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1. 发明申请

US20200017887A1 Non-Pressurised Pre-Treatment, Enzymatic Hydrolysis And Fermentation Of Waste Fractions 审中-公开
公开(公告)号：US20200017887A1
公开(公告)日：2020-01-16
申请号：US16580516
申请日：2019-09-24
申请人： RENESCIENCE A/S
发明人： Jan Larsen , Nanna Drayer Nørholm , Frank Krogh Iversen
IPC分类号： C12P7/10 , C12P7/06 , C12M1/00 , C12M1/08 , C12M1/06 , B09B3/00 , C12P19/00
摘要： The present invention relates to a process for production of fermentation products, including bioethanol by non-pressurised pre-treatment, enzymatic hydrolysis and fermentation of waste fractions containing mono- and/or polysaccharides, having a relatively high dry matter content. The process in its entirety, i.e. from non-pressurised pre-treatment over enzymatic hydrolysis and fermentation to sorting of fermentable and non-fermentable solids can be processed at a relatively high dry matter content in a single vessel or similar device using free fall mixing for the mechanical processing of the waste fraction.

2. 发明授权

US10344302B2 Cyclic bioconversion processes and bioreactor assemblies 有权
公开(公告)号：US10344302B2
公开(公告)日：2019-07-09
申请号：US15378997
申请日：2016-12-14
申请人： Microvi Biotech, Inc.
发明人： Fatemeh Razavi-Shirazi , Mohammad Ali Dorri , Ameen Razavi
IPC分类号： C12P7/00 , C12P7/04 , C12M1/00 , C12M1/12 , C12M1/08 , C12N11/00 , C12P7/26 , C12P7/64
摘要： Bioconversion processes are disclosed in which biocatalysts including microorganisms or isolated enzymes that are substantially irreversibly retained in the interior of an open, porous, highly hydrophilic polymer are cycled between at least two different fluid media for the bioconversion of one or more substrates to one or more bioproducts. The processes are particularly attractive for using gas phase or using liquid feedstocks containing the substrate.

3. 发明授权

US09914944B2 Non-pressurised pre-treatment, enzymatic hydrolysis and fermentation of waste fractions 有权
$Non-pressurised pre-treatment, enzymatic hydrolysis and fermentation of waste fractions$
公开(公告)号：US09914944B2
公开(公告)日：2018-03-13
申请号：US12088431
申请日：2006-09-29
申请人： Nanna Dreyer Nørholm , Jan Larsen , Frank Krogh Iversen
发明人： Nanna Dreyer Nørholm , Jan Larsen , Frank Krogh Iversen
IPC分类号： C12P7/10 , C12P7/06 , C12P19/00 , B09B3/00 , C12M1/06 , C12M1/08 , C12M1/00 , C12N9/42 , C12N9/48 , C12N9/26 , C12N9/20 , C12N9/24
CPC分类号： C12P7/10 , B09B3/00 , B09B3/0091 , C12M27/02 , C12M27/06 , C12M27/24 , C12M45/04 , C12M45/06 , C12M45/20 , C12N9/20 , C12N9/2411 , C12N9/2437 , C12N9/2477 , C12N9/48 , C12P7/06 , C12P19/00 , Y02E50/16 , Y02E50/17 , Y02E50/343
摘要： The present invention relates to a process for production of fermentation products, including bioethanol by non-pressurized pre-treatment, enzymatic hydrolysis and fermentation of waste fractions containing mono- and/or polysaccharides, having a relatively high dry matter content. The process in its entirety, i.e. from non-pressurized pre-treatment over enzymatic hydrolysis and fermentation to sorting of fermentable and non-fermentable solids can be processed at a relatively high dry matter content in a single vessel or similar device using free fall mixing for the mechanical processing of the waste fraction.

4. 发明申请

US20170191018A1 BIOCHEMICAL REACTOR WITH SIDE NOZZLES 审中-公开
公开(公告)号：US20170191018A1
公开(公告)日：2017-07-06
申请号：US15468033
申请日：2017-03-23
申请人： MIH WATER TREATMENT, INC.
发明人： Peter J. Hall
IPC分类号： C12M1/00 , C12M1/08
CPC分类号： C12M29/06 , A43B3/105 , A43B3/12 , A43B23/24 , A43B23/25 , A45C13/001 , A45C13/08 , C12M23/02 , C12M27/24 , C12M29/04 , Y10T29/49826 , Y10T29/49963
摘要： This disclosure describes a biochemical reactor with side nozzles. The biochemical reactor may include a tank configured to house immobilized carriers and fluid. The biochemical reactor may include a circulation conduit at least partially disposed within the tank. The circulation conduit may include a circulation inlet opening and a circulation outlet opening. The biochemical reactor may include one or more vanes disposed proximate to the circulation outlet opening. The one or more vanes may be configured to cause the immobilized carrier and the fluid exiting the circulation outlet opening to enter into a helical pattern. The biochemical reactor may include one or more side nozzles configured to induce a tangential flow of fluid within the tank. The one or more side nozzles may be disposed proximate to the circulation inlet opening and/or the circulation outlet opening.

