40 , C07F9/06 , C07F9/08 , C07F9/32 , C07F9/36 , C08F130/02 , C08F122/02 , C08F30/02 , C08F8/40 , C08F8/30 , C08F16/14 , C08F216/14 , C08F116/14
摘要： New ampholyte biomaterial compounds containing ampholyte moieties are synthesized and integrated into polymeric assemblies to provide hydrophilic polymers exhibiting improved biocompatibility, haemocompatibility, hydrophilicity non-thrombogenicity, anti-bacterial ability, and mechanical strength, as well as suitability as a drug delivery platform.

5. 发明申请

US20170151375A1 BIOCOMPATIBLE, BIOMIMETIC AMPHOLYTE MATERIALS 审中-公开
公开(公告)号：US20170151375A1
公开(公告)日：2017-06-01
申请号：US15429835
申请日：2017-02-10
申请人： BioInteractions Ltd.
发明人： Fanny Burrows , John E. Mckendrick , Alan Rhodes , Simon J. Onis , Shivpal S. Sandhu
IPC分类号： A61L33/00 , C09D133/14 , C08F220/28 , G02B1/04 , A61L29/14 , A61L31/10 , A61L33/06 , C07F9/09 , A61L31/14 , C08F220/18 , A61L29/08
CPC分类号： A61L33/0023 , A61L27/34 , A61L29/085 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/064 , C07B2200/11 , C07F9/062 , C07F9/08 , C07F9/091 , C07F9/106 , C07F9/32 , C07F9/3205 , C07F9/36 , C07F9/40 , C07F9/4078 , C07F9/65742 , C08F8/30 , C08F8/40 , C08F16/14 , C08F18/22 , C08F30/02 , C08F116/14 , C08F122/02 , C08F130/02 , C08F216/14 , C08F220/18 , C08F220/28 , C08F222/02 , C08F230/02 , C08F2220/1825 , C08F2220/281 , C08F2220/285 , C09D133/14 , G02B1/043 , C08L33/26 , C08L33/10 , C08L33/12
摘要： New ampholyte biomaterial compounds containing ampholyte moieties are synthesized and integrated into polymeric assemblies to provide hydrophilic polymers exhibiting improved biocompatibility, haemocompatibility, hydrophilicity non-thrombogenicity, anti-bacterial ability, and mechanical strength, as well as suitability as a drug delivery platform.

6. 发明授权

US11441092B2 Coating solutions, coatings formed therefrom, and coated medical devices 有权
公开(公告)号：US11441092B2
公开(公告)日：2022-09-13
申请号：US15777983
申请日：2016-11-24
申请人： BioInteractions Ltd.
发明人： Alan Rhodes , Bethany Sheila Huddart
IPC分类号： C10M107/42 , A61L29/08 , C10M169/04 , C10M173/00 , C08F226/10 , A61L29/14 , C09D5/00 , C09D139/06 , C10M149/18 , C10N40/00 , C10N50/02 , C10N50/08 , C10N70/00 , B05D1/18 , B05D3/06
摘要： A method of making a coating solution includes the steps of polymerising an initial monomer feed comprising an N-vinyl pyrrolidone and an acrylate, preferably methacrylate, salt in water to synthesise a copolymer thereof, acidifying the resulting copolymer-water mixture to give free carboxylic acid groups along the copolymer backbone, diluting the aqueous solution down with alcohol, and adding a cross-linking agent which is capable of reacting with the carboxylic acid groups and curing the copolymer at a later stage after the coating solution has been applied to a substrate and the copolymer coated thereon. Also disclosed are a coating solution in storage, a method of coating a substrate which is on, or is part of, a medical device or other article, a substrate, article or medical device having a coating so applied, and a coated medical device packaged in a hydration solution. The aqueous-alcoholic coating solution may be stored for an extended period, suitably for at least one month and desirably for substantially longer, without deteriorating.