5. 发明申请

US20170088860A1 CYCLIC BIOCONVERSION PROCESSES AND BIOREACTOR ASSEMBLIES 审中-公开
公开(公告)号：US20170088860A1
公开(公告)日：2017-03-30
申请号：US15378997
申请日：2016-12-14
申请人： Microvi Biotech, Inc.
发明人： Fatemeh RAZAVI-SHIRAZI , Mohammad Ali DORRI , Ameen RAZAVI
IPC分类号： C12P7/04 , C12M1/12 , C12N11/00 , C12P7/64 , C12P7/26 , C12M1/00 , C12M1/08
CPC分类号： C12P7/04 , C12M23/34 , C12M25/20 , C12M27/24 , C12M29/18 , C12N11/00 , C12P7/26 , C12P7/649 , Y02P20/142
摘要： Bioconversion processes are disclosed in which biocatalysts including microorganisms or isolated enzymes that are substantially irreversibly retained in the interior of an open, porous, highly hydrophilic polymer are cycled between at least two different fluid media for the bioconversion of one or more substrates to one or more bioproducts. The processes are particularly attractive for using gas phase or using liquid feedstocks containing the substrate.

6. 发明授权

US09181521B2 Bioreactor with upward flowing impeller system for use in a mammalian cell culture process 有权
标题翻译：具有向上流动的叶轮系统的生物反应器用于哺乳动物细胞培养过程
公开(公告)号：US09181521B2
公开(公告)日：2015-11-10
申请号：US13559957
申请日：2012-07-27
申请人： Alan T. Y. Cheng , Ying Zhou , Amitabh Gupta , Balazs Hunek , Nigel Grinter
发明人： Alan T. Y. Cheng , Ying Zhou , Amitabh Gupta , Balazs Hunek , Nigel Grinter
IPC分类号： C12M1/06 , C12M1/00 , C12N1/38 , C12M1/08 , C12M1/34 , C12M1/36
CPC分类号： C12M27/20 , C12M27/02 , C12M27/24 , C12M29/06 , C12M41/12 , C12M41/26 , C12M41/32 , C12M41/48 , C12N1/38
摘要： A bioreactor with an upward flowing impeller system for controlling a mammalian cell culture process is provided. The disclosed system enables control of the cell culture process by controlling the level of dissolved carbon dioxide in the cell culture media and prevent increases in the osmolality level is achieved by enhanced stripping of carbon dioxide via surface gas exchange with little or no damage to the mammalian cells. The use of an upward flow impeller combined with vertical baffles converts the swirling motions of the cell culture media into a largely vertical flow and promotes the removal of dissolved carbon dioxide via surface gas exchange with a sweep gas flowing over the top surface of the cell culture media within the bioreactor vessel.
摘要翻译：提供了一种具有向上流动的叶轮系统用于控制哺乳动物细胞培养过程的生物反应器。所公开的系统能够通过控制细胞培养基中溶解的二氧化碳的水平来控制细胞培养过程，并且通过经由表面气体交换增强汽提二氧化碳来实现渗透压浓度的增加，对哺乳动物几乎没有或没有损伤细胞。使用与垂直挡板结合的向上流动叶轮将细胞培养基的旋转运动转化为大体垂直的流动，并通过与流过细胞培养物顶表面的吹扫气体的表面气体交换促进去除溶解的二氧化碳生物反应器容器内的介质。

7. 发明申请

US20120244609A1 Composite sensor assemblies for single use bioreactors 有权
标题翻译：用于单次生物反应器的复合传感器组件
公开(公告)号：US20120244609A1
公开(公告)日：2012-09-27
申请号：US13385100
申请日：2012-02-02
申请人： Mark Selker , Barbara Paldus , Timothy Johnston
发明人： Mark Selker , Barbara Paldus , Timothy Johnston
IPC分类号： C12M1/34 , C12M1/02 , B32B38/00 , C12M1/08
CPC分类号： C12M27/14 , C12M23/00 , C12M29/00 , C12M29/06 , G01N21/359 , G01N21/552 , G01N21/65 , G01N21/8507
摘要： A composite sensor assembly for monitoring bio-processes which is suitable for use with a polymeric bioprocess vessel or with downstream equipment, and comprises: i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, the base plate portion being fusibly sealable to the bioreactor vessel at a hole in the wall thereof; ii) a generally opaque polymeric monitoring sensor assembly including electrical, and/or optical measurement components. The sensor assembly fits inside the bore of the hollow tubular portion of the port, and is adhesively retained therein.
摘要翻译：一种用于监测适用于聚合物生物过程容器或与下游设备的生物过程的复合传感器组件，包括：i）包含具有中空管状部分和底板部分的高表面张力热塑性塑料的端口，板部分在其壁的孔处易于密封到生物反应器容器; ii）包括电和/或光学测量部件的通常不透明的聚合物监测传感器组件。传感器组件装配在端口的中空管状部分的孔内，并且粘合地保持在其中。

8. 发明申请

US20070275452A1 Biological reaction method and bioreactor 有权
标题翻译：生物反应法和生物反应器
公开(公告)号：US20070275452A1
公开(公告)日：2007-11-29
申请号：US11783671
申请日：2007-04-11
申请人： Kazuyuki Yamasaki , Kazuyuki Sakata , Kazumi Chuhjoh , Masaki Kataoka
发明人： Kazuyuki Yamasaki , Kazuyuki Sakata , Kazumi Chuhjoh , Masaki Kataoka
IPC分类号： C12N1/02 , C12M1/06 , C12N1/20 , C12M1/08
CPC分类号： C12M27/02 , B01F2215/0073 , C12M29/02 , C12M29/06 , C12M37/02
摘要： In a bioreactor, a culture solution derived from a cultivation tank is separated into bacteria cells and filtrate by a bacteria cell filter. The filtrate is introduced from the bacteria cell filter into a micro-nano bubble generation tank where micro-nano-bubbles are mixed with the filtrate. The filtrate containing micro-nano-bubbles is returned to the cultivation tank to activate the microorganisms therein, so that a biological reaction time is reduced by the activated microorganisms.
摘要翻译：在生物反应器中，将来自培养槽的培养液分离成细菌细胞并用细菌细胞过滤器滤液。将滤液从细菌细胞过滤器引入到微纳米气泡生成罐中，其中将微纳米气泡与滤液混合。将含有微纳米气泡的滤液返回到培养槽中以活化其中的微生物，从而通过活化的微生物降低生物反应时间。

9. 发明授权

US5934012A Process for production of mushroom inoculum 失效
标题翻译：生产蘑菇接种物的方法
公开(公告)号：US5934012A
公开(公告)日：1999-08-10
申请号：US344243
申请日：1994-11-23
申请人： Richard Barry Holtz , Michael J. McCulloch
发明人： Richard Barry Holtz , Michael J. McCulloch
IPC分类号： A01G1/04 , A23L1/28 , C12M1/08
CPC分类号： C12M29/08 , A01G1/04 , A23L31/00
摘要： This invention relates to a submerged fermentation process for producing high biomass levels of mushrooms mycelia in liquid media suitable for semi-continuous or continuous mushroom spawn production. The process provides a sterile, log phase inoculum for a solid substrate that, when based on biomass, exceeds normal inoculation levels by several thousand fold mycelia substrate production. The liquid inoculum so produced can be aseptically transferred to bulk sterilizer to inoculate a sterilizer grain or sawdust substrate for commercial mushroom production. The liquid inoculum may also be inoculated directly onto the mushroom compost. This invention further relates to microcapsules used to enhance the fermentation process and the equipment used to conduct such process.
摘要翻译：本发明涉及用于在适于半连续或连续的蘑菇产卵生产的液体培养基中产生高生物量的蘑菇菌丝体的浸没发酵方法。该方法为固体底物提供无菌的对数期接种物，当基于生物量时，超过正常接种水平达数千倍的菌丝体底物生产。如此生产的液体接种物可以无菌转移到大容量灭菌器中以接种用于商业蘑菇生产的杀菌剂颗粒或锯屑底物。液体接种物也可以直接接种在蘑菇堆肥上。本发明还涉及用于增强发酵过程的微胶囊和用于进行该方法的设备。

10. 发明授权

US5198362A Sterile aerobic fermentation process 失效
标题翻译：纯天然气发酵过程
公开(公告)号：US5198362A
公开(公告)日：1993-03-30
申请号：US350770
申请日：1989-05-11
申请人： Malcolm W. Forsyth , Stephen H. Hind
发明人： Malcolm W. Forsyth , Stephen H. Hind
IPC分类号： C12M1/08 , B01F3/04 , B01F5/10 , C12M1/04 , C12N1/00
CPC分类号： B01F5/106 , B01F3/04531 , C12M27/02 , C12M29/06 , C12M29/18 , B01F2003/0468 , B01F2003/04879
摘要： The present invention is directed to a fermentation process and a fermenter, wherein aeration is improved by injecting substantially pure oxygen into culture medium by outside the fermenter means including a venturi located outside the main body of the fermenter. The oxygen is preferably injected at the throat of the venturi. The volume of the culture medium outside the fermenter is not greater than 5% of the total volume of the culture medium. The invention is particularly suitable for use in the fermentation of viscous cultures, such as cultures of filamentous fungi.

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