7. 发明申请

US20140322287A1 BIOACTIVE COATINGS 审中-公开
标题翻译：生物涂料
公开(公告)号：US20140322287A1
公开(公告)日：2014-10-30
申请号：US14263387
申请日：2014-04-28
申请人： BioInteractions Ltd.
发明人： Simon Onis , Fanny Burrows , Krishan Kapoor , Alan Rhodes , Ajay Luthra
IPC分类号： A61K31/728 , A61K47/32 , A61K31/131 , A61K9/00 , A61K31/727 , A61K31/14
CPC分类号： A61K31/728 , A61K9/0012 , A61K31/131 , A61K31/14 , A61K31/727 , A61K47/32 , A61L27/16 , A61L27/26 , A61L27/34 , A61L27/54 , A61L29/041 , A61L29/049 , A61L29/085 , A61L29/16 , A61L31/041 , A61L31/048 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L33/064 , A61L2300/206 , A61L2300/208 , A61L2300/236 , A61L2300/404 , A61L2300/42 , A61L2300/44 , A61L2300/45
摘要： Antimicrobial and antithrombogenic polymer or polymeric blend, compounds, coatings, and materials containing the same, as well as articles made with, or coated with the same, and methods of making the same exhibiting improved antimicrobial properties and reduced platelet adhesion. Embodiments include polymers with antimicrobial and antithrombogenic groups bound to a single polymer backbone, an antimicrobial polymer blended with an antithrombogenic polymer, and medical devices coated with the antimicrobial and antithrombogenic polymer or polymeric blend.
摘要翻译：抗微生物和抗血栓形成聚合物或聚合物共混物，化合物，涂料和含有它们的材料，以及用其制备或涂覆的制品以及制备该抗体的方法显示改进的抗微生物性能和降低的血小板粘附。实施方案包括具有结合单个聚合物主链的抗微生物和抗血栓形成基团的聚合物，与抗血栓形成聚合物共混的抗微生物聚合物，以及用抗微生物剂和抗血栓形成聚合物或聚合物共混物涂覆的医疗器械。

8. 发明申请

US20030229376A1 Coated surfaces for immobilizing negatively charged anticoagulating agents from blood fluid 有权
标题翻译：用于从血液中固定带负电荷的抗凝剂的涂层表面
公开(公告)号：US20030229376A1
公开(公告)日：2003-12-11
申请号：US10389696
申请日：2003-03-14
申请人： BioInteractions Ltd.
发明人： Shivpal S. Sandhu
IPC分类号： A61D001/00
CPC分类号： A61B17/00491 , A61B17/0057 , Y10T428/2996 , Y10T428/31928
摘要： A wound closure apparatus is provided which utilizes blood fluid by activating the clotting cascade of blood fluid outside the body within a substantially enclosed sterile container then introducing, the blood fluid to the wound site to complete clotting. An apparatus for providing ways of inhibiting anticoagulating agents, and slowing fibrin clot degradation are also disclosed. Kits for practicing the invention singularly or in combination with, and/or associated with preferred procedures are also disclosed. The invention provides a clotting cascade initiation apparatus (1) including a substantially enclosed sterile containment chamber within which an aliquot of blood fluid, either autologous or from donor sources can be received, and retained. In preferred embodiments, the sterile containment chamber further includes a heparin binding agent which will bind heparin and remove it from the blood fluid. In further embodiments, the containment chamber will also include a procoagulating agent, wherein a clotting cascade can be initiated when the blood fluid is accepted into the sterile containment chamber.
摘要翻译：提供了一种创伤闭合装置，其利用血液流体，通过在基本上封闭的无菌容器内激活身体外部的血液流体的凝血级联，然后将血液流体引入伤口部位以完成凝血。还公开了一种用于提供抑制抗凝剂的方法以及减缓纤维蛋白凝块降解的装置。还公开了单独实施本发明或与优选方法组合和/或与其相关联的试剂盒。本发明提供了一种凝血级联引发装置（1），其包括基本上封闭的无菌容纳室，其中可以接收自体或来自供体来源的血液的等分试样并保留。在优选的实施方案中，无菌容纳室还包括肝素结合剂，其将结合肝素并将其从血液中除去。在另外的实施方案中，容纳室还将包括促凝剂，其中当血液流体被接受到无菌容纳室中时可以开始凝血级联。

